TDR Targets

Basic information

Technical information

TDR Targets ID: 1440086
Name: STK286456
MW: 461.465 | Formula: C29H19NO5
H donors: 0 H acceptors: 3 LogP: 4.56 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccco1)Oc1cccc(c1)N1C(=O)C2C(C1=O)C1c3c(C2c2c1cccc2)cccc3
InChi: 1S/C29H19NO5/c31-27-25-23-18-9-1-2-10-19(18)24(21-12-4-3-11-20(21)23)26(25)28(32)30(27)16-7-5-8-17(15-16)35-29(33)22-13-6-14-34-22/h1-15,23-26H
InChiKey: GIDBELGXGGFGOY-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-(16,18-dioxo-17-azapentacyclo[6.6.5.0~2,7~.0~9,14~.0~15,19~]nonadeca-2,4,6,9,11,13-hexaen-17-yl)phenyl 2-furoate
MLS000577931
SMR000198333

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	tumor protein p53	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038
Echinococcus granulosus	tumor protein p63	Get druggable targets OG5_140038	All targets in OG5_140038

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	sterol O-acyltransferase 1	0.0356	0.067	0.078
Schistosoma mansoni	membrane-bound acyltransferase/hhat	0.0356	0.067	0.078
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0232	0.0409	0.0409
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0376	0.0712	0.0712
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.026	0.0467	0.6322
Entamoeba histolytica	hypothetical protein	0.126	0.2562	0.7895
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0108	0.015	0.0164
Loa Loa (eye worm)	phosphatidylinositol 3	0.0376	0.0712	0.0819
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0232	0.0409	0.0465
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.026	0.0467	0.1037
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.026	0.0467	0.0534
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1567	0.3205	0.9381
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.015	0.015
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0356	0.067	0.067
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0376	0.0712	0.0712
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0467	0.129
Loa Loa (eye worm)	hypothetical protein	0.0356	0.067	0.077
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0285	0.0751
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.289	0.5979	0.6962
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.1567	0.3205	0.9381
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.026	0.0467	0.1037
Loa Loa (eye worm)	phosphatidylinositol 3	0.0376	0.0712	0.0819
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0376	0.0712	0.0712
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0376	0.0712	0.1609
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0356	0.067	0.067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0108	0.015	0.1108
Schistosoma mansoni	leukocyte receptor cluster (lrc) member 4 protein	0.0356	0.067	0.078
Toxoplasma gondii	FATC domain-containing protein	0.0232	0.0409	0.5443
Schistosoma mansoni	hypothetical protein	0.0041	0.0009	0.0011
Entamoeba histolytica	hypothetical protein	0.0356	0.067	0.1701
Leishmania major	hypothetical protein, conserved	0.0356	0.067	0.1488
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0356	0.067	0.1701
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.015	0.0164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.015	0.0164
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.0049	0.0047
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0173	0.0285	0.0386
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Mycobacterium ulcerans	hypothetical protein	0.0192	0.0326	0.5
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0376	0.0712	0.2013
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0356	0.067	0.078
Echinococcus granulosus	sterol O acyltransferase 1	0.0356	0.067	0.067
Trypanosoma cruzi	glycerol uptake protein, putative	0.0356	0.067	0.1889
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0467	0.129
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0232	0.0409	0.0846
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0074	0.0077	0.009
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.067	0.1701
Entamoeba histolytica	vacuolar protein sorting 26	0.0356	0.067	0.1701
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0232	0.0409	0.0409
Trichomonas vaginalis	transmembrane protein nessy, putative	0.0356	0.067	0.1701
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0376	0.0712	0.6311
Loa Loa (eye worm)	hypothetical protein	0.0529	0.1032	0.1193
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.026	0.0467	0.6099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.015	0.0164
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0376	0.0712	0.1839
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.1324	0.2696	0.3132
Echinococcus granulosus	tumor protein p63	0.0408	0.0778	0.0778
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.015	0.015
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.4809	1	1
Loa Loa (eye worm)	MBOAT family protein	0.0356	0.067	0.077
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0108	0.015	0.0175
Echinococcus granulosus	serine protein kinase ATM	0.0232	0.0409	0.0409
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.1458	0.2978	0.9257
Onchocerca volvulus		0.0356	0.067	1
Loa Loa (eye worm)	hypothetical protein	0.0356	0.067	0.077
Loa Loa (eye worm)	MBOAT family protein	0.0356	0.067	0.077
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0062	0.0054	0.0069
Loa Loa (eye worm)	membrane bound O-acyltransferase domain containing 1	0.0356	0.067	0.077
Loa Loa (eye worm)	hypothetical protein	0.006	0.0048	0.0045
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0232	0.0409	0.0476
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0232	0.0409	0.0476
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0108	0.015	0.0175
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0376	0.0712	0.0819
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0356	0.067	0.067
Echinococcus multilocularis	serine protein kinase ATM	0.0232	0.0409	0.0409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Echinococcus multilocularis	membrane bound acyltransferase:hhat	0.0356	0.067	0.067
Echinococcus multilocularis	tumor protein p63	0.0408	0.0778	0.0778
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.026	0.0467	0.0544
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0253	0.0453	0.6116
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.026	0.0467	0.6099
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma cruzi	GUP1, putative	0.0356	0.067	0.1889
Treponema pallidum	alginate O-acetylation protein (algI)	0.0356	0.067	0.5
Brugia malayi	Hhat protein	0.0356	0.067	0.077
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0356	0.067	0.078
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0108	0.015	0.0175
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0356	0.067	0.077
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0232	0.0409	0.1117
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0376	0.0712	0.6311
Onchocerca volvulus		0.0108	0.015	0.1639
Trypanosoma cruzi	target of rapamycin kinase 3	0.0376	0.0712	0.2013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0356	0.067	0.077
Mycobacterium leprae	conserved hypothetical protein	0.0108	0.015	0.5
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0376	0.0712	1
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0356	0.067	0.1701
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Leishmania major	mitochondrial DNA polymerase beta	0.0365	0.0687	0.1538
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.026	0.0467	0.1037
Brugia malayi	MBOAT family protein	0.0356	0.067	0.077
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.1037	0.2096	0.2096
Echinococcus granulosus	lysophospholipid acyltransferase 7	0.0356	0.067	0.067
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0789	0.1576	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.1096	0.2219	0.6773
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma cruzi	hypothetical protein, conserved	0.1667	0.3415	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0467	0.4043
Loa Loa (eye worm)	hhat protein	0.0356	0.067	0.077
Loa Loa (eye worm)	phosphatidylinositol 3	0.2583	0.5336	0.6209
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Onchocerca volvulus		0.0108	0.015	0.1639
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0687	0.194
Leishmania major	phosphatidylinositol 3-kinase, putative	0.026	0.0467	0.0908
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0108	0.015	0.0353
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0356	0.067	0.9367
Loa Loa (eye worm)	hypothetical protein	0.0253	0.0453	0.0518
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.026	0.0467	0.1037
Schistosoma mansoni	cellular tumor antigen P53	0.006	0.0048	0.0056
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0376	0.0712	0.0819
Echinococcus granulosus	membrane bound acyltransferase:hhat	0.0356	0.067	0.067
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.026	0.0467	0.1037
Loa Loa (eye worm)	hypothetical protein	0.0108	0.015	0.0164
Trypanosoma cruzi	glycerol uptake protein, putative	0.0356	0.067	0.1889
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.289	0.5979	0.5979
Leishmania major	glycerol uptake protein, putative	0.0356	0.067	0.1488
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0226	0.0253
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0365	0.0687	0.6083
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0567	0.111	1
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.067	0.1701
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0356	0.067	0.078
Leishmania major	glycerol uptake protein, putative	0.0356	0.067	0.1488
Echinococcus granulosus	Membrane bound O acyl transferase MBOAT	0.0356	0.067	0.067
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.015	0.0164
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.026	0.0467	0.6322
Loa Loa (eye worm)	hhat protein	0.0356	0.067	0.077
Leishmania major	hypothetical protein, conserved	0.1775	0.3642	1
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0356	0.067	0.067
Trichomonas vaginalis	porcupine, putative	0.0356	0.067	0.1701
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0567	0.111	0.319
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0123	0.0182	0.0103
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0192	0.0326	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.026	0.0467	0.0467
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0108	0.015	0.0353
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.026	0.0467	0.0544
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0108	0.015	0.1108
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0108	0.015	0.1559
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.0049	0.0047
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0356	0.067	0.067
Entamoeba histolytica	hypothetical protein, conserved	0.0356	0.067	0.1701
Loa Loa (eye worm)	hypothetical protein	0.0356	0.067	0.077
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0232	0.0409	0.0465
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0356	0.067	1
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0376	0.0712	0.1609
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0108	0.015	0.1108
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0376	0.0712	0.6311
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.015	0.0164
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1037	0.2096	0.2433
Schistosoma mansoni	hypothetical protein	0.0356	0.067	0.078
Schistosoma mansoni	hypothetical protein	0.0145	0.0226	0.0264
Echinococcus granulosus	protein cysteine N palmitoyltransferase	0.4135	0.8588	0.8588
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0567	0.111	0.1283
Loa Loa (eye worm)	phosphatidylinositol 3	0.0458	0.0883	0.1019
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0376	0.0712	0.1609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Trichomonas vaginalis	conserved hypothetical protein	0.0356	0.067	0.1701
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.1037	0.2096	0.2096
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.126	0.2562	0.7895
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0567	0.111	0.1293
Schistosoma mansoni	zinc finger protein	0.4135	0.8588	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0458	0.0883	0.2519
Loa Loa (eye worm)	MBOAT family protein	0.4135	0.8588	1
Echinococcus granulosus	zinc finger protein	0.3779	0.7841	0.7841
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0108	0.015	0.0353
Schistosoma mansoni	hypothetical protein	0.0108	0.015	0.0175
Echinococcus multilocularis	protein cysteine N palmitoyltransferase	0.4135	0.8588	0.8588
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0253	0.0453	0.0993
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0108	0.015	0.0164
Trypanosoma cruzi	glycerol uptake protein, putative	0.0356	0.067	0.1889
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0376	0.0712	0.1839
Loa Loa (eye worm)	hypothetical protein	0.0123	0.0182	0.0201
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.289	0.5979	0.5979
Trichomonas vaginalis	conserved hypothetical protein	0.0123	0.0182	0.0103
Schistosoma mansoni	o-acyltransferase (membrane bound) domain containing protein	0.0356	0.067	0.078
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.1567	0.3205	1
Entamoeba histolytica	hypothetical protein	0.0232	0.0409	0.0846
Echinococcus multilocularis		0.0108	0.015	0.015
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0376	0.0712	0.2013
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0066	0.0061	0.0217
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0567	0.111	0.3142
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0108	0.015	0.1559
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Brugia malayi	MBOAT family protein	0.0356	0.067	0.077
Loa Loa (eye worm)	hypothetical protein	0.1037	0.2096	0.2433
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Echinococcus multilocularis	Zinc finger, PHD finger	0.026	0.0467	0.0467
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0376	0.0712	0.0829
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1567	0.3205	0.3726
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Echinococcus multilocularis	Membrane bound O acyl transferase, MBOAT	0.0356	0.067	0.067
Toxoplasma gondii	hypothetical protein	0.0356	0.067	0.9367
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.015	0.015
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0415	0.0793	0.4509
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Loa Loa (eye worm)	phosphatidylinositol 3	0.0108	0.015	0.0164
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0567	0.111	0.3142
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0567	0.111	0.3142
Trypanosoma cruzi	GUP1, putative	0.0356	0.067	0.1889
Loa Loa (eye worm)	hypothetical protein	0.0232	0.0409	0.0465
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.1567	0.3205	1
Loa Loa (eye worm)	hypothetical protein	0.006	0.0049	0.0047
Brugia malayi	MBOAT family protein	0.4135	0.8588	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0173	0.0285	0.2355
Trichomonas vaginalis	conserved hypothetical protein	0.0145	0.0226	0.025
Brugia malayi	diacylglycerol acyltransferase	0.0356	0.067	0.077
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0356	0.067	0.067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.026	0.0467	0.0534
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.1567	0.3205	1
Echinococcus multilocularis	zinc finger protein	0.3779	0.7841	0.7841
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0232	0.0409	0.3502
Entamoeba histolytica	protein kinase rad3, putative	0.0232	0.0409	0.0846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma brucei	glycerol uptake protein, putative	0.0356	0.067	0.5921
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0145	0.0226	0.0226
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.073	0.1453	0.4265
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0365	0.0687	0.194
Brugia malayi	MBOAT family protein	0.0356	0.067	0.077
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0108	0.015	0.1559
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0145	0.0226	0.0226
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0108	0.015	0.015
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0567	0.111	0.3142
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.0049	0.0047
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0376	0.0712	0.0712
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Echinococcus multilocularis	lysophospholipid acyltransferase 7	0.0356	0.067	0.067
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0376	0.0712	0.1609
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0567	0.111	0.3142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Leishmania major	glycerol uptake protein, putative	0.0356	0.067	0.1488
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0108	0.015	0.015
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.026	0.0467	0.0467
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0356	0.067	1
Echinococcus multilocularis	sterol O acyltransferase 1	0.0356	0.067	0.067
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0108	0.015	0.0353
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.1567	0.3205	1
Brugia malayi	MBOAT family protein	0.0356	0.067	0.077
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.026	0.0467	0.0467
Trichomonas vaginalis	conserved hypothetical protein	0.0253	0.0453	0.0993
Entamoeba histolytica	membrane-bound O-acyltransferase (MBOAT ) family protein	0.0356	0.067	0.1701
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0376	0.0712	0.1609
Giardia lamblia	GTOR	0.0376	0.0712	0.3939
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0123	0.0182	0.0446
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma brucei	glycerol uptake protein, putative	0.0356	0.067	0.5921
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0253	0.0453	0.3917
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0356	0.067	0.9367
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0108	0.015	0.0353
Brugia malayi	FAT domain containing protein	0.0145	0.0226	0.0253
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0376	0.0712	0.6311
Leishmania major	glycerol uptake protein, putative	0.0356	0.067	0.1488
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.026	0.0467	0.0908
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0376	0.0712	0.2013
Echinococcus granulosus	o acyltransferase membrane bound domain	0.0356	0.067	0.067
Leishmania major	glycerol uptake protein, putative	0.0356	0.067	0.1488
Echinococcus multilocularis	o acyltransferase (membrane bound) domain	0.0356	0.067	0.067
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0376	0.0712	0.0829
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0232	0.0409	0.1117
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0376	0.0712	0.6311
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.1096	0.2219	0.6773
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0376	0.0712	0.2013
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0232	0.0409	0.0846
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0376	0.0712	0.1839

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	28.5 uM	PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
IC50 (functional)	33.4 uM	PubChem BioAssay. Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.5012 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	0.5623 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Agonists. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	8.9125 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	11.6891 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference
Potency (functional)	19.9526 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 22.3872 um	PUBCHEM_BIOASSAY: qHTS Fluorescence Polarization Assay for Inhibitors of MLL CXXC domain - DNA interaction. (Class of assay: confirmatory) [Related pubchem assays: 2698 (Summary assay.)]	ChEMBL.	No reference
Potency (functional)	= 39.8107 um	PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))]	ChEMBL.	No reference
Potency (binding)	= 44.6684 um	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23
Homo sapiens	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1606285

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1440086