Detailed information for compound 1451473

Basic information

Technical information
  • TDR Targets ID: 1451473
  • Name: 1-(2,5-dichlorophenyl)sulfonylpiperidine
  • MW: 294.197 | Formula: C11H13Cl2NO2S
  • H donors: 0 H acceptors: 2 LogP: 3.17 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1S(=O)(=O)N1CCCCC1)Cl
  • InChi: 1S/C11H13Cl2NO2S/c12-9-4-5-10(13)11(8-9)17(15,16)14-6-2-1-3-7-14/h4-5,8H,1-3,6-7H2
  • InChiKey: BXSVOWIFQVJUKH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(2,5-Dichloro-benzenesulfonyl)-piperidine
  • MLS000029314
  • SMR000001237
  • ZINC00143763
  • Oprea1_014780
  • Oprea1_528431
  • IDI1_031522
  • Cerep_001821
  • Maybridge4_000940
  • BAS 00228376

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens arachidonate 15-lipoxygenase Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Equus caballus Ferritin light chain Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus arachidonate 5 lipoxygenase arachidonate 15-lipoxygenase 662 aa 590 aa 23.9 %
Schistosoma japonicum Ferritin, putative Ferritin light chain   175 aa 144 aa 24.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 146 aa 28.8 %
Echinococcus granulosus expressed protein Ferritin light chain   175 aa 146 aa 28.8 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 44.4 %
Echinococcus multilocularis expressed protein Ferritin light chain   175 aa 146 aa 30.1 %
Schistosoma mansoni apoferritin-2 Ferritin light chain   175 aa 142 aa 29.6 %
Schistosoma mansoni ferritin Ferritin light chain   175 aa 171 aa 43.9 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis RUN 0.0024 0.0226 0.0226
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0226 0.5
Echinococcus granulosus dnaJ subfamily B 0.0405 0.5815 0.5815
Schistosoma mansoni apoferritin-2 0.001 0.0027 0.0046
Schistosoma mansoni hypothetical protein 0.0024 0.0226 0.0388
Schistosoma mansoni intermediate filament proteins 0.0026 0.0265 0.0455
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0686 0.0686
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0974 0.1312
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.0853 0.0853
Onchocerca volvulus 0.0079 0.1037 0.2106
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0781 0.1343
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.0176 0.2452 0.3349
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0686 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.1037 0.1396
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0079 0.1037 0.1398
Schistosoma mansoni ferritin 0.001 0.0027 0.0046
Loa Loa (eye worm) hypothetical protein 0.0013 0.0064 0.0053
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.0176 0.2452 0.2452
Brugia malayi Choline O-acetyltransferase 0.0079 0.1037 0.1398
Echinococcus granulosus expressed protein 0.001 0.0027 0.0027
Echinococcus multilocularis tumor protein p63 0.0691 1 1
Loa Loa (eye worm) hypothetical protein 0.011 0.1482 0.2011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0686 0.0686
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0176 0.2452 0.335
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.0176 0.2452 0.4385
Onchocerca volvulus 0.0101 0.1359 0.2943
Schistosoma mansoni rab6-interacting 0.0024 0.0226 0.0388
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0265 0.033
Echinococcus multilocularis musashi 0.0026 0.0265 0.0265
Loa Loa (eye worm) TAR-binding protein 0.0127 0.1736 0.236
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0414 0.0536
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.1359 0.2337
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0385 0.0498
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0686 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0414 0.0712
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0686 0.118
Onchocerca volvulus 0.0026 0.0265 0.0102
Schistosoma mansoni apoferritin-2 0.001 0.0027 0.0046
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0226 0.0226
Schistosoma mansoni cpg binding protein 0.003 0.0318 0.0546
Echinococcus multilocularis lamin dm0 0.0026 0.0265 0.0265
Brugia malayi RNA recognition motif domain containing protein 0.0127 0.1736 0.2362
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0299 0.4264 1
Loa Loa (eye worm) hypothetical protein 0.0505 0.7271 1
Echinococcus multilocularis expressed protein 0.001 0.0027 0.0027
Schistosoma mansoni lipoxygenase 0.0067 0.0853 0.1468
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.5815 0.5815
Echinococcus multilocularis lamin 0.0026 0.0265 0.0265
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0044
Echinococcus granulosus lamin dm0 0.0026 0.0265 0.0265
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0226 0.0226
Echinococcus multilocularis cpg binding protein 0.003 0.0318 0.0318
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.0299 0.4264 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.3567 0.4888
Schistosoma mansoni ferritin light chain 0.001 0.0027 0.0046
Brugia malayi RNA binding protein 0.0127 0.1736 0.2362
Schistosoma mansoni hypothetical protein 0.0405 0.5815 1
Onchocerca volvulus 0.0079 0.1037 0.2106
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0385 0.0496
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0385 0.0385
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.0853 0.0853
Loa Loa (eye worm) hypothetical protein 0.0075 0.0974 0.131
Treponema pallidum bacterioferrin (TpF1) 0.001 0.0027 0.5
Echinococcus multilocularis ferritin 0.001 0.0027 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1736 0.2985
Brugia malayi Pre-SET motif family protein 0.0037 0.0414 0.0539
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.0505 0.7271 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0385 0.0385
Brugia malayi TAR-binding protein 0.0127 0.1736 0.2362
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.0176 0.2452 0.2452
Loa Loa (eye worm) hypothetical protein 0.0101 0.1359 0.184
Schistosoma mansoni ferritin light chain 0.001 0.0027 0.0046
Echinococcus multilocularis GPCR, family 2 0.0035 0.0385 0.0385
Leishmania major carnitine palmitoyltransferase-like protein 0.0176 0.2452 0.4385
Plasmodium vivax SET domain protein, putative 0.0037 0.0414 1
Onchocerca volvulus 0.0079 0.1037 0.2106
Schistosoma mansoni rab6-interacting 0.0024 0.0226 0.0388
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0226 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1736 0.2985
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.0299 0.4264 1
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.0176 0.2452 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0025 0.0025
Echinococcus multilocularis choline O acetyltransferase 0.0079 0.1037 0.1037
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.001 0.0027 0.5
Mycobacterium tuberculosis Bacterioferritin BfrB 0.001 0.0027 0.5
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1736 0.2985
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0386 0.0386
Loa Loa (eye worm) hypothetical protein 0.0026 0.0258 0.0321
Mycobacterium ulcerans bacterioferritin BfrA 0.001 0.0027 0.5
Onchocerca volvulus 0.0026 0.0265 0.0102
Echinococcus granulosus lamin 0.0026 0.0265 0.0265
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0414 0.0414
Brugia malayi hypothetical protein 0.0024 0.0226 0.0279
Onchocerca volvulus 0.0287 0.4076 1
Schistosoma mansoni ferritin 0.001 0.0027 0.0046
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.1482 0.2013
Schistosoma mansoni hypothetical protein 0.0035 0.0385 0.0662
Schistosoma mansoni lamin 0.0026 0.0265 0.0455
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0226 0.0226
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.0299 0.4264 0.4264
Echinococcus granulosus cpg binding protein 0.003 0.0318 0.0318
Loa Loa (eye worm) hypothetical protein 0.0012 0.0057 0.0044
Echinococcus granulosus intermediate filament protein 0.0026 0.0265 0.0265
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0064 0.0064
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0265 0.033
Schistosoma mansoni polycystin 1-related 0.0024 0.0226 0.0388
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0294 0.0371
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.1482 0.2013
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0414 0.0712
Schistosoma mansoni choline o-acyltransferase 0.0079 0.1037 0.1783
Schistosoma mansoni loxhd1 0.0024 0.0226 0.0388
Onchocerca volvulus 0.0037 0.0414 0.0489
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.001 0.0027 0.5
Echinococcus granulosus tar DNA binding protein 0.0127 0.1736 0.1736
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0265 0.0333
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0276
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0686 0.118
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0085 0.0084
Onchocerca volvulus 0.0079 0.1037 0.2106
Loa Loa (eye worm) hypothetical protein 0.0026 0.0265 0.033
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0127 0.1736 0.236
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3974 0.5449
Schistosoma mansoni hypothetical protein 0.0035 0.0385 0.0662
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1736 0.2985
Schistosoma mansoni lamin 0.0026 0.0265 0.0455
Schistosoma mansoni hypothetical protein 0.0035 0.0385 0.0662
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0035 0.0385 0.0496
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0385 0.0385
Trichomonas vaginalis set domain proteins, putative 0.0287 0.4076 1
Schistosoma mansoni hypothetical protein 0.0075 0.0974 0.1676
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.0079 0.1037 0.1396
Loa Loa (eye worm) hypothetical protein 0.0024 0.0226 0.0276
Mycobacterium ulcerans bacterioferritin BfrB 0.001 0.0027 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0686 0.118
Echinococcus granulosus choline O acetyltransferase 0.0079 0.1037 0.1037
Brugia malayi intermediate filament protein 0.0026 0.0265 0.0333
Brugia malayi follicle stimulating hormone receptor 0.028 0.3974 0.545
Echinococcus granulosus RUN 0.0024 0.0226 0.0226
Brugia malayi CXXC zinc finger family protein 0.0028 0.0294 0.0373
Schistosoma mansoni tar DNA-binding protein 0.0127 0.1736 0.2985
Schistosoma mansoni ferritin 0.001 0.0027 0.0046
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0385 0.0385
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.001 0.0027 0.5
Schistosoma mansoni ferritin 0.001 0.0027 0.0046
Echinococcus multilocularis tar DNA binding protein 0.0127 0.1736 0.1736
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0686 0.0912
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0226 0.0226
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0226 0.0226
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0414 0.0414
Schistosoma mansoni lipoxygenase 0.0024 0.0226 0.0388
Schistosoma mansoni cpg binding protein 0.0028 0.0294 0.0505
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0686 0.0914
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.1482 0.2011
Brugia malayi hypothetical protein 0.0024 0.0226 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0414 0.0712
Schistosoma mansoni cpg binding protein 0.003 0.0318 0.0546
Echinococcus granulosus ferritin 0.001 0.0027 0.0027
Echinococcus granulosus GPCR family 2 0.0035 0.0385 0.0385
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0085 0.0082
Brugia malayi Pre-SET motif family protein 0.0252 0.3567 0.489
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0385 0.0498
Schistosoma mansoni hypothetical protein 0.0035 0.0385 0.0662
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.0299 0.4264 0.4264
Schistosoma mansoni choline o-acyltransferase 0.0079 0.1037 0.1783
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0226 0.0276
Loa Loa (eye worm) RNA binding protein 0.0127 0.1736 0.236
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0414 0.0712
Brugia malayi Doublecortin family protein 0.0024 0.0226 0.0279
Onchocerca volvulus 0.0028 0.0294 0.0177
Loa Loa (eye worm) choline O-acetyltransferase 0.0079 0.1037 0.1396
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0686 0.0686
Brugia malayi Choline O-acetyltransferase 0.0079 0.1037 0.1398

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.3981 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 17.7828 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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