TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.771 | Formula: C13H12ClN3O2S
H donors: 3 H acceptors: 2 LogP: 3.85 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)NC(=O)N=[S+](c1ccccc1)(N)[O-]
InChi: 1S/C13H12ClN3O2S/c14-10-6-8-11(9-7-10)16-13(18)17-20(15,19)12-4-2-1-3-5-12/h1-9H,(H3-,15,16,17,18,19)
InChiKey: BLEQOQKAWHHMKG-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Trypanosoma brucei	cytochrome P450, putative	0.0016	0.0087	0.0931
Echinococcus granulosus	serotonin receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	amine GPCR	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	Polycystic kidney disease protein	0.0019	0.0143	0.0245
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0129	0.1721	0.1744
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0017	0.0012
Echinococcus multilocularis	ATP dependent DNA helicase Q1	0.002	0.0144	0.0248
Schistosoma mansoni	amine GPCR	0.0129	0.1721	0.3348
Onchocerca volvulus		0.0129	0.1721	0.1707
Schistosoma mansoni	serine/threonine RGC	0.0011	0.0017	0.0033
Plasmodium vivax	vivapain-2	0.0017	0.01	0.7027
Brugia malayi	sulfakinin receptor protein	0.0129	0.1721	0.342
Echinococcus multilocularis	adenylate cyclase 9	0.0253	0.352	0.6837
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Onchocerca volvulus		0.0019	0.0143	0.0126
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0016
Onchocerca volvulus		0.0017	0.01	0.0083
Echinococcus granulosus	g protein coupled receptor	0.0129	0.1721	0.3326
Onchocerca volvulus	Adenylate cyclase type 2 homolog	0.0253	0.352	0.3509
Schistosoma mansoni	biogenic amine receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	opsin-like receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Toxoplasma gondii	5'-nucleotidase, C-terminal domain-containing protein	0.0311	0.4362	1
Toxoplasma gondii	guanylyl cyclase	0.0011	0.0017	0.0039
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0143	0.0277
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0144	1
Brugia malayi	Cathepsin L-like precursor	0.0017	0.01	0.0167
Echinococcus granulosus	neuropeptide receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	neuropeptide F-like receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	lipocalin/cytosolic fatty-acid binding protein family protein	0.0297	0.4155	0.4218
Echinococcus granulosus	neuropeptide receptor A26	0.0129	0.1721	0.3326
Loa Loa (eye worm)	G-protein coupled receptor	0.0129	0.1721	0.1744
Echinococcus granulosus	fatty acid binding protein FABP2	0.0297	0.4155	0.8077
Onchocerca volvulus		0.0017	0.01	0.0083
Brugia malayi	hypothetical protein	0.0019	0.0143	0.0252
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0011	0.0021	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus granulosus	allatostatin A receptor	0.0129	0.1721	0.3326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	Bloom's syndrome protein homolog	0.002	0.0144	0.0255
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Brugia malayi	hypothetical protein	0.0019	0.0143	0.0252
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Schistosoma mansoni	hypothetical protein	0.019	0.2604	0.5067
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Schistosoma mansoni	alkaline phosphatase	0.0365	0.514	1
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.0365	0.514	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	cysteine protease	0.0017	0.01	0.0096
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0129	0.1721	0.3326
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0017	0.0152
Loa Loa (eye worm)	fibroinase	0.0017	0.01	0.0096
Loa Loa (eye worm)	G-protein coupled receptor	0.0129	0.1721	0.1744
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0143	0.0245
Leishmania major	cathepsin L-like protease	0.0017	0.01	0.1102
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.0727	0.1386
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Loa Loa (eye worm)	TYRA-2 protein	0.0129	0.1721	0.1744
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0129	0.1721	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0129	0.1721	0.1744
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.001	0.0005	0.00000000011839
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0355	0.5	0.5076
Toxoplasma gondii	adenylate and guanylate cyclase catalytic domain-containing protein	0.0011	0.0017	0.0039
Schistosoma mansoni	hypothetical protein	0.0011	0.0017	0.0033
Schistosoma mansoni	adenylate cyclase	0.0011	0.0017	0.0033
Schistosoma mansoni	protein tyrosine kinase	0.0011	0.0017	0.0033
Schistosoma mansoni	hypothetical protein	0.0129	0.1721	0.3348
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus granulosus	alkaline phosphatase	0.0365	0.514	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0129	0.1721	0.342
Schistosoma mansoni	loxhd1	0.0019	0.0143	0.0277
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.01	0.6956
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0129	0.1721	0.3348
Brugia malayi	Cathepsin L-like precursor	0.0017	0.01	0.0167
Echinococcus granulosus	orexin receptor type 2	0.0129	0.1721	0.3326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0727	0.1414
Echinococcus multilocularis	g-protein coupled receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	neuropeptide s receptor	0.0129	0.1721	0.3326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Brugia malayi	G protein-coupled receptor	0.0129	0.1721	0.342
Brugia malayi	Dopamine receptor protein 2	0.0129	0.1721	0.342
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0129	0.1721	0.3326
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0129	0.1721	0.3326
Leishmania major	cathepsin L-like protease	0.0063	0.0771	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	neuropeptide receptor A26	0.0129	0.1721	0.3326
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0129	0.1721	0.3326
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0771	1
Echinococcus multilocularis	orexin receptor type 2	0.0129	0.1721	0.3326
Echinococcus multilocularis	serotonin receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	RUN	0.0019	0.0143	0.0245
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0727	1
Echinococcus granulosus	g-protein coupled receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus granulosus	neuropeptides capa receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0297	0.4155	0.8077
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0129	0.1721	0.3326
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0771	1
Giardia lamblia	Sgs1 DNA helicase, putative	0.002	0.0144	0.0753
Echinococcus granulosus	neuropeptide s receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	ATP dependent DNA helicase Q5	0.002	0.0144	0.0248
Brugia malayi	follicle stimulating hormone receptor	0.0355	0.5	1
Schistosoma mansoni	amine GPCR	0.0129	0.1721	0.3348
Echinococcus granulosus	dro:myosuppressin receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0129	0.1721	0.3326
Leishmania major	cathepsin L-like protease	0.0017	0.01	0.1102
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0144	0.033
Echinococcus multilocularis	serotonin receptor	0.0129	0.1721	0.3326
Brugia malayi	neuropeptide F receptor	0.0129	0.1721	0.342
Brugia malayi	Serotonin receptor	0.0129	0.1721	0.342
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0116	0.1543	0.2978
Echinococcus granulosus	neuropeptide Y receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Schistosoma mansoni	amine GPCR	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Leishmania major	cytochrome p450-like protein	0.0016	0.0087	0.0931
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0129	0.1721	0.3326
Schistosoma mansoni	23-cyclic-nucleotide 2-phosphodiesterase	0.031	0.4349	0.846
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.0365	0.514	1
Echinococcus granulosus	sex peptide receptor	0.0129	0.1721	0.3326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	G protein-coupled receptor F59B2.13	0.0129	0.1721	0.342
Brugia malayi	Serotonin receptor	0.0129	0.1721	0.342
Echinococcus granulosus	G protein coupled receptor 139	0.0129	0.1721	0.3326
Echinococcus granulosus	fmrfamide receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0129	0.1721	0.3326
Toxoplasma gondii	adenylate and guanylate cyclase catalytic domain-containing protein	0.0011	0.0017	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0143	0.0245
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Onchocerca volvulus		0.0253	0.352	0.3509
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.0727	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0017	0.0012
Schistosoma mansoni	alkaline phosphatase	0.0365	0.514	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	hypothetical protein	0.0129	0.1721	0.3348
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0129	0.1721	0.342
Mycobacterium leprae	Probable conserved transmembrane protein	0.0011	0.0017	0.5
Echinococcus multilocularis	fmrfamide receptor	0.0129	0.1721	0.3326
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0016	0.0087	0.0988
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0129	0.1721	0.3326
Brugia malayi	Melatonin receptor type 1A	0.0129	0.1721	0.342
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.01	0.0083
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0129	0.1721	0.1707
Loa Loa (eye worm)	ctsf protein	0.0017	0.01	0.0096
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0129	0.1721	0.3348
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	biogenic amine receptor	0.0129	0.1721	0.3348
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0129	0.1721	0.342
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0017	0.0012
Schistosoma mansoni	fatty acid binding protein	0.0297	0.4155	0.8083
Schistosoma mansoni	rab6-interacting	0.0019	0.0143	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	Cathepsin L-like precursor	0.0017	0.01	0.0167
Loa Loa (eye worm)	hypothetical protein	0.069	0.9844	1
Echinococcus granulosus	g protein coupled receptor	0.0129	0.1721	0.3326
Onchocerca volvulus		0.0011	0.0021	0.0004
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0129	0.1721	0.3326
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.01	0.0195
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	cysteine protease	0.0017	0.01	0.0162
Plasmodium vivax	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0011	0.0017	0.1202
Plasmodium falciparum	LCCL domain-containing protein	0.0019	0.0143	0.9885
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.01	0.6545
Loa Loa (eye worm)	hypothetical protein	0.0253	0.352	0.3572
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.0144	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	AKH receptor	0.0129	0.1721	0.342
Brugia malayi	cathepsin L-like precursor	0.0011	0.0021	0.0008
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Echinococcus granulosus	neuropeptide FF receptor 2	0.0129	0.1721	0.3326
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Echinococcus granulosus	neuropeptides capa receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	amine GPCR	0.0129	0.1721	0.3348
Onchocerca volvulus		0.0017	0.01	0.0083
Loa Loa (eye worm)	doublecortin family protein	0.0019	0.0143	0.0139
Leishmania major	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0144	0.1683
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.01	0.6545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Toxoplasma gondii	adenylate cyclase, putative	0.0011	0.0017	0.0039
Schistosoma mansoni	neuropeptide f receptor 76f	0.0129	0.1721	0.3348
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.001	0.0005	0.0013
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0129	0.1721	0.3348
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0129	0.1721	0.3326
Entamoeba histolytica	recQ family DNA helicase	0.001	0.0005	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0016
Trypanosoma brucei	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0144	0.1683
Onchocerca volvulus		0.0019	0.0143	0.0126
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0727	1
Schistosoma mansoni	lipoxygenase	0.0116	0.1543	0.3001
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0129	0.1721	0.3326
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Treponema pallidum	5'-nucleotidase (ushA)	0.0311	0.4362	1
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0087	0.1069
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0129	0.1721	0.3348
Treponema pallidum	adenylate cyclase	0.0011	0.0017	0.0027
Echinococcus granulosus	biogenic amine 5HT receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	fatty acid binding protein FABP2	0.0297	0.4155	0.8077
Echinococcus granulosus	Polycystic kidney disease protein	0.0019	0.0143	0.0245
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Loa Loa (eye worm)	neuropeptide F receptor	0.0129	0.1721	0.1744
Schistosoma mansoni	23-cyclic-nucleotide 2-phosphodiesterase	0.0311	0.4362	0.8485
Schistosoma mansoni	neuropeptide receptor	0.0129	0.1721	0.3348
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Plasmodium vivax	guanylyl cyclase, putative	0.0011	0.0017	0.1202
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Schistosoma mansoni	rab6-interacting	0.0019	0.0143	0.0277
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus granulosus	intestinal type alkaline phosphatase	0.0365	0.514	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0129	0.1721	0.3326
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Loa Loa (eye worm)	guanylyl cyclase/natriuretic peptide receptor	0.0011	0.0017	0.0012
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0129	0.1721	0.3348
Brugia malayi	larval opioid receptor	0.0129	0.1721	0.342
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.01	0.0096
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Schistosoma mansoni	polycystin 1-related	0.0019	0.0143	0.0277
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0087	0.0083
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.01	0.0162
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.0727	0.1667
Trypanosoma cruzi	cytochrome P450, putative	0.0016	0.0087	0.1069
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Onchocerca volvulus		0.0129	0.1721	0.1707
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.001	0.0005	0.0385
Schistosoma mansoni	neuropeptide receptor	0.0129	0.1721	0.3348
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0129	0.1721	0.1744
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.01	0.6956
Echinococcus granulosus	7TM GPCR rhodopsin	0.0129	0.1721	0.3326
Onchocerca volvulus		0.0129	0.1721	0.1707
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.01	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0129	0.1721	0.342
Echinococcus granulosus	adenylate cyclase 9	0.0253	0.352	0.6837
Brugia malayi	Dopamine receptor	0.0129	0.1721	0.342
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Onchocerca volvulus		0.0129	0.1721	0.1707
Schistosoma mansoni	histamine h1 receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	DNA helicase recq1	0.002	0.0144	0.028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Entamoeba histolytica	recQ family helicase, putative	0.002	0.0144	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.01	0.0083
Entamoeba histolytica	cysteine proteinase, putative	0.0011	0.0021	0.1476
Echinococcus granulosus	neuropeptide Y receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0129	0.1721	0.3326
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0087	0.0141
Schistosoma mansoni	myosin xvIII	0.0129	0.1721	0.3348
Onchocerca volvulus		0.0129	0.1721	0.1707
Brugia malayi	GnHR receptor homolog	0.0129	0.1721	0.342
Schistosoma mansoni	fatty acid binding protein	0.0297	0.4155	0.8083
Echinococcus granulosus	cathepsin l1	0.0017	0.01	0.0162
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Onchocerca volvulus		0.0129	0.1721	0.1707
Trypanosoma cruzi	cysteine peptidase, putative	0.0063	0.0771	1
Onchocerca volvulus		0.0017	0.01	0.0083
Trichomonas vaginalis	DNA helicase recq1, putative	0.002	0.0144	1
Schistosoma mansoni	hypothetical protein	0.0129	0.1721	0.3348
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.01	0.6545
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.01	0.1102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.0365	0.514	1
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0144	0.033
Loa Loa (eye worm)	ATP-dependent DNA helicase	0.002	0.0144	0.0141
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Toxoplasma gondii	5'-nucleotidase, C-terminal domain-containing protein	0.0128	0.1714	0.393
Entamoeba histolytica	cysteine protease, putative	0.0017	0.01	0.6956
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	adenylyl cyclase 3	0.0253	0.352	0.3572
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	G protein coupled receptor 139	0.0129	0.1721	0.3326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus granulosus	ATP dependent DNA helicase Q5	0.002	0.0144	0.0248
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Echinococcus multilocularis	cysteine protease	0.0017	0.01	0.0162
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.01	0.0083
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.0727	0.9419
Onchocerca volvulus		0.0017	0.01	0.0083
Echinococcus granulosus	RUN	0.0019	0.0143	0.0245
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Trypanosoma cruzi	ATP-dependent DEAD/H DNA helicase recQ, putative	0.002	0.0144	0.181
Brugia malayi	Cathepsin L-like precursor	0.0017	0.01	0.0167
Schistosoma mansoni	opsin-like receptor	0.0129	0.1721	0.3348
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0129	0.1721	0.342
Echinococcus multilocularis	g protein coupled receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	RecQ helicase	0.002	0.0144	0.0141
Schistosoma mansoni	neuropeptide receptor	0.0129	0.1721	0.3348
Leishmania major	cathepsin L-like protease	0.0017	0.01	0.1102
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Plasmodium falciparum	ATP-dependent DNA helicase Q1	0.002	0.0144	1
Brugia malayi	Adenylyl cyclase protein	0.0253	0.352	0.703
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	G-protein coupled receptor	0.0129	0.1721	0.342
Echinococcus multilocularis	bloom syndrome protein	0.002	0.0144	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.01	0.6545
Echinococcus multilocularis	neuropeptide Y receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	cytochrome P450 family protein	0.0016	0.0087	0.0083
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.01	0.0162
Loa Loa (eye worm)	hypothetical protein	0.002	0.0144	0.0141
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.01	0.6545
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0021	0.0325
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.01	0.0162
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0019	0.0143	0.0245
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Schistosoma mansoni	protein kinase	0.0011	0.0017	0.0033
Brugia malayi	RE15519p	0.0129	0.1721	0.342
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.0727	1
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.01	0.0162
Brugia malayi	Cathepsin L-like precursor	0.0017	0.01	0.0167
Trypanosoma cruzi	cruzipain precursor, putative	0.0063	0.0771	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0129	0.1721	0.3326
Mycobacterium leprae	conserved hypothetical protein	0.0011	0.0017	0.5
Brugia malayi	putative neuropeptide receptor	0.0129	0.1721	0.342
Schistosoma mansoni	lipoxygenase	0.0081	0.1037	0.2017
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0116	0.1543	0.2978
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Echinococcus multilocularis	sex peptide receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0129	0.1721	0.3348
Echinococcus granulosus	7tm_1 domain containing protein	0.0129	0.1721	0.3326
Schistosoma mansoni	receptor-type adenylate cyclase	0.0011	0.0017	0.0033
Schistosoma mansoni	biogenic amine receptor	0.0129	0.1721	0.3348
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	g protein coupled receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.01	0.0162
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0021	0.0008
Echinococcus granulosus	fatty acid binding protein FABP2	0.0297	0.4155	0.8077
Brugia malayi	Cytochrome P450 family protein	0.0016	0.0087	0.0141
Echinococcus granulosus	lipoxygenase domain containing protein	0.0019	0.0143	0.0245
Plasmodium vivax	multidomain scavenger receptor, putative	0.0019	0.0143	1
Toxoplasma gondii	cathepsin CPL	0.0017	0.01	0.023
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0129	0.1721	0.3326
Trypanosoma cruzi	major cysteine proteinase, putative	0.0049	0.0576	0.7457
Onchocerca volvulus		0.0017	0.01	0.0083
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.01	0.1237
Loa Loa (eye worm)	neuropeptide F receptor	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0017	0.01	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Echinococcus granulosus	somatostatin receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0144	0.0255
Brugia malayi	G-protein coupled receptor	0.0129	0.1721	0.342
Echinococcus granulosus	g protein coupled receptor	0.0129	0.1721	0.3326
Brugia malayi	Lipocalin / cytosolic fatty-acid binding protein family protein	0.0297	0.4155	0.8304
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Schistosoma mansoni	adenylate cyclase	0.0011	0.0017	0.0033
Brugia malayi	Doublecortin family protein	0.0019	0.0143	0.0252
Echinococcus multilocularis	somatostatin receptor	0.0129	0.1721	0.3326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0129	0.1721	0.3326
Onchocerca volvulus		0.0129	0.1721	0.1707
Schistosoma mansoni	cathepsin F (C01 family)	0.0011	0.0021	0.0041
Brugia malayi	ORL1-like opioid receptor	0.0129	0.1721	0.342
Leishmania major	cathepsin L-like protease	0.0017	0.01	0.1102
Brugia malayi	Dopamine receptor protein 1	0.0129	0.1721	0.342
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Schistosoma mansoni	hypothetical protein	0.0011	0.0017	0.0033
Echinococcus granulosus	cathepsin l1	0.0011	0.0021	0.0008
Plasmodium vivax	adenylyl cyclase beta, putative	0.0011	0.0017	0.1202
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Leishmania major	cathepsin L-like protease	0.0063	0.0771	1
Onchocerca volvulus		0.0129	0.1721	0.1707
Schistosoma mansoni	receptor-type adenylate cyclase	0.0011	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus granulosus	bloom syndrome protein	0.002	0.0144	0.0248
Echinococcus granulosus	tm gpcr rhodopsin	0.0129	0.1721	0.3326
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.01	0.0167
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0129	0.1721	0.3348
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0129	0.1721	0.3326
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.0727	0.1414
Echinococcus granulosus	biogenic amine 5HT receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0129	0.1721	0.3348
Schistosoma mansoni	adenylate cyclase	0.0011	0.0017	0.0033
Schistosoma mansoni	hypothetical protein	0.0011	0.0017	0.0033
Schistosoma mansoni	DNA helicase recq5	0.002	0.0144	0.028
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Onchocerca volvulus		0.0129	0.1721	0.1707
Brugia malayi	Cathepsin L-like precursor	0.0011	0.0021	0.0008
Brugia malayi	neuropeptide F receptor	0.0129	0.1721	0.342
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Echinococcus granulosus	tm gpcr rhodopsin	0.0129	0.1721	0.3326
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0129	0.1721	0.342
Echinococcus multilocularis	g protein coupled receptor	0.0129	0.1721	0.3326
Onchocerca volvulus		0.0017	0.01	0.0083
Brugia malayi	putative neuropeptide receptor NPR1	0.0129	0.1721	0.342
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	hypothetical protein	0.0129	0.1721	0.342
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Brugia malayi	Cathepsin L-like precursor	0.0017	0.01	0.0167
Echinococcus multilocularis	neuropeptides capa receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0129	0.1721	0.3326
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0129	0.1721	0.3326
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Echinococcus granulosus	ATP dependent DNA helicase Q1	0.002	0.0144	0.0248
Loa Loa (eye worm)	CYP4Cod1	0.0016	0.0087	0.0083
Leishmania major	cathepsin L-like protease	0.0017	0.01	0.1102
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0011	0.0021	0.0325
Echinococcus multilocularis	allatostatin A receptor	0.0129	0.1721	0.3326
Echinococcus granulosus	hypothetical protein	0.0129	0.1721	0.3326
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.01	0.0195
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.0365	0.514	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.01	0.6545
Brugia malayi	ATP-dependent DNA helicase, RecQ family protein	0.002	0.0144	0.0255
Schistosoma mansoni	opsin-like receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Echinococcus multilocularis	neuropeptide receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0129	0.1721	0.3348
Onchocerca volvulus		0.0242	0.3364	0.3353
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.0365	0.514	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0129	0.1721	0.3326
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0129	0.1721	0.3348
Leishmania major	cathepsin L-like protease	0.0063	0.0771	1
Schistosoma mansoni	neuropeptide receptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	melatonin receptor type 1A	0.0129	0.1721	0.1744
Schistosoma mansoni	adenoreceptor	0.0129	0.1721	0.3348
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.01	0.0096
Echinococcus granulosus	neuropeptide receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0143	0.0139
Schistosoma mansoni	growth hormone secretagogue receptor	0.0129	0.1721	0.3348
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.0727	0.1386
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0021	0.0016
Trypanosoma cruzi	receptor-type adenylate cyclase, putative	0.0011	0.0017	0.0152
Schistosoma mansoni	soluble guanylate cyclase gcy	0.0011	0.0017	0.0033
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Mycobacterium leprae	possible transcriptional regulatory protein	0.0011	0.0017	0.5
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Plasmodium vivax	vivapain-2	0.0017	0.01	0.7027
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0011	0.0017	0.0152
Echinococcus multilocularis	neuropeptide Y receptor	0.0129	0.1721	0.3326
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0017	0.0012
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0063	0.0771	1
Onchocerca volvulus		0.0129	0.1721	0.1707
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0143	0.0139
Echinococcus multilocularis	neuropeptide receptor	0.0129	0.1721	0.3326
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Loa Loa (eye worm)	hypothetical protein	0.0129	0.1721	0.1744
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0129	0.1721	0.1744
Schistosoma mansoni	hypothetical protein	0.0129	0.1721	0.3348
Schistosoma mansoni	blooms syndrome DNA helicase	0.001	0.0005	0.0011
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0129	0.1721	0.3348
Echinococcus granulosus	tm gpcr rhodopsin	0.0129	0.1721	0.3326
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.01	0.6545
Echinococcus multilocularis	alkaline phosphatase	0.0365	0.514	1
Trichomonas vaginalis	DNA helicase recq, putative	0.002	0.0144	1
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0057	0.0692	0.8969
Echinococcus multilocularis	fmrfamide receptor	0.0129	0.1721	0.3326
Echinococcus multilocularis	dro:myosuppressin receptor	0.0129	0.1721	0.3326
Echinococcus granulosus	rhodopsin orphan GPCR	0.0129	0.1721	0.3326
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0011	0.0017	0.0012
Giardia lamblia	Hypothetical protein	0.0127	0.1701	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 20 ug ml-1	In vitro cytotoxicity against CCRF-CEM cells	ChEMBL.	9083492
Inhibition (functional)	= 0 %	In vivo antitumor activity against subaxillary implanted 6C3HED lymphosarcoma implanted in C3H mice at a dose of 300 mg/kg administered perorally twice daily for a period of 8 days.	ChEMBL.	9083492

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1627222

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1468505