Detailed information for compound 148281

Basic information

Technical information
  • TDR Targets ID: 148281
  • Name: 7-(4-hydroxypentoxy)-1,3-dihydroimidazo[4,5-b ]quinolin-2-one
  • MW: 287.314 | Formula: C15H17N3O3
  • H donors: 3 H acceptors: 4 LogP: 2.22 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(CCCOc1ccc2c(c1)cc1c([nH]2)nc(n1)O)O
  • InChi: 1S/C15H17N3O3/c1-9(19)3-2-6-21-11-4-5-12-10(7-11)8-13-14(16-12)18-15(20)17-13/h4-5,7-9,19H,2-3,6H2,1H3,(H2,16,17,18,20)
  • InChiKey: AOAQFGRPXBJZPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens purinergic receptor P2Y, G-protein coupled, 12 Starlite/ChEMBL References
Homo sapiens phosphodiesterase 3B, cGMP-inhibited References
Homo sapiens phosphodiesterase 3A, cGMP-inhibited Starlite/ChEMBL References
Sus scrofa Phosphodiesterase 4A Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Cryptosporidium parvum membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132613 All targets in OG5_132613
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing Get druggable targets OG5_128242 All targets in OG5_128242
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128242 All targets in OG5_128242
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein Get druggable targets OG5_132613 All targets in OG5_132613
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative Get druggable targets OG5_128242 All targets in OG5_128242
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B Get druggable targets OG5_128242 All targets in OG5_128242
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase Get druggable targets OG5_128242 All targets in OG5_128242
Schistosoma japonicum cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative Get druggable targets OG5_128242 All targets in OG5_128242
Neospora caninum cAMP-specific phosphodiesterase, putative Get druggable targets OG5_128242 All targets in OG5_128242
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans similar to a group of Candida orfs that show weak similarity to Leucine-rich repeat viral proteins Phosphodiesterase 4A   118 aa 97 aa 26.8 %
Onchocerca volvulus SH3 domain-binding glutamic acid-rich protein homolog Phosphodiesterase 4A   118 aa 112 aa 28.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Giardia lamblia hypothetical protein 0.0027 0.0114 0.0376
Schistosoma mansoni hypothetical protein 0.0339 0.3194 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.0829 0.6259
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0344 0.0344
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0464 0.0584
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Schistosoma mansoni hypothetical protein 0.0291 0.2724 0.853
Loa Loa (eye worm) hypothetical protein 0.0147 0.1302 0.1302
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Echinococcus multilocularis neuropeptide s receptor 0.047 0.4494 0.5655
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Entamoeba histolytica valyl tRNA synthetase, putative 0.0052 0.0362 0.256
Schistosoma mansoni valine-tRNA ligase 0.0052 0.0362 0.1133
Brugia malayi isoleucyl-tRNA synthetase 0.0147 0.1302 0.1302
Echinococcus granulosus isoleucyl trna synthetase mitochondrial 0.0116 0.0992 0.2208
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0048 0.0106
Leishmania major basic transcription factor 3a, putative 0.0035 0.0187 0.1437
Echinococcus granulosus leucyl tRNA synthetase 0.0052 0.0362 0.0805
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Mycobacterium tuberculosis Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA glycosylase) 0.0274 0.2558 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0223 0.2053 0.4567
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0464 0.1454
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0114 0.0114
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0027 0.0114 0.0114
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0039 0.0296
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0027 0.0114 0.0358
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0039 0.0039
Giardia lamblia Hypothetical protein 0.0027 0.0114 0.0376
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0048 0.006
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0021 0.0052 0.0107
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Giardia lamblia Isoleucyl-tRNA synthetase 0.0147 0.1302 0.6274
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0098
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.001
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.1319
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0187 0.1177
Brugia malayi hypothetical protein 0.0124 0.107 0.107
Echinococcus granulosus methionyl tRNA synthetase cytoplasmic 0.0031 0.0156 0.0346
Echinococcus multilocularis transcription factor btf3 0.0035 0.0187 0.0236
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Loa Loa (eye worm) hypothetical protein 0.0116 0.0992 0.0992
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0039 0.0048
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Entamoeba histolytica hypothetical protein 0.0035 0.0187 0.1177
Giardia lamblia Leucyl-tRNA synthetase 0.0021 0.0052 0.0067
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0223 0.2053 1
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Giardia lamblia Valine-tRNA ligase 0.0052 0.0362 0.1606
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.0829 0.1044
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0098 0.0749
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0223 0.2053 1
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0114 0.0878
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Loa Loa (eye worm) PDE1B protein 0.0027 0.0114 0.0114
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Brugia malayi steroid hormone receptor 0.002 0.0048 0.0048
Wolbachia endosymbiont of Brugia malayi formamidopyrimidine-DNA glycosylase 0.0274 0.2558 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0114
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0052 0.0362 0.256
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0048
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0039
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0048 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0048
Brugia malayi MH2 domain containing protein 0.0121 0.1039 0.1039
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0106
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0003 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0114 0.06
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0274 0.2558 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0052 0.0362 0.278
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0114 0.06
Echinococcus multilocularis protein patched 0.0043 0.0268 0.0337
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0098 0.0317
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0027 0.0114 0.0144
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0048 0.0106
Loa Loa (eye worm) hypothetical protein 0.0027 0.0114 0.0114
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0027 0.0114 0.0878
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0031 0.0156 0.1196
Echinococcus multilocularis valyl tRNA synthetase 0.0052 0.0362 0.0455
Plasmodium falciparum phosphodiesterase gamma, putative 0.0027 0.0114 0.0372
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0098 0.0749
Schistosoma mansoni nuclear hormone receptor 0.002 0.0048 0.0149
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.006
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0003 0.0007
Toxoplasma gondii isoleucyl-tRNA synthetase, putative 0.0052 0.0362 0.1764
Trypanosoma brucei valyl-tRNA synthetase, putative 0.0052 0.0362 0.278
Echinococcus granulosus valyl tRNA synthetase 0.0052 0.0362 0.0805
Plasmodium falciparum leucine--tRNA ligase, putative 0.0052 0.0362 0.1178
Schistosoma mansoni patched 1 0.0043 0.0268 0.0839
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0048 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0048
Plasmodium falciparum valine--tRNA ligase, putative 0.0052 0.0362 0.1178
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0878
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0048 0.0149
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0039 0.0296
Loa Loa (eye worm) hypothetical protein 0.0031 0.0156 0.0156
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0187 0.1177
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.0296
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Toxoplasma gondii tRNA synthetase, putative 0.0052 0.0362 0.1764
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0327 0.3074 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0039 0.0296
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0196 0.1784 0.2245
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0027 0.0114 0.0358
Echinococcus multilocularis Niemann Pick C1 protein 0.0142 0.1252 0.1575
Echinococcus granulosus expressed conserved protein 0.0093 0.077 0.1713
Echinococcus granulosus X box binding protein 1 0.0291 0.2724 0.6061
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0223 0.2053 0.6427
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0003 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0187 0.1177
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0464 0.1454
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0003 0.0003
Echinococcus granulosus neuropeptide receptor A26 0.047 0.4494 1
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0196 0.1784 0.1784
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0021 0.0052 0.0107
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0027 0.0114 0.0144
Schistosoma mansoni hypothetical protein 0.0041 0.0253 0.0791
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0027 0.0114 0.0372
Echinococcus granulosus dna polymerase kappa 0.002 0.0039 0.0086
Schistosoma mansoni isoleucine--tRNA ligase 0.0147 0.1302 0.4077
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0048
Plasmodium falciparum phosphodiesterase delta, putative 0.0027 0.0114 0.0372
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0003 0.0003
Brugia malayi hypothetical protein 0.0025 0.0098 0.0098
Toxoplasma gondii Isoleucine-tRNA ligase 0.0021 0.0052 0.0253
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0039 0.0039
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0021 0.0052 0.0107
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0039 0.0121
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0268 0.0337
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Echinococcus granulosus geminin 0.0339 0.3194 0.7106
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0048 0.0048
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.001
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.1039 0.1039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0048
Onchocerca volvulus 0.0052 0.0362 0.3076
Echinococcus granulosus transcription factor btf3 0.0035 0.0187 0.0416
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0464 0.1454
Mycobacterium tuberculosis Probable valyl-tRNA synthase protein ValS (valyl-tRNA synthetase) (valine--tRNA ligase) (valine translase) 0.0052 0.0362 0.1415
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Onchocerca volvulus 0.0031 0.0156 0.1057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0048
Entamoeba histolytica valyl-tRNA synthetase, putative 0.0052 0.0362 0.256
Echinococcus multilocularis X box binding protein 1 0.0291 0.2724 0.3428
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0362 0.278
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0027 0.0114 0.0878
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0268 0.0268
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0187 0.1437
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0027 0.0114 0.0254
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0027 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.01 0.0829 0.0829
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.0829 0.0829
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0048 0.0149
Loa Loa (eye worm) hypothetical protein 0.1 0.9731 0.9731
Schistosoma mansoni leucyl-tRNA synthetase 0.0021 0.0052 0.0163
Echinococcus granulosus tar DNA binding protein 0.0063 0.0464 0.1033
Trypanosoma cruzi leucyl-tRNA synthetase, putative 0.0021 0.0052 0.0399
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0464 0.0464
Echinococcus granulosus dna polymerase eta 0.002 0.0039 0.0086
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0048 0.0149
Brugia malayi hypothetical protein 0.0016 0.0008 0.0008
Loa Loa (eye worm) VRS-2 protein 0.0021 0.0052 0.0052
Schistosoma mansoni leucyl-tRNA synthetase 0.0052 0.0362 0.1133
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0098 0.0749
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Echinococcus multilocularis GPCR, family 2 0.0016 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0223 0.2053 0.2053
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0039 0.0296
Brugia malayi TAR-binding protein 0.0063 0.0464 0.0464
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0048 0.0106
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0196 0.1784 0.1784
Toxoplasma gondii isoleucyl-tRNA synthetase family protein 0.0147 0.1302 0.6344
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0027 0.0114 0.0144
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0114 0.0878
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0027 0.0114 0.0254
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0344 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0114 0.06
Echinococcus granulosus neuropeptide s receptor 0.047 0.4494 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0048 0.0149
Onchocerca volvulus Huntingtin homolog 0.0124 0.107 1
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0027 0.0114 0.0254
Wolbachia endosymbiont of Brugia malayi isoleucyl-tRNA synthetase 0.0147 0.1302 0.4282
Leishmania major hypothetical protein, conserved 0.0025 0.0098 0.0749
Schistosoma mansoni hypothetical protein 0.0036 0.0205 0.0642
Mycobacterium ulcerans valyl-tRNA synthetase 0.0052 0.0362 0.1284
Mycobacterium leprae isoleucyl-tRNA synthetase IleS 0.0147 0.1302 0.4282
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0027 0.0114 0.0144
Schistosoma mansoni coup transcription factor 0.002 0.0048 0.0149
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.0829 0.1845
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0027 0.0114 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0048
Toxoplasma gondii valyl-tRNA synthetase 0.0052 0.0362 0.1764
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0187 0.1177
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0039 0.0151
Mycobacterium tuberculosis Possible DNA glycosylase 0.0274 0.2558 1
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0114 0.06
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0114 0.0878
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0223 0.2053 0.2583
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0149
Echinococcus multilocularis geminin 0.0339 0.3194 0.4019
Echinococcus granulosus GPCR family 2 0.0016 0.0003 0.0007
Leishmania major leucyl-tRNA synthetase, putative 0.0052 0.0362 0.278
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0223 0.2053 0.2583
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0878
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.1319
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0031 0.0156 0.0927
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0464 0.1454
Leishmania major cAMP-specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Brugia malayi protein ZK524.3 0.0021 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.006
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0106
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0021 0.0052 0.0399
Loa Loa (eye worm) hypothetical protein 0.0124 0.107 0.107
Trypanosoma brucei isoleucyl-tRNA synthetase, putative 0.0147 0.1302 1
Echinococcus multilocularis valyl tRNA synthetase 0.0052 0.0362 0.0455
Loa Loa (eye worm) hypothetical protein 0.0031 0.0156 0.0156
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0048 0.0149
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis isoleucyl, leucyl, tyrosyl, valyl and methionyl-tRNA synthetases, putative 0.0031 0.0156 0.0927
Loa Loa (eye worm) hypothetical protein 0.0043 0.0268 0.0268
Plasmodium vivax phosphodiesterase gamma, putative 0.0027 0.0114 0.0878
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0027 0.0114 0.0358
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0027 0.0114 0.0254
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.006
Brugia malayi Valyl-tRNA synthetase 0.0052 0.0362 0.0362
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.1319
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0039 0.0296
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0187 0.1437
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0048
Mycobacterium tuberculosis Isoleucyl-tRNA synthetase IleS 0.0095 0.0786 0.3073
Mycobacterium ulcerans isoleucyl-tRNA synthetase 0.0147 0.1302 0.5016
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0372
Echinococcus multilocularis methionyl tRNA synthetase, cytoplasmic 0.0031 0.0156 0.0196
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0106
Brugia malayi nuclear receptor NHR-88 0.002 0.0048 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0106
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0027 0.0114 0.0144
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Chlamydia trachomatis valine--tRNA ligase 0.0052 0.0362 0.18
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Schistosoma mansoni leucyl-tRNA synthetase 0.0021 0.0052 0.0163
Loa Loa (eye worm) hypothetical protein 0.0052 0.0363 0.0363
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0205 0.0258
Trichomonas vaginalis isoleucyl tRNA synthetase, putative 0.0147 0.1302 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0048
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0187 0.0609
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0021 0.0052 0.0107
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0048
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0106
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.1039 0.1039
Mycobacterium ulcerans formamidopyrimidine-DNA glycosylase 0.0274 0.2558 1
Entamoeba histolytica leucyl-tRNA synthetase, putative 0.0052 0.0362 0.256
Trypanosoma cruzi valyl-tRNA synthetase, putative 0.0052 0.0362 0.278
Leishmania major hypothetical protein, conserved 0.0027 0.0114 0.0878
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0223 0.2053 0.4567
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0039 0.0296
Echinococcus granulosus FTZ F1 alpha 0.002 0.0048 0.0106
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni hypothetical protein 0.0041 0.0253 0.0791
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Loa Loa (eye worm) hypothetical protein 0.0124 0.107 0.107
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Toxoplasma gondii leucyl-tRNA synthetase 0.0052 0.0362 0.1764
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0048 0.006
Echinococcus granulosus Niemann Pick C1 protein 0.0142 0.1252 0.2785
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0027 0.0114 0.0254
Echinococcus multilocularis leucyl tRNA synthetase 0.0052 0.0362 0.0455
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0048 0.0149
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0268 0.0596
Leishmania major valyl-tRNA synthetase, putative 0.0052 0.0362 0.278
Loa Loa (eye worm) RNA binding protein 0.0063 0.0464 0.0464
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0039 0.0086
Echinococcus granulosus leucyl tRNA synthetase 0.0052 0.0362 0.0805
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0187 0.0912
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0372
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0114 0.0878
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0464 0.0464
Mycobacterium leprae Probable formamidopyrimidine-DNA glycosylase Fpg (FAPY-DNA GLYCOSYLASE) 0.0274 0.2558 1
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0027 0.0114 0.0254
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0027 0.0114 0.0114
Plasmodium vivax isoleucine--tRNA ligase, putative 0.0147 0.1302 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0027 0.0114 0.0358
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trypanosoma brucei unspecified product 0.002 0.0039 0.0296
Echinococcus multilocularis expressed conserved protein 0.0093 0.077 0.0968
Echinococcus granulosus isoleucyl tRNA synthetase, cytoplasmic 0.0147 0.1302 0.2897
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Plasmodium vivax valine--tRNA ligase, putative 0.0021 0.0052 0.0399
Leishmania major isoleucyl-tRNA synthetase, putative 0.0147 0.1302 1
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0027 0.0114 0.0878
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0048 0.006
Schistosoma mansoni isoleucine--tRNA ligase 0.0147 0.1302 0.4077
Brugia malayi valyl-tRNA synthetase family protein 0.0052 0.0362 0.0362
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0027 0.0114 0.0878
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Onchocerca volvulus Huntingtin homolog 0.0124 0.107 1
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0027 0.0114 0.0372
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0196 0.1784 0.3969
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0098 0.0317
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0205 0.0456
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0464 0.1454
Echinococcus granulosus valyl tRNA synthetase 0.0052 0.0362 0.0805
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0048
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0039 0.0121
Echinococcus multilocularis protein dispatched 1 0.0049 0.0327 0.0412
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0031 0.0156 0.0927
Plasmodium vivax valine--tRNA ligase, putative 0.0052 0.0362 0.278
Echinococcus multilocularis isoleucyl tRNA synthetase, cytoplasmic 0.0147 0.1302 0.1638
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Brugia malayi nuclear hormone receptor 0.002 0.0048 0.0048
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0878
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0048 0.0048
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0344 0.0344
Leishmania major DNA polymerase eta, putative 0.002 0.0039 0.0296
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0268 0.1815
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0114 0.0878
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0027 0.0114 0.06
Schistosoma mansoni valine-tRNA ligase 0.0052 0.0362 0.1133
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Echinococcus multilocularis dna polymerase eta 0.002 0.0039 0.0048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0187 0.1437
Schistosoma mansoni hypothetical protein 0.0016 0.0003 0.001
Brugia malayi ecdysteroid receptor 0.002 0.0048 0.0048
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0268 0.0596
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0187 0.0187
Leishmania major hypothetical protein, conserved 0.0027 0.0114 0.0878
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0039 0.0039
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0027 0.0114 0.0878
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Treponema pallidum isoleucyl-tRNA synthetase 0.0147 0.1302 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0003 0.0003
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Plasmodium falciparum isoleucine--tRNA ligase, putative 0.0147 0.1302 0.4236
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Echinococcus multilocularis leucyl tRNA synthetase 0.0052 0.0362 0.0455
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Schistosoma mansoni transcription factor btf3 0.0035 0.0187 0.0586
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.082 0.7948 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.0296
Brugia malayi beta-NAC-like protein 0.0035 0.0187 0.0187
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Brugia malayi isoleucyl-tRNA synthetase family protein 0.0147 0.1302 0.1302
Toxoplasma gondii leucyl-tRNA synthetase (LeuRS2) 0.0052 0.0362 0.1764
Plasmodium falciparum leucine--tRNA ligase, putative 0.0021 0.0052 0.0169
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0048 0.0149
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0048 0.0048
Echinococcus multilocularis dna polymerase kappa 0.002 0.0039 0.0048
Echinococcus multilocularis neuropeptide receptor A26 0.047 0.4494 0.5655
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0048
Echinococcus multilocularis isoleucyl tRNA synthetase, mitochondrial 0.0116 0.0992 0.1248
Brugia malayi CHE-14 protein 0.0043 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0048 0.0048
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0048 0.006
Schistosoma mansoni hypothetical protein 0.0034 0.0186 0.0583
Leishmania major DNA polymerase kappa, putative 0.002 0.0039 0.0296
Trichomonas vaginalis leucyl-tRNA synthetase, putative 0.0052 0.0362 0.256
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0187 0.1437
Schistosoma mansoni hypothetical protein 0.0041 0.0253 0.0791
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0027 0.0114 0.0878
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Mycobacterium ulcerans leucyl-tRNA synthetase 0.0031 0.0156 0.0465
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0186 0.0186
Loa Loa (eye worm) hypothetical protein 0.005 0.0344 0.0344
Trypanosoma cruzi isoleucyl-tRNA synthetase, putative 0.0147 0.1302 1
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0048 0.0048
Chlamydia trachomatis isoleucine--tRNA ligase 0.0147 0.1302 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.006
Onchocerca volvulus 0.0116 0.0992 0.9241
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0027 0.0114 0.0114
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0114 0.0878
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0048
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0039 0.0151
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.0296
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0048
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0464 0.0464
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Plasmodium falciparum valine--tRNA ligase, putative 0.0052 0.0362 0.1178
Entamoeba histolytica hypothetical protein 0.0036 0.0205 0.1319
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0098 0.0475
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0027 0.0114 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Loa Loa (eye worm) isoleucyl-tRNA synthetase 0.0147 0.1302 0.1302
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0027 0.0114 0.06
Entamoeba histolytica isoleucyl-tRNA synthetase, putative 0.0147 0.1302 1
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0878
Loa Loa (eye worm) hypothetical protein 0.0034 0.0186 0.0186
Schistosoma mansoni DNA polymerase eta 0.002 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0048
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0039 0.0296
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.0878
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0048
Brugia malayi RNA binding protein 0.0063 0.0464 0.0464
Loa Loa (eye worm) hypothetical protein 0.1027 1 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.0845 0.2644
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0149
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0039 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0114 0.0878
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0027 0.0114 0.0878
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0027 0.0114 0.06
Brugia malayi hypothetical protein 0.0036 0.0205 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0114 0.06
Loa Loa (eye worm) hypothetical protein 0.0052 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0041 0.0253 0.0791
Treponema pallidum valyl-tRNA synthetase 0.0052 0.0362 0.18
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0027 0.0114 0.0878
Trichomonas vaginalis valyl-tRNA synthetase, putative 0.0021 0.0052 0.0107
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0205 0.0642
Brugia malayi leucyl-tRNA synthetase 0.0052 0.0362 0.0362
Schistosoma mansoni hypothetical protein 0.0339 0.3194 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0027 0.0114 0.0557
Trypanosoma brucei leucyl-tRNA synthetase, putative 0.0052 0.0362 0.278
Schistosoma mansoni methionine-tRNA synthetase 0.0031 0.0156 0.0488

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 0.07 uM Inhibition of platelet aggregation using collagen as activating agent in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 0.1 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 0.1 uM Inhibition of platelet aggregation using adenosine diphosphate (ADP) as activating agent in human platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 0.52 uM Inhibition of ADP-induced platelet aggregation in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
EC50 (functional) = 0.52 uM Inhibition of ADP-induced platelet aggregation in rabbit platelet rich plasma (PRP) ChEMBL. 1321910
IC50 (binding) uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) 0 uM Inhibition of human platelet PDE by inhibiting cyclic Guanosine monophosphate (cGMP) hydrolysis; Not tested ChEMBL. 1321910
IC50 (binding) = 0.1 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910
IC50 (binding) = 0.1 uM Inhibition of human platelet PDE by inhibiting cyclic Adenosine monophosphate (cAMP) hydrolysis ChEMBL. 1321910

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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