TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 316.435 | Formula: C20H28O3
H donors: 2 H acceptors: 2 LogP: 3.47 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: COC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CCC([C@]1(CC2)C)O
InChi: 1S/C20H28O3/c1-20-8-7-16-15-4-3-14(21)10-12(15)9-13(11-23-2)19(16)17(20)5-6-18(20)22/h3-4,10,13,16-19,21-22H,5-9,11H2,1-2H3/t13-,16+,17-,18?,19+,20-/m0/s1
InChiKey: RRBNIVRNNUXLBK-LYGQZRIASA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Loa Loa (eye worm)	hypothetical protein	0.0677	0.8348	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	Mastin	0.0151	0.1765	0.1763
Brugia malayi	GCC2 and GCC3 family protein	0.0258	0.3105	0.372
Echinococcus multilocularis	mitogen activated protein kinase 3	0.006	0.0619	0.0618
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus multilocularis	mitogen activated protein kinase	0.006	0.0619	0.0618
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0034	0.0293	0.0349
Onchocerca volvulus		0.0151	0.1765	0.1827
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0543	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Onchocerca volvulus		0.0151	0.1765	0.1827
Brugia malayi	notch-like transmembrane receptor	0.0258	0.3105	0.372
Loa Loa (eye worm)	Notch2	0.0258	0.3105	0.3719
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.006	0.0619	0.074
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Schistosoma mansoni	notch	0.0258	0.3105	0.2898
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0032	0.0272	0.0828
Onchocerca volvulus	Putative cubilin	0.0258	0.3105	0.3492
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Brugia malayi	Cadherin domain containing protein	0.0258	0.3105	0.372
Brugia malayi	Delta serrate ligand family protein	0.0258	0.3105	0.372
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Toxoplasma gondii	EGF family domain-containing protein	0.0258	0.3105	0.3456
Mycobacterium ulcerans	hypothetical protein	0.0151	0.1765	0.5
Echinococcus multilocularis	fat cadherin tumor suppressor	0.0258	0.3105	0.3104
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	Tolloid protein 1	0.0677	0.8348	0.8348
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1669	0.1998
Onchocerca volvulus	Arrow homolog	0.0677	0.8348	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.006	0.0619	0.0352
Brugia malayi	MAP kinase sur-1	0.006	0.0619	0.0742
Onchocerca volvulus		0.0258	0.3105	0.3492
Schistosoma mansoni	laminin gamma-3 chain	0.0258	0.3105	0.2898
Echinococcus granulosus	protein jagged 2	0.0258	0.3105	0.3104
Echinococcus granulosus	mitogen activated protein kinase 3	0.006	0.0619	0.0618
Loa Loa (eye worm)	trypsin family protein	0.0151	0.1765	0.2112
Echinococcus granulosus	neurogenic locus notch protein	0.0258	0.3105	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0677	0.8348	1
Echinococcus granulosus	mitogen activated protein kinase	0.006	0.0619	0.0618
Toxoplasma gondii	kringle domain-containing protein	0.0191	0.2265	0.2407
Trypanosoma brucei	protein kinase, putative	0.006	0.0619	1
Giardia lamblia	Kinase, CMGC MAPK	0.006	0.0619	0.1749
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0543	0.0541
Loa Loa (eye worm)	ThiF family protein	0.0037	0.0337	0.0402
Schistosoma mansoni	notch	0.0258	0.3105	0.2898
Schistosoma mansoni	notch	0.0258	0.3105	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Loa Loa (eye worm)	bone morphogenetic protein 1b	0.0677	0.8348	1
Echinococcus granulosus	dnaJ subfamily B	0.048	0.5875	0.5874
Echinococcus multilocularis	neurogenic locus protein delta	0.0258	0.3105	0.3104
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0191	0.2265	1
Brugia malayi	Chymotrypsin-like protease CTRL-1 precursor	0.0151	0.1765	0.2114
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Schistosoma mansoni	microtubule-associated protein tau	0.0809	1	1
Plasmodium falciparum	SUMO-activating enzyme subunit 1	0.0057	0.0579	0.1255
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus multilocularis	dnaJ subfamily B	0.048	0.5875	0.5874
Brugia malayi	CXXC zinc finger family protein	0.0034	0.0293	0.0351
Echinococcus granulosus	transmembrane protease serine 3	0.0151	0.1765	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Loa Loa (eye worm)	TK/ROR protein kinase	0.0191	0.2265	0.2712
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0677	0.8348	1
Schistosoma mansoni	septate junction protein	0.0258	0.3105	0.2898
Echinococcus multilocularis	fibrillin 1	0.0677	0.8348	0.8348
Echinococcus granulosus	slit 2 protein	0.0258	0.3105	0.3104
Giardia lamblia	High cysteine protein	0.0258	0.3105	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0619	0.2426
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0064	0.067	0.0416
Brugia malayi	Kringle domain containing protein	0.0191	0.2265	0.2713
Toxoplasma gondii	hypothetical protein	0.0057	0.0579	0.0302
Onchocerca volvulus		0.0258	0.3105	0.3492
Plasmodium vivax	ubiquitin activating enzyme, putative	0.0057	0.0579	0.1255
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Brugia malayi	ThiF family protein	0.0057	0.0579	0.0693
Echinococcus multilocularis	slit 2 protein	0.0258	0.3105	0.3104
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0543	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Onchocerca volvulus	Slit protein homolog	0.0258	0.3105	0.3492
Echinococcus granulosus	neurogenic locus notch protein 4	0.0258	0.3105	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0191	0.2265	0.2712
Brugia malayi	Transmembrane cell adhesion receptor mua-3 precursor, putative	0.0258	0.3105	0.372
Echinococcus multilocularis	protein jagged 1	0.0258	0.3105	0.3104
Loa Loa (eye worm)	multiple epidermal growth factor-like domains 6	0.0677	0.8348	1
Echinococcus multilocularis	neurogenic locus notch protein	0.0258	0.3105	0.3104
Onchocerca volvulus	Neurogenic locus notch protein homolog	0.0258	0.3105	0.3492
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.006	0.0619	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	enteropeptidase	0.0151	0.1765	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus multilocularis	SUMO activating enzyme subunit 2	0.0037	0.0337	0.0335
Echinococcus granulosus	enteropeptidase	0.0151	0.1765	0.1763
Plasmodium falciparum	cysteine repeat modular protein 1	0.0191	0.2265	1
Schistosoma mansoni	serine/threonine protein kinase	0.006	0.0619	0.0336
Echinococcus multilocularis	SUMO activating enzyme subunit 1	0.0057	0.0579	0.0577
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Schistosoma mansoni	hypothetical protein	0.048	0.5875	0.575
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Echinococcus multilocularis	protein jagged 2	0.0258	0.3105	0.3104
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Onchocerca volvulus		0.0151	0.1765	0.1827
Echinococcus granulosus	Peptidase S1 S6 chymotrypsin Hap	0.0151	0.1765	0.1763
Echinococcus granulosus	neurogenic locus notch protein	0.0258	0.3105	0.3104
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.006	0.0619	0.1464
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0543	0.0541
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	tissue type plasminogen activator	0.0191	0.2265	0.2263
Brugia malayi	Protein kinase domain containing protein	0.0191	0.2265	0.2713
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus multilocularis	transmembrane protease serine 3	0.0151	0.1765	0.1763
Schistosoma mansoni	hypothetical protein	0.0151	0.1765	0.1516
Echinococcus multilocularis	laminin	0.0677	0.8348	0.8348
Loa Loa (eye worm)	hypothetical protein	0.0677	0.8348	1
Echinococcus granulosus	protein jagged 1	0.0258	0.3105	0.3104
Onchocerca volvulus		0.0151	0.1765	0.1827
Schistosoma mansoni	cpg binding protein	0.0036	0.0317	0.0025
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0619	1
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Leishmania major	hypothetical protein, conserved	0.0191	0.2265	1
Echinococcus granulosus	tissue type plasminogen activator	0.0191	0.2265	0.2263
Onchocerca volvulus	Neurogenic locus notch homolog	0.0258	0.3105	0.3492
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0619	1
Echinococcus granulosus	SUMO activating enzyme subunit 1	0.0057	0.0579	0.0577
Echinococcus granulosus	neurogenic locus protein delta	0.0258	0.3105	0.3104
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Onchocerca volvulus		0.0191	0.2265	0.2448
Trypanosoma cruzi	hypothetical protein, conserved	0.0191	0.2265	1
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	microtubule associated protein 2	0.0809	1	1
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Brugia malayi	hypothetical protein	0.0151	0.1765	0.2114
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Echinococcus granulosus	sumo-activating enzyme subunit 2	0.0037	0.0337	0.0335
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Brugia malayi	Fibulin-1 precursor	0.0677	0.8348	1
Brugia malayi	Trypsin family protein	0.0151	0.1765	0.2114
Toxoplasma gondii	calcium binding egf domain-containing protein	0.0677	0.8348	1
Echinococcus granulosus	Tolloid protein 1	0.0677	0.8348	0.8348
Brugia malayi	Muscle positioning protein 4	0.0258	0.3105	0.372
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Schistosoma mansoni	ubiquitin-activating enzyme E1b	0.0037	0.0337	0.0045
Trypanosoma cruzi	ubiquitin-activating enzyme, putative	0.0037	0.0337	0.1127
Onchocerca volvulus		0.0258	0.3105	0.3492
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0619	1
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0619	1
Schistosoma mansoni	notch	0.0258	0.3105	0.2898
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Schistosoma mansoni	egf-like domain protein	0.0677	0.8348	0.8298
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Schistosoma mansoni	Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)]	0.0258	0.3105	0.2898
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0051	0.0514	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus multilocularis	notch	0.0258	0.3105	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Onchocerca volvulus	Huntingtin homolog	0.0144	0.1669	0.1709
Schistosoma mansoni	notch	0.0258	0.3105	0.2898
Echinococcus granulosus	notch	0.0258	0.3105	0.3104
Echinococcus multilocularis	neurogenic locus notch protein 4	0.0258	0.3105	0.3104
Brugia malayi	Calcium binding EGF domain containing protein	0.0258	0.3105	0.372
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Brugia malayi	Calcium binding EGF domain containing protein	0.0258	0.3105	0.372
Entamoeba histolytica	ubiquitin-activating enzyme, putative	0.0018	0.0092	0.5
Echinococcus multilocularis	glycoprotein Antigen 5	0.0151	0.1765	0.1763
Brugia malayi	Low-density lipoprotein receptor repeat class B containing protein	0.0677	0.8348	1
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Onchocerca volvulus		0.0151	0.1765	0.1827
Brugia malayi	hypothetical protein	0.0144	0.1669	0.2
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0543	0.0257
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	neural cadherin	0.0258	0.3105	0.3104
Echinococcus granulosus	protein jagged 2	0.0258	0.3105	0.3104
Echinococcus multilocularis	neurogenic locus notch protein	0.0258	0.3105	0.3104
Schistosoma mansoni	hypothetical protein	0.0258	0.3105	0.2898
Schistosoma mansoni	cell polarity protein	0.0258	0.3105	0.2898
Brugia malayi	Calcium binding EGF domain containing protein	0.0677	0.8348	1
Loa Loa (eye worm)	hypothetical protein	0.0677	0.8348	1
Brugia malayi	ThiF family protein	0.0037	0.0337	0.0403
Echinococcus multilocularis	protein jagged 1	0.0258	0.3105	0.3104
Onchocerca volvulus		0.0258	0.3105	0.3492
Echinococcus granulosus	laminin	0.0677	0.8348	0.8348
Schistosoma mansoni	cpg binding protein	0.0036	0.0317	0.0025
Echinococcus multilocularis	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1669	0.1998
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.006	0.0619	0.2426
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.006	0.0619	0.1464
Brugia malayi	Trypsin family protein	0.0151	0.1765	0.2114
Echinococcus multilocularis	cpg binding protein	0.0036	0.0317	0.0315
Onchocerca volvulus		0.0258	0.3105	0.3492
Brugia malayi	Calcium binding EGF domain containing protein	0.0258	0.3105	0.372
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0543	0.0648
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.0765	0.0487
Onchocerca volvulus	Huntingtin homolog	0.0144	0.1669	0.1709
Loa Loa (eye worm)	notch protein	0.0258	0.3105	0.3719
Brugia malayi	Trypsin-like protease protein 5	0.0151	0.1765	0.2114
Brugia malayi	Trypsin family protein	0.0151	0.1765	0.2114
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.006	0.0619	0.2426
Schistosoma mansoni	slit	0.0258	0.3105	0.2898
Schistosoma mansoni	sumo-1-activating enzyme E1a	0.0057	0.0579	0.0295
Echinococcus granulosus	fibropellin Ia	0.0258	0.3105	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus granulosus	glycoprotein Antigen 5	0.0151	0.1765	0.1763
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Echinococcus granulosus	delta-like protein 1	0.0258	0.3105	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0151	0.1765	0.2112
Onchocerca volvulus		0.0151	0.1765	0.1827
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Schistosoma mansoni	subfamily M12A unassigned peptidase (M12 family)	0.0677	0.8348	0.8298
Echinococcus granulosus	subfamily S1A unassigned peptidase S01 family	0.0151	0.1765	0.1763
Brugia malayi	Trypsin family protein	0.0151	0.1765	0.2114
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0543	0.0541
Echinococcus multilocularis	fibropellin Ia	0.0258	0.3105	0.3104
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0543	0.065
Schistosoma mansoni	hypothetical protein	0.0191	0.2265	0.2031
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.006	0.0619	0.2426
Brugia malayi	EGF-like domain containing protein	0.0258	0.3105	0.372
Loa Loa (eye worm)	hypothetical protein	0.0258	0.3105	0.3719
Echinococcus multilocularis	neurogenic locus protein delta	0.0258	0.3105	0.3104
Schistosoma mansoni	subfamily S1A unassigned peptidase (S01 family)	0.0151	0.1765	0.1516
Loa Loa (eye worm)	low-density lipoprotein receptor repeat class B containing protein	0.0677	0.8348	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0543	0.0257
Brugia malayi	Cadherin domain containing protein	0.0258	0.3105	0.372
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus granulosus	Mastin	0.0151	0.1765	0.1763
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0579	0.0691
Schistosoma mansoni	notch	0.0258	0.3105	0.2898
Echinococcus granulosus	cpg binding protein	0.0036	0.0317	0.0315
Echinococcus granulosus	protein jagged 1	0.0258	0.3105	0.3104
Schistosoma mansoni	hypothetical protein	0.0151	0.1765	0.1516
Schistosoma mansoni	cercarial elastase (S01 family)	0.0151	0.1765	0.1516
Echinococcus multilocularis	Peptidase S1 S6, chymotrypsin Hap	0.0151	0.1765	0.1763
Echinococcus granulosus	neural cadherin	0.0258	0.3105	0.3104
Loa Loa (eye worm)	hypothetical protein	0.0677	0.8348	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1627701

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1472580