Detailed information for compound 1494601

Basic information

Technical information
  • TDR Targets ID: 1494601
  • Name: [2-oxo-2-(phenylmethyl-propan-2-ylamino)ethyl ] 4-morpholin-4-ylsulfonylbenzoate
  • MW: 460.543 | Formula: C23H28N2O6S
  • H donors: 0 H acceptors: 4 LogP: 2.37 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(N(C(=O)COC(=O)c1ccc(cc1)S(=O)(=O)N1CCOCC1)Cc1ccccc1)C
  • InChi: 1S/C23H28N2O6S/c1-18(2)25(16-19-6-4-3-5-7-19)22(26)17-31-23(27)20-8-10-21(11-9-20)32(28,29)24-12-14-30-15-13-24/h3-11,18H,12-17H2,1-2H3
  • InChiKey: NPVFMPSILSIAPC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(isopropyl-(phenylmethyl)amino)-2-oxo-ethyl] 4-morpholinosulfonylbenzoate
  • 4-morpholinosulfonylbenzoic acid [2-(isopropyl-(phenylmethyl)amino)-2-oxoethyl] ester
  • 4-morpholinosulfonylbenzoic acid [2-(benzyl-isopropyl-amino)-2-keto-ethyl] ester
  • [2-oxo-2-(phenylmethyl-propan-2-yl-amino)ethyl] 4-morpholin-4-ylsulfonylbenzoate
  • ZINC03246802
  • T0516-4639

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus cathepsin l1 0.0072 0.0705 0.0705
Trypanosoma cruzi cysteine protease, putative 0.0056 0.0531 0.1073
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0117 0.0117
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0705 0.5946
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Schistosoma mansoni cpg binding protein 0.0029 0.0233 0.0227
Trypanosoma cruzi cysteine proteinase, putative 0.0056 0.0531 0.1073
Schistosoma mansoni lamin 0.003 0.0244 0.0238
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0298 0.0298
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Brugia malayi intermediate filament protein 0.003 0.0244 0.0238
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0298 0.0292
Loa Loa (eye worm) hypothetical protein 0.0072 0.0705 0.0705
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0152 0.1608 0.4168
Entamoeba histolytica cysteine proteinase, putative 0.0072 0.0705 0.5946
Schistosoma mansoni lamin 0.003 0.0244 0.0238
Schistosoma mansoni hypothetical protein 0.0011 0.0026 0.002
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0177 0.0214
Leishmania major cathepsin L-like protease 0.0105 0.1079 0.2605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0105 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0157
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1079 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0903 1 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0157
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0157 0.0151
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0024 0.0177 0.0177
Trypanosoma cruzi cysteine peptidase, putative 0.0056 0.0531 0.1073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Toxoplasma gondii cathepsin CPL 0.0105 0.1079 0.2647
Schistosoma mansoni hypothetical protein 0.0019 0.0117 0.011
Schistosoma mansoni hypothetical protein 0.0019 0.0117 0.011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0157 0.0151
Schistosoma mansoni cathepsin F (C01 family) 0.0072 0.0705 0.0699
Echinococcus granulosus cathepsin b 0.0152 0.1608 0.1608
Loa Loa (eye worm) MH1 domain-containing protein 0.0009 0.0006 0.0006
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0105 0.1079 0.1079
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0068 0.0068
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Brugia malayi cathepsin L-like cysteine proteinase 0.0023 0.0157 0.0151
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0117 0.0117
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0177 0.0214
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0322 0.3504 0.9613
Echinococcus multilocularis lamin dm0 0.003 0.0244 0.0244
Echinococcus multilocularis mothers against decapentaplegic 5 0.0009 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0105 0.1079 0.1073
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0531 0.0525
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0157
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0063 0.0606 0.06
Echinococcus multilocularis GPCR, family 2 0.0019 0.0117 0.0117
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0105 0.1079 1
Echinococcus granulosus prolyl endopeptidase 0.0334 0.3639 0.3639
Entamoeba histolytica cysteine proteinase 2 0.0056 0.0531 0.4054
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0322 0.3504 0.9613
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Leishmania major cathepsin L-like protease 0.0105 0.1079 0.2605
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Trypanosoma cruzi cysteine peptidase, putative 0.0201 0.2147 0.5716
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Leishmania major cysteine peptidase A (CPA) 0.0105 0.1079 0.2605
Echinococcus multilocularis prolyl endopeptidase 0.0334 0.3639 0.3639
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0157 0.0157
Echinococcus multilocularis serotonin receptor 0.0124 0.1292 0.1292
Plasmodium falciparum cysteine proteinase falcipain 3 0.0105 0.1079 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0577 0.0577
Onchocerca volvulus Cathepsin F homolog 0.0105 0.1079 0.0936
Loa Loa (eye worm) Smad1 0.0009 0.0006 0.0006
Toxoplasma gondii hypothetical protein 0.0097 0.099 0.2391
Onchocerca volvulus 0.0028 0.0216 0.006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0086 0.0086
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0097 0.099 0.0984
Loa Loa (eye worm) hypothetical protein 0.0095 0.0965 0.0965
Brugia malayi Cathepsin L-like precursor 0.0072 0.0705 0.0699
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Trypanosoma cruzi cruzipain precursor, putative 0.0033 0.0277 0.0345
Entamoeba histolytica prolyl oligopeptidase family protein 0.0097 0.099 0.9032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0177 0.0214
Echinococcus granulosus acylamino acid releasing enzyme 0.0097 0.099 0.099
Onchocerca volvulus 0.0105 0.1079 0.0936
Echinococcus multilocularis cathepsin L cysteine protease 0.0105 0.1079 0.1079
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0097 0.099 0.9032
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0023 0.0157 0.0157
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Schistosoma mansoni cpg binding protein 0.0029 0.0233 0.0227
Trichomonas vaginalis conserved hypothetical protein 0.0097 0.099 0.9032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Onchocerca volvulus 0.003 0.0244 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Echinococcus granulosus cathepsin L 0.0056 0.0531 0.0531
Echinococcus granulosus cathepsin l cysteine peptidase 0.0105 0.1079 0.1079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0105 0.1079 0.1079
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0177 0.0057
Schistosoma mansoni cpg binding protein 0.0028 0.0216 0.0209
Schistosoma mansoni hypothetical protein 0.0041 0.0364 0.0358
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0023 0.0157 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0097 0.099 0.2391
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0175 0.1856 0.488
Brugia malayi prolyl oligopeptidase family protein 0.0097 0.099 0.0984
Trypanosoma cruzi cysteine peptidase, putative 0.0201 0.2147 0.5716
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0105 0.1079 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0364 0.0364
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0322 0.3504 0.35
Leishmania major cathepsin L-like protease 0.0201 0.2147 0.5691
Loa Loa (eye worm) hypothetical protein 0.003 0.0238 0.0238
Onchocerca volvulus Cathepsin L homolog 0.0105 0.1079 0.0936
Plasmodium falciparum peptidase, putative 0.0097 0.099 0.9032
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Echinococcus granulosus smad 0.0009 0.0006 0.0006
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0334 0.3639 0.3635
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0177 0.0057
Loa Loa (eye worm) prolyl oligopeptidase 0.0903 1 1
Leishmania major cathepsin L-like protease 0.0105 0.1079 0.2605
Trypanosoma cruzi cysteine proteinase, putative 0.0056 0.0531 0.1073
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0216 0.0216
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0903 1 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0577 0.0571
Brugia malayi Cathepsin L-like precursor 0.0105 0.1079 0.1073
Loa Loa (eye worm) hypothetical protein 0.0033 0.0277 0.0277
Schistosoma mansoni transient receptor potential channel 0.0095 0.0965 0.0959
Echinococcus granulosus Dipeptidyl peptidase 9 0.0322 0.3504 0.3504
Loa Loa (eye worm) hypothetical protein 0.0072 0.0705 0.0705
Brugia malayi prolyl oligopeptidase family protein 0.0334 0.3639 0.3635
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0606 0.0606
Trypanosoma cruzi cysteine peptidase, putative 0.0105 0.1079 0.2647
Brugia malayi cathepsin F-like cysteine proteinase 0.0023 0.0157 0.0151
Loa Loa (eye worm) hypothetical protein 0.003 0.0244 0.0244
Entamoeba histolytica hypothetical protein, conserved 0.0097 0.099 0.9032
Brugia malayi Papain family cysteine protease containing protein 0.0056 0.0531 0.0525
Trypanosoma brucei prolyl oligopeptidase, putative 0.0175 0.1856 0.4851
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0157
Echinococcus multilocularis cathepsin L 0.0023 0.0157 0.0157
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0531 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0237 0.2553 1
Echinococcus multilocularis cathepsin b 0.0152 0.1608 0.1608
Echinococcus granulosus cathepsin L cysteine protease 0.0056 0.0531 0.0531
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0023 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0015 0.0068 0.0068
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.099 0.2391
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0117 0.011
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0965 0.0965
Onchocerca volvulus 0.0072 0.0705 0.0557
Onchocerca volvulus 0.0105 0.1079 0.0936
Toxoplasma gondii cathepsin B 0.0063 0.0606 0.1289
Brugia malayi CXXC zinc finger family protein 0.0028 0.0216 0.0209
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.093 0.093
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0334 0.3639 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0175 0.1856 0.4851
Echinococcus granulosus lamin dm0 0.003 0.0244 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0157 0.0151
Echinococcus granulosus mothers against decapentaplegic 5 0.0009 0.0006 0.0006
Brugia malayi Cathepsin L-like cysteine proteinase 0.0072 0.0705 0.0699
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0105 0.1079 1
Loa Loa (eye worm) ctsf protein 0.0105 0.1079 0.1079
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0117 0.0117
Echinococcus granulosus cathepsin l1 0.0105 0.1079 0.1079
Schistosoma mansoni cathepsin B (C01 family) 0.0023 0.0157 0.0151
Brugia malayi hypothetical protein 0.0225 0.2418 0.2413
Echinococcus granulosus Smad4 0.0009 0.0006 0.0006
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0531 0.0525
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0157 0.0151
Schistosoma mansoni cathepsin s 0.0033 0.0277 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0531 0.4054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0117 0.0117
Loa Loa (eye worm) hypothetical protein 0.0072 0.0705 0.0705
Echinococcus multilocularis cpg binding protein 0.0029 0.0233 0.0233
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0322 0.3504 0.9613
Brugia malayi Cathepsin L-like precursor 0.0105 0.1079 0.1073
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0023 0.0157 0.0151
Trypanosoma cruzi oligopeptidase b 0.0175 0.1856 0.488
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0786 0.8693 0.8693
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0033 0.0277 0.0277
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0023 0.0157 0.0151
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0009 0.0006 0.0006
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.1413 0.1413
Echinococcus granulosus cathepsin L cysteine proteinase 0.0105 0.1079 0.1079
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0177 0.0057
Loa Loa (eye worm) cysteine protease 0.0105 0.1079 0.1079
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0322 0.3504 0.3504
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0063 0.0606 0.1289
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Echinococcus granulosus cathepsin L 0.0023 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0157
Echinococcus multilocularis serotonin receptor 0.0124 0.1292 0.1292
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0531 0.4054
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0152 0.1608 0.1603
Giardia lamblia Alanyl dipeptidyl peptidase 0.0097 0.099 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0068 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Echinococcus multilocularis cysteine protease 0.0105 0.1079 0.1079
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0531 0.0525
Schistosoma mansoni hypothetical protein 0.0019 0.0117 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0531 0.1022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.1608 0.1603
Echinococcus granulosus intermediate filament protein 0.003 0.0244 0.0244
Toxoplasma gondii prolyl endopeptidase 0.0334 0.3639 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0063 0.0606 0.4869
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0565 0.0559
Plasmodium vivax hypothetical protein, conserved 0.0097 0.099 0.9032
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0023 0.0157 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0056 0.0531 0.4054
Trypanosoma brucei oligopeptidase b 0.0175 0.1856 0.4851
Onchocerca volvulus Prolyl endopeptidase homolog 0.0334 0.3639 0.3537
Brugia malayi prolyl oligopeptidase family protein 0.0097 0.099 0.0984
Loa Loa (eye worm) hypothetical protein 0.006 0.057 0.057
Brugia malayi hypothetical protein 0.0016 0.008 0.0074
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0965 0.0959
Entamoeba histolytica prolyl oligopeptidase family protein 0.0097 0.099 0.9032
Echinococcus granulosus cysteine protease 0.0056 0.0531 0.0531
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0157 0.0151
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0244 0.0238
Schistosoma mansoni hypothetical protein 0.0397 0.4348 0.4344
Onchocerca volvulus 0.0105 0.1079 0.0936
Entamoeba histolytica cysteine protease, putative 0.0105 0.1079 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0277 0.0277
Loa Loa (eye worm) fibroinase 0.0105 0.1079 0.1079
Schistosoma mansoni cathepsin S (C01 family) 0.0023 0.0157 0.0151
Schistosoma mansoni intermediate filament proteins 0.003 0.0244 0.0238
Leishmania major oligopeptidase b 0.0175 0.1856 0.4851
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0105 0.1079 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0105 0.1079 0.1079
Echinococcus multilocularis acylamino acid releasing enzyme 0.0097 0.099 0.099
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4348 0.4348
Echinococcus multilocularis cathepsin L 0.0056 0.0531 0.0531
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0056 0.0531 0.0525
Onchocerca volvulus 0.0105 0.1079 0.0936
Echinococcus multilocularis musashi 0.003 0.0244 0.0244
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0157 0.0151
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0167 0.1773 0.4642
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0062
Brugia malayi prolyl oligopeptidase family protein 0.0322 0.3504 0.35
Echinococcus granulosus biogenic amine 5HT receptor 0.0124 0.1292 0.1292
Entamoeba histolytica cysteine proteinase 1, putative 0.0056 0.0531 0.4054
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0023 0.0157 0.0151
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0175 0.1856 0.4851
Entamoeba histolytica prolyl oligopeptidase family protein 0.0097 0.099 0.9032
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0056 0.0531 0.1022
Leishmania major cathepsin L-like protease 0.0201 0.2147 0.5691
Giardia lamblia Cathepsin B precursor 0.0063 0.0606 0.5391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0277 0.0345
Trypanosoma cruzi cruzipain precursor, putative 0.0201 0.2147 0.5716
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4348 0.4348
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0495 0.097
Loa Loa (eye worm) hypothetical protein 0.0334 0.3639 0.3639
Echinococcus multilocularis cysteine protease 0.0105 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0014 0.0062 0.0062
Trypanosoma cruzi oligopeptidase b 0.0175 0.1856 0.488
Leishmania major cathepsin L-like protease 0.0105 0.1079 0.2605
Giardia lamblia Cathepsin B precursor 0.0063 0.0606 0.5391
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Brugia malayi Cathepsin L-like precursor 0.0033 0.0277 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0056 0.0531 0.1073
Schistosoma mansoni cathepsin F (C01 family) 0.0105 0.1079 0.1073
Echinococcus multilocularis smad 0.0009 0.0006 0.0006
Onchocerca volvulus Cathepsin L homolog 0.0105 0.1079 0.0936
Plasmodium vivax unspecified product 0.0033 0.0277 0.1304
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0117 0.011
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0606 0.0606
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.1608 0.1603
Echinococcus multilocularis lamin 0.003 0.0244 0.0244
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0152 0.1608 0.1603
Loa Loa (eye worm) hypothetical protein 0.006 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0097 0.099 0.099
Brugia malayi hypothetical protein 0.0024 0.0177 0.017
Entamoeba histolytica cysteine proteinase, putative 0.0105 0.1079 1
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0086 0.008
Onchocerca volvulus 0.003 0.0244 0.0089
Plasmodium vivax vivapain-1 0.0056 0.0531 0.4054
Giardia lamblia Alanyl dipeptidyl peptidase 0.0097 0.099 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Trypanosoma cruzi prolyl endopeptidase 0.0334 0.3639 1
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0322 0.3504 0.9611
Loa Loa (eye worm) hypothetical protein 0.0124 0.1292 0.1292
Schistosoma mansoni transient receptor potential channel 0.0063 0.0606 0.06
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0033 0.0277 0.0271
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0097 0.099 0.9032
Plasmodium falciparum cysteine proteinase falcipain 1 0.0056 0.0531 0.4054
Leishmania major cathepsin L-like protease 0.0201 0.2147 0.5691
Echinococcus granulosus cpg binding protein 0.0029 0.0233 0.0233
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0322 0.3504 0.9611
Brugia malayi Cathepsin L-like precursor 0.0072 0.0705 0.0699
Brugia malayi cathepsin L precursor 0.0023 0.0157 0.0151
Schistosoma mansoni biogenic amine (5HT) receptor 0.0124 0.1292 0.1287
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0175 0.1856 0.5
Echinococcus granulosus TGF beta signal transducer SmadC 0.0009 0.0006 0.0006
Loa Loa (eye worm) cathepsin B 0.0063 0.0606 0.0606
Brugia malayi Papain family cysteine protease containing protein 0.0105 0.1079 0.1073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.093 0.093
Trypanosoma brucei prolyl endopeptidase 0.0334 0.3639 1
Leishmania major cathepsin L-like protease 0.0105 0.1079 0.2605
Onchocerca volvulus 0.0105 0.1079 0.0936
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0105 0.1079 0.1079
Loa Loa (eye worm) hypothetical protein 0.0033 0.0277 0.0277
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0298 0.0298
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Loa Loa (eye worm) MH2 domain-containing protein 0.0009 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0105 0.1079 0.1073
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0097 0.099 0.9032
Brugia malayi fibroinase precursor 0.0023 0.0157 0.0151
Brugia malayi Cathepsin L-like precursor 0.0105 0.1079 0.1073
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Trypanosoma brucei cysteine peptidase C (CPC) 0.0063 0.0606 0.1239
Trypanosoma cruzi major cysteine proteinase, putative 0.0118 0.1225 0.3068
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0903 1 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.1413 0.1413
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0023 0.0157 0.0151
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0903 1 1
Echinococcus multilocularis Smad4 0.0009 0.0006 0.0006
Loa Loa (eye worm) intermediate filament protein 0.003 0.0244 0.0244
Plasmodium vivax vivapain-3 0.0056 0.0531 0.4054
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0097 0.099 0.9032
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0097 0.099 0.2348
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0072 0.0705 0.5946
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Schistosoma mansoni hypothetical protein 0.0019 0.0117 0.011
Plasmodium vivax vivapain-2 0.0105 0.1079 1
Trypanosoma cruzi hypothetical protein, conserved 0.0097 0.099 0.2391
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0606 0.0606
Onchocerca volvulus 0.0105 0.1079 0.0936
Brugia malayi Cathepsin L-like precursor 0.0105 0.1079 0.1073
Brugia malayi cathepsin F-like cysteine proteinase 0.0033 0.0277 0.0271
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0175 0.1856 0.488
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0334 0.3639 0.3635
Loa Loa (eye worm) hypothetical protein 0.0225 0.2418 0.2418
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Echinococcus multilocularis cathepsin b 0.0152 0.1608 0.1608
Loa Loa (eye worm) hypothetical protein 0.0019 0.0117 0.0117
Schistosoma mansoni cathepsin C 0.0023 0.0157 0.0151
Plasmodium vivax vivapain-2 0.0105 0.1079 1
Loa Loa (eye worm) hypothetical protein 0.0097 0.099 0.099
Loa Loa (eye worm) prolyl oligopeptidase 0.0097 0.099 0.099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0577 0.0571
Schistosoma mansoni transient receptor potential channel 0.0063 0.0606 0.06
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0531 0.4054
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0965 0.0965
Trypanosoma cruzi cysteine peptidase, putative 0.0201 0.2147 0.5716
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0175 0.1856 0.5
Brugia malayi cathepsin L-like precursor 0.0072 0.0705 0.0699
Schistosoma mansoni cathepsin F (C01 family) 0.0105 0.1079 0.1073
Giardia lamblia Cathepsin B precursor 0.0063 0.0606 0.5391
Loa Loa (eye worm) hypothetical protein 0.0035 0.0298 0.0298
Echinococcus granulosus cathepsin b 0.0152 0.1608 0.1608
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Brugia malayi MH2 domain containing protein 0.0135 0.1413 0.1407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0105 0.1079 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0201 0.2147 0.5691
Loa Loa (eye worm) hypothetical protein 0.0152 0.1608 0.1608
Brugia malayi Papain family cysteine protease containing protein 0.0023 0.0157 0.0151
Entamoeba histolytica cysteine proteinase, putative 0.0056 0.0531 0.4054
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0105 0.1079 1
Loa Loa (eye worm) hypothetical protein 0.0124 0.1292 0.1292
Plasmodium vivax unspecified product 0.0056 0.0531 0.4054
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0105 0.1079 0.1079
Onchocerca volvulus 0.0105 0.1079 0.0936
Loa Loa (eye worm) hypothetical protein 0.0032 0.0263 0.0263
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0063 0.0606 0.1239
Echinococcus granulosus GPCR family 2 0.0019 0.0117 0.0117
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0606 0.0606
Brugia malayi cathepsin Z-like cysteine proteinase 0.0023 0.0157 0.0151
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0097 0.099 0.0984
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0322 0.3504 0.9611
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0364 0.0358
Echinococcus granulosus lamin 0.003 0.0244 0.0244
Brugia malayi cathepsin Z-like cysteine proteinase 0.0023 0.0157 0.0151
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0244 0.0244
Entamoeba histolytica cysteine protease, putative 0.0056 0.0531 0.4054
Brugia malayi cathepsin B-like cysteine proteinase 0.0152 0.1608 0.1603

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 25.929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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