TDR Targets

Basic information

Technical information

TDR Targets ID: 1489819
Name: tert-butyl 4-[2-[[4-(5-cyano-7-methyl-1,3-ben zoxazol-2-yl)phenyl]amino]-2-oxoethoxy]piperi dine-1-carboxylate
MW: 490.551 | Formula: C27H30N4O5
H donors: 1 H acceptors: 4 LogP: 4.01 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: N#Cc1cc(C)c2c(c1)nc(o2)c1ccc(cc1)NC(=O)COC1CCN(CC1)C(=O)OC(C)(C)C
InChi: 1S/C27H30N4O5/c1-17-13-18(15-28)14-22-24(17)35-25(30-22)19-5-7-20(8-6-19)29-23(32)16-34-21-9-11-31(12-10-21)26(33)36-27(2,3)4/h5-8,13-14,21H,9-12,16H2,1-4H3,(H,29,32)
InChiKey: HQRMXEXHPLDOAQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

tert-butyl 4-[2-[[4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)phenyl]amino]-2-oxo-ethoxy]piperidine-1-carboxylate
4-[2-[[4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)phenyl]amino]-2-oxoethoxy]-1-piperidinecarboxylic acid tert-butyl ester
4-[2-[[4-(5-cyano-7-methyl-1,3-benzoxazol-2-yl)phenyl]amino]-2-keto-ethoxy]piperidine-1-carboxylic acid tert-butyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cholesteryl ester transfer protein, plasma	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma cruzi	hypothetical protein, conserved	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Brugia malayi	Diacylglycerol kinase protein 2	0.0432	0.0366	1
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0044	0.0016	0.0013
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0044	0.0016	0.0429
Mycobacterium tuberculosis	Probable fructose-bisphosphate aldolase Fba	0.015	0.0112	0.0102
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0044	0.0016	0.0429
Brugia malayi	Neuronal acetylcholine receptor protein, alpha-2 chain precursor	0.0044	0.0016	0.0429
Trypanosoma brucei	Diacylglycerol kinase catalytic domain containing protein, putative	0.0432	0.0366	1
Echinococcus multilocularis	serotonin receptor	0.0315	0.0261	0.0257
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Echinococcus multilocularis	Diacylglycerol kinase zeta	0.0432	0.0366	0.0363
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Onchocerca volvulus		0.0095	0.0062	0.1593
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0095	0.0062	0.1695
Entamoeba histolytica	diacylglycerol kinase, putative	0.0432	0.0366	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Entamoeba histolytica	hypothetical protein	0.0104	0.007	0.0048
Echinococcus multilocularis	neuronal acetylcholine receptor subunit alpha 4	0.0095	0.0062	0.0059
Mycobacterium ulcerans	hypothetical protein	1.1098	1	1
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0095	0.0062	0.0059
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.007	0.0039	0.1059
Echinococcus multilocularis	nAChR subunit	0.0051	0.0022	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Onchocerca volvulus		0.0041	0.0013	0.023
Trichomonas vaginalis	conserved hypothetical protein	0.0432	0.0366	1
Trypanosoma brucei	Sphingosine kinase	0.0432	0.0366	1
Brugia malayi	hypothetical protein	0.0044	0.0016	0.0429
Brugia malayi	Pre-SET motif family protein	0.0031	0.0004	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0095	0.0062	0.0059
Schistosoma mansoni	sphingoid long chain base kinase	1.1098	1	1
Onchocerca volvulus		0.0044	0.0016	0.0312
Leishmania major	diacylglycerol kinase-like protein	0.0432	0.0366	1
Onchocerca volvulus		0.0145	0.0107	0.2827
Echinococcus multilocularis	gamma aminobutyric acid receptor subunit	0.0044	0.0016	0.0013
Mycobacterium tuberculosis	Conserved protein	1.1098	1	1
Brugia malayi	hypothetical protein	0.0044	0.0016	0.0429
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.007	0.0039	0.1059
Brugia malayi	Eye-specific diacylglycerol kinase	0.0432	0.0366	1
Echinococcus granulosus	Diacylglycerol kinase zeta	0.0432	0.0366	0.0363
Entamoeba histolytica	Rad52/22 family double-strand break repair protein, putative	0.0104	0.007	0.0048
Trichomonas vaginalis	bmru protein, putative	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0067	0.0067
Mycobacterium ulcerans	fructose-bisphosphate aldolase	0.015	0.0112	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0013	0.0013
Brugia malayi	hypothetical protein	0.0044	0.0016	0.0429
Loa Loa (eye worm)	GABA receptor subunit	0.0051	0.0022	0.0022
Onchocerca volvulus		0.0041	0.0013	0.023
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0039	0.1059
Echinococcus multilocularis	sphingosine kinase 1	1.1098	1	1
Loa Loa (eye worm)	excitatory GABA receptor EXP-1A	0.0095	0.0062	0.0062
Schistosoma mansoni	nAChR subunit	0.0044	0.0016	0.0013
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0051	0.0022	0.002
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0432	0.0366	1
Onchocerca volvulus		0.0145	0.0107	0.2827
Brugia malayi	hypothetical protein	0.0044	0.0016	0.0429
Plasmodium falciparum	diacylglycerol kinase, putative	0.0432	0.0366	1
Schistosoma mansoni	diacylglycerol kinase zeta iota	0.0432	0.0366	0.0364
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0095	0.0062	0.1695
Trichomonas vaginalis	diacylglycerol kinase, epsilon, putative	0.0432	0.0366	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0044	0.0016	0.0429
Echinococcus granulosus	glycine receptor subunit beta	0.0095	0.0062	0.0059
Loa Loa (eye worm)	LGC-31 protein	0.0095	0.0062	0.0062
Echinococcus granulosus	nicotinic acetylcholine receptor a11 subunit	0.0157	0.0118	0.0115
Onchocerca volvulus		0.0051	0.0022	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0261	0.0261
Onchocerca volvulus		0.0095	0.0062	0.1593
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Entamoeba histolytica	diacylglycerol kinase, putative	0.0432	0.0366	0.0345
Brugia malayi	Cation transporter family protein	0.0095	0.0062	0.1695
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Echinococcus granulosus	gamma aminobutyric acid receptor subunit	0.0044	0.0016	0.0013
Brugia malayi	Ceramide kinase	0.0432	0.0366	1
Plasmodium vivax	SET domain protein, putative	0.0031	0.0004	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.007	0.0039	0.0036
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0095	0.0062	0.0059
Echinococcus granulosus	transcription factor Dp 1	0.004	0.0012	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Echinococcus granulosus	microtubule associated protein 2	0.0727	0.0632	0.0629
Onchocerca volvulus		0.0038	0.001	0.0162
Loa Loa (eye worm)	neuronal acetylcholine receptor protein	0.0044	0.0016	0.0016
Brugia malayi	diacylglycerol kinase	0.0432	0.0366	1
Echinococcus granulosus	nicotinic acetylcholine receptor beta 1 subunit	0.0095	0.0062	0.0059
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0308	0.0254	0.0232
Onchocerca volvulus	Putative nachr subunit	0.0157	0.0118	0.314
Echinococcus multilocularis	glycine receptor subunit beta	0.0095	0.0062	0.0059
Brugia malayi	Cation transporter family protein	0.0095	0.0062	0.1695
Echinococcus multilocularis	ceramide kinase	0.0432	0.0366	0.0363
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Echinococcus multilocularis	Diacylglycerol kinase theta	0.0432	0.0366	0.0363
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0095	0.0062	0.0059
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0432	0.0366	1
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.007	0.0039	0.0036
Echinococcus granulosus	neuronal acetylcholine receptor subunit alpha 4	0.0095	0.0062	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Loa Loa (eye worm)	ligand-Gated ion Channel family member	0.0095	0.0062	0.0062
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0041	0.0013	0.0347
Echinococcus multilocularis	Cys loop ligand gated ion channel subunit	0.0095	0.0062	0.0059
Schistosoma mansoni	diacylglycerol kinase theta	0.0432	0.0366	0.0364
Echinococcus multilocularis	nAChR subunit	0.0095	0.0062	0.0059
Trichomonas vaginalis	sphingosine kinase, putative	0.0432	0.0366	1
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Onchocerca volvulus		0.0044	0.0016	0.0312
Brugia malayi	acetylcholine receptor protein, alpha-like chain, putative	0.0095	0.0062	0.1695
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0432	0.0366	0.0364
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0432	0.0366	0.0366
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.001
Schistosoma mansoni	neurotransmitter gated ion channel	0.0044	0.0016	0.0013
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0095	0.0062	0.0059
Echinococcus granulosus	nicotinic acetylcholine receptor alpha subunit	0.0157	0.0118	0.0115
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0044	0.0016	0.0016
Echinococcus multilocularis	nicotinic acetylcholine receptor alpha subunit	0.0157	0.0118	0.0115
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.007	0.0039	0.0039
Schistosoma mansoni	survival motor neuron protein	0.0051	0.0022	0.0019
Brugia malayi	gamma-aminobutyric-acid receptor beta subunit precursor	0.0095	0.0062	0.1695
Brugia malayi	beta-lactamase	0.0038	0.001	0.028
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit type	0.0044	0.0016	0.0013
Schistosoma mansoni	neurotransmitter gated ion channel	0.0051	0.0022	0.002
Mycobacterium leprae	Probable fructose bisphosphate aldolase Fba	0.015	0.0112	1
Loa Loa (eye worm)	hypothetical protein	0.0432	0.0366	0.0366
Entamoeba histolytica	fructose-1,6-bisphosphate aldolase, putative	0.0308	0.0254	0.0232
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0004	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Onchocerca volvulus		0.0051	0.0022	0.0497
Onchocerca volvulus		0.0041	0.0013	0.023
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0004	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	Cys-loop ligand gated ion channel subunit	0.0095	0.0062	0.0059
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Toxoplasma gondii	diacylglycerol kinase, putative	0.0432	0.0366	1
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0219	0.0174	0.0174
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0004	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.001
Loa Loa (eye worm)	ACC-1 protein	0.0095	0.0062	0.0062
Entamoeba histolytica	DNA repair and recombination protein RAD52, putative	0.0366	0.0307	0.0285
Onchocerca volvulus		0.0145	0.0107	0.2827
Echinococcus multilocularis	epidermal growth factor receptor	0.0056	0.0027	0.0023
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0107	0.0107
Schistosoma mansoni	hypothetical protein	0.0051	0.0022	0.0019
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.001	0.028
Brugia malayi	acetylcholine receptor alpha subunit precursor, putative	0.0095	0.0062	0.1695
Leishmania major	sphingosine kinase A, B, putative	0.0432	0.0366	1
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0095	0.0062	0.1695
Echinococcus granulosus	epidermal growth factor receptor	0.0056	0.0027	0.0023
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.001	0.028
Plasmodium vivax	diacylglycerol kinase, putative	0.0432	0.0366	1
Trichomonas vaginalis	diacylglycerol kinase, zeta, iota, putative	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.001
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0315	0.0261	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.001
Mycobacterium tuberculosis	Diacylglycerol kinase	0.0432	0.0366	0.0357
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0095	0.0062	0.1695
Echinococcus multilocularis	nicotinic acetylcholine receptor a11 subunit	0.0157	0.0118	0.0115
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.001	0.0007
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0095	0.0062	0.0059
Loa Loa (eye worm)	hypothetical protein	1.1098	1	1
Echinococcus granulosus	acylglycerol kinase mitochondrial	0.0432	0.0366	0.0363
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0095	0.0062	0.0059
Brugia malayi	hypothetical protein	0.0432	0.0366	1
Echinococcus granulosus	glycine receptor subunit alpha 1	0.0095	0.0062	0.0059
Brugia malayi	glutamate-gated chloride channel alpha3A subunit, putative	0.0051	0.0022	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Loa Loa (eye worm)	glutamate-gated chloride channel alpha3A subunit	0.0095	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Treponema pallidum	fructose-bisphosphate aldolase	0.0308	0.0254	0.5
Loa Loa (eye worm)	ceramide kinase	0.0432	0.0366	0.0366
Echinococcus multilocularis	nicotinic acetylcholine receptor beta 1 subunit	0.0095	0.0062	0.0059
Trypanosoma cruzi	Sphingosine kinase	0.0432	0.0366	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.001	0.028
Echinococcus granulosus	survival motor neuron protein 1	0.0249	0.0201	0.0198
Loa Loa (eye worm)	diacylglycerol kinase 2	0.0432	0.0366	0.0366
Plasmodium vivax	diacylglycerol kinase, putative	0.0432	0.0366	1
Onchocerca volvulus		0.0044	0.0016	0.0312
Echinococcus multilocularis	acylglycerol kinase, mitochondrial	0.0432	0.0366	0.0363
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0242	0.0195	0.0185
Brugia malayi	hypothetical protein	0.0249	0.0201	0.5484
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.007	0.0039	0.0016
Loa Loa (eye worm)	LBP/BPI/CETP family domain-containing protein	0.0041	0.0013	0.0013
Echinococcus granulosus	nicotinic acetylcholine receptor subunit alpha 8	0.0157	0.0118	0.0115
Trypanosoma cruzi	Diacylglycerol kinase catalytic domain containing protein, putative	0.0432	0.0366	1
Onchocerca volvulus		0.0041	0.0013	0.023
Brugia malayi	diacylglycerol kinase	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.001	0.028
Onchocerca volvulus		0.0041	0.0013	0.023
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.001	0.0007
Loa Loa (eye worm)	acetylcholine receptor protein	0.0044	0.0016	0.0016
Mycobacterium ulcerans	diacylglycerol kinase	0.0432	0.0366	0.0357
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0051	0.0022	0.0611
Echinococcus granulosus	ceramide kinase	0.0432	0.0366	0.0363
Trypanosoma brucei	diacylglycerol kinase, putative	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Giardia lamblia	DNA repair protein RAD52	0.0366	0.0307	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0051	0.0022	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Brugia malayi	Acetylcholine receptor protein, alpha-like chain 1 precursor	0.0044	0.0016	0.0429
Loa Loa (eye worm)	hypothetical protein	0.0145	0.0107	0.0107
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0039	0.1059
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0095	0.0062	0.1695
Brugia malayi	hypothetical protein	0.0044	0.0016	0.0429
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.001	0.0007
Entamoeba histolytica	diacylglycerol kinase, putative	0.0432	0.0366	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0095	0.0062	0.1695
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Onchocerca volvulus		0.0041	0.0013	0.023
Entamoeba histolytica	hypothetical protein, conserved	1.1098	1	1
Schistosoma mansoni	nicotinic acetylcholine receptor alpha	0.0051	0.0022	0.002
Onchocerca volvulus		0.0432	0.0366	1
Brugia malayi	nicotinic acetylcholine receptor beta-1 chain precursor	0.0095	0.0062	0.1695
Leishmania major	hypothetical protein, conserved	0.0432	0.0366	1
Loa Loa (eye worm)	beta-lactamase	0.0038	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0315	0.0261	0.0261
Echinococcus granulosus	biogenic amine 5HT receptor	0.0315	0.0261	0.0257
Schistosoma mansoni	diacylglycerol kinase theta	0.0432	0.0366	0.0364
Brugia malayi	Pre-SET motif family protein	0.0219	0.0174	0.4748
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0004	0.0002
Onchocerca volvulus		0.0038	0.001	0.0162
Toxoplasma gondii	diacylglycerol kinase accessory domain (presumed) domain-containing protein	0.0432	0.0366	1
Brugia malayi	Hypothetical glycine receptor like protein T20B12.9 in chromosome III	0.0051	0.0022	0.0611
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Loa Loa (eye worm)	eye-specific diacylglycerol kinase	0.0432	0.0366	0.0366
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0095	0.0062	0.1695
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0145	0.0107	0.0104
Brugia malayi	nicotinic acetylcholine receptor alpha subunit, putative	0.0157	0.0118	0.3222
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	neurotransmitter gated ion channel	0.0044	0.0016	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Brugia malayi	excitatory GABA receptor EXP-1A	0.0095	0.0062	0.1695
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Trichomonas vaginalis	diacylglycerol kinase, putative	0.0432	0.0366	1
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Loa Loa (eye worm)	nicotinic acetylcholine receptor non-alpha subunit	0.0095	0.0062	0.0062
Brugia malayi	LBP / BPI / CETP family, C-terminal domain containing protein	0.0041	0.0013	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0118	0.0118
Echinococcus granulosus	acetylcholine receptor subunit beta 1	0.0095	0.0062	0.0059
Onchocerca volvulus		0.0051	0.0022	0.0483
Loa Loa (eye worm)	hypothetical protein	0.0432	0.0366	0.0366
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0095	0.0062	0.1695
Plasmodium falciparum	diacylglycerol kinase, putative	0.0432	0.0366	1
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.007	0.0039	0.1059
Loa Loa (eye worm)	nicotinic acetylcholine receptor alpha subunit	0.0157	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0249	0.0201	0.0201
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Onchocerca volvulus		0.0095	0.0062	0.1593
Schistosoma mansoni	acetylcholine receptor subunit beta	0.0044	0.0016	0.0013
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0145	0.0107	0.0104
Brugia malayi	Cation transporter family protein	0.0145	0.0107	0.2913
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	hypothetical protein	0.0432	0.0366	0.0364
Schistosoma mansoni	tyrosine kinase	0.0056	0.0027	0.0024
Echinococcus multilocularis	microtubule associated protein 2	0.0727	0.0632	0.0629
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.001	0.001
Brugia malayi	beta-lactamase family protein	0.0038	0.001	0.028
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0051	0.0022	0.0598
Trichomonas vaginalis	bmru protein, putative	0.0432	0.0366	1
Echinococcus granulosus	glycine receptor subunit beta	0.0095	0.0062	0.0059
Echinococcus granulosus	Cys loop ligand gated ion channel subunit	0.0044	0.0016	0.0013
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0004	0.0002
Schistosoma mansoni	acetylcholine receptor-related	0.0044	0.0016	0.0013
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Toxoplasma gondii	diacylglycerol kinase catalytic domain-containing protein	0.0432	0.0366	1
Echinococcus multilocularis	acetylcholine receptor subunit beta 1	0.0095	0.0062	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.001
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Echinococcus granulosus	Diacylglycerol kinase theta	0.0432	0.0366	0.0363
Loa Loa (eye worm)	acetylcholine receptor alpha subunit	0.0095	0.0062	0.0062
Onchocerca volvulus		0.0038	0.001	0.0162
Trichomonas vaginalis	fructose-bisphosphate aldolase, putative	0.0308	0.0254	0.6844
Trypanosoma cruzi	diacylglycerol kinase, putative	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Echinococcus multilocularis	glycine receptor subunit beta	0.0095	0.0062	0.0059
Trichomonas vaginalis	sphingosine kinase, putative	0.0432	0.0366	1
Leishmania major	diacylglycerol kinase, putative	0.0432	0.0366	1
Brugia malayi	beta-lactamase family protein	0.0038	0.001	0.028
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.001	0.0007
Echinococcus granulosus	nAChR subunit	0.0051	0.0022	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Onchocerca volvulus	Ceramide kinase 1 homolog	0.0432	0.0366	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0249	0.0201	0.0198
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0095	0.0062	0.1695
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	sphingosine kinase A B	1.1098	1	1
Loa Loa (eye worm)	ACC-1 protein	0.0095	0.0062	0.0062
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	0.0044	0.0016	0.0429
Trypanosoma cruzi	Sphingosine kinase	0.0432	0.0366	1
Brugia malayi	Neurotransmitter-gated ion-channel transmembrane region family protein	0.0095	0.0062	0.1695
Trypanosoma brucei	hypothetical protein, conserved	0.0432	0.0366	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Schistosoma mansoni	nAChR subunit	0.0044	0.0016	0.0013
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0004	0.0001
Echinococcus multilocularis	transcription factor Dp 1	0.004	0.0012	0.0009
Onchocerca volvulus		0.0041	0.0013	0.023
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Schistosoma mansoni	nAChR subunit (ShAR1-beta2-like)	0.0095	0.0062	0.0059
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.001	0.028
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0004	0.0001
Onchocerca volvulus		0.0249	0.0201	0.544
Brugia malayi	LBP / BPI / CETP family, N-terminal domain containing protein	0.0041	0.0013	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0022	0.0022
Leishmania major	hypothetical protein, conserved	0.0432	0.0366	1
Entamoeba histolytica	diacylglycerol kinase, putative	0.0432	0.0366	0.0345
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0062	0.0062
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0056	0.0027	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0038	0.001	0.001
Toxoplasma gondii	ABC1 family protein	0.0038	0.001	0.028
Onchocerca volvulus		0.0041	0.0013	0.023
Brugia malayi	Furin-like cysteine rich region family protein	0.0056	0.0027	0.0725
Echinococcus granulosus	nicotinic acetylcholine receptor subunit type	0.0095	0.0062	0.0059
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.007	0.0039	0.0036
Echinococcus multilocularis	nicotinic acetylcholine receptor subunit alpha 8	0.0157	0.0118	0.0115
Schistosoma mansoni	microtubule-associated protein tau	0.0727	0.0632	0.063
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	nAChR subunit	0.0095	0.0062	0.0059
Trichomonas vaginalis	set domain proteins, putative	0.0249	0.0201	0.5365
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0016	0.0016
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0004	0.0002
Brugia malayi	acetylcholine receptor, alpha-type subunit unc-38 precursor	0.0095	0.0062	0.1695
Trypanosoma cruzi	diacylglycerol kinase-like protein, putative	0.0432	0.0366	1
Leishmania major	hypothetical protein, conserved	0.0038	0.001	0.028
Echinococcus granulosus	nAChR subunit	0.0095	0.0062	0.0059
Echinococcus multilocularis	serotonin receptor	0.0315	0.0261	0.0257
Echinococcus multilocularis	glycine receptor subunit alpha 1	0.0095	0.0062	0.0059

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 17 mg/dl	Cardioprotective activity in transgenic B6 mouse harboring cynomolgus CETP assessed as increase in blood HDL-cholesterol level at 20 mg/kg, po after 24 hrs	ChEMBL.	21094047
IC50 (binding)	= 91 nM	Inhibition of human recombinant CETP-mediated cholesteryl ester transfer by fluorescence-based assay	ChEMBL.	21094047
IC50 (binding)	= 92 nM	Inhibition of human recombinant CETP-mediated triglyceride transfer by fluorescence-based assay	ChEMBL.	21094047

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1642930

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1489819