Detailed information for compound 1444598

Basic information

Technical information
  • TDR Targets ID: 1444598
  • Name: 5-bromo-N-(3-chloro-2-pyrrolidin-1-ylphenyl)f uran-2-carboxamide
  • MW: 369.641 | Formula: C15H14BrClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.42 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc(o1)C(=O)Nc1cccc(c1N1CCCC1)Cl
  • InChi: 1S/C15H14BrClN2O2/c16-13-7-6-12(21-13)15(20)18-11-5-3-4-10(17)14(11)19-8-1-2-9-19/h3-7H,1-2,8-9H2,(H,18,20)
  • InChiKey: HQQJPMDLXCJWKU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-bromo-N-(3-chloro-2-pyrrolidin-1-yl-phenyl)furan-2-carboxamide
  • 5-bromo-N-(3-chloro-2-1-pyrrolidinylphenyl)-2-furancarboxamide
  • 5-bromo-N-(3-chloro-2-pyrrolidin-1-yl-phenyl)-2-furamide
  • MLS000051596
  • ZINC01050631
  • 5-bromo-N-[3-chloro-2-(1-pyrrolidinyl)phenyl]-2-furamide
  • STK336583
  • SMR000080080

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Streptococcus pyogenes serotype M1 Streptokinase A Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) ICD-1 protein Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Cryptosporidium parvum BTF domain, basal transcription factor Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium falciparum basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii NAC domain-containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Babesia bovis NAC domain containing protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01527 nascent polypeptide-associated complex subunit beta, putative Get druggable targets OG5_127333 All targets in OG5_127333
Candida albicans similar to S. cerevisiae GAL4 enhancer protein EGD1 (YPL037C) subunit alpha of the nascent polypeptide-associated chaperone comp Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania infantum basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania major basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Schistosoma mansoni transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana basic transcription factor 3a, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium knowlesi basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium vivax basic transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Theileria parva transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi transcription factor btf3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Plasmodium yoelii basic transcription factor 3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Cryptosporidium hominis NAC domain protein Get druggable targets OG5_127333 All targets in OG5_127333
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi beta-NAC-like protein Get druggable targets OG5_127333 All targets in OG5_127333
Trypanosoma brucei gambiense nascent polypeptide associated complex alpha subunit, putative Get druggable targets OG5_127333 All targets in OG5_127333
Entamoeba histolytica transcription factor BTF3, putative Get druggable targets OG5_127333 All targets in OG5_127333
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_127333 All targets in OG5_127333
Plasmodium berghei transcription factor 3b, putative Get druggable targets OG5_127333 All targets in OG5_127333
Echinococcus multilocularis transcription factor btf3 Get druggable targets OG5_127333 All targets in OG5_127333
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1328 0.137
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1305 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1328 0.137
Echinococcus granulosus transcription factor btf3 0.0042 0.1195 0.1233
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.1328 0.137
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0607 0.0627
Brugia malayi Inositol-1 0.0045 0.1305 0.1346
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0607 0.0627
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0607 0.0627
Trypanosoma brucei Emopamil binding protein, putative 0.0147 0.6003 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.1305 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.1305 0.5
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.109 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1328 0.137
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1305 0.1545
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1305 0.1545
Echinococcus multilocularis vesicular acetylcholine transporter 0.0227 0.9693 1
Loa Loa (eye worm) RNA binding protein 0.0062 0.2127 0.2194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1328 0.137
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.8695 0.8971
Plasmodium falciparum basic transcription factor 3b, putative 0.0042 0.1195 1
Leishmania major hypothetical protein, conserved 0.0147 0.6003 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.2127 0.2194
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0607 0.0627
Brugia malayi RNA binding protein 0.0062 0.2127 0.2194
Brugia malayi hypothetical protein 0.0026 0.0447 0.0461
Schistosoma mansoni inositol monophosphatase 0.0045 0.1305 0.1346
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2127 0.2194
Brugia malayi hypothetical protein 0.0017 0.0024 0.0024
Loa Loa (eye worm) ICD-1 protein 0.0042 0.1195 0.1233
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.1195 0.1347
Leishmania major 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0147 0.6003 1
Brugia malayi TAR-binding protein 0.0062 0.2127 0.2194
Loa Loa (eye worm) TAR-binding protein 0.0062 0.2127 0.2194
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0227 0.9693 0.9673
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0867 0.0894
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.1305 0.0124
Plasmodium vivax basic transcription factor 3b, putative 0.0042 0.1195 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.1305 0.5
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1305 0.1545
Loa Loa (eye worm) hypothetical protein 0.0026 0.0447 0.0461
Toxoplasma gondii NAC domain-containing protein 0.0042 0.1195 0.8723
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2127 0.2194
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.1328 0.137
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2127 0.2194
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.1305 0.1346
Trypanosoma cruzi Emopamil binding protein, putative 0.0147 0.6003 1
Trypanosoma cruzi Emopamil binding protein, putative 0.0147 0.6003 1
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.1305 0.1346
Loa Loa (eye worm) inositol-1 0.0045 0.1305 0.1346
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.1305 0.1545
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.1305 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.1614 0.1665
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2127 0.2194
Schistosoma mansoni tar DNA-binding protein 0.0062 0.2127 0.2194
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.109 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0607 0.0627
Trypanosoma cruzi transcription factor btf3, putative 0.0042 0.1195 0.1347
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0607 0.0627
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.2127 0.2194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.1328 0.137
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0227 0.9693 1
Schistosoma mansoni vesicular acetylcholine transporter 0.0227 0.9693 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0607 0.0627
Brugia malayi beta-NAC-like protein 0.0042 0.1195 0.1233
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.1305 0.0124
Onchocerca volvulus 0.0147 0.6003 0.5745
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.1328 0.137
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0147 0.6003 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.1614 0.1665
Loa Loa (eye worm) hypothetical protein 0.0035 0.0867 0.0894
Echinococcus multilocularis transcription factor btf3 0.0042 0.1195 0.1233
Echinococcus granulosus vesicular acetylcholine transporter 0.0227 0.9693 1
Trypanosoma brucei transcription factor BTF3, putative 0.0042 0.1195 0.1347
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.1328 0.137
Schistosoma mansoni transcription factor btf3 0.0042 0.1195 0.1233
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.1614 0.1665
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0558 0.0575
Brugia malayi Pre-SET motif family protein 0.0205 0.8695 0.8971
Plasmodium vivax SET domain protein, putative 0.0029 0.0607 0.2146
Schistosoma mansoni inositol monophosphatase 0.0045 0.1305 0.1346
Trypanosoma cruzi 3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative 0.0147 0.6003 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.1614 0.1665
Leishmania major basic transcription factor 3a, putative 0.0042 0.1195 0.1347
Trichomonas vaginalis set domain proteins, putative 0.0234 1 1
Schistosoma mansoni hypothetical protein 0.0035 0.0867 0.0894
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0607 0.0627
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0607 0.1872
Brugia malayi vesicular acetylcholine transporter unc-17 0.0227 0.9693 1
Echinococcus granulosus tar DNA binding protein 0.0062 0.2127 0.2194
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0607 0.0627
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.2127 0.2194

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 5.819 um PUBCHEM_BIOASSAY: Luminescence Microorganism-Based Dose Confirmation HTS to Identify Inhibitors of Streptokinase Promotor Activity. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1662 (Primary HTS)] ChEMBL. No reference
EC50 (functional) > 150 um PUBCHEM_BIOASSAY: Absorbance Microorganism-Based Dose Response HTS to Identify Inhibitors of Streptokinase Expression. (Class of assay: confirmatory) [Related pubchem assays: 1677 (Project Summary), 1902 (Retest at Dose), 1900 (Counter Screen), 1662 (Primary HTS)] ChEMBL. No reference
Potency (functional) = 0.0562 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 89.1251 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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