TDR Targets

Basic information

Technical information

TDR Targets ID: 1460271
Name: N-[4-(cyclohexylamino)-2-oxochromen-3-yl]-4-f luorobenzenesulfonamide
MW: 416.466 | Formula: C21H21FN2O4S
H donors: 2 H acceptors: 3 LogP: 4.26 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc(cc1)S(=O)(=O)Nc1c(=O)oc2c(c1NC1CCCCC1)cccc2
InChi: 1S/C21H21FN2O4S/c22-14-10-12-16(13-11-14)29(26,27)24-20-19(23-15-6-2-1-3-7-15)17-8-4-5-9-18(17)28-21(20)25/h4-5,8-13,15,23-24H,1-3,6-7H2
InChiKey: ZNYHONHMICQSPN-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

N-[4-(cyclohexylamino)-2-oxo-chromen-3-yl]-4-fluoro-benzenesulfonamide
N-[4-(cyclohexylamino)-2-oxo-3-chromenyl]-4-fluorobenzenesulfonamide
N-[4-(cyclohexylamino)-2-keto-chromen-3-yl]-4-fluoro-benzenesulfonamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	glucagon-like peptide 1 receptor	Starlite/ChEMBL	No references
Homo sapiens	ATM serine/threonine kinase	Starlite/ChEMBL	No references
Homo sapiens	polo-like kinase 1	Starlite/ChEMBL	No references
Homo sapiens	vitamin D (1,25- dihydroxyvitamin D3) receptor	Starlite/ChEMBL	No references
Homo sapiens	glycoprotein hormones, alpha polypeptide	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	polo-like protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	IPR000971,Globin;IPR012292,Globin-related;IPR009050,Globin-like,domain-containing	Get druggable targets OG5_128955	All targets in OG5_128955
Entamoeba histolytica	serine/threonine protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Neospora caninum	phosphatidylinositol 3- and 4-kinase domain- containing protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Giardia lamblia	Kinase, PLK	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania donovani	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania infantum	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus multilocularis	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K04728 ataxia telangectasia mutated family protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	polo-like protein kinase,protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Loa Loa (eye worm)	PLK/PLK1 protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Onchocerca volvulus	Serine\/threonine kinase homolog	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania mexicana	phosphatidylinositol 3-kinase-like protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	PIKK family atypical protein kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	Serine/threonine-protein kinase PLK1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus multilocularis	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Leishmania mexicana	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania infantum	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Toxoplasma gondii	FATC domain-containing protein	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	identical to the C terminus of CaP19.5580 potential phosphatidylinositol kinase	Get druggable targets OG5_128955	All targets in OG5_128955
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Schistosoma japonicum	ko:K06631 polo-like kinase 1, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Trichomonas vaginalis	CAMK family protein kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Echinococcus granulosus	serine:threonine protein kinase PLK1	Get druggable targets OG5_127396	All targets in OG5_127396
Leishmania braziliensis	protein kinase, putative,polo-like protein kinase, putative	Get druggable targets OG5_127396	All targets in OG5_127396
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128955	All targets in OG5_128955
Trypanosoma brucei gambiense	phosphatidylinositol kinase domain protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Brugia malayi	serine/threonine-protein kinase plk-2	Get druggable targets OG5_127396	All targets in OG5_127396
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	Get druggable targets OG5_128955	All targets in OG5_128955
Echinococcus granulosus	serine protein kinase ATM	Get druggable targets OG5_128955	All targets in OG5_128955
Candida albicans	protein serine/threonine kinase	Get druggable targets OG5_127396	All targets in OG5_127396
Candida albicans	similar to putative phosphatidylinositol kinase involved in telomere length regulation	Get druggable targets OG5_128955	All targets in OG5_128955

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	glucagon-like peptide 1 receptor	463 aa	388 aa	25.8 %
Brugia malayi	steroid hormone receptor	vitamin D (1,25- dihydroxyvitamin D3) receptor	427 aa	416 aa	24.5 %
Toxoplasma gondii	intraflagellar transport protein 172, putative	glycoprotein hormones, alpha polypeptide	116 aa	94 aa	26.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0201	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Latrophilin receptor protein 2	0.0019	0.0145	0.0707
Onchocerca volvulus	Serine\/threonine kinase homolog	0.0114	0.2025	0.3948
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0012	0.001	0.001
Onchocerca volvulus	Bile acid receptor homolog	0.0012	0.001	0.0015
Plasmodium vivax	multidrug resistance protein 1, putative	0.0012	0.0003	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0886	0.4366
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0201	0.098
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0012	0.001	0.001
Echinococcus multilocularis	ecdysone induced protein 78C	0.0012	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0201	0.5511
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0012	0.001	0.0037
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0012	0.0048
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0019	0.0145	0.0145
Schistosoma mansoni	hypothetical protein	0.0019	0.0145	0.0707
Loa Loa (eye worm)	PLK/PLK1 protein kinase	0.0114	0.2025	1
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0022	0.0201	0.0387
Schistosoma mansoni	hypothetical protein	0.0019	0.0145	0.0707
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.006	0.096	0.4738
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0012	0.001	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.001	0.0037
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0201	0.0201
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0012	0.001	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0012	0.001	0.005
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Toxoplasma gondii	FATC domain-containing protein	0.003	0.0362	1
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0003	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Entamoeba histolytica	protein kinase rad3, putative	0.0012	0.0012	0.0048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0012	0.001	0.0037
Schistosoma mansoni	RAR-like nuclear receptor	0.0012	0.001	0.0037
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0003	0.0003
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0201	0.0316
Entamoeba histolytica	hypothetical protein	0.003	0.0362	0.1777
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0012	0.001	0.001
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0003	0.0003
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0003	0.0013
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0012	0.001	0.001
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0201	0.098
Trypanosoma cruzi	C-14 sterol reductase, putative	0.009	0.154	0.2987
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0019	0.0145	0.0145
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0201	0.0991
Echinococcus multilocularis	serine:threonine protein kinase PLK1	0.0114	0.2025	0.2025
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0201	0.0368
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0201	0.098
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Onchocerca volvulus		0.0012	0.001	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0279	0.1377
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.003	0.0362	0.1777
Loa Loa (eye worm)	steroid hormone receptor	0.0012	0.001	0.005
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0201	0.0316
Onchocerca volvulus	Protein ultraspiracle homolog	0.0012	0.001	0.0015
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.003	0.0362	0.1777
Schistosoma mansoni	serine/threonine protein kinase	0.0114	0.2025	1
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.004	0.0186
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0012	0.001	0.0015
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0003	0.0003
Leishmania major	C-14 sterol reductase, putative	0.009	0.154	0.3
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0012	0.001	0.001
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0201	0.098
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0022	0.0202	0.0388
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.006	0.096	0.4731
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0012	0.0012	0.0012
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0003	0.0003
Loa Loa (eye worm)	hypothetical protein	0.0014	0.004	0.0198
Schistosoma mansoni	hypothetical protein	0.0019	0.0145	0.0707
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0022	0.0201	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0012	0.001	0.0037
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0022	0.0201	0.0387
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0012	0.001	0.005
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.001	0.0037
Schistosoma mansoni	kinase	0.0058	0.0916	0.4514
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0201	0.098
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.0012	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0022	0.0201	0.0387
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0012	0.001	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0201	0.0368
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0003	0.0003
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0271	0.5126	1
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.2025	0.3937
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0201	0.0991
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0012	0.001	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0012	0.001	0.0037
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0003	0.0003
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.003	0.0362	0.0633
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Brugia malayi	steroid hormone receptor	0.0012	0.001	0.0037
Plasmodium falciparum	multidrug resistance protein 1	0.0012	0.0003	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.001	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Trypanosoma brucei	C-14 sterol reductase, putative	0.009	0.154	0.2948
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0012	0.001	0.0037
Loa Loa (eye worm)	ATP-binding cassette sub-family B member 2	0.0012	0.0003	0.0013
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0201	0.0316
Brugia malayi	Nuclear hormone receptor-like 1	0.0012	0.001	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0003	0.0003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.003	0.0362	0.0684
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0583	0.2877
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0012	0.001	0.001
Schistosoma mansoni	thyroid hormone receptor	0.0012	0.001	0.0037
Trypanosoma cruzi	Emopamil binding protein, putative	0.0271	0.5126	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.004	0.0186
Schistosoma mansoni	hypothetical protein	0.0019	0.0145	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0012	0.0061
Brugia malayi	nuclear receptor NHR-88	0.0012	0.001	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Schistosoma mansoni	nuclear hormone receptor	0.0012	0.001	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0019	0.0145	0.0718
Trichomonas vaginalis	PIKK family atypical protein kinase	0.003	0.0362	0.1777
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0201	0.0316
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0003	0.0003
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Echinococcus multilocularis	multidrug resistance protein 1	0.0012	0.0003	0.0003
Leishmania major	sterol C-24 reductase, putative	0.0047	0.0689	0.1339
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0012	0.001	0.0037
Leishmania major	protein kinase, putative,polo-like protein kinase, putative	0.0114	0.2025	0.3948
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Schistosoma mansoni	hypothetical protein	0.0041	0.0583	0.2869
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0012	0.001	0.0037
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0517	1	1
Echinococcus multilocularis	serine protein kinase ATM	0.003	0.0362	0.0362
Brugia malayi	photoreceptor-specific nuclear receptor	0.0012	0.001	0.0037
Echinococcus granulosus	ATP binding cassette subfamily B MDR:TAP	0.0012	0.0003	0.0003
Trichomonas vaginalis	CAMK family protein kinase	0.0056	0.0886	0.4366
Entamoeba histolytica	serine/threonine protein kinase, putative	0.0114	0.2025	1
Giardia lamblia	Kinase, PLK	0.0114	0.2025	1
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.0012	0.0003	0.5
Loa Loa (eye worm)	hypothetical protein	0.006	0.096	0.4738
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Loa Loa (eye worm)	hypothetical protein	0.0012	0.001	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Echinococcus granulosus	lamin b receptor	0.009	0.154	0.154
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0012	0.001	0.001
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0047	0.0689	0.1323
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0012	0.001	0.0037
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.0202	0.037
Echinococcus multilocularis	GPCR, family 2	0.0019	0.0145	0.0145
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0012	0.001	0.005
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Schistosoma mansoni	retinoic acid receptor RXR	0.0012	0.001	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0012	0.001	0.005
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0012	0.001	0.0037
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0012	0.001	0.005
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0012	0.001	0.0037
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0019	0.0145	0.0145
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0145	0.0718
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0201	0.0368
Trypanosoma cruzi	C-14 sterol reductase, putative	0.009	0.154	0.2987
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0201	0.098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Echinococcus multilocularis	FTZ F1 alpha	0.0012	0.001	0.001
Trypanosoma cruzi	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0271	0.5126	1
Trypanosoma brucei	Emopamil binding protein, putative	0.0271	0.5126	1
Leishmania major	hypothetical protein, conserved	0.0271	0.5126	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0003	0.0013
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0012	0.0012	0.0048
Loa Loa (eye worm)	multidrug resistance protein 3	0.0012	0.0003	0.0013
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0201	0.0201
Onchocerca volvulus		0.0271	0.5126	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0019	0.0145	0.0145
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0201	0.0201
Brugia malayi	serine/threonine-protein kinase plk-2	0.0114	0.2025	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0012	0.001	0.0037
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0012	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Leishmania major	3-Beta-hydroxysteroid-delta(8), delta(7)-isomerase, putative	0.0271	0.5126	1
Trypanosoma cruzi	sterol C-24 reductase, putative	0.0047	0.0689	0.1323
Brugia malayi	Calcitonin receptor-like protein seb-1	0.006	0.096	0.4731
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0201	0.0368
Brugia malayi	Steroid receptor seven-up type 2	0.0012	0.001	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Echinococcus multilocularis	lamin b receptor	0.009	0.154	0.154
Brugia malayi	ecdysteroid receptor	0.0012	0.001	0.0037
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0012	0.001	0.0037
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0026	0.0279	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0689	0.34
Trypanosoma cruzi	Emopamil binding protein, putative	0.0271	0.5126	1
Trypanosoma brucei	polo-like protein kinase	0.0114	0.2025	0.3903
Schistosoma mansoni	Lamin B receptor (ERG24)	0.009	0.154	0.7598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.001	0.0037
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0201	0.098
Brugia malayi	latrophilin 2 splice variant baaae	0.0041	0.0583	0.2869
Echinococcus granulosus	GPCR family 2	0.0019	0.0145	0.0145
Trypanosoma cruzi	polo-like protein kinase, putative	0.0114	0.2025	0.3937
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.0012	0.0048
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0014	0.004	0.1046
Echinococcus granulosus	ecdysone induced protein 78C	0.0012	0.001	0.001
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0012	0.001	0.001
Trichomonas vaginalis	CAMK family protein kinase	0.0114	0.2025	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0012	0.001	0.0037
Echinococcus granulosus	serine:threonine protein kinase PLK1	0.0114	0.2025	0.2025
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0012	0.001	0.001
Echinococcus granulosus	serine protein kinase ATM	0.003	0.0362	0.0362
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Echinococcus multilocularis	ATP binding cassette subfamily B (MDR:TAP)	0.0012	0.0003	0.0003
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0012	0.001	0.0037
Schistosoma mansoni	coup transcription factor	0.0012	0.001	0.0037
Echinococcus granulosus	FTZ F1 alpha	0.0012	0.001	0.001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0012	0.0048
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0201	0.0368
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0012	0.001	0.001
Echinococcus granulosus	multidrug resistance protein 1	0.0012	0.0003	0.0003
Brugia malayi	nuclear hormone receptor	0.0012	0.001	0.0037
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0012	0.001	0.0037
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0022	0.0201	0.0387
Mycobacterium tuberculosis	Probable transmembrane multidrug efflux pump	0.0012	0.0003	0.5
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0019	0.0145	0.0707

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.9953 uM	PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	3.3587 uM	PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	= 7.0795 um	PUBCHEM_BIOASSAY: qHTS Assay for Identifying a Potential Treatment of Ataxia-Telangiectasia. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	12.5893 uM	PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	17.7828 uM	PUBCHEM_BIOASSAY: Inhibitors of the vitamin D receptor (VDR): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504855]	ChEMBL.	No reference
Potency (functional)	20.7865 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	22.3872 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]	ChEMBL.	No reference
Potency (functional)	23.1093 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]	ChEMBL.	No reference
Potency (functional)	29.0929 uM	PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	35.4813 uM	PubChem BioAssay. qHTS for Inhibitors of Glutaminase (GLS). (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1610297

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1460271