TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 632.786 | Formula: C37H48N2O7
H donors: 1 H acceptors: 4 LogP: 6.07 Rotable bonds: 20
Rule of 5 violations (Lipinski): 2
SMILES: COc1ccc(cc1OC)CCN(C(=O)[C@@H](c1ccccc1)OC(=O)C(C(O)(C)C)N(C(=O)CCCCCc1ccccc1)C)C
InChi: 1S/C37H48N2O7/c1-37(2,43)34(39(4)32(40)21-15-8-12-18-27-16-10-7-11-17-27)36(42)46-33(29-19-13-9-14-20-29)35(41)38(3)25-24-28-22-23-30(44-5)31(26-28)45-6/h7,9-11,13-14,16-17,19-20,22-23,26,33-34,43H,8,12,15,18,21,24-25H2,1-6H3/t33-,34?/m1/s1
InChiKey: HFJLCZURLFCCFE-BONSOQDYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Candida albicans	similar to S. cerevisiae AUR1 (YKL004W) inositolphosphorylceramide (IPC) synthase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	similar to S. cerevisiae AUR1 (YKL004W) inositolphosphorylceramide (IPC) synthase	Get druggable targets OG5_133771	All targets in OG5_133771
Candida albicans	similar to S. cerevisiae AUR1 (YKL004W) inositolphosphorylceramide (IPC) synthase	Get druggable targets OG5_133771	All targets in OG5_133771

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tubulin alpha 3 chain	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin gamma chain, putative	0.0722	0.4505	0.3601
Trypanosoma brucei	beta tubulin	0.0722	0.4505	0.4505
Echinococcus granulosus	beta tubulin	0.1447	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.1447	1	1
Plasmodium vivax	tubulin alpha chain, putative	0.0932	0.6096	0.6096
Toxoplasma gondii	alpha-tubulin I, putative	0.0932	0.6096	0.6096
Loa Loa (eye worm)	tubulin beta-2A chain	0.1447	1	1
Echinococcus granulosus	tubulin subunit TubB	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin delta chain	0.0313	0.1412	0.1412
Plasmodium vivax	tubulin epsilon chain, putative	0.0722	0.4505	0.4505
Mycobacterium leprae	cell division protein FtsZ	0.0313	0.1412	0.5
Toxoplasma gondii	beta-tubulin, putative	0.1447	1	1
Brugia malayi	Cell division protein ftsZ	0.0313	0.1412	0.1412
Brugia malayi	tubulin alpha-2 chain	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin alpha chain	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin alpha chain, putative	0.0408	0.2131	0.0838
Loa Loa (eye worm)	hypothetical protein	0.0153	0.0198	0.0198
Schistosoma mansoni	alpha tubulin	0.0932	0.6096	0.6096
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0722	0.4505	0.4505
Echinococcus granulosus	Tubulin beta 2C chain	0.1447	1	1
Echinococcus granulosus	geminin	0.1361	0.9351	0.9351
Echinococcus granulosus	tubulin alpha 3 chain	0.0932	0.6096	0.6096
Giardia lamblia	Beta tubulin	0.1447	1	1
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Trypanosoma brucei	epsilon tubulin	0.0722	0.4505	0.4505
Echinococcus granulosus	tubulin beta 1 chain	0.1447	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0932	0.6096	0.5455
Schistosoma mansoni	tubulin subunit beta	0.1447	1	1
Giardia lamblia	Alpha-tubulin	0.0932	0.6096	0.5455
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Leishmania major	beta tubulin	0.1447	1	1
Echinococcus granulosus	peroxisome assembly protein 26	0.0932	0.6096	0.6096
Echinococcus granulosus	Tubulin alpha 1 chain	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin gamma 1 chain	0.0722	0.4505	0.4505
Leishmania major	delta tubulin, putative	0.0313	0.1412	0.1412
Brugia malayi	alpha-tubulin	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin beta chain, putative	0.0932	0.6096	0.5455
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Schistosoma mansoni	alpha tubulin	0.0932	0.6096	0.6096
Leishmania major	beta tubulin	0.1447	1	1
Schistosoma mansoni	hypothetical protein	0.1361	0.9351	0.9351
Echinococcus multilocularis	tubulin alpha 3 chain	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin beta 1 chain	0.1447	1	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0153	0.0198	0.0198
Echinococcus multilocularis	tubulin epsilon chain	0.0722	0.4505	0.4505
Loa Loa (eye worm)	tubulin beta-1 chain	0.1447	1	1
Loa Loa (eye worm)	tubulin alpha 2	0.021	0.063	0.063
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Trypanosoma brucei	beta tubulin	0.1447	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0932	0.6096	0.6096
Leishmania major	beta tubulin	0.1447	1	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0313	0.1412	0.1412
Echinococcus multilocularis	tubulin alpha chain	0.0932	0.6096	0.6096
Brugia malayi	hypothetical protein	0.0216	0.0678	0.0678
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1447	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.1447	1	1
Trypanosoma cruzi	tubulin gamma chain	0.0722	0.4505	0.4505
Loa Loa (eye worm)	tubulin alpha chain	0.0932	0.6096	0.6096
Entamoeba histolytica	tubulin alpha chain, putative	0.0932	0.6096	0.5812
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Brugia malayi	Tubulin alpha chain	0.0932	0.6096	0.6096
Plasmodium falciparum	tubulin delta chain, putative	0.0313	0.1412	0.1412
Echinococcus granulosus	tubulin alpha chain	0.0932	0.6096	0.6096
Leishmania major	beta tubulin	0.1447	1	1
Trypanosoma brucei	tubulin gamma chain	0.0722	0.4505	0.4505
Schistosoma mansoni	transcription factor LCR-F1	0.0216	0.0678	0.0678
Trypanosoma cruzi	alpha tubulin, putative	0.0932	0.6096	0.6096
Echinococcus granulosus	Tubulin alpha 1 chain	0.0932	0.6096	0.6096
Leishmania major	hypothetical protein, conserved	0.0153	0.0198	0.0198
Trichomonas vaginalis	tubulin beta chain, putative	0.1447	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0932	0.6096	0.5455
Echinococcus granulosus	tubulin alpha 3 chain	0.0932	0.6096	0.6096
Echinococcus granulosus	tubulin alpha 1C chain	0.0932	0.6096	0.6096
Plasmodium vivax	tubulin beta chain, putative	0.1447	1	1
Loa Loa (eye worm)	tubulin beta chain	0.1447	1	1
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Echinococcus multilocularis	Tubulin beta 2C chain	0.1447	1	1
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0618	0.3723	0.2691
Echinococcus granulosus	Tubulin beta 2C chain	0.1447	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0313	0.1412	0.1412
Schistosoma mansoni	hypothetical protein	0.1361	0.9351	0.9351
Echinococcus granulosus	tubulin alpha chain	0.0932	0.6096	0.6096
Toxoplasma gondii	alpha tubulin TUBA1	0.0932	0.6096	0.6096
Schistosoma mansoni	tubulin subunit alpha	0.0932	0.6096	0.6096
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0139	0.0091	0.0091
Toxoplasma gondii	beta-1 tubulin, putative	0.1447	1	1
Trypanosoma cruzi	tubulin delta chain	0.0313	0.1412	0.1412
Echinococcus multilocularis	Tubulin beta 2C chain	0.1447	1	1
Brugia malayi	hypothetical protein	0.0153	0.0198	0.0198
Entamoeba histolytica	tubulin gamma chain	0.0722	0.4505	0.4105
Schistosoma mansoni	tubulin subunit beta	0.1447	1	1
Loa Loa (eye worm)	hypothetical protein	0.0618	0.3723	0.3723
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0216	0.0678	0.0678
Giardia lamblia	Beta tubulin	0.1447	1	1
Trypanosoma cruzi	zeta tubulin, putative	0.0313	0.1412	0.1412
Echinococcus granulosus	tubulin alpha chain	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1447	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0722	0.4505	0.3601
Mycobacterium tuberculosis	Cell division protein FtsZ	0.0313	0.1412	1
Trypanosoma brucei	alpha tubulin	0.0932	0.6096	0.6096
Trypanosoma brucei	alpha tubulin	0.0932	0.6096	0.6096
Leishmania major	beta tubulin	0.1447	1	1
Trypanosoma brucei	alpha tubulin	0.0932	0.6096	0.6096
Leishmania major	beta tubulin	0.1447	1	1
Leishmania major	beta tubulin	0.1447	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0932	0.6096	0.6096
Loa Loa (eye worm)	tubulin alpha 2	0.0618	0.3723	0.3723
Echinococcus granulosus	Tubulin alpha 1 chain	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin subunit TubB	0.0932	0.6096	0.6096
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Echinococcus multilocularis	beta tubulin	0.1447	1	1
Mycobacterium ulcerans	cell division protein FtsZ	0.0313	0.1412	0.5
Treponema pallidum	cell division protein FtsZ	0.0313	0.1412	0.5
Plasmodium falciparum	tubulin beta chain	0.1447	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0139	0.0091	0.0091
Trypanosoma brucei	epsilon tubulin	0.0722	0.4505	0.4505
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.0091	0.0091
Echinococcus granulosus	alpha tubulin	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0408	0.2131	0.0838
Plasmodium vivax	ataxin-2 like protein, putative	0.0153	0.0198	0.0198
Trypanosoma brucei	beta tubulin	0.1447	1	1
Echinococcus multilocularis	tubulin alpha chain	0.0932	0.6096	0.6096
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0139	0.0091	0.0091
Plasmodium falciparum	alpha tubulin 1	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0523	0.3004	0.1853
Trichomonas vaginalis	tubulin alpha chain, putative	0.0408	0.2131	0.0838
Trypanosoma cruzi	beta tubulin, putative	0.1447	1	1
Echinococcus granulosus	tubulin alpha chain	0.0932	0.6096	0.6096
Echinococcus multilocularis	Tubulin beta 2C chain	0.1447	1	1
Brugia malayi	Tubulin alpha chain	0.0313	0.1412	0.1412
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0523	0.3004	0.3004
Leishmania major	beta tubulin	0.1447	1	1
Trypanosoma brucei	zeta tubulin, putative	0.0313	0.1412	0.1412
Schistosoma mansoni	tubulin subunit alpha	0.0313	0.1412	0.1412
Plasmodium falciparum	tubulin gamma chain	0.0722	0.4505	0.4505
Wolbachia endosymbiont of Brugia malayi	cell division protein FtsZ	0.0313	0.1412	0.5
Plasmodium falciparum	ataxin-2 like protein, putative	0.0153	0.0198	0.0198
Leishmania major	beta tubulin	0.1447	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0932	0.6096	0.5455
Echinococcus multilocularis	tubulin alpha chain	0.0932	0.6096	0.6096
Trypanosoma cruzi	tubulin delta chain	0.0313	0.1412	0.1412
Trichomonas vaginalis	tubulin alpha chain, putative	0.0408	0.2131	0.0838
Echinococcus granulosus	Tubulin beta 2C chain	0.1447	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0408	0.2131	0.0838
Trichomonas vaginalis	tubulin beta chain, putative	0.0932	0.6096	0.5455
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0139	0.0091	0.0091
Echinococcus multilocularis	Tubulin beta 2C chain	0.1447	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.1447	1	1
Brugia malayi	Tubulin alpha-2 chain	0.0932	0.6096	0.6096
Trypanosoma cruzi	PAB1-binding protein , putative	0.0153	0.0198	0.0198
Loa Loa (eye worm)	BEN-1 protein	0.1447	1	1
Trypanosoma brucei	alpha tubulin, putative	0.0408	0.2131	0.2131
Giardia lamblia	Alpha-tubulin	0.0932	0.6096	0.5455
Onchocerca volvulus		0.0408	0.2131	0.7389
Loa Loa (eye worm)	BEN-1 protein	0.1447	1	1
Plasmodium falciparum	alpha tubulin 2	0.0932	0.6096	0.6096
Echinococcus granulosus	tubulin alpha chain	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin subunit beta	0.1447	1	1
Trichomonas vaginalis	tubulin, putative	0.1447	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0932	0.6096	0.5455
Brugia malayi	Tubulin beta chain	0.0408	0.2131	0.2131
Giardia lamblia	Gamma tubulin	0.0722	0.4505	0.3601
Echinococcus granulosus	tubulin gamma 1 chain	0.0722	0.4505	0.4505
Schistosoma mansoni	tubulin subunit beta	0.1447	1	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0153	0.0198	0.0198
Echinococcus granulosus	tubulin alpha 1C chain	0.0932	0.6096	0.6096
Plasmodium falciparum	tubulin epsilon chain, putative	0.0722	0.4505	0.4505
Plasmodium vivax	tubulin alpha chain, putative	0.0932	0.6096	0.6096
Schistosoma mansoni	hypothetical protein	0.0216	0.0678	0.0678
Schistosoma mansoni	tubulin subunit beta	0.0313	0.1412	0.1412
Leishmania major	beta tubulin	0.1447	1	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0932	0.6096	0.6096
Leishmania major	epsilon tubulin, putative	0.0722	0.4505	0.4505
Entamoeba histolytica	hypothetical protein, conserved	0.0542	0.3146	0.2648
Echinococcus multilocularis	tubulin alpha chain	0.0932	0.6096	0.6096
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0313	0.1412	0.1412
Loa Loa (eye worm)	hypothetical protein	0.0932	0.6096	0.6096
Brugia malayi	Pax transcription factor protein 2	0.0498	0.2808	0.2808
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0932	0.6096	0.6096
Entamoeba histolytica	tubulin family protein	0.1447	1	1
Echinococcus granulosus	tubulin epsilon chain	0.0722	0.4505	0.4505
Trypanosoma brucei	beta tubulin	0.1447	1	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0715	0.4457	0.4457
Trypanosoma cruzi	epsilon tubulin, putative	0.0722	0.4505	0.4505
Schistosoma mansoni	tubulin subunit epsilon	0.0722	0.4505	0.4505
Echinococcus granulosus	tubulin subunit beta	0.1447	1	1
Leishmania major	gamma-tubulin	0.0722	0.4505	0.4505
Loa Loa (eye worm)	beta-tubulin	0.1447	1	1
Leishmania major	beta tubulin	0.1447	1	1
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1447	1	1
Loa Loa (eye worm)	alpha-tubulin	0.0932	0.6096	0.6096
Schistosoma mansoni	alpha tubulin	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0932	0.6096	0.5455
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0139	0.0091	0.0091
Trypanosoma brucei	alpha tubulin	0.0932	0.6096	0.6096
Brugia malayi	Tubulin beta chain	0.0313	0.1412	0.1412
Loa Loa (eye worm)	tubulin alpha chain	0.0932	0.6096	0.6096
Schistosoma mansoni	tubulin subunit beta	0.1447	1	1
Echinococcus multilocularis	peroxisome assembly protein 26	0.0932	0.6096	0.6096
Toxoplasma gondii	beta tubulin	0.1447	1	1
Echinococcus multilocularis	beta tubulin	0.1447	1	1
Entamoeba histolytica	tubulin alpha-1 chain	0.0932	0.6096	0.5812
Leishmania major	zeta tubulin, putative	0.0313	0.1412	0.1412
Echinococcus granulosus	tubulin beta 4A class IVa	0.1447	1	1
Echinococcus granulosus	beta tubulin	0.1447	1	1
Trichomonas vaginalis	tubulin, putative	0.0408	0.2131	0.0838
Schistosoma mansoni	tubulin subunit alpha	0.0932	0.6096	0.6096
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.0618	0.3723	0.3723
Leishmania major	beta tubulin	0.1447	1	1
Plasmodium vivax	tubulin gamma chain, putative	0.0722	0.4505	0.4505
Loa Loa (eye worm)	pax transcription factor protein 2	0.0498	0.2808	0.2808
Onchocerca volvulus		0.0498	0.2808	1
Echinococcus granulosus	tubulin delta chain	0.0313	0.1412	0.1412
Leishmania major	beta tubulin	0.1447	1	1
Loa Loa (eye worm)	tubulin gamma chain	0.0722	0.4505	0.4505
Loa Loa (eye worm)	hypothetical protein	0.0523	0.3004	0.3004
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0932	0.6096	0.5455
Leishmania major	beta tubulin	0.1447	1	1
Trypanosoma brucei	beta tubulin	0.1447	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0153	0.0198	0.0198
Leishmania major	beta tubulin	0.1447	1	1
Echinococcus granulosus	tubulin alpha	0.0722	0.4505	0.4505
Leishmania major	beta tubulin	0.1447	1	1
Brugia malayi	beta-tubulin, identical	0.1447	1	1
Trichomonas vaginalis	tubulin, putative	0.0408	0.2131	0.0838
Giardia lamblia	Beta tubulin	0.1447	1	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0932	0.6096	0.5455
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.0091	0.0091
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0139	0.0091	0.0091
Schistosoma mansoni	tubulin subunit beta	0.1447	1	1
Brugia malayi	MH2 domain containing protein	0.0715	0.4457	0.4457
Trypanosoma brucei	epsilon tubulin	0.0722	0.4505	0.4505
Brugia malayi	tubulin alpha chain - mouse	0.0932	0.6096	0.6096
Echinococcus multilocularis	Tubulin beta 2C chain	0.1447	1	1
Schistosoma mansoni	tubulin subunit delta	0.0313	0.1412	0.1412
Toxoplasma gondii	LsmAD domain-containing protein	0.0153	0.0198	0.0198
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0932	0.6096	0.6096
Brugia malayi	Tubulin gamma chain	0.0722	0.4505	0.4505
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0139	0.0091	0.0091
Echinococcus granulosus	Tubulin beta 2C chain	0.1447	1	1
Echinococcus multilocularis	geminin	0.1361	0.9351	0.9351
Plasmodium vivax	delta tubulin, putative	0.0313	0.1412	0.1412
Leishmania major	beta tubulin	0.1447	1	1
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0216	0.0678	0.0678
Schistosoma mansoni	tubulin subunit gamma	0.0722	0.4505	0.4505
Echinococcus multilocularis	tubulin alpha	0.0722	0.4505	0.4505
Schistosoma mansoni	tubulin subunit beta	0.1447	1	1
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Echinococcus multilocularis	tubulin alpha 1C chain	0.0932	0.6096	0.6096
Loa Loa (eye worm)	MH2 domain-containing protein	0.0715	0.4457	0.4457
Trichomonas vaginalis	tubulin alpha chain, putative	0.1447	1	1
Trypanosoma brucei	zeta tubulin	0.0313	0.1412	0.1412
Trypanosoma cruzi	epsilon tubulin, putative	0.0722	0.4505	0.4505
Brugia malayi	hypothetical protein	0.0156	0.0218	0.0218
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0932	0.6096	0.6096
Loa Loa (eye worm)	hypothetical protein	0.0156	0.0218	0.0218
Loa Loa (eye worm)	tubulin alpha 2	0.0618	0.3723	0.3723
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Trichomonas vaginalis	tubulin alpha chain, putative	0.0722	0.4505	0.3601
Trypanosoma cruzi	zeta tubulin, putative	0.0313	0.1412	0.1412
Trypanosoma brucei	tubulin delta chain	0.0313	0.1412	0.1412
Entamoeba histolytica	tubulin family protein	0.1447	1	1
Leishmania major	beta tubulin	0.1447	1	1
Leishmania major	alpha tubulin	0.0932	0.6096	0.6096
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0932	0.6096	0.6096
Schistosoma mansoni	tubulin subunit alpha	0.0932	0.6096	0.6096
Echinococcus multilocularis	hypothetical protein	0.0932	0.6096	0.6096

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 10.5 uM	Inhibition of Candida albicans ATCC 38247 inositol phosphorylceramide synthase preincubated for 30 mins	ChEMBL.	19047657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1631584

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1463744