Detailed information for compound 1452059

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 392.883 | Formula: C18H25ClN6O2
  • H donors: 1 H acceptors: 3 LogP: 3.18 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccccc1Nc1nc(nc(n1)N1CCOCC1)N1CCOCC1.Cl
  • InChi: 1S/C18H24N6O2.ClH/c1-14-4-2-3-5-15(14)19-16-20-17(23-6-10-25-11-7-23)22-18(21-16)24-8-12-26-13-9-24;/h2-5H,6-13H2,1H3,(H,19,20,21,22);1H
  • InChiKey: PFXFNSKXKYPOFY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0064 0.0071
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0185 0.0957 0.0957
Giardia lamblia Cathepsin B precursor 0.0045 0.0101 0.5587
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0125 0.0139
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0058 0.0181 0.0181
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0045 0.0101 0.1472
Toxoplasma gondii cathepsin B 0.0045 0.0101 0.083
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0504 1
Schistosoma mansoni Mername-AA248 (C02 family) 0.0061 0.0197 0.022
Schistosoma mansoni ATP-binding cassette transporter 0.0131 0.0628 0.07
Schistosoma mansoni ap endonuclease 0.0039 0.0062 0.0069
Trypanosoma cruzi Aph-1 protein, putative 0.0581 0.3386 0.7842
Brugia malayi beta-lactamase 0.0111 0.0504 0.0563
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0185 0.0957 0.1699
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0062 0.0649
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0054 0.0156 0.0174
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0062 0.0062
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0143 0.0701 0.0782
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0504 0.1144
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0504 0.1168
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0054 0.0156 0.0174
Trypanosoma brucei kinesin, putative 0.0043 0.0085 0.0126
Echinococcus granulosus glutamate receptor 2 0.016 0.0803 0.0896
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0065 0.0223 0.0517
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0054 0.0156 0.3485
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0064 0.4077
Trypanosoma brucei Aph-1 protein, putative 0.0581 0.3386 0.7827
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0541 0.0604
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0541 0.0604
Echinococcus granulosus transmembrane protease serine 3 0.0038 0.0058 0.0064
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0197 0.0457
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0062 0.2461
Echinococcus multilocularis glutamate receptor 2 0.0111 0.0506 0.0506
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0054 0.0156 0.2635
Schistosoma mansoni cpg binding protein 0.009 0.0377 0.042
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0049 0.0125 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0388
Leishmania major pyruvate kinase 0.0034 0.0031 0.0072
Brugia malayi Trypsin family protein 0.0038 0.0058 0.0064
Mycobacterium ulcerans beta-lactamase 0.0111 0.0504 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0062 0.0858
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0504 0.1144
Onchocerca volvulus 0.009 0.0377 0.0669
Brugia malayi MH2 domain containing protein 0.0117 0.0541 0.0604
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0166 0.0185
Trypanosoma cruzi kinesin, putative 0.0043 0.0085 0.0198
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0058 0.0064
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0062 0.0074
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0071 0.0261 0.0536
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0064 0.0147
Trypanosoma cruzi protein farnesyltransferase, putative 0.0054 0.0156 0.0361
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0062 0.0143
Leishmania major oligopeptidase b 0.0065 0.0223 0.0517
Loa Loa (eye worm) hypothetical protein 0.0143 0.07 0.0781
Echinococcus multilocularis glutamate receptor 2 0.016 0.0803 0.0803
Schistosoma mansoni cpg binding protein 0.0095 0.0408 0.0455
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0168 0.0857 0.0956
Echinococcus granulosus neuropeptide s receptor 0.05 0.2887 0.3221
Onchocerca volvulus 0.0262 0.143 0.2538
Loa Loa (eye worm) hypothetical protein 0.0044 0.0094 0.0105
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0143 0.0701 0.0782
Echinococcus granulosus caspase 2 0.0305 0.1694 0.189
Echinococcus multilocularis neuropeptide receptor A26 0.05 0.2887 0.2887
Brugia malayi Metabotropic glutamate receptor precursor. 0.0065 0.0221 0.0246
Schistosoma mansoni hypothetical protein 0.0038 0.0058 0.0064
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0074 0.0277 0.0277
Loa Loa (eye worm) hypothetical protein 0.0305 0.1694 0.189
Loa Loa (eye worm) MBCTL1 0.0056 0.0166 0.0185
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0038 0.0058 0.0064
Brugia malayi calpain 5 0.0043 0.0085 0.0095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0045 0.0101 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0092 0.0389 0.0901
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0197 0.0457
Echinococcus granulosus calpain 7 C02 family 0.0061 0.0197 0.022
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.024 0.1297 0.1297
Echinococcus granulosus calpain 0.0061 0.0197 0.022
Echinococcus granulosus Mastin 0.0038 0.0058 0.0064
Trypanosoma cruzi kinesin, putative 0.0043 0.0085 0.0198
Echinococcus multilocularis glycoprotein Antigen 5 0.0038 0.0058 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.0024
Echinococcus multilocularis cathepsin b 0.0136 0.0661 0.0661
Echinococcus granulosus dnaJ subfamily B 0.0433 0.248 0.2766
Trypanosoma cruzi lanosterol synthase, putative 0.0059 0.0188 0.0435
Onchocerca volvulus 0.0038 0.0058 0.0102
Echinococcus multilocularis apoptotic protease activating factor 1 0.0305 0.1694 0.1694
Mycobacterium tuberculosis Probable peptidase 0.0065 0.0223 0.0465
Schistosoma mansoni glutamate receptor kainate 0.0131 0.0628 0.07
Brugia malayi Glutamate receptor 1 precursor 0.0131 0.0628 0.07
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0064 0.0685
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0065 0.0223 0.4061
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0125 0.0139
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0282 0.1556 0.1736
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0504 0.1144
Trypanosoma cruzi oligopeptidase b 0.0065 0.0223 0.0517
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0071 0.0261 0.0604
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0035 0.004 0.0044
Brugia malayi Glutamate receptor 2 precursor 0.0131 0.0628 0.07
Echinococcus granulosus nmda type glutamate receptor 0.0253 0.1378 0.1538
Onchocerca volvulus 0.03 0.1663 0.2951
Onchocerca volvulus 0.0038 0.0058 0.0102
Brugia malayi hypothetical protein 0.0038 0.0058 0.0064
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0136 0.0661 0.1532
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0065 0.0223 0.0517
Echinococcus granulosus metabotropic glutamate receptor 5 0.0074 0.0277 0.0309
Schistosoma mansoni hypothetical protein 0.0688 0.4041 0.4508
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0504 1
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0161 0.0812 0.0906
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0031 0.0072
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0136 0.0661 0.0738
Mycobacterium ulcerans hypothetical protein 0.0111 0.0504 1
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0058 0.0064
Echinococcus granulosus Dipeptidyl peptidase 9 0.0071 0.0261 0.0291
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0733 0.4317 0.4816
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0054 0.0156 1
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0453 0.2604 0.2905
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0054 0.0156 0.2635
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0071 0.0261 0.0604
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0504 0.0563
Schistosoma mansoni glutamate receptor AMPA 0.0131 0.0628 0.07
Loa Loa (eye worm) cathepsin B 0.0045 0.0101 0.0112
Schistosoma mansoni calpain C (C02 family) 0.0061 0.0197 0.022
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0125 0.0139
Echinococcus granulosus cpg binding protein 0.0095 0.0408 0.0455
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0048 0.0122 0.0122
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0031 0.0035
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0062 0.0649
Entamoeba histolytica protein kinase, putative 0.0043 0.0085 0.5475
Brugia malayi mbt repeat family protein 0.0049 0.0125 0.0139
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0143 0.0701 0.1624
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0054 0.0156 0.0291
Onchocerca volvulus Deterin homolog 0.0948 0.5636 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0064 0.0685
Onchocerca volvulus 0.0038 0.0058 0.0102
Loa Loa (eye worm) glutamate receptor 1 0.0131 0.0628 0.07
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0197 0.0388
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0156 0.2635
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0062 0.3966
Schistosoma mansoni inhibitor of apoptosis protein 0.0948 0.5636 0.6288
Loa Loa (eye worm) hypothetical protein 0.03 0.1663 0.1856
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0031 0.0035
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0036 0.0045 0.0051
Echinococcus multilocularis glutamate receptor 2 0.0131 0.0628 0.0628
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0064 0.0685
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0038 0.0058 0.0058
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0054 0.0156 0.0174
Mycobacterium ulcerans hypothetical protein 0.0038 0.0058 0.056
Loa Loa (eye worm) prolyl oligopeptidase 0.0185 0.0957 0.1068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0504 0.0563
Trypanosoma brucei cysteine peptidase C (CPC) 0.0045 0.0101 0.0163
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0201 0.1055 0.1055
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0064 0.0064
Echinococcus granulosus metabotropic glutamate receptor 2 0.0058 0.0181 0.0202
Loa Loa (eye worm) hypothetical protein 0.01 0.044 0.0491
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0125 0.0125
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0031 0.0055
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0064
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0062 0.0072
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0185 0.0957 0.1068
Onchocerca volvulus Cell death protein 3 homolog 0.0305 0.1694 0.3005
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.1491 0.8963 1
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0504 0.1104
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0533 0.3092 0.3092
Schistosoma mansoni calpain (C02 family) 0.0061 0.0197 0.022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Schistosoma mansoni hypothetical protein 0.0092 0.0389 0.0434
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0061 0.0197 0.0388
Echinococcus granulosus neuropeptide receptor A26 0.05 0.2887 0.3221
Loa Loa (eye worm) hypothetical protein 0.0305 0.1694 0.189
Loa Loa (eye worm) glutamate receptor 0.0065 0.0221 0.0246
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0168 0.0857 0.0956
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0661 0.0738
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0058 0.0064
Schistosoma mansoni hypothetical protein 0.0305 0.1696 0.1892
Onchocerca volvulus 0.0305 0.1694 0.3005
Mycobacterium leprae Probable lipase LipE 0.0111 0.0504 1
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0048 0.0122 0.0122
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.016 0.0803 0.0896
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Schistosoma mansoni hypothetical protein 0.0305 0.1694 0.189
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0116 0.0535 0.1218
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0024 0.0026
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0062 0.0069
Trypanosoma brucei prolyl endopeptidase 0.0143 0.0701 0.1563
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0504 0.1144
Brugia malayi beta-lactamase family protein 0.0111 0.0504 0.0563
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1556 0.1736
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0031 0.0055
Echinococcus multilocularis calpain 7 (C02 family) 0.0061 0.0197 0.0197
Mycobacterium ulcerans lipase LipD 0.0111 0.0504 1
Echinococcus multilocularis calpain 5 0.0061 0.0197 0.0197
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0062 0.0649
Brugia malayi Kringle domain containing protein 0.0092 0.0389 0.0434
Echinococcus granulosus nmda type glutamate receptor 0.0185 0.0956 0.1067
Loa Loa (eye worm) hypothetical protein 0.0056 0.0166 0.0185
Schistosoma mansoni hypothetical protein 0.0948 0.5636 0.6288
Schistosoma mansoni hypothetical protein 0.0051 0.0139 0.0155
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0045 0.0102 0.0113
Schistosoma mansoni metabotropic glutamate receptor 0.0044 0.0096 0.0107
Loa Loa (eye worm) hypothetical protein 0.0111 0.0504 0.0563
Echinococcus multilocularis nmda type glutamate receptor 0.0185 0.0956 0.0956
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0038 0.0156
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0038 0.0058 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0504 1
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0048 0.0122 0.0136
Echinococcus multilocularis NMDA receptor 0.0048 0.0122 0.0122
Brugia malayi Trypsin family protein 0.0038 0.0058 0.0064
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0031 0.0055
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0733 0.4317 1
Brugia malayi Inositol-1 0.0039 0.0064 0.0071
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0504 0.0504
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0504 0.1168
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0166 0.0185
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0058 0.0064
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0058 0.0064
Echinococcus multilocularis tissue type plasminogen activator 0.0092 0.0389 0.0389
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0064 0.0386
Loa Loa (eye worm) hypothetical protein 0.0032 0.0024 0.0026
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0504 0.0563
Brugia malayi prolyl oligopeptidase family protein 0.0185 0.0957 0.1068
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0504 1
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0054 0.0156 0.2635
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0092 0.0389 0.7561
Loa Loa (eye worm) hypothetical protein 0.0074 0.0277 0.0309
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0504 1
Schistosoma mansoni inositol monophosphatase 0.0039 0.0064 0.0071
Loa Loa (eye worm) hypothetical protein 0.0733 0.4317 0.4816
Chlamydia trachomatis glutamine binding protein 0.0049 0.0125 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Echinococcus granulosus glutamate receptor 2 0.0111 0.0506 0.0564
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0661 0.0738
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1556 0.1556
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0064
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.0377 0.042
Schistosoma mansoni metabotropic glutamate receptor 0.0058 0.0181 0.0202
Loa Loa (eye worm) beta-lactamase 0.0111 0.0504 0.0563
Trypanosoma brucei antigen, putative 0.0061 0.0197 0.0388
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0168 0.0857 0.0857
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0031 0.0035
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0054 0.0156 0.1486
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0136 0.0661 0.0738
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Echinococcus granulosus pyruvate kinase 0.0034 0.0031 0.0035
Brugia malayi hypothetical protein 0.0232 0.1244 0.1388
Leishmania major farnesyltransferase beta subunit 0.0054 0.0156 0.0361
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0453 0.2604 0.2905
Trypanosoma brucei prolyl oligopeptidase, putative 0.0065 0.0223 0.0448
Onchocerca volvulus 0.0038 0.0058 0.0102
Loa Loa (eye worm) calpain 5 0.0043 0.0085 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0504 1
Echinococcus multilocularis calpain family protein 1, d 0.0119 0.0552 0.0552
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0103 0.0454 0.0506
Schistosoma mansoni glutamate receptor NMDA 0.0316 0.1759 0.1963
Onchocerca volvulus Prolyl endopeptidase homolog 0.0143 0.0701 0.1244
Brugia malayi hypothetical protein 0.0044 0.0094 0.0105
Trichomonas vaginalis esterase, putative 0.0111 0.0504 1
Echinococcus granulosus glutamate receptor NMDA 0.0156 0.0781 0.0871
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0071 0.0261 0.2736
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Echinococcus granulosus cathepsin b 0.0136 0.0661 0.0738
Toxoplasma gondii kringle domain-containing protein 0.0092 0.0389 0.4263
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0504 1
Brugia malayi prolyl oligopeptidase family protein 0.0143 0.0701 0.0782
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.0255 0.0284
Leishmania major pyruvate kinase 0.0034 0.0031 0.0072
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0168 0.0857 0.0956
Echinococcus granulosus apoptotic protease activating factor 1 0.0305 0.1694 0.189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0136 0.0661 0.0738
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.03 0.1663 0.1856
Onchocerca volvulus 0.0111 0.0504 0.0895
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0026
Brugia malayi Trypsin-like protease protein 5 0.0038 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0111 0.0504 0.0563
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0045 0.0101 0.0233
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0031 0.0035
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.0024
Toxoplasma gondii exonuclease III APE 0.0039 0.0062 0.0366
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0049 0.0125 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0031 0.0031
Trypanosoma brucei lanosterol synthase 0.0059 0.0188 0.0366
Loa Loa (eye worm) glutamate receptor 2 0.0131 0.0628 0.07
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0031 0.0072
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.007 0.0255 0.0284
Schistosoma mansoni gamma-secretase subunit aph-1 0.1491 0.8963 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0062 0.0143
Brugia malayi follicle stimulating hormone receptor 0.0251 0.1363 0.1521
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0039 0.0066 0.0737
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0048 0.0122 0.0136
Loa Loa (eye worm) TK/ROR protein kinase 0.0092 0.0389 0.0434
Entamoeba histolytica calpain large subunit domain III containing protein 0.0043 0.0085 0.5475
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0948 0.5636 0.6288
Echinococcus granulosus cathepsin b 0.0136 0.0661 0.0738
Loa Loa (eye worm) hypothetical protein 0.0034 0.0031 0.0035
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0024 0.0026
Leishmania major hypothetical protein, conserved 0.0092 0.0389 0.0901
Loa Loa (eye worm) hypothetical protein 0.0092 0.0389 0.0434
Onchocerca volvulus 0.0111 0.0504 0.0895
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0197 0.0457
Loa Loa (eye worm) hypothetical protein 0.0119 0.0552 0.0616
Loa Loa (eye worm) hypothetical protein 0.0111 0.0504 0.0563
Trypanosoma brucei oligopeptidase b 0.0065 0.0223 0.0448
Echinococcus multilocularis calpain A 0.0168 0.0857 0.0857
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0251 0.1363 0.1521
Mycobacterium tuberculosis Conserved protein 0.0111 0.0504 0.1144
Echinococcus granulosus calpain A 0.0061 0.0197 0.022
Toxoplasma gondii prolyl endopeptidase 0.0143 0.0701 0.798
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0166 0.0166
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.016 0.0803 0.0896
Leishmania major C-8 sterol isomerase-like protein 0.0733 0.4317 1
Echinococcus granulosus glutamate NMDA receptor subunit 0.024 0.1297 0.1447
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0197 0.022
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0282 0.1556 0.1736
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1556 0.1736
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0049 0.0125 0.0227
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0065 0.0223 0.0465
Trypanosoma cruzi protein farnesyltransferase, putative 0.0054 0.0156 0.0361
Onchocerca volvulus 0.0948 0.5636 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0064 0.0147
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0504 1
Schistosoma mansoni glutamate receptor kainate 0.0131 0.0628 0.07
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1244 0.1388
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0197 0.0457
Brugia malayi prolyl oligopeptidase family protein 0.0071 0.0261 0.0291
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.016 0.0803 0.0896
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0166 0.0185
Brugia malayi mbt repeat family protein 0.0049 0.0125 0.0139
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0504 0.1144
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.016 0.0803 0.0803
Schistosoma mansoni glutamate receptor NMDA 0.024 0.1297 0.1447
Echinococcus granulosus max protein X 0.0453 0.2604 0.2905
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0062 0.0069
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0038 0.0058 0.0064
Trypanosoma cruzi Aph-1 protein, putative 0.0581 0.3386 0.7842
Schistosoma mansoni hypothetical protein 0.007 0.0255 0.0284
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0048 0.0122 0.0136
Schistosoma mansoni caspase-7 (C14 family) 0.0305 0.1694 0.189
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1244 0.1244
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0058 0.0064
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0062 0.0649
Loa Loa (eye worm) calpain family protein 1 0.0119 0.0552 0.0616
Schistosoma mansoni hypothetical protein 0.0048 0.0122 0.0136
Onchocerca volvulus 0.0111 0.0504 0.0895
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0156 0.2635
Toxoplasma gondii ABC1 family protein 0.0111 0.0504 0.5638
Loa Loa (eye worm) trypsin family protein 0.0038 0.0058 0.0064
Echinococcus multilocularis cpg binding protein 0.0095 0.0408 0.0408
Brugia malayi cathepsin B-like cysteine proteinase 0.0136 0.0661 0.0738
Loa Loa (eye worm) hypothetical protein 0.0111 0.0504 0.0563
Echinococcus multilocularis pyruvate kinase 0.0034 0.0031 0.0031
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0035 0.004 0.0044
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0948 0.5636 0.5636
Leishmania major kinesin, putative 0.0043 0.0085 0.0198
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0031 0.0035
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0024 0.0026
Schistosoma mansoni glutamate receptor kainate 0.0131 0.0628 0.07
Echinococcus granulosus geminin 0.0688 0.4041 0.4508
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1556 0.1736
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0197 0.0388
Echinococcus multilocularis calpain 0.0061 0.0197 0.0197
Trypanosoma brucei C-8 sterol isomerase, putative 0.0733 0.4317 1
Loa Loa (eye worm) calpain 0.0061 0.0197 0.022
Brugia malayi calpain family protein 1 0.0161 0.0812 0.0906
Loa Loa (eye worm) hypothetical protein 0.03 0.1663 0.1856
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0038 0.0058 0.0058
Echinococcus multilocularis geminin 0.0688 0.4041 0.4041
Loa Loa (eye worm) hypothetical protein 0.0111 0.0504 0.0563
Onchocerca volvulus 0.0049 0.0125 0.0221
Brugia malayi Cell death protein 3 precursor 0.0305 0.1694 0.189
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0038 0.0018
Onchocerca volvulus 0.0047 0.0114 0.0203
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Toxoplasma gondii histone lysine methyltransferase SET1 0.0171 0.0871 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0061 0.0197 0.0457
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0064 0.0685
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0026
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0125 0.0139
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0054 0.0156 0.2635
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0948 0.5636 0.6288
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Onchocerca volvulus 0.0038 0.0058 0.0102
Schistosoma mansoni cpg binding protein 0.0095 0.0408 0.0455
Echinococcus granulosus gamma secretase subunit aph 1 0.1491 0.8963 1
Echinococcus granulosus prolyl endopeptidase 0.0143 0.0701 0.0782
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0125 0.0125
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.016 0.0803 0.0803
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0054 0.0156 0.2635
Brugia malayi hypothetical protein 0.0305 0.1694 0.189
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0064 0.0076
Brugia malayi Receptor family ligand binding region containing protein 0.0035 0.004 0.0044
Schistosoma mansoni inositol monophosphatase 0.0039 0.0064 0.0071
Echinococcus multilocularis neuropeptide s receptor 0.05 0.2887 0.2887
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0064 1
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.248 0.248
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0166 0.0166
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0064 0.0147
Echinococcus granulosus tm gpcr rhodopsin 0.0533 0.3092 0.345
Echinococcus granulosus enteropeptidase 0.0038 0.0058 0.0064
Echinococcus granulosus glycoprotein Antigen 5 0.0038 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0103 0.0454 0.0506
Loa Loa (eye worm) hypothetical protein 0.0143 0.0701 0.0782
Loa Loa (eye worm) calpain family protein 1 0.0161 0.0812 0.0906
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0996 0.1111
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0201 0.1055 0.1176
Giardia lamblia Cathepsin B precursor 0.0045 0.0101 0.5587
Brugia malayi Trypsin family protein 0.03 0.1663 0.1856
Echinococcus granulosus GPCR family 2 0.0032 0.0024 0.0026
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0048 0.0122 0.0122
Leishmania major lanosterol synthase, putative 0.0045 0.0098 0.0227
Echinococcus multilocularis hypothetical protein 0.0061 0.0197 0.0197
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0024 0.0026
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0024 0.0026
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0097 0.0422 0.0422
Brugia malayi beta-lactamase family protein 0.0111 0.0504 0.0563
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0026
Schistosoma mansoni pyruvate kinase 0.0034 0.0031 0.0035
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0045 0.0101 0.0233
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0065 0.0223 0.0517
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0061 0.0197 0.0457
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0054 0.0156 0.0174
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0049 0.0125 0.1983
Giardia lamblia Cathepsin B precursor 0.0045 0.0101 0.5587
Schistosoma mansoni survival motor neuron protein 0.0047 0.0114 0.0127
Schistosoma mansoni hypothetical protein 0.0433 0.248 0.2766
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0071 0.0261 0.0291
Echinococcus multilocularis inhibitor of apoptosis protein 0.0948 0.5636 0.5636
Echinococcus multilocularis enteropeptidase 0.0038 0.0058 0.0058
Schistosoma mansoni pyruvate kinase 0.0034 0.0031 0.0035
Schistosoma mansoni hypothetical protein 0.0038 0.0058 0.0064
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0065 0.0223 0.0448
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0948 0.5636 0.6288
Loa Loa (eye worm) hypothetical protein 0.0161 0.0812 0.0906
Loa Loa (eye worm) hypothetical protein 0.0049 0.0125 0.0139
Giardia lamblia Prenyltransferase 0.0054 0.0156 1
Plasmodium vivax calpain, putative 0.0061 0.0197 0.3512
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0166 0.0185
Echinococcus granulosus calpain A 0.0168 0.0857 0.0956
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.016 0.0803 0.0803
Brugia malayi gamma-secretase subunit aph-1 0.1491 0.8963 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0125 0.0139
Echinococcus multilocularis caspase 2 0.0305 0.1694 0.1694
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0064
Loa Loa (eye worm) inositol-1 0.0039 0.0064 0.0071
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0282 0.1556 0.1736
Brugia malayi calpain 7 0.0061 0.0197 0.022
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0071 0.0261 0.0261
Plasmodium falciparum cysteine repeat modular protein 1 0.0092 0.0389 1
Echinococcus granulosus inhibitor of apoptosis protein 0.0948 0.5636 0.6288
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0125 0.0139
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0504 0.1144
Onchocerca volvulus 0.01 0.044 0.078
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0061 0.0197 0.0457
Schistosoma mansoni hypothetical protein 0.0032 0.0024 0.0026
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0062 0.0143
Schistosoma mansoni ap endonuclease 0.0039 0.0062 0.0069
Echinococcus multilocularis nmda type glutamate receptor 0.0253 0.1378 0.1378
Mycobacterium tuberculosis Conserved protein 0.0111 0.0504 0.1144
Brugia malayi Trypsin family protein 0.0038 0.0058 0.0064
Loa Loa (eye worm) hypothetical protein 0.0232 0.1244 0.1388
Loa Loa (eye worm) hypothetical protein 0.0948 0.5636 0.6288
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0948 0.5636 0.6288
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0185 0.0957 0.1068
Schistosoma mansoni hypothetical protein 0.0047 0.0114 0.0127
Echinococcus multilocularis prolyl endopeptidase 0.0143 0.0701 0.0701
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0453 0.2604 0.2905
Brugia malayi calpain family protein 1 0.0161 0.0812 0.0906
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0054 0.0156 0.0156
Echinococcus multilocularis glutamate receptor NMDA 0.0156 0.0781 0.0781
Loa Loa (eye worm) hypothetical protein 0.0035 0.004 0.0044
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0197 0.0388
Leishmania major hypothetical protein, conserved 0.0111 0.0504 0.1168
Onchocerca volvulus 0.0092 0.0389 0.069
Trypanosoma brucei calpain-like protein, putative 0.0061 0.0197 0.0388
Echinococcus multilocularis max protein X 0.0453 0.2604 0.2604
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0504 0.0563
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0504 0.0563
Echinococcus multilocularis GPCR, family 2 0.0032 0.0024 0.0024
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.016 0.0803 0.0896
Brugia malayi CXXC zinc finger family protein 0.009 0.0377 0.042
Loa Loa (eye worm) hypothetical protein 0.0111 0.0504 0.0563
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0049 0.0125 1
Schistosoma mansoni glutamate receptor AMPA 0.0131 0.0628 0.07
Echinococcus granulosus calpain 5 0.0061 0.0197 0.022
Mycobacterium tuberculosis Conserved protein 0.0111 0.0504 0.1144
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0071 0.0261 0.0536
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.03 0.1663 0.1856
Schistosoma mansoni bhlhzip transcription factor bigmax 0.0453 0.2604 0.2905
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0282 0.1556 0.1556
Echinococcus granulosus tissue type plasminogen activator 0.0092 0.0389 0.0434
Trypanosoma cruzi oligopeptidase b 0.0065 0.0223 0.0517
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0504 1
Echinococcus multilocularis transmembrane protease serine 3 0.0038 0.0058 0.0058
Trypanosoma cruzi prolyl endopeptidase 0.0143 0.0701 0.1624
Echinococcus multilocularis Mastin 0.0038 0.0058 0.0058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0103 0.0454 0.0506
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0059 0.0188 0.0379
Schistosoma mansoni hypothetical protein 0.0688 0.4041 0.4508
Echinococcus granulosus pyruvate kinase 0.0034 0.0031 0.0035
Brugia malayi Calcitonin receptor-like protein seb-1 0.0103 0.0454 0.0506
Loa Loa (eye worm) hypothetical protein 0.0948 0.5636 0.6288
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0065 0.0223 0.4061
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0125 0.0221
Loa Loa (eye worm) hypothetical protein 0.0375 0.2121 0.2366
Echinococcus multilocularis gamma secretase subunit aph 1 0.1491 0.8963 0.8963
Brugia malayi metabotropic glutamate receptor type 2 0.0044 0.0096 0.0107
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0062 0.0069
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0504 0.1144
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0282 0.1556 0.1736
Loa Loa (eye worm) hypothetical protein 0.0038 0.0058 0.0064
Brugia malayi Protein kinase domain containing protein 0.0092 0.0389 0.0434
Echinococcus granulosus glutamate receptor subunit protein glur 0.0048 0.0122 0.0136
Echinococcus multilocularis cathepsin b 0.0136 0.0661 0.0661
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0114 0.0127
Trypanosoma cruzi lanosterol synthase, putative 0.0059 0.0188 0.0435
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0071 0.0261 0.0604
Schistosoma mansoni calpain-7 (C02 family) 0.0061 0.0197 0.022
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.016 0.0803 0.0803
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0708 0.4167 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0038 0.0058 0.0064

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3294 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 9.1962 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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