Detailed information for compound 1483582

Basic information

Technical information
  • TDR Targets ID: 1483582
  • Name: N-[3-(1,3-benzodioxol-5-ylmethylamino)-3-oxop ropyl]-3,4,5-trimethoxybenzamide
  • MW: 416.424 | Formula: C21H24N2O7
  • H donors: 2 H acceptors: 2 LogP: 1.67 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc(c1OC)OC)C(=O)NCCC(=O)NCc1ccc2c(c1)OCO2
  • InChi: 1S/C21H24N2O7/c1-26-17-9-14(10-18(27-2)20(17)28-3)21(25)22-7-6-19(24)23-11-13-4-5-15-16(8-13)30-12-29-15/h4-5,8-10H,6-7,11-12H2,1-3H3,(H,22,25)(H,23,24)
  • InChiKey: RYAFCXITHUMHAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[3-(1,3-benzodioxol-5-ylmethylamino)-3-oxo-propyl]-3,4,5-trimethoxy-benzamide
  • N-[3-(1,3-benzodioxol-5-ylmethylamino)-3-keto-propyl]-3,4,5-trimethoxy-benzamide
  • MLS000046159
  • SMR000031768

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi nuclear receptor NHR-88 0.0074 0.0519 0.0506
Schistosoma mansoni lamin 0.003 0.0135 0.0038
Echinococcus multilocularis muscleblind protein 0.0153 0.1204 0.2681
Echinococcus multilocularis nuclear receptor nhr 48 0.0074 0.0519 0.1157
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0157 0.1242 0.123
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.058 1
Brugia malayi Nuclear hormone receptor E75 0.0074 0.0519 0.0506
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0275 0.0275
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0206 0.0577
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0275 0.0262
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0323 0.2293
Mycobacterium ulcerans hypothetical protein 0.0027 0.0109 0.0572
Loa Loa (eye worm) nuclear receptor NHR-67 0.0074 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.1242 0.3978
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Loa Loa (eye worm) nuclear hormone receptor 0.0074 0.0519 0.0519
Brugia malayi nuclear receptor RXR 0.0074 0.0519 0.0506
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0121
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0214 0.1316
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0157 0.1242 0.123
Brugia malayi hypothetical protein 0.0504 0.4267 0.4259
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0171 0.1089
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.1242 0.2766
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0157 0.1242 0.123
Brugia malayi hypothetical protein 0.0074 0.0519 0.0506
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.1294 0.269
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0157 0.1242 0.257
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.005 0.0076
Loa Loa (eye worm) hypothetical protein 0.0153 0.1204 0.1204
Loa Loa (eye worm) hypothetical protein 0.0027 0.0109 0.0109
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0373 0.3122 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Echinococcus multilocularis musashi 0.003 0.0135 0.03
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0206 0.0964
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0157 0.1242 0.3978
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0074 0.0519 0.0917
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0118 0.0379
Schistosoma mansoni coup transcription factor 0.0157 0.1242 0.257
Echinococcus granulosus lamin dm0 0.003 0.0135 0.0432
Brugia malayi ecdysone receptor 0.0074 0.0519 0.0506
Echinococcus granulosus thymidylate synthase 0.0157 0.1239 0.3968
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0157 0.1242 0.123
Schistosoma mansoni inositol monophosphatase 0.0038 0.0206 0.02
Loa Loa (eye worm) hypothetical protein 0.0081 0.058 0.058
Schistosoma mansoni steroid hormone receptor ad4bp 0.0157 0.1242 0.257
Schistosoma mansoni hypothetical protein 0.0076 0.0536 0.0955
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0157 0.1242 0.3978
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1399 0.3116
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0326 0.2713 0.2713
Brugia malayi thymidylate synthase 0.0157 0.1239 0.1227
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0157 0.1239 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0206 0.0577
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0597 0.0584
Echinococcus granulosus Nuclear hormone receptor HR96 0.0074 0.0519 0.1664
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0108 0.0812 0.0812
Loa Loa (eye worm) steroid hormone receptor 0.0157 0.1242 0.1242
Echinococcus granulosus carbonic anhydrase 0.0163 0.1294 0.4145
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0171 0.0157
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0135 0.0121
Schistosoma mansoni nuclear receptor 0.0074 0.0519 0.0917
Echinococcus multilocularis Protein lozenge 0.0063 0.0425 0.0947
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0157 0.1242 0.1242
Schistosoma mansoni carbonic anhydrase 0.0163 0.1294 0.269
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0157 0.1242 0.1242
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0171 0.0548
Mycobacterium ulcerans thymidylate synthase 0.0157 0.1239 1
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Loa Loa (eye worm) hypothetical protein 0.0074 0.0515 0.0515
Schistosoma mansoni ap endonuclease 0.0039 0.0214 0.0218
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0157 0.1242 0.1242
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0597 0.1094
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0206 0.0577
Echinococcus multilocularis FTZ F1 alpha 0.0157 0.1242 0.2766
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Echinococcus granulosus carbonic anhydrase 0.0163 0.1294 0.4145
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0275 0.0881
Schistosoma mansoni nuclear hormone receptor 0.0074 0.0519 0.0917
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.1294 0.269
Entamoeba histolytica hypothetical protein 0.0076 0.0536 0.427
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0157 0.1239 0.4195
Brugia malayi hypothetical protein 0.0263 0.2167 0.2156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0157 0.1242 0.123
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0214 0.1377
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0214 0.0214
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1356 0.4344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0275 0.0613
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0157 0.1242 0.123
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0206 0.1375
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0206 0.0458
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0214 0.0605
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0109 0.0572
Echinococcus granulosus carbonic anhydrase II 0.0347 0.2896 0.9279
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Brugia malayi intermediate filament protein 0.003 0.0135 0.0121
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0074 0.0519 0.1157
Brugia malayi ecdysteroid receptor 0.0157 0.1242 0.123
Echinococcus multilocularis ecdysone induced protein 78C 0.0157 0.1242 0.2766
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0171 0.0157
Echinococcus granulosus nuclear receptor nhr 48 0.0074 0.0519 0.1664
Schistosoma mansoni lamin 0.003 0.0135 0.0038
Onchocerca volvulus 0.003 0.0135 0.0061
Echinococcus multilocularis jun protein 0.0335 0.2793 0.6222
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0109 0.0572
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0118 0.0264
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0206 0.0577
Loa Loa (eye worm) hypothetical protein 0.0153 0.1204 0.1204
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0157 0.1242 0.2766
Loa Loa (eye worm) inositol-1 0.0038 0.0206 0.0206
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0347 0.2896 0.6356
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0039 0.0214 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.013 0.013
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0074 0.0519 0.0519
Toxoplasma gondii hypothetical protein 0.0163 0.1294 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0536 0.1716
Onchocerca volvulus 0.0157 0.1239 0.2716
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0074 0.0519 0.0986
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.005 0.008
Echinococcus multilocularis thyroid hormone receptor alpha 0.053 0.4489 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0347 0.2896 0.6356
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0163 0.1294 0.1282
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Loa Loa (eye worm) hypothetical protein 0.0163 0.1294 0.1294
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0163 0.1294 0.1294
Schistosoma mansoni jun-related protein 0.0272 0.2247 0.4869
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0157 0.1242 0.1242
Brugia malayi hypothetical protein 0.0083 0.0597 0.0584
Loa Loa (eye worm) hypothetical protein 0.0163 0.1294 0.1294
Brugia malayi Death domain containing protein 0.0028 0.0118 0.0105
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0074 0.0519 0.0917
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0157 0.1242 0.123
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0041 0.0041
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0214 0.1442
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0323 0.1075
Brugia malayi hypothetical protein 0.0074 0.0519 0.0506
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Echinococcus multilocularis lamin 0.003 0.0135 0.03
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0118 0.0379
Brugia malayi Cytochrome P450 family protein 0.0019 0.0041 0.0027
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0347 0.2896 0.2887
Loa Loa (eye worm) hypothetical protein 0.0504 0.4267 0.4267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0214 0.0605
Brugia malayi nuclear hormone receptor family member nhr-6 0.0074 0.0519 0.0506
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0109 0.0572
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0109 0.0572
Loa Loa (eye worm) intermediate filament protein 0.003 0.0135 0.0135
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0214 0.0476
Echinococcus multilocularis carbonic anhydrase 0.0163 0.1294 0.2882
Brugia malayi Protein kinase domain containing protein 0.0028 0.0118 0.0105
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0109 0.024
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.1294 0.1282
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0171 0.0548
Onchocerca volvulus 0.0074 0.0519 0.0986
Echinococcus granulosus GPCR family 2 0.0034 0.0171 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0157 0.1242 0.1242
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.1294 0.1282
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0951 0.76
Echinococcus granulosus jun protein 0.0335 0.2793 0.8949
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Schistosoma mansoni hypothetical protein 0.0074 0.0515 0.0909
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0109 0.0572
Loa Loa (eye worm) hypothetical protein 0.0027 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0239 0.1953 0.1953
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0285 0.1956
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.058 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0157 0.1242 0.3978
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0335 0.2793 0.8949
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0157 0.1242 0.3978
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Echinococcus granulosus Ankyrin 0.0028 0.012 0.0386
Mycobacterium tuberculosis Hypothetical protein 0.0075 0.0523 0.4031
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0157 0.1239 0.4195
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.1107 0.3735
Echinococcus multilocularis muscleblind protein 1 0.0153 0.1204 0.2681
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0157 0.1242 0.123
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0041 0.0041
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0597 0.0584
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.058 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.012 0.012
Schistosoma mansoni nuclear hormone receptor 0.0157 0.1242 0.257
Loa Loa (eye worm) hypothetical protein 0.0163 0.1294 0.1294
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0275 0.0613
Brugia malayi nuclear receptor NHR-67 0.0074 0.0519 0.0506
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0157 0.1239 0.9493
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0157 0.1242 0.123
Leishmania major carbonic anhydrase-like protein 0.0347 0.2896 1
Brugia malayi steroid hormone receptor 0.0157 0.1242 0.123
Echinococcus granulosus lamin 0.003 0.0135 0.0432
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0275 0.0359
Brugia malayi latrophilin 2 splice variant baaae 0.0074 0.0515 0.0502
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0275 0.0881
Schistosoma mansoni nuclear receptor 0.0074 0.0519 0.0917
Echinococcus multilocularis transcription factor Dp 1 0.0082 0.0588 0.131
Loa Loa (eye worm) hypothetical protein 0.0083 0.0597 0.0597
Echinococcus granulosus muscleblind protein 0.0153 0.1204 0.3856
Schistosoma mansoni zinc finger protein 0.0074 0.0519 0.0917
Onchocerca volvulus 0.0263 0.2167 0.4948
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0157 0.1239 0.9557
Brugia malayi hypothetical protein 0.0075 0.0523 0.051
Loa Loa (eye worm) hypothetical protein 0.0504 0.4267 0.4267
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0214 0.0605
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0081 0.058 0.1857
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0109 0.0096
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0121
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Brugia malayi NAD-dependent deacetylase SIRT1 0.0081 0.058 0.0567
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0951 0.6851
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0157 0.1242 0.257
Echinococcus granulosus transcription factor Dp 1 0.0082 0.0588 0.1884
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0135 0.0135
Loa Loa (eye worm) DR-78 0.0074 0.0519 0.0519
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0951 0.1905
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0157 0.1242 0.2766
Brugia malayi nuclear receptor NHR-88 0.0157 0.1242 0.123
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.005 0.5
Onchocerca volvulus 0.0504 0.4267 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0171 0.0171
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0083 0.0597 0.1912
Echinococcus multilocularis Ankyrin 0.0028 0.012 0.0268
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0323 0.3126
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0142 0.1107 0.2467
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0075 0.0523 0.169
Loa Loa (eye worm) hypothetical protein 0.003 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0083 0.0597 0.0597
Schistosoma mansoni ap endonuclease 0.0039 0.0214 0.0218
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0118 0.000000032385
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Treponema pallidum exodeoxyribonuclease (exoA) 0.0039 0.0214 0.5
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0347 0.2896 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0335 0.2793 0.6222
Brugia malayi Steroid receptor seven-up type 2 0.0157 0.1242 0.123
Brugia malayi orphan nuclear receptor NR2E1 0.0074 0.0519 0.0506
Echinococcus multilocularis lamin dm0 0.003 0.0135 0.03
Brugia malayi hypothetical protein 0.0083 0.0597 0.0584
Onchocerca volvulus 0.0157 0.1242 0.2724
Echinococcus granulosus nuclear factor of activated T cells 5 0.0144 0.1125 0.3603
Loa Loa (eye worm) hypothetical protein 0.007 0.0487 0.0487
Onchocerca volvulus Bile acid receptor homolog 0.0157 0.1242 0.2724
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1399 0.1387
Brugia malayi Muscleblind-like protein 0.0153 0.1204 0.1192
Brugia malayi Uncoordinated protein 44 0.0028 0.0118 0.0105
Echinococcus granulosus death domain containing protein 0.0028 0.0118 0.0379
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0142 0.1107 0.1107
Schistosoma mansoni lozenge 0.0063 0.0425 0.0702
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0109 0.0576
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0074 0.0519 0.0986
Loa Loa (eye worm) hypothetical protein 0.002 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0083 0.0597 0.0597
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0347 0.2896 0.2896
Brugia malayi Calcitonin receptor-like protein seb-1 0.0108 0.0812 0.08
Trypanosoma brucei carbonic anhydrase-like protein 0.0347 0.2896 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0083 0.0597 0.0597
Brugia malayi conserved hypotetical protein 0.0074 0.0519 0.0506
Schistosoma mansoni thyroid hormone receptor 0.053 0.4489 1
Loa Loa (eye worm) thymidylate synthase 0.0157 0.1239 0.1239
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0108 0.0812 0.08
Toxoplasma gondii exonuclease III APE 0.0039 0.0214 0.0074
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0163 0.1294 0.1282
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0144 0.1125 0.2505
Entamoeba histolytica hypothetical protein 0.0076 0.0536 0.427
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0214 0.0605
Echinococcus granulosus ecdysone induced protein 78C 0.0157 0.1242 0.3978
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0347 0.2896 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0951 0.3188
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0109 0.024
Brugia malayi nuclear receptor RXR 0.0083 0.0597 0.0584
Entamoeba histolytica hypothetical protein 0.0076 0.0536 0.427
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.2045 0.2045
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0285 0.1891
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0083 0.0597 0.1329
Schistosoma mansoni inositol monophosphatase 0.0038 0.0206 0.02
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0951 0.76
Schistosoma mansoni hypothetical protein 0.0272 0.2247 0.4869
Onchocerca volvulus Protein ultraspiracle homolog 0.0157 0.1242 0.2724
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0081 0.058 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Brugia malayi Cytochrome P450 family protein 0.0019 0.0041 0.0027
Loa Loa (eye worm) hypothetical protein 0.0034 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0083 0.0597 0.0597
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0157 0.1242 0.123
Schistosoma mansoni RAR-like nuclear receptor 0.0157 0.1242 0.257
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0109 0.0096
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0285 0.1762
Echinococcus granulosus thyroid hormone receptor alpha 0.0074 0.0519 0.1664
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0014 0.0014
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0536 0.0955
Echinococcus granulosus carbonic anhydrase 0.0163 0.1294 0.4145
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0118 0.0264
Loa Loa (eye worm) hypothetical protein 0.0108 0.0812 0.0812
Echinococcus multilocularis thymidylate synthase 0.0157 0.1239 0.2759
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0074 0.0519 0.0506
Entamoeba histolytica hypothetical protein 0.0076 0.0536 0.427
Echinococcus multilocularis hormone sensitive lipase 0.0239 0.1953 0.4351
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.012 0.0005
Echinococcus granulosus FTZ F1 alpha 0.0157 0.1242 0.3978
Plasmodium falciparum carbonic anhydrase 0.0163 0.1294 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0157 0.1242 0.3978
Schistosoma mansoni retinoic acid receptor RXR 0.0157 0.1242 0.257
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.1107 0.3735
Echinococcus multilocularis carbonic anhydrase II 0.0347 0.2896 0.6452
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0074 0.0519 0.1157
Onchocerca volvulus Netrin receptor homolog 0.0028 0.0118 0.0022
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0157 0.1242 0.123
Schistosoma mansoni intermediate filament proteins 0.003 0.0135 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0951 0.76
Echinococcus granulosus Nuclear hormone receptor HR96 0.0074 0.0519 0.1664
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0142 0.1107 1
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0121
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0951 0.7601
Schistosoma mansoni carbonic anhydrase-related 0.0163 0.1294 0.269
Echinococcus granulosus hormone sensitive lipase 0.0239 0.1953 0.6257
Loa Loa (eye worm) hypothetical protein 0.0027 0.0109 0.0109
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0171 0.0381
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0214 0.0684
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0157 0.1242 0.3978
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0118 0.0118
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0142 0.1107 0.2263
Brugia malayi nuclear hormone receptor 0.0074 0.0519 0.0506
Loa Loa (eye worm) hypothetical protein 0.0028 0.0118 0.0118
Brugia malayi tailless protein 0.0074 0.0519 0.0506
Loa Loa (eye worm) runx1 0.0063 0.0425 0.0425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0275 0.0359
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0157 0.1242 0.257
Brugia malayi hypothetical protein 0.0076 0.0536 0.0522
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0074 0.0519 0.1664
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0214 0.0214
Brugia malayi nuclear hormone receptor family member odr-7 0.0074 0.0519 0.0506
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0083 0.0597 0.1094
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0323 0.1033
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0171 0.0545
Echinococcus multilocularis carbonic anhydrase 0.0163 0.1294 0.2882
Brugia malayi Nuclear hormone receptor-like 1 0.0157 0.1242 0.123
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0214 0.1045
Brugia malayi bZIP transcription factor family protein 0.0335 0.2793 0.2783
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0109 0.0572
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0074 0.0519 0.1157
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0323 0.3126
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0163 0.1294 0.1282
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0157 0.1239 0.4195
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0157 0.1242 0.123
Schistosoma mansoni chromatin regulatory protein sir2 0.0081 0.058 0.1055
Schistosoma mansoni thyroid hormone receptor 0.053 0.4489 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0275 0.0359
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0373 0.3122 0.6954
Echinococcus multilocularis carbonic anhydrase 0.0163 0.1294 0.2882
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0074 0.0519 0.1157
Brugia malayi Nuclear hormone receptor E75 0.0074 0.0519 0.0506
Schistosoma mansoni hypothetical protein 0.0373 0.3122 0.6871
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0951 0.1905
Schistosoma mansoni hypothetical protein 0.0163 0.1294 0.269
Brugia malayi Inositol-1 0.0038 0.0206 0.0192
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0523 0.8494
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0081 0.058 0.1291
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0039 0.0214 0.1446
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0951 0.2119
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0142 0.1107 0.3735
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0157 0.1242 0.257
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0239 0.1953 0.4198
Loa Loa (eye worm) CYP4Cod1 0.0019 0.0041 0.0041
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0142 0.1107 0.3548
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0239 0.1953 0.4198
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0109 0.024
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0214 0.02
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0109 0.0572
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0206 0.0659
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0142 0.1107 0.1095
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0157 0.1239 0.2563
Brugia malayi follicle stimulating hormone receptor 0.0249 0.2045 0.2034
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1399 0.2929
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0074 0.0519 0.1157
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0347 0.2896 0.2887
Onchocerca volvulus 0.003 0.0135 0.0061
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0536 0.1193
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0118 0.0105
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0109 0.0576
Loa Loa (eye worm) hypothetical protein 0.0157 0.1242 0.1242
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0109 0.0096
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0157 0.1242 0.123
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0157 0.1242 0.257
Schistosoma mansoni hormone-sensitive lipase (S09 family) 0.0239 0.1953 0.4198
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0074 0.0519 0.1664
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.1107 0.3735
Echinococcus granulosus intermediate filament protein 0.003 0.0135 0.0432
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0157 0.1242 0.2724
Brugia malayi photoreceptor-specific nuclear receptor 0.0157 0.1242 0.123
Brugia malayi nuclear hormone receptor 0.0157 0.1242 0.123
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0157 0.1239 1
Onchocerca volvulus 0.0074 0.0519 0.0986
Loa Loa (eye worm) hypothetical protein 0.0074 0.0519 0.0519
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0157 0.1242 0.1242
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0157 0.1242 0.1242
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0157 0.1242 0.2766
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0081 0.058 1
Loa Loa (eye worm) hypothetical protein 0.1163 1 1
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0157 0.1239 1
Schistosoma mansoni nuclear receptor nhr-48 0.0074 0.0519 0.0917
Loa Loa (eye worm) hypothetical protein 0.0083 0.0597 0.0597
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0157 0.1242 0.2766
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0171 0.0381
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0323 0.1075
Loa Loa (eye worm) acetyltransferase 0.0175 0.1399 0.1399
Echinococcus multilocularis GPCR, family 2 0.0034 0.0171 0.0381
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0951 0.3047
Schistosoma mansoni hypothetical protein 0.0034 0.0171 0.0121
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0157 0.1242 0.257
Schistosoma mansoni nuclear hormone receptor 0.0074 0.0519 0.0917
Loa Loa (eye worm) carbonic anhydrase 3 0.0347 0.2896 0.2896
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0214 0.0214
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0157 0.1242 0.2766

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 0.446683592 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 25.11886432 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 28.18382931 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 0.8275 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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