Detailed information for compound 1473500

Basic information

Technical information
  • TDR Targets ID: 1473500
  • Name: 4-amino-1-(2-chlorophenothiazin-10-yl)butan-1 -one
  • MW: 318.821 | Formula: C16H15ClN2OS
  • H donors: 1 H acceptors: 1 LogP: 2.96 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCCC(=O)N1c2ccccc2Sc2c1cc(Cl)cc2
  • InChi: 1S/C16H15ClN2OS/c17-11-7-8-15-13(10-11)19(16(20)6-3-9-18)12-4-1-2-5-14(12)21-15/h1-2,4-5,7-8,10H,3,6,9,18H2
  • InChiKey: LQQZXHJCWOGKAN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 4-amino-1-(2-chloro-10-phenothiazinyl)butan-1-one
  • Oprea1_624165
  • STOCK2S-88064
  • EU-0006854
  • Oprea1_517077

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0139 0.0415
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0009
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0196 0.0939 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0086 0.039 0.0778
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0004
Schistosoma mansoni lamin 0.0025 0.0084 0.0273
Brugia malayi intermediate filament protein 0.0025 0.0084 0.007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0062
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0012 0.0023 0.0009
Entamoeba histolytica protein kinase domain containing protein 0.013 0.061 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0036 0.0141 0.2
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0139 0.0258
Echinococcus multilocularis paired box protein pax 6 0.0039 0.0153 0.0288
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0019 0.0011
Onchocerca volvulus 0.0025 0.0084 0.0061
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0196 0.0939 0.1343
Schistosoma mansoni intermediate filament proteins 0.0025 0.0084 0.0273
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0139 0.1966
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0084 0.007
Trichomonas vaginalis AGC family protein kinase 0.013 0.061 0.0891
Echinococcus granulosus neuroglian 0.0012 0.0023 0.003
Schistosoma mansoni ap endonuclease 0.0036 0.0141 0.0462
Brugia malayi serine/threonine kinase 12 0.013 0.061 0.0596
Schistosoma mansoni paired box protein pax-6 0.0039 0.0153 0.0503
Brugia malayi TATA binding protein associated factor 0.0013 0.0023 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0086 0.039 0.1251
Onchocerca volvulus 0.0677 0.3338 0.3323
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0062
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0013 0.0023 0.0073
Brugia malayi CXXC zinc finger family protein 0.0035 0.0134 0.012
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.138 0.6841 1
Brugia malayi Pre-SET motif family protein 0.0595 0.2929 0.2919
Schistosoma mansoni serine/threonine protein kinase 0.013 0.061 0.2017
Echinococcus granulosus Immunoglobulin 0.0057 0.0246 0.0773
Brugia malayi Immunoglobulin I-set domain containing protein 0.0057 0.0246 0.0232
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0012 0.0023 0.0019
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0388 0.1894 0.1883
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0009
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0141 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.0624
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0196 0.0939 0.1301
Echinococcus granulosus aurora kinase A 0.013 0.061 0.1983
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0077 0.0343 0.1134
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0036 0.0141 0.2
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0019 0.006
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0036 0.0141 0.0125
Echinococcus granulosus defective proboscis extension response 0.0057 0.0246 0.0773
Brugia malayi Intermediate filament tail domain containing protein 0.0025 0.0084 0.007
Echinococcus multilocularis tyrosine protein kinase otk 0.0012 0.0023 0.0019
Brugia malayi Fibronectin type III domain containing protein 0.0057 0.0246 0.0232
Echinococcus multilocularis Immunoglobulin 0.0057 0.0246 0.0481
Echinococcus granulosus paired box protein pax 6 0.0039 0.0153 0.0463
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0057 0.0246 0.0812
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0082 0.037 0.1186
Loa Loa (eye worm) hypothetical protein 0.0057 0.0246 0.0232
Echinococcus multilocularis microtubule associated protein 2 0.0613 0.3018 0.622
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0139 0.0125
Loa Loa (eye worm) aminopeptidase N 0.0036 0.0139 0.0125
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0036 0.0141 0.2
Brugia malayi hypothetical protein 0.0036 0.0139 0.0125
Brugia malayi cytoplasmic intermediate filament protein 0.0013 0.0027 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0196 0.0939 0.0926
Echinococcus multilocularis roundabout 2 0.007 0.0308 0.0609
Trypanosoma brucei aurora B kinase 0.013 0.061 1
Onchocerca volvulus 0.0318 0.1548 0.1529
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0057 0.0246 0.0481
Onchocerca volvulus 0.0036 0.0139 0.0116
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2424 0.8022
Echinococcus multilocularis hemicentin 1 0.0012 0.0023 0.0019
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0036 0.0139 0.0455
Treponema pallidum exodeoxyribonuclease (exoA) 0.0036 0.0141 0.5
Schistosoma mansoni cell adhesion molecule 0.0012 0.0023 0.0072
Entamoeba histolytica protein kinase, putative 0.013 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0036 0.0139 0.1966
Brugia malayi paired box pox-meso protein 0.0039 0.0153 0.0139
Loa Loa (eye worm) hypothetical protein 0.0023 0.0076 0.0062
Brugia malayi vab-3 gene. 0.0039 0.0153 0.0139
Schistosoma mansoni hypothetical protein 0.0494 0.2424 0.803
Echinococcus granulosus hemicentin 1 0.0012 0.0023 0.003
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0056 0.0556
Plasmodium falciparum serine/threonine protein kinase, putative 0.013 0.061 0.6403
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.138 0.6841 1
Brugia malayi Isocitrate dehydrogenase 0.0019 0.0056 0.0042
Echinococcus multilocularis paired box protein pax 6 0.0039 0.0153 0.0288
Echinococcus granulosus roundabout 2 0.0012 0.0023 0.003
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0057 0.0246 0.0812
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.0624
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0012 0.0023 0.0009
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0139 0.0258
Schistosoma mansoni microtubule-associated protein tau 0.0613 0.3018 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0086 0.039 0.0778
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0056 0.0356
Schistosoma mansoni nephrin 0.0063 0.0273 0.0902
Schistosoma mansoni cpg binding protein 0.0037 0.0144 0.0472
Loa Loa (eye worm) histone methyltransferase 0.0014 0.003 0.0016
Echinococcus multilocularis roundabout 2 0.0012 0.0023 0.0019
Loa Loa (eye worm) TATA binding protein associated factor 0.0013 0.0023 0.0009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0139
Mycobacterium ulcerans aminopeptidase N PepN 0.0036 0.0139 0.0169
Loa Loa (eye worm) hypothetical protein 0.0057 0.0246 0.0232
Onchocerca volvulus 0.0086 0.039 0.0368
Plasmodium vivax SET domain protein, putative 0.0086 0.039 0.4002
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0012 0.0023 0.003
Onchocerca volvulus 0.2013 1 1
Schistosoma mansoni septate junction protein 0.0012 0.0023 0.0072
Brugia malayi serine/threonine protein kinase 6 0.013 0.061 0.0596
Trypanosoma cruzi aurora B kinase, putative 0.013 0.061 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.039 0.1288
Schistosoma mansoni cpg binding protein 0.0037 0.0144 0.0472
Echinococcus granulosus serine:threonine protein kinase 12 B 0.013 0.061 0.1983
Echinococcus granulosus microtubule associated protein 2 0.0613 0.3018 1
Echinococcus granulosus ornithine aminotransferase 0.0196 0.0939 0.3079
Echinococcus granulosus roundabout 2 0.0012 0.0023 0.003
Onchocerca volvulus Huntingtin homolog 0.0118 0.055 0.0528
Onchocerca volvulus Tyrosine kinase homolog 0.0329 0.1601 0.1582
Echinococcus granulosus lamin dm0 0.0025 0.0084 0.0232
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0139
Schistosoma mansoni cpg binding protein 0.0035 0.0134 0.0439
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0013 0.0023 0.0009
Echinococcus multilocularis neuroglian 0.0012 0.0023 0.0019
Echinococcus granulosus Aminotransferase class III 0.0196 0.0939 0.3079
Brugia malayi Peptidase family M1 containing protein 0.0036 0.0139 0.0125
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0139
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.138 0.6841 1
Echinococcus granulosus contactin 0.0012 0.0023 0.003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0196 0.0939 0.1301
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0012 0.0023 0.0019
Echinococcus multilocularis hemicentin 1 0.0012 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0076 0.0248
Schistosoma mansoni septate junction protein 0.0012 0.0023 0.0072
Schistosoma mansoni neuroglian 0.0012 0.0023 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0388 0.1894 0.1883
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0036 0.0139 0.1966
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0139 0.0258
Echinococcus multilocularis neuroglian 0.0063 0.0273 0.0537
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.4843 1
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0196 0.0939 0.3108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Echinococcus granulosus lamin 0.0025 0.0084 0.0232
Echinococcus granulosus intermediate filament protein 0.0025 0.0084 0.0232
Brugia malayi exodeoxyribonuclease III family protein 0.0036 0.0141 0.0127
Brugia malayi hypothetical protein 0.0118 0.055 0.0537
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0013 0.0023 0.0019
Echinococcus granulosus paired box protein pax 1 0.0039 0.0153 0.0463
Brugia malayi hypothetical protein 0.0013 0.0023 0.0009
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.0295
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0196 0.0939 0.1343
Echinococcus multilocularis aurora kinase A 0.013 0.061 0.1233
Entamoeba histolytica protein kinase, putative 0.013 0.061 1
Schistosoma mansoni cell adhesion molecule 0.0012 0.0023 0.0072
Echinococcus granulosus lachesin 0.0012 0.0023 0.003
Plasmodium vivax ornithine aminotransferase, putative 0.0196 0.0939 1
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0023 0.0019
Brugia malayi isocitrate dehydrogenase 0.0019 0.0056 0.0042
Echinococcus granulosus leukotriene A 4 hydrolase 0.0013 0.0023 0.0031
Echinococcus multilocularis lachesin 0.0012 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0057 0.0246 0.0232
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0139 0.0258
Schistosoma mansoni titin 0.0012 0.0023 0.0072
Schistosoma mansoni protein kinase 0.013 0.061 0.2017
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0196 0.0939 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.0056 0.0042
Brugia malayi Pre-SET motif family protein 0.0086 0.039 0.0376
Mycobacterium ulcerans hypothetical protein 0.138 0.6841 1
Onchocerca volvulus 0.0039 0.0153 0.013
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0141 0.1281
Schistosoma mansoni tyrosine kinase 0.0018 0.0049 0.0158
Onchocerca volvulus 0.0025 0.0084 0.0061
Echinococcus granulosus aminopeptidase N 0.0036 0.0139 0.0415
Leishmania major protein kinase, putative 0.013 0.061 1
Toxoplasma gondii aurora kinase 0.013 0.061 0.6403
Loa Loa (eye worm) hypothetical protein 0.0057 0.0246 0.0232
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0036 0.0139 0.1966
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.013 0.061 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0139 0.0415
Loa Loa (eye worm) vab-3 0.0039 0.0153 0.0139
Loa Loa (eye worm) AUR protein kinase 0.013 0.061 0.0596
Schistosoma mansoni roundabout 0.0012 0.0023 0.0072
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0139 0.0415
Trichomonas vaginalis ap endonuclease, putative 0.0036 0.0141 0.0205
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.019 0.0584
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Echinococcus granulosus paired box protein pax 6 0.0039 0.0153 0.0463
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0196 0.0939 0.1301
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.019 0.0584
Echinococcus multilocularis roundabout 2 0.0012 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0013 0.0023 0.0009
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0196 0.0939 0.1343
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2424 0.4989
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.019 0.0624
Giardia lamblia Aurora kinase 0.013 0.061 1
Loa Loa (eye worm) hypothetical protein 0.0057 0.0246 0.0232
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0036 0.0141 0.0127
Loa Loa (eye worm) hypothetical protein 0.0057 0.0246 0.0232
Entamoeba histolytica protein kinase , putative 0.013 0.061 1
Onchocerca volvulus 0.0035 0.0134 0.0111
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.013 0.061 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0087
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0139
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0134 0.012
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0036 0.0141 0.1281
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0036 0.0139 0.0258
Echinococcus granulosus twitchin 0.0064 0.0279 0.0881
Echinococcus granulosus peroxidasin 0.0012 0.0023 0.003
Brugia malayi 'Paired box' domain containing protein 0.0039 0.0153 0.0139
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0023 0.0031
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0056 0.0556
Brugia malayi paired box protein 0.0039 0.0153 0.0139
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0139 0.0203
Schistosoma mansoni paired box protein pax-1-related 0.0039 0.0153 0.0503
Schistosoma mansoni aminopeptidase A (M01 family) 0.0013 0.0023 0.0073
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.003 0.0053
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0076 0.09
Onchocerca volvulus 0.0036 0.0139 0.0116
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0196 0.0939 0.5
Loa Loa (eye worm) hypothetical protein 0.0118 0.055 0.0537
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0012 0.0023 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.039 0.1288
Loa Loa (eye worm) paired box protein 0.0039 0.0153 0.0139
Echinococcus multilocularis Aminotransferase class III 0.0196 0.0939 0.1915
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0012 0.0023 0.0019
Loa Loa (eye worm) intermediate filament protein 0.0025 0.0084 0.007
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.013 0.061 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.013 0.061 0.1233
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0036 0.0139 0.0455
Schistosoma mansoni paired box protein pax-6 0.0039 0.0153 0.0503
Toxoplasma gondii exonuclease III APE 0.0036 0.0141 0.1281
Loa Loa (eye worm) hypothetical protein 0.0064 0.0281 0.0267
Brugia malayi hypothetical protein 0.0057 0.0246 0.0232
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0012 0.002 0.0012
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0013 0.0023 0.0031
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0019 0.0056 0.0556
Loa Loa (eye worm) hypothetical protein 0.007 0.0308 0.0295
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0012 0.0019 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0087
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.0056 0.0087
Brugia malayi 'Paired box' domain containing protein 0.0039 0.0153 0.0139
Echinococcus multilocularis paired box protein pax 6 0.0039 0.0153 0.0288
Loa Loa (eye worm) hypothetical protein 0.0086 0.039 0.0376
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.019 0.0363
Onchocerca volvulus 0.0039 0.0153 0.013
Echinococcus granulosus roundabout 2 0.007 0.0308 0.098
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0086 0.039 0.4002
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0086 0.039 0.1288
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0036 0.0139 0.0415
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0139 0.1966
Loa Loa (eye worm) hypothetical protein 0.0118 0.055 0.0537
Mycobacterium ulcerans acetylornithine aminotransferase 0.0196 0.0939 0.1343
Echinococcus multilocularis lamin dm0 0.0025 0.0084 0.0144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0081 0.0067
Loa Loa (eye worm) hypothetical protein 0.0012 0.002 0.0006
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0012 0.002 0.002
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0595 0.2929 0.2919
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0029 0.0015
Echinococcus multilocularis ornithine aminotransferase 0.0196 0.0939 0.1915
Toxoplasma gondii isocitrate dehydrogenase 0.0019 0.0056 0.0356
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0014 0.0028 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.019 0.0176
Brugia malayi Peptidase family M1 containing protein 0.0013 0.0023 0.0009
Trichomonas vaginalis AGC family protein kinase 0.013 0.061 0.0891
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Plasmodium vivax serine/threonine protein kinase 6, putative 0.013 0.061 0.6403
Schistosoma mansoni nephrin 0.0012 0.0023 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0023 0.0009
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.138 0.6841 1
Echinococcus granulosus tyrosine protein kinase otk 0.0012 0.0023 0.003
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.0056 0.0556
Echinococcus multilocularis lamin 0.0025 0.0084 0.0144
Trichomonas vaginalis AGC family protein kinase 0.013 0.061 0.0891
Echinococcus granulosus neuroglian 0.0063 0.0273 0.0864
Mycobacterium tuberculosis Probable aminotransferase 0.138 0.6841 1
Echinococcus granulosus cpg binding protein 0.0037 0.0144 0.0431
Trichomonas vaginalis AGC family protein kinase 0.013 0.061 0.0891
Brugia malayi 'Paired box' domain containing protein 0.0039 0.0153 0.0139
Schistosoma mansoni lamin 0.0025 0.0084 0.0273
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0036 0.0141 0.0262
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0036 0.0141 0.2
Echinococcus multilocularis paired box protein pax 1 0.0039 0.0153 0.0288
Schistosoma mansoni cell adhesion molecule 0.0064 0.0281 0.0927
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0036 0.0141 0.0172
Loa Loa (eye worm) AUR protein kinase 0.013 0.061 0.0596
Echinococcus multilocularis musashi 0.0025 0.0084 0.0144
Brugia malayi Gooseberry protein 0.0039 0.0153 0.0139
Schistosoma mansoni ap endonuclease 0.0036 0.0141 0.0462
Plasmodium falciparum ornithine aminotransferase 0.0196 0.0939 1
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0196 0.0939 0.1301
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0036 0.0139 0.0203
Trypanosoma cruzi Aminopeptidase M1, putative 0.0036 0.0139 0.1966
Echinococcus multilocularis aminopeptidase N 0.0036 0.0139 0.0258
Brugia malayi Prion-like- 0.0012 0.0023 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Onchocerca volvulus Retinal homeobox protein Rx homolog 0.0039 0.0153 0.013
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0036 0.0141 0.0421
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0064 0.0281 0.0889
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0019 0.0056 0.0356
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0196 0.0939 0.1343
Mycobacterium ulcerans L-lysine aminotransferase 0.0196 0.0939 0.1343
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.0056 0.0181
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.0056 0.0556
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0036 0.0141 0.0042
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0012 0.0023 0.0072
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0076 0.0128
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0012 0.0023 0.0019
Echinococcus multilocularis cpg binding protein 0.0037 0.0144 0.0268
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0025 0.0084 0.007
Schistosoma mansoni cell adhesion molecule 0.0012 0.0023 0.0072
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.0056 0.0087
Echinococcus granulosus paired box gene 3/7 (eyeless, eyegone, twin of eyeless) 0.0039 0.0153 0.0463
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0019 0.0018
Schistosoma mansoni vesicular amine transporter 0.0057 0.0246 0.0812
Brugia malayi Immunoglobulin I-set domain containing protein 0.0012 0.0023 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.019 0.0363
Loa Loa (eye worm) hypothetical protein 0.0039 0.0153 0.0139
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.019 0.0176
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0036 0.0139 0.0258
Echinococcus multilocularis Immunoglobulin 0.0057 0.0246 0.0481
Trichomonas vaginalis set domain proteins, putative 0.0677 0.3338 0.488
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0013 0.0027 0.0013
Loa Loa (eye worm) peptidase family M1 containing protein 0.0013 0.0023 0.0009
Brugia malayi Peroxidasin 0.0012 0.0023 0.0009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.003 0.0033
Onchocerca volvulus Huntingtin homolog 0.0118 0.055 0.0528
Loa Loa (eye worm) AUR protein kinase 0.013 0.061 0.0596
Trypanosoma cruzi aminopeptidase, putative 0.0036 0.0139 0.1966
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0013 0.0023 0.0034
Schistosoma mansoni paired box protein pax-6 0.0039 0.0153 0.0503
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0304 0.3066
Echinococcus granulosus mixed lineage leukemia protein mll 0.0012 0.0019 0.0018
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.0056 0.0087
Loa Loa (eye worm) pax transcription factor protein 2 0.2013 1 1
Echinococcus multilocularis peroxidasin 0.0012 0.0023 0.0019
Brugia malayi serine/threonine-protein kinase 6 0.013 0.061 0.0596
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0013 0.0023 0.0073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.039 0.1288
Trypanosoma brucei Aminopeptidase M1, putative 0.0036 0.0139 0.1966
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0012 0.0023 0.0072
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0019 0.0056 0.0356
Echinococcus multilocularis ornithine aminotransferase 0.0196 0.0939 0.1915

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.