TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 240.729 | Formula: C12H17ClN2O
H donors: 2 H acceptors: 1 LogP: 2.39 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C([C@@H]1CCCN1)Nc1ccccc1C.Cl
InChi: 1S/C12H16N2O.ClH/c1-9-5-2-3-6-10(9)14-12(15)11-7-4-8-13-11;/h2-3,5-6,11,13H,4,7-8H2,1H3,(H,14,15);1H/t11-;/m0./s1
InChiKey: BTHJLNCNPRFCID-MERQFXBCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Brugia malayi	hypothetical protein	0.0102	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0542	0.0542
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 128 Cyp128	0.0011	0.0001	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0102	0.0478	0.0704
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0216	0.1074	0.158
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Brugia malayi	steroid hormone receptor	0.0216	0.1074	0.1074
Leishmania major	cytochrome p450-like protein	0.0011	0.0001	0.014
Brugia malayi	cytochrome P450	0.0011	0.0001	0.0001
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Schistosoma mansoni	nuclear receptor	0.0102	0.0478	0.0647
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0102	0.0478	0.0647
Brugia malayi	Nuclear hormone receptor-like 1	0.0216	0.1074	0.1074
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0114	0.0542	0.0798
Leishmania major	cytochrome p450-like protein	0.0011	0.0001	0.014
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0216	0.1074	0.1074
Trichomonas vaginalis	abcb9, putative	0.001	0	0.5
Entamoeba histolytica	P-glycoprotein-2	0.001	0	0.5
Entamoeba histolytica	P-glyco protein 6, putative	0.001	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 141 Cyp141	0.0011	0.0001	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0102	0.0478	0.0478
Brugia malayi	hypothetical protein	0.0102	0.0478	0.0478
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0093	0.0093
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0093	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0216	0.1074	0.1074
Brugia malayi	Nuclear hormone receptor-like 1	0.0114	0.0542	0.0542
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0216	0.1074	0.158
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0216	0.1074	0.1074
Echinococcus granulosus	thyroid hormone receptor alpha	0.0102	0.0478	0.0647
Brugia malayi	nuclear hormone receptor	0.0102	0.0478	0.0478
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0028	0.0093	1
Echinococcus granulosus	cytochrome P450 2K1	0.0011	0.0001	0.0002
Loa Loa (eye worm)	DR-78	0.0102	0.0478	0.0478
Onchocerca volvulus		0.0216	0.1074	0.1074
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0102	0.0478	0.0478
Loa Loa (eye worm)	steroid hormone receptor	0.0216	0.1074	0.1074
Entamoeba histolytica	P-glycoprotein-2	0.001	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 124 Cyp124	0.0011	0.0001	1
Schistosoma mansoni	thyroid hormone receptor	0.0216	0.1074	0.1453
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0216	0.1074	0.1453
Brugia malayi	nuclear receptor RXR	0.0102	0.0478	0.0478
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0102	0.0478	0.0647
Mycobacterium tuberculosis	Probable cytochrome P450 143 Cyp143	0.0011	0.0001	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0102	0.0478	0.0478
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 136 Cyp136	0.0011	0.0001	1
Onchocerca volvulus	Bile acid receptor homolog	0.1929	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0216	0.1074	0.1453
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0216	0.1074	0.1453
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Mycobacterium tuberculosis	Probable cytochrome P450 monooxygenase 142 Cyp142	0.0011	0.0001	1
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0	0.5
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0216	0.1074	0.1074
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0216	0.1074	0.1074
Leishmania major	cytochrome p450-like protein	0.0028	0.0093	1
Schistosoma mansoni	nuclear hormone receptor	0.0102	0.0478	0.0647
Mycobacterium tuberculosis	Probable cytochrome P450 138 Cyp138	0.0011	0.0001	1
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0011	0.0001	0.014
Onchocerca volvulus		0.0102	0.0478	0.0478
Mycobacterium tuberculosis	Probable cytochrome P450 123 Cyp123	0.0011	0.0001	1
Trichomonas vaginalis	ABC transporter, putative	0.001	0	0.5
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0216	0.1074	0.1074
Brugia malayi	Cytochrome P450 family protein	0.0011	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0542	0.0542
Brugia malayi	photoreceptor-specific nuclear receptor	0.0216	0.1074	0.1074
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0	0.5
Brugia malayi	orphan nuclear receptor NR2E1	0.0102	0.0478	0.0478
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0216	0.1074	0.1074
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0102	0.0478	0.0647
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0216	0.1074	0.1453
Entamoeba histolytica	P-glycoprotein 5, putative	0.001	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0216	0.1074	0.1074
Brugia malayi	nuclear receptor NHR-67	0.0102	0.0478	0.0478
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0114	0.0542	0.0542
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0216	0.1074	0.158
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0216	0.1074	0.158
Schistosoma mansoni	hypothetical protein	0.0011	0.0001	0.0002
Echinococcus multilocularis		0.0011	0.0001	0.0002
Mycobacterium tuberculosis	Probable cytochrome P450 125 Cyp125	0.0011	0.0001	1
Mycobacterium tuberculosis	Probable cytochrome P450 140 Cyp140	0.0011	0.0001	1
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Brugia malayi	hypothetical protein	0.0114	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Mycobacterium tuberculosis	Probable cytochrome P450 139 Cyp139	0.0011	0.0001	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Schistosoma mansoni	nuclear receptor	0.0102	0.0478	0.0647
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0216	0.1074	0.1453
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0216	0.1074	0.1074
Schistosoma mansoni	zinc finger protein	0.0102	0.0478	0.0647
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0102	0.0478	0.0478
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0102	0.0478	0.0478
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0216	0.1074	0.1074
Echinococcus multilocularis	nuclear receptor nhr 48	0.0102	0.0478	0.0704
Loa Loa (eye worm)	CYP4Cod1	0.0028	0.0093	0.0093
Mycobacterium tuberculosis	Possible cytochrome P450 135A1 Cyp135A1	0.0011	0.0001	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0216	0.1074	0.1453
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.1429	0.7392	1
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0216	0.1074	0.1074
Echinococcus granulosus	nuclear receptor nhr 48	0.0102	0.0478	0.0647
Mycobacterium tuberculosis	Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM)	0.0011	0.0001	1
Schistosoma mansoni	cytochrome P450	0.0011	0.0001	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Schistosoma mansoni	thyroid hormone receptor	0.0216	0.1074	0.1453
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0216	0.1074	0.1074
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Brugia malayi	nuclear receptor RXR	0.0114	0.0542	0.0542
Mycobacterium leprae	Conserved hypothetical protein	0.0011	0.0001	0.5
Plasmodium falciparum	multidrug resistance protein 1	0.001	0	0.5
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0216	0.1074	0.1453
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0216	0.1074	0.1074
Onchocerca volvulus	Protein ultraspiracle homolog	0.0216	0.1074	0.1074
Schistosoma mansoni	nuclear receptor nhr-48	0.0102	0.0478	0.0647
Brugia malayi	Cytochrome P450 family protein	0.0028	0.0093	0.0093
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Mycobacterium tuberculosis	Cytochrome P450 121 Cyp121	0.0011	0.0001	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0102	0.0478	0.0478
Echinococcus multilocularis	ecdysone induced protein 78C	0.0216	0.1074	0.158
Brugia malayi	ecdysone receptor	0.0102	0.0478	0.0478
Trichomonas vaginalis	abcb9, putative	0.001	0	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.0099	0.0099
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Brugia malayi	conserved hypotetical protein	0.0102	0.0478	0.0478
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0114	0.0542	0.0733
Trichomonas vaginalis	abcb9, putative	0.001	0	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0028	0.0093	0.0093
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0114	0.0542	0.0733
Brugia malayi	Steroid receptor seven-up type 2	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0542	0.0542
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0102	0.0478	0.0647
Trypanosoma cruzi	cytochrome P450, putative	0.0028	0.0093	1
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0216	0.1074	0.1453
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0102	0.0478	0.0647
Trichomonas vaginalis	taga, putative	0.001	0	0.5
Onchocerca volvulus		0.0102	0.0478	0.0478
Mycobacterium tuberculosis	Possible cytochrome P450 126 Cyp126	0.0011	0.0001	1
Brugia malayi	tailless protein	0.0102	0.0478	0.0478
Toxoplasma gondii	cytochrome p450 superfamily protein	0.0011	0.0001	1
Brugia malayi	nuclear receptor NHR-88	0.0216	0.1074	0.1074
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0216	0.1074	0.1453
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0216	0.1074	0.158
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Brugia malayi	Nuclear hormone receptor E75	0.0102	0.0478	0.0478
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0216	0.1074	0.1453
Loa Loa (eye worm)	hypothetical protein	0.1929	1	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0216	0.1074	0.1453
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0216	0.1074	0.1074
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0102	0.0478	0.0478
Brugia malayi	Nuclear hormone receptor E75	0.0102	0.0478	0.0478
Mycobacterium tuberculosis	Probable cytochrome P450 137 Cyp137	0.0011	0.0001	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0102	0.0478	0.0704
Trichomonas vaginalis	ATP-binding cassette transporter, putative	0.001	0	0.5
Plasmodium vivax	multidrug resistance protein 1, putative	0.001	0	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0102	0.0478	0.0478
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0102	0.0478	0.0704
Mycobacterium leprae	putative cytochrome p450	0.0011	0.0001	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0216	0.1074	0.1453
Trichomonas vaginalis	ABC transporter, half transporter, putative	0.001	0	0.5
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0102	0.0478	0.0704
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0102	0.0478	0.0647
Mycobacterium tuberculosis	Possible cytochrome P450 135B1 Cyp135B1	0.0011	0.0001	1
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0216	0.1074	0.158
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0478	0.0478
Entamoeba histolytica	P-glycoprotein-5	0.001	0	0.5
Entamoeba histolytica	P-glycoprotein-1	0.001	0	0.5
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0216	0.1074	0.158
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0216	0.1074	0.1453
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1314	0.6796	1
Trypanosoma brucei	cytochrome P450, putative	0.0028	0.0093	1
Loa Loa (eye worm)	cytochrome P450	0.0011	0.0001	0.0001
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0216	0.1074	0.1453
Brugia malayi	nuclear hormone receptor	0.0216	0.1074	0.1074
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0216	0.1074	0.1074
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0038	0.0038
Trichomonas vaginalis	ABC transporter, putative	0.001	0	0.5
Schistosoma mansoni	coup transcription factor	0.0216	0.1074	0.1453
Entamoeba histolytica	P-glycoprotein-2, putative	0.001	0	0.5
Brugia malayi	hypothetical protein	0.0114	0.0542	0.0542
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0114	0.0542	0.0733
Trichomonas vaginalis	lipid A export ATP-binding/permease protein msba, putative	0.001	0	0.5
Mycobacterium tuberculosis	Probable cytochrome P450 130 Cyp130	0.0011	0.0001	1
Brugia malayi	nuclear receptor NHR-88	0.0102	0.0478	0.0478
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0216	0.1074	0.1074
Trichomonas vaginalis	ABC transporter, putative	0.001	0	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0102	0.0478	0.0647
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0216	0.1074	0.1074
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0216	0.1074	0.1074
Trichomonas vaginalis	multidrug resistance protein 1, 2, putative	0.001	0	0.5
Echinococcus multilocularis	FTZ F1 alpha	0.0216	0.1074	0.158
Mycobacterium tuberculosis	Probable cytochrome P450 144 Cyp144	0.0011	0.0001	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0542	0.0542
Loa Loa (eye worm)	hypothetical protein	0.0216	0.1074	0.1074
Echinococcus granulosus	FTZ F1 alpha	0.0216	0.1074	0.1453
Mycobacterium tuberculosis	Probable cytochrome P450 132 Cyp132	0.0011	0.0001	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0114	0.0542	0.0542
Schistosoma mansoni	RAR-like nuclear receptor	0.0216	0.1074	0.1453
Chlamydia trachomatis	ABC transporter ATP binding protein/permease	0.001	0	0.5
Schistosoma mansoni	retinoic acid receptor RXR	0.1429	0.7392	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0216	0.1074	0.1453
Brugia malayi	Cytochrome P450 family protein	0.0029	0.0099	0.0099
Trichomonas vaginalis	ABC transporter, putative	0.001	0	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	79.4328 uM	PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404]	ChEMBL.	No reference
Potency (functional)	89.1251 uM	PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1700214

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1492958