Detailed information for compound 1457984

Basic information

Technical information
  • TDR Targets ID: 1457984
  • Name: 5-[[4-(benzoyl)phenyl]hydrazinylidene]-1,3-di azinane-2,4,6-trione
  • MW: 336.302 | Formula: C17H12N4O4
  • H donors: 3 H acceptors: 4 LogP: 2.48 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)c1ccc(cc1)NN=C1C(=O)NC(=O)NC1=O
  • InChi: 1S/C17H12N4O4/c22-14(10-4-2-1-3-5-10)11-6-8-12(9-7-11)20-21-13-15(23)18-17(25)19-16(13)24/h1-9,20H,(H2,18,19,23,24,25)
  • InChiKey: PVKGXQSTLKIFAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-[[4-(benzoyl)phenyl]hydrazono]hexahydropyrimidine-2,4,6-trione
  • 5-[[4-(oxo-phenylmethyl)phenyl]hydrazono]hexahydropyrimidine-2,4,6-trione
  • 5-[[4-(benzoyl)phenyl]hydrazono]barbituric acid
  • 5-[(4-phenylcarbonylphenyl)hydrazinylidene]-1,3-diazinane-2,4,6-trione
  • 5-[(4-Benzoyl-phenyl)-hydrazono]-pyrimidine-2,4,6-trione
  • BAS 00488677
  • STK034755
  • ZINC04714103
  • MLS000712902
  • SMR000282669

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glutaminase Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens muscleblind-like splicing regulator 1 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens glycoprotein hormones, alpha polypeptide Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens Bloom syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), beta Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi glutaminase DH11.1 Get druggable targets OG5_129245 All targets in OG5_129245
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis glutaminase, putative Get druggable targets OG5_129245 All targets in OG5_129245
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132352 All targets in OG5_132352
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Conserved hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trypanosoma brucei gambiense mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_130965 All targets in OG5_130965
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) glutaminase Get druggable targets OG5_129245 All targets in OG5_129245
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis muscleblind protein Get druggable targets OG5_132352 All targets in OG5_132352
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis muscleblind protein 1 Get druggable targets OG5_132352 All targets in OG5_132352
Leishmania mexicana mitochondrial DNA polymerase beta Get druggable targets OG5_130965 All targets in OG5_130965
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) glutaminase 2 Get druggable targets OG5_129245 All targets in OG5_129245
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
Brugia malayi Muscleblind-like protein Get druggable targets OG5_132352 All targets in OG5_132352
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense mitochondrial DNA polymerase beta, putative Get druggable targets OG5_130965 All targets in OG5_130965
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative polymerase (DNA directed), beta 335 aa 303 aa 32.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Toxoplasma gondii intraflagellar transport protein 172, putative glycoprotein hormones, alpha polypeptide 116 aa 94 aa 26.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0148 0.1724 0.439
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0462 0.0429
Echinococcus granulosus dnaJ subfamily B 0.0494 0.5902 0.5888
Brugia malayi TAR-binding protein 0.0317 0.3761 0.9582
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0011 0.0065 0.0032
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0007
Loa Loa (eye worm) hypothetical protein 0.018 0.2115 0.5389
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0034 0.008
Schistosoma mansoni cpg binding protein 0.0035 0.0356 0.0353
Schistosoma mansoni hypothetical protein 0.0043 0.0462 0.0459
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0248 0.0556
Brugia malayi RNA recognition motif domain containing protein 0.0317 0.3761 0.9582
Echinococcus multilocularis GPCR, family 2 0.0082 0.0923 0.0892
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0462 0.0429
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0011 0.0065 0.0032
Toxoplasma gondii histone lysine methyltransferase SET1 0.0066 0.073 0.8878
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0082 0.0923 0.0892
Schistosoma mansoni tar DNA-binding protein 0.0317 0.3761 0.3759
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0604 0.1534
Mycobacterium ulcerans glutaminase 0.033 0.3923 1
Schistosoma mansoni hypothetical protein 0.0494 0.5902 0.5901
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0065 0.008
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0365 0.4341 1
Leishmania major mitochondrial DNA polymerase beta 0.0365 0.4341 1
Brugia malayi glutaminase DH11.1 0.033 0.3923 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0317 0.3761 0.9585
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0082 0.0923 0.2286
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0041 0.0007
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0062 0.0692 0.1589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0604 0.0602
Onchocerca volvulus Huntingtin homolog 0.0148 0.1724 1
Entamoeba histolytica recQ family helicase, putative 0.0014 0.0103 0.2237
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0539 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0032 0.00000000013611
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.2067 0.5227
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0082 0.0923 0.0892
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0822 1
Echinococcus multilocularis cpg binding protein 0.0037 0.038 0.0347
Loa Loa (eye worm) RNA binding protein 0.0317 0.3761 0.9585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0604 0.0602
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0768
Schistosoma mansoni DNA helicase recq1 0.0011 0.0065 0.0063
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0081
Echinococcus granulosus cpg binding protein 0.0037 0.038 0.0347
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0556 0.1276
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0604 0.1466
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0014 0.0103 0.0232
Toxoplasma gondii hypothetical protein 0.0059 0.0647 0.7864
Mycobacterium ulcerans hypothetical protein 0.0192 0.2257 0.4626
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0002 0.0054
Schistosoma mansoni smad 0.0008 0.0034 0.0032
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0539 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0768
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0082 0.0923 0.0892
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0604 0.0602
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0032 0.00000000013611
Loa Loa (eye worm) hypothetical protein 0.0176 0.2067 0.5266
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.0825 0.0823
Schistosoma mansoni tar DNA-binding protein 0.0317 0.3761 0.3759
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0032 0.00000000013611
Echinococcus granulosus tar DNA binding protein 0.0317 0.3761 0.3739
Giardia lamblia Sgs1 DNA helicase, putative 0.0011 0.0065 0.5
Brugia malayi MH2 domain containing protein 0.0118 0.1361 0.3411
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0017 0.0145 0.1737
Entamoeba histolytica hypothetical protein 0.0043 0.0462 1
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0248 0.0551
Echinococcus multilocularis microtubule associated protein 2 0.0833 1 1
Brugia malayi RNA binding protein 0.0317 0.3761 0.9582
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0462 0.0459
Schistosoma mansoni tar DNA-binding protein 0.0317 0.3761 0.3759
Loa Loa (eye worm) hypothetical protein 0.005 0.0539 0.1369
Brugia malayi Muscleblind-like protein 0.018 0.2115 0.5351
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0147 0.2733
Leishmania major hypothetical protein, conserved 0.005 0.0539 0.1029
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.1361 0.3464
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0065 0.0081
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0539 0.1237
Loa Loa (eye worm) glutaminase 0.033 0.3923 1
Brugia malayi hypothetical protein 0.0043 0.0462 0.11
Echinococcus granulosus mixed lineage leukemia protein mll 0.0009 0.0041 0.0007
Echinococcus granulosus bloom syndrome protein 0.0026 0.0248 0.0215
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0207 0.0174
Schistosoma mansoni hypothetical protein 0.0082 0.0923 0.0921
Echinococcus granulosus GPCR family 2 0.0082 0.0923 0.0892
Trichomonas vaginalis glutaminase, putative 0.033 0.3923 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0032
Schistosoma mansoni hypothetical protein 0.0082 0.0923 0.0921
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0011 0.0065 0.0032
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0173 0.2021 0.4526
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0822 0.1697
Echinococcus multilocularis tar DNA binding protein 0.0317 0.3761 0.3739
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0539 1
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0539 0.1237
Loa Loa (eye worm) hypothetical protein 0.0082 0.0923 0.2348
Mycobacterium tuberculosis Conserved hypothetical protein 0.0192 0.2257 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0822 0.082
Loa Loa (eye worm) TAR-binding protein 0.0317 0.3761 0.9585
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0604 0.0572
Loa Loa (eye worm) hypothetical protein 0.0011 0.0065 0.0161
Schistosoma mansoni hypothetical protein 0.0176 0.2067 0.2065
Schistosoma mansoni DNA helicase recq5 0.0011 0.0065 0.0063
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0032
Entamoeba histolytica hypothetical protein 0.0043 0.0462 1
Schistosoma mansoni glutaminase 0.033 0.3923 0.3922
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0011 0.0067 0.0033
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2021 0.4526
Loa Loa (eye worm) Smad1 0.0008 0.0034 0.008
Brugia malayi hypothetical protein 0.005 0.0539 0.1299
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0008 0.0032 0.00000000013611
Schistosoma mansoni cpg binding protein 0.0037 0.038 0.0377
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0183 0.018
Entamoeba histolytica hypothetical protein 0.0043 0.0462 1
Schistosoma mansoni tar DNA-binding protein 0.0317 0.3761 0.3759
Schistosoma mansoni hypothetical protein 0.0022 0.0207 0.0205
Echinococcus granulosus muscleblind protein 0.018 0.2115 0.2088
Entamoeba histolytica hypothetical protein 0.0043 0.0462 1
Loa Loa (eye worm) hypothetical protein 0.018 0.2115 0.5389
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.5902 0.5888
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0051 0.0556 0.1069
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0011 0.0065 0.0032
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0173 0.2021 0.4653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0032 0.00000000013611
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0032 0.00000000013611
Loa Loa (eye worm) hypothetical protein 0.0258 0.3053 0.778
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0034 0.0032
Brugia malayi hypothetical protein 0.0148 0.1724 0.4344
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0009 0.0041 0.0007
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0051 0.0556 0.1276
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0604 0.0572
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0604 0.0572
Brugia malayi Latrophilin receptor protein 2 0.0082 0.0923 0.2286
Schistosoma mansoni Smad4 0.0008 0.0034 0.0032
Schistosoma mansoni smad1 5 8 and 0.0008 0.0034 0.0032
Brugia malayi hypothetical protein 0.0032 0.0326 0.075
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0556 0.1276
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0822 0.0791
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0207 0.0174
Loa Loa (eye worm) hypothetical protein 0.0148 0.1724 0.439
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.021 0.3058
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0822 0.0791
Schistosoma mansoni hypothetical protein 0.0082 0.0923 0.0921
Brugia malayi Calcitonin receptor-like protein seb-1 0.0258 0.3053 0.7762
Loa Loa (eye worm) latrophilin receptor protein 2 0.0082 0.0923 0.2348
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0822 0.082
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0032 0.00000000013611
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4341 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0034 0.008
Loa Loa (eye worm) hypothetical protein 0.0021 0.0185 0.0466
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0365 0.4341 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0011 0.0067 0.0033
Echinococcus multilocularis muscleblind protein 0.018 0.2115 0.2088
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0258 0.3053 0.7762
Brugia malayi CXXC zinc finger family protein 0.0035 0.0356 0.0827
Schistosoma mansoni cpg binding protein 0.0037 0.038 0.0377
Schistosoma mansoni hypothetical protein 0.0082 0.0923 0.0921
Schistosoma mansoni tar DNA-binding protein 0.0317 0.3761 0.3759
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0539 0.6547
Treponema pallidum ATP-dependent DNA helicase 0.0005 0.0002 0.5
Loa Loa (eye worm) RecQ helicase 0.0026 0.0248 0.0627
Schistosoma mansoni microtubule-associated protein tau 0.0833 1 1
Loa Loa (eye worm) glutaminase 2 0.033 0.3923 1
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0539 0.1029
Echinococcus multilocularis muscleblind protein 1 0.018 0.2115 0.2088
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0009 0.0041 0.0039
Loa Loa (eye worm) histone methyltransferase 0.0011 0.0067 0.0163
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0604 0.0572
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0258 0.3053 0.778
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0248 0.0215
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0082 0.0923 0.0892
Trichomonas vaginalis DNA helicase recq, putative 0.0014 0.0103 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0008 0.0032 0.00000000013611
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0011 0.0065 0.0161
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0356 0.0901
Onchocerca volvulus Huntingtin homolog 0.0148 0.1724 1
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.1361 0.3464
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0248 0.0556

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1 uM PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) 1.7783 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 3.1623 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS of Nrf2 Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 14.1254 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 16.5113 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 19.9526 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM). (Class of assay: confirmatory) [Related pubchem assays: 593 (Fluorescein region spectral profiling screen), 2386 (Probe Development Summary for Inhibitors of Bloom's syndrome helicase (BLM)), 594 (Rhodamine region spectral profiling screen), 2364 (qHTS Validation Assay for Inhibitors of Bloom's syndrome helicase (BLM))] ChEMBL. No reference
Potency (functional) 22.3872 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 50.1187 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 79.4328 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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