Detailed information for compound 1438999

Basic information

Technical information
  • TDR Targets ID: 1438999
  • Name: 3-(4-methylphenyl)-1-(3-morpholin-4-ylpropyl) -1-(pyridin-2-ylmethyl)thiourea
  • MW: 384.538 | Formula: C21H28N4OS
  • H donors: 1 H acceptors: 1 LogP: 2.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)NC(=S)N(Cc1ccccn1)CCCN1CCOCC1
  • InChi: 1S/C21H28N4OS/c1-18-6-8-19(9-7-18)23-21(27)25(17-20-5-2-3-10-22-20)12-4-11-24-13-15-26-16-14-24/h2-3,5-10H,4,11-17H2,1H3,(H,23,27)
  • InChiKey: RORLOCLZRAEOIW-UHFFFAOYSA-N  

Network

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Synonyms

  • 3-(4-methylphenyl)-1-(3-morpholinopropyl)-1-(2-pyridylmethyl)thiourea
  • MLS000586296
  • N'-(4-methylphenyl)-N-(3-morpholin-4-ylpropyl)-N-(pyridin-2-ylmethyl)thiourea
  • SMR000204659

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0225 0.0625 0.5
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0225 0.0625 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0871 0.4806 0.6234
Mycobacterium ulcerans polyketide synthase Pks13 0.1313 0.7675 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0871 0.4806 0.5931
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0225 0.0625 1
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0225 0.0625 0.1108
Onchocerca volvulus Fatty acid synthase homolog 0.1615 0.9625 1
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0102 0.0051
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0837 0.4588 0.5947
Giardia lamblia Methyltransferase like 2 0.027 0.0916 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0567 0.2842 0.3145
Mycobacterium ulcerans polyketide synthase 0.0926 0.5167 0.6442
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0225 0.0625 0.5
Toxoplasma gondii type I fatty acid synthase, putative 0.0926 0.5167 1
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0219 0.0586 0.0693
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0868 0.4791 0.6214
Mycobacterium ulcerans polyketide synthase MbtD 0.0275 0.0952 0.0464
Mycobacterium ulcerans thioesterase TesA 0.0746 0.4002 0.4791
Schistosoma mansoni methyltransferase-related 0.027 0.0916 1
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0281 0.0991 0.1224
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.1313 0.7675 1
Trichomonas vaginalis conserved hypothetical protein 0.027 0.0916 0.6079
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0837 0.4588 0.5211
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0926 0.5167 0.6442
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0696 0.3673 0.4746
Mycobacterium ulcerans polyketide synthase Pks9 0.0567 0.2842 0.3145
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0926 0.5167 0.6707
Loa Loa (eye worm) hypothetical protein 0.1479 0.875 1
Onchocerca volvulus 0.1559 0.9264 0.9605
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0281 0.0991 0.1224
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0225 0.0625 0.0651
Mycobacterium ulcerans Type I modular polyketide synthase 0.0871 0.4806 0.5931
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1188 1
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0225 0.0625 0.5
Leishmania major hypothetical protein, conserved 0.027 0.0916 1
Mycobacterium ulcerans fatty acid synthase Fas 0.0281 0.0991 0.0519
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0225 0.0625 0.5
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0871 0.4806 0.6234
Onchocerca volvulus 0.0837 0.4588 0.4484
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0696 0.3673 0.4324
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1188 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0871 0.4806 0.5931
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0926 0.5167 0.6707
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0926 0.5167 0.6707
Mycobacterium ulcerans thioesterase 0.0746 0.4002 0.4791
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0581 0.2931 0.5624
Mycobacterium ulcerans Type I modular polyketide synthase 0.0871 0.4806 0.5931
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0746 0.4002 0.5178
Brugia malayi AMP-binding enzyme family protein 0.0275 0.0952 0.0858
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1188 1
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0565 0.1027
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0707 0.3749 0.4846
Mycobacterium ulcerans polyketide synthase 0.0871 0.4806 0.5931
Mycobacterium tuberculosis Hypothetical protein 0.027 0.0916 0.1126
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0643 0.3335 0.4302
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0696 0.3673 0.4324
Mycobacterium leprae Polyketide synthase Pks13 0.1313 0.7675 1
Mycobacterium tuberculosis Conserved protein 0.027 0.0916 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1188 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0871 0.4806 0.6234
Loa Loa (eye worm) fatty acid synthase 0.0884 0.4892 0.5561
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0926 0.5167 0.6707
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.1188 0.13
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0102 0.0051
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0871 0.4806 0.6234
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0567 0.2842 0.3654
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0565 0.1027
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0926 0.5167 0.6442
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0225 0.0625 0.0528
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0871 0.4806 0.6234
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0868 0.4791 0.6214
Mycobacterium leprae Probable polyketide synthase Pks1 0.0926 0.5167 0.6707
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0283 0.1 0.1236
Mycobacterium tuberculosis Polyketide synthase Pks13 0.1313 0.7675 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0362 0.1514 0.1911
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0509 0.2466 0.3161
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0871 0.4806 0.4753
Loa Loa (eye worm) hypothetical protein 0.0477 0.2256 0.2528
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0453 0.21 0.3997
Mycobacterium tuberculosis Probable thioesterase TesA 0.0746 0.4002 0.5178
Brugia malayi Methyltransferase-like protein 4 0.027 0.0916 0.0822
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0225 0.0625 0.5
Loa Loa (eye worm) acyl carrier protein 0.0412 0.1836 0.2045
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0225 0.0625 0.5
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1188 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0926 0.5167 0.6707
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0225 0.0625 0.5
Brugia malayi AMP-binding enzyme family protein 0.0837 0.4588 0.4532
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.1188 1
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0275 0.0952 0.1173
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.1188 0.1097
Toxoplasma gondii type I fatty acid synthase, putative 0.0638 0.3298 0.6341

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0045 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 0.0158 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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