Detailed information for compound 1469283

Basic information

Technical information
  • TDR Targets ID: 1469283
  • Name: 7a-methyl-N-naphthalen-1-yl-5-oxo-2,3,6,7-tet rahydropyrrolo[2,1-b][1,3]thiazole-3-carboxam ide
  • MW: 326.413 | Formula: C18H18N2O2S
  • H donors: 1 H acceptors: 2 LogP: 2.75 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CSC2(N1C(=O)CC2)C)Nc1cccc2c1cccc2
  • InChi: 1S/C18H18N2O2S/c1-18-10-9-16(21)20(18)15(11-23-18)17(22)19-14-8-4-6-12-5-2-3-7-13(12)14/h2-8,15H,9-11H2,1H3,(H,19,22)
  • InChiKey: XPFPQOKTHOIUPS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7a-methyl-N-(1-naphthyl)-5-oxo-2,3,6,7-tetrahydropyrrolo[2,1-b]thiazole-3-carboxamide
  • 5-keto-7a-methyl-N-(1-naphthyl)-2,3,6,7-tetrahydropyrrolo[2,1-b]thiazole-3-carboxamide
  • SMR000068664
  • T5346245
  • MLS000098652

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0126 0.4303 0.5034
Schistosoma mansoni coup transcription factor 0.0239 0.8547 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1192 0.6118
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.1192 0.6118
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0062 0.1865 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0239 0.8547 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.064 0.2932
Echinococcus granulosus Nuclear hormone receptor HR96 0.0113 0.3794 0.4439
Mycobacterium ulcerans beta-lactamase 0.0043 0.1185 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0239 0.8547 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.1192 0.6118
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1185 0.6079
Echinococcus multilocularis bloom syndrome protein 0.0029 0.064 0.0749
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1185 0.6079
Brugia malayi nuclear receptor NHR-88 0.0239 0.8547 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1865 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.1185 0.1387
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.6952 0.8133
Brugia malayi Nuclear hormone receptor-like 1 0.0126 0.4303 0.5034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0239 0.8547 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0239 0.8547 1
Trypanosoma brucei glucosidase, putative 0.0044 0.1192 0.6118
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0239 0.8547 1
Echinococcus granulosus FTZ F1 alpha 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Brugia malayi beta-lactamase family protein 0.0043 0.1185 0.1387
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0162 0.0168
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0162 0.0168
Plasmodium vivax hypothetical protein, conserved 0.0043 0.1185 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Giardia lamblia Kinase, CMGC MAPK 0.0062 0.1865 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1185 0.1387
Mycobacterium leprae conserved hypothetical protein 0.0043 0.1185 0.5
Brugia malayi photoreceptor-specific nuclear receptor 0.0239 0.8547 1
Loa Loa (eye worm) steroid hormone receptor 0.0239 0.8547 1
Onchocerca volvulus 0.0113 0.3794 0.4332
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0062 0.1865 1
Brugia malayi nuclear receptor NHR-88 0.0113 0.3794 0.4439
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0113 0.3794 0.4332
Trypanosoma brucei protein kinase, putative 0.0062 0.1865 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0239 0.8547 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.6952 0.8133
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1185 0.1387
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0162 0.0168
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1192 0.6118
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1865 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0113 0.3794 0.4439
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0239 0.8547 1
Brugia malayi Nuclear hormone receptor E75 0.0113 0.3794 0.4439
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.1192 0.6118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0239 0.8547 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0162 0.0168
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.1192 0.1395
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.00000000020503 0.0000000010995
Brugia malayi conserved hypotetical protein 0.0113 0.3794 0.4439
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.1192 0.1395
Schistosoma mansoni nuclear hormone receptor 0.0113 0.3794 0.4439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0162 0.0189
Loa Loa (eye worm) RecQ helicase 0.0029 0.064 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0239 0.8547 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0062 0.1865 0.2182
Schistosoma mansoni alpha glucosidase 0.0044 0.1192 0.1395
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1185 0.1387
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0113 0.3794 0.4439
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0162 0.0168
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0062 0.1865 0.2182
Onchocerca volvulus 0.0043 0.1185 0.1221
Loa Loa (eye worm) nuclear receptor NHR-67 0.0113 0.3794 0.4439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0239 0.8547 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0239 0.8547 1
Echinococcus granulosus mitogen activated protein kinase 0.0062 0.1865 0.2182
Leishmania major glycosyl hydrolase-like protein 0.0016 0.0162 0.0168
Echinococcus granulosus ecdysone induced protein 78C 0.0239 0.8547 1
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1185 0.6079
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0239 0.8547 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.1185 0.6079
Brugia malayi nuclear receptor RXR 0.0113 0.3794 0.4439
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0239 0.8547 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0239 0.8547 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0126 0.4303 0.5034
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.1192 0.6394
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.1185 0.5
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0062 0.1865 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0239 0.8547 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0062 0.1865 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Onchocerca volvulus 0.0113 0.3794 0.4332
Schistosoma mansoni thyroid hormone receptor 0.0239 0.8547 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.5039 0.5896
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1185 0.6079
Brugia malayi Nuclear hormone receptor-like 1 0.0239 0.8547 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0239 0.8547 1
Toxoplasma gondii ABC1 family protein 0.0043 0.1185 0.6358
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0113 0.3794 0.4439
Schistosoma mansoni nuclear receptor 0.0113 0.3794 0.4439
Echinococcus multilocularis thyroid hormone receptor alpha 0.0239 0.8547 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.1192 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0239 0.8547 1
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.1185 0.6079
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1192 0.6118
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.1192 0.1395
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0239 0.8547 1
Echinococcus multilocularis mitogen activated protein kinase 0.0062 0.1865 0.2182
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0239 0.8547 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0239 0.8547 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0113 0.3794 0.4332
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0239 0.8547 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0113 0.3794 0.4439
Brugia malayi Nuclear hormone receptor-like 1 0.0126 0.4303 0.5034
Loa Loa (eye worm) hypothetical protein 0.0126 0.4303 0.5034
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.1185 0.1387
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0239 0.8547 1
Trichomonas vaginalis maltase-glucoamylase, putative 0.0016 0.0162 0.0168
Mycobacterium leprae Probable lipase LipE 0.0043 0.1185 0.5
Brugia malayi ecdysone receptor 0.0113 0.3794 0.4439
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0239 0.8547 1
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1865 1
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.064 0.2932
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Echinococcus multilocularis ecdysone induced protein 78C 0.0239 0.8547 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0113 0.3794 0.4439
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0239 0.8547 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0239 0.8547 1
Brugia malayi tailless protein 0.0113 0.3794 0.4439
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.1185 0.5
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Trichomonas vaginalis CMGC family protein kinase 0.0062 0.1865 1
Brugia malayi MAP kinase sur-1 0.0062 0.1865 0.2182
Onchocerca volvulus 0.0114 0.3831 0.4376
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0016 0.0162 0.0168
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0239 0.8547 1
Brugia malayi hypothetical protein 0.0126 0.4303 0.5034
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0126 0.4303 0.5034
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0126 0.4303 0.5034
Schistosoma mansoni thyroid hormone receptor 0.0239 0.8547 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0113 0.3794 0.4439
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0239 0.8547 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0239 0.8547 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.1185 0.1387
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0239 0.8547 1
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0508 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.6952 0.8133
Loa Loa (eye worm) DR-78 0.0113 0.3794 0.4439
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0113 0.3794 0.4439
Schistosoma mansoni alpha-glucosidase 0.0169 0.5921 0.6927
Brugia malayi Steroid receptor seven-up type 2 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1185 0.1387
Brugia malayi steroid hormone receptor 0.0239 0.8547 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.1192 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0239 0.8547 1
Onchocerca volvulus 0.0043 0.1185 0.1221
Loa Loa (eye worm) hypothetical protein 0.0126 0.4303 0.5034
Brugia malayi ecdysteroid receptor 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1185 0.1387
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Leishmania major hypothetical protein, conserved 0.0043 0.1185 0.6079
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Brugia malayi beta-lactamase 0.0043 0.1185 0.1387
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.064 0.0749
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.1192 0.6118
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.1185 0.1387
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0016 0.0162 0.0274
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Brugia malayi Nuclear hormone receptor E75 0.0113 0.3794 0.4439
Loa Loa (eye worm) nuclear hormone receptor 0.0113 0.3794 0.4439
Loa Loa (eye worm) beta-lactamase 0.0043 0.1185 0.1387
Mycobacterium ulcerans lipase LipD 0.0043 0.1185 0.5
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Trichomonas vaginalis esterase, putative 0.0043 0.1185 0.6079
Brugia malayi nuclear hormone receptor family member nhr-6 0.0113 0.3794 0.4439
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.1185 0.1387
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.1185 0.6079
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1192 0.6118
Brugia malayi nuclear hormone receptor 0.0239 0.8547 1
Brugia malayi nuclear hormone receptor 0.0113 0.3794 0.4439
Mycobacterium ulcerans hypothetical protein 0.0043 0.1185 0.5
Onchocerca volvulus 0.0239 0.8547 1
Echinococcus granulosus nuclear receptor nhr 48 0.0113 0.3794 0.4439
Brugia malayi nuclear hormone receptor family member odr-7 0.0113 0.3794 0.4439
Onchocerca volvulus 0.0043 0.1185 0.1221
Brugia malayi beta-lactamase family protein 0.0043 0.1185 0.1387
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0239 0.8547 1
Schistosoma mansoni nuclear receptor nhr-48 0.0113 0.3794 0.4439
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.1185 0.1387
Schistosoma mansoni nuclear receptor 0.0113 0.3794 0.4439
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.1192 0.6118
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.6952 0.8133
Brugia malayi nuclear receptor RXR 0.0126 0.4303 0.5034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0239 0.8547 1
Schistosoma mansoni zinc finger protein 0.0113 0.3794 0.4439
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1192 0.6118
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Schistosoma mansoni steroid hormone receptor ad4bp 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0126 0.4303 0.5034
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0113 0.3794 0.4439
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1865 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0062 0.1865 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0239 0.8547 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0239 0.8547 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0113 0.3794 0.4439
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0113 0.3794 0.4439
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Loa Loa (eye worm) hypothetical protein 0.0043 0.1185 0.1387
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.1192 0.1395
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0162 0.0168
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0278 0.1493
Schistosoma mansoni nuclear hormone receptor 0.0239 0.8547 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.0062 0.1865 0.2182
Schistosoma mansoni RAR-like nuclear receptor 0.0239 0.8547 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0239 0.8547 1
Brugia malayi orphan nuclear receptor NR2E1 0.0113 0.3794 0.4439
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.1192 0.6118
Brugia malayi hypothetical protein 0.0113 0.3794 0.4439
Brugia malayi hypothetical protein 0.0113 0.3794 0.4439
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0113 0.3794 0.4439
Echinococcus granulosus bloom syndrome protein 0.0029 0.064 0.0749
Brugia malayi hypothetical protein 0.0126 0.4303 0.5034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0239 0.8547 1
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.1192 0.6118
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0016 0.0162 0.0168
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0113 0.3794 0.4439
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0239 0.8547 1
Brugia malayi nuclear receptor NHR-67 0.0113 0.3794 0.4439
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0126 0.4303 0.5034
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0062 0.1865 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.1185 0.6079
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0062 0.1865 1
Schistosoma mansoni alpha-glucosidase 0.0169 0.5921 0.6927
Loa Loa (eye worm) hypothetical protein 0.0126 0.4303 0.5034
Loa Loa (eye worm) hypothetical protein 0.0126 0.4303 0.5034
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0239 0.8547 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0113 0.3794 0.4439
Brugia malayi Glycosyl hydrolases family 31 protein 0.0016 0.0162 0.0189
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.6952 0.8133
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0113 0.3794 0.4439
Schistosoma mansoni retinoic acid receptor RXR 0.0239 0.8547 1
Schistosoma mansoni serine/threonine protein kinase 0.0062 0.1865 0.2182
Trypanosoma brucei glycosyl hydrolase-like protein 0.0016 0.0162 0.0168
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Schistosoma mansoni nuclear hormone receptor 0.0113 0.3794 0.4439
Echinococcus multilocularis FTZ F1 alpha 0.0239 0.8547 1
Loa Loa (eye worm) hypothetical protein 0.0239 0.8547 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0411 0.0481
Loa Loa (eye worm) hypothetical protein 0.0113 0.3794 0.4439
Trichomonas vaginalis alpha-glucosidase, putative 0.0016 0.0162 0.0168

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 260 uM PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493224] ChEMBL. No reference
Potency (functional) = 2.5119 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 17.7828 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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