Detailed information for compound 1438193

Basic information

Technical information
  • TDR Targets ID: 1438193
  • Name: 2-methylpropyl N-[5-(phenylmethyl)-1,3,4-thia diazol-2-yl]carbamate
  • MW: 291.369 | Formula: C14H17N3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.57 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(COC(=O)Nc1nnc(s1)Cc1ccccc1)C
  • InChi: 1S/C14H17N3O2S/c1-10(2)9-19-14(18)15-13-17-16-12(20-13)8-11-6-4-3-5-7-11/h3-7,10H,8-9H2,1-2H3,(H,15,17,18)
  • InChiKey: PODSUWFXVDWCHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • isobutyl N-[5-(phenylmethyl)-1,3,4-thiadiazol-2-yl]carbamate
  • N-[5-(phenylmethyl)-1,3,4-thiadiazol-2-yl]carbamic acid isobutyl ester
  • N-[5-(benzyl)-1,3,4-thiadiazol-2-yl]carbamic acid isobutyl ester
  • SMR000280979
  • ZINC00322742
  • (5-Benzyl-[1,3,4]thiadiazol-2-yl)-carbamic acid isobutyl ester
  • BAS 00450582
  • Oprea1_698453
  • Oprea1_772469
  • MLS000711212

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0212 0.0635
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0212 0.0635
Schistosoma mansoni hypothetical protein 0.0022 0.0021 0.0034
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.0402
Loa Loa (eye worm) MBCTL1 0.0057 0.0258 0.1155
Echinococcus granulosus muscleblind protein 0.018 0.1093 0.3462
Wolbachia endosymbiont of Brugia malayi phenylalanyl-tRNA synthetase subunit alpha 0.15 1 1
Echinococcus granulosus sodium channel protein 0.0158 0.0944 0.2984
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0034 0.0067
Schistosoma mansoni hypothetical protein 0.0043 0.0169 0.07
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.3132 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0296 0.0906
Brugia malayi MH2 domain containing protein 0.0144 0.0849 0.3654
Loa Loa (eye worm) hypothetical protein 0.0044 0.0176 0.0787
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0169 0.0498
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0641 0.2869
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0212 0.0635
Echinococcus multilocularis muscleblind protein 1 0.018 0.1093 0.3462
Loa Loa (eye worm) hypothetical protein 0.0074 0.0374 0.1672
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.3132 1
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0641 0.2596
Brugia malayi 6-phosphofructokinase 0.0113 0.0641 0.2703
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.0641 0.0522
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0198 0.083
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.0402
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0849 0.3799
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0198 0.0672
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0113 0.0449
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0641 0.2596
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0113 0.032
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.0654 0.2054
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.0641 0.2869
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0258 0.1101
Chlamydia trachomatis phenylalanine--tRNA ligase subunit beta 0.0037 0.0125 0.0043
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.0641 0.2012
Brugia malayi mbt repeat family protein 0.005 0.0212 0.0735
Mycobacterium leprae Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.0217 0.1339 1
Echinococcus granulosus lysine specific demethylase 5A 0.0045 0.0177 0.0523
Toxoplasma gondii Ferredoxin-fold anticodon binding domain-containing protein 0.0233 0.1451 0.6361
Echinococcus multilocularis muscleblind protein 0.018 0.1093 0.3462
Brugia malayi Bromodomain containing protein 0.0038 0.013 0.0361
Schistosoma mansoni hypothetical protein 0.0035 0.0113 0.0449
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0641 0.2826
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0196 0.1199 0.3802
Plasmodium vivax phenylalanine--tRNA ligase alpha subunit, putative 0.0349 0.2234 1
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0206 0.0618
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0258 0.0784
Brugia malayi 6-phosphofructokinase 0.0113 0.0641 0.2703
Onchocerca volvulus 0.005 0.0212 1
Echinococcus multilocularis phenylalanyl tRNA synthetase alpha chain B 0.0349 0.2234 0.7121
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0212 0.0947
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0258 0.0784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0198 0.083
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0849 0.3799
Echinococcus multilocularis sodium channel protein 0.0158 0.0944 0.2984
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0113 0.0143
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0233 0.1451 0.6361
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0212 0.0892
Mycobacterium ulcerans phenylalanyl-tRNA synthetase subunit alpha 0.15 1 1
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.0641 0.2012
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0196 0.1199 0.3802
Loa Loa (eye worm) hypothetical protein 0.0042 0.0162 0.0727
Giardia lamblia Phenylalanyl-tRNA synthetase alpha chain 0.0349 0.2234 1
Echinococcus granulosus phenylalanyl tRNA synthetase 0.0233 0.1451 0.461
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0177 0.0735
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0169 0.07
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0641 0.2596
Schistosoma mansoni jumonji/arid domain-containing protein 0.0045 0.0177 0.0735
Brugia malayi PHD-finger family protein 0.0035 0.0113 0.0285
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0212 0.0892
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0258 0.0784
Brugia malayi jmjC domain containing protein 0.0115 0.0654 0.2762
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0212 0.0635
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0129 0.0369
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.0402
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2234 1
Brugia malayi Bromodomain containing protein 0.0078 0.0404 0.1616
Echinococcus granulosus geminin 0.0205 0.1257 0.3987
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0158 0.0944 0.2984
Plasmodium falciparum phenylalanine--tRNA ligase 0.0233 0.1451 0.6361
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0034 0.0094
Loa Loa (eye worm) phosphofructokinase 0.0113 0.0641 0.2869
Echinococcus multilocularis phenylalanyl tRNA synthetase 0.0233 0.1451 0.461
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0641 0.2596
Brugia malayi phenylalanyl-tRNA synthetase, mitochondrial precursor, putative 0.0233 0.1451 0.6414
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.0641 0.0522
Giardia lamblia PHD finger protein 15 0.0035 0.0113 0.0143
Brugia malayi phosphofructokinase 0.0113 0.0641 0.2703
Loa Loa (eye worm) jmjC domain-containing protein 0.0045 0.0177 0.0791
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.0366 0.1639
Brugia malayi mbt repeat family protein 0.005 0.0212 0.0735
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0296 0.0906
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0771 0.3199
Leishmania major phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2234 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0258 0.0784
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0129 0.0369
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0198 0.0591
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0163 0.048
Trypanosoma brucei phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2234 1
Loa Loa (eye worm) hypothetical protein 0.018 0.1093 0.4893
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0113 0.0507
Echinococcus granulosus neuropeptide s receptor 0.0482 0.3132 1
Echinococcus multilocularis peregrin 0.0038 0.013 0.0373
Loa Loa (eye worm) hypothetical protein 0.018 0.1093 0.4893
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0198 0.0591
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0349 0.2234 1
Treponema pallidum phenylalanyl-tRNA synthetase subunit alpha 0.0349 0.2234 1
Schistosoma mansoni hypothetical protein 0.0303 0.1918 0.8574
Echinococcus granulosus phenylalanyl tRNA synthetase alpha chain B 0.0349 0.2234 0.7121
Entamoeba histolytica hypothetical protein 0.0043 0.0169 0.0402
Loa Loa (eye worm) hypothetical protein 0.0057 0.0258 0.1155
Loa Loa (eye worm) hypothetical protein 0.004 0.0146 0.0653
Mycobacterium tuberculosis Probable phenylalanyl-tRNA synthetase, alpha chain PheS 0.15 1 1
Entamoeba histolytica phenylalanyl-tRNA synthetase alpha subunit, putative 0.0349 0.2234 1
Plasmodium falciparum phd finger protein, putative 0.0035 0.0113 0.0143
Loa Loa (eye worm) hypothetical protein 0.005 0.0212 0.0947
Toxoplasma gondii phenylalanyl-tRNA synthetase alpha chain A, putative 0.0349 0.2234 1
Schistosoma mansoni bromodomain containing protein 0.0066 0.0321 0.1386
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0641 0.2596
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0034 0.0067
Schistosoma mansoni phenylalanyl-tRNA synthetase subunit alpha 0.0133 0.0771 0.341
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0113 0.0143
Loa Loa (eye worm) hypothetical protein 0.0035 0.0113 0.0507
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0212 0.0892
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0113 0.0143
Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit 0.0349 0.2234 1
Schistosoma mansoni phenylalanyl-tRNA synthetase mitochondrial 0.0233 0.1451 0.6474
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.3132 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0212 1
Brugia malayi hypothetical protein 0.0043 0.0169 0.054
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0158 0.0944 0.1901
Echinococcus granulosus peregrin 0.0038 0.013 0.0373
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0494 0.2164
Loa Loa (eye worm) hypothetical protein 0.006 0.0283 0.1267
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.0641 0.2596
Echinococcus multilocularis geminin 0.0205 0.1257 0.3987
Plasmodium vivax phenylalanine--tRNA ligase, putative 0.0133 0.0771 0.3199
Trypanosoma cruzi phenylalanyl-tRNA synthetase alpha chain, putative 0.0349 0.2234 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0113 0.032
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0021 0.0094
Schistosoma mansoni hypothetical protein 0.0205 0.1257 0.5599
Brugia malayi Muscleblind-like protein 0.018 0.1093 0.4774
Brugia malayi jmjC domain containing protein 0.0045 0.0177 0.0576
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.0641 0.2596
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0198 0.0591
Schistosoma mansoni hypothetical protein 0.0205 0.1257 0.5599
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0258 0.0948
Trichomonas vaginalis phenylalanyl-tRNA synthetase alpha chain, putative 0.0133 0.0771 0.3199
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0198 0.0885
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.0641 0.2596
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0198 0.083
Plasmodium falciparum phenylalanine--tRNA ligase 0.017 0.102 0.4359
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0206 0.0618
Brugia malayi phenylalanyl (f) trna synthetase protein 1 0.0349 0.2234 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0169 0.0498
Loa Loa (eye worm) hypothetical protein 0.0349 0.2234 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0198 0.0591
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.0654 0.2054
Brugia malayi Bromodomain containing protein 0.004 0.0145 0.0432
Loa Loa (eye worm) phenylalanyl-tRNA synthetase 0.0233 0.1451 0.6495
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.0641 0.2826

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.3601 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 19.9526 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 37.6858 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504856] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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