Detailed information for compound 149543

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 603.647 | Formula: C29H42N5O7P
  • H donors: 4 H acceptors: 7 LogP: 0.65 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCCCC1NC(=O)[C@@H]2CCCN2C(=O)CCP(=O)(O)[C@H](NC(=O)[C@H]2N(C(=O)CNC1=O)CCC2)Cc1ccccc1
  • InChi: 1S/C29H42N5O7P/c1-2-3-11-21-27(37)30-19-26(36)34-16-8-13-23(34)29(39)32-24(18-20-9-5-4-6-10-20)42(40,41)17-14-25(35)33-15-7-12-22(33)28(38)31-21/h4-6,9-10,21-24H,2-3,7-8,11-19H2,1H3,(H,30,37)(H,31,38)(H,32,39)(H,40,41)/t21?,22-,23+,24+/m1/s1
  • InChiKey: QLXCQCDAJMULKF-KCNMBCDYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Matrixin family protein 0.0021 0.0053 0.0185
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0042 0.0226 0.0374
Plasmodium vivax phosphoglycerate kinase, putative 0.0176 0.1312 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.021 0.0805
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0984 0.0979
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0006 0.0021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0045 0.0155
Toxoplasma gondii ABC1 family protein 0.0077 0.0509 0.3742
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0207 0.0719
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0135
Brugia malayi jmjC domain containing protein 0.0038 0.0188 0.0651
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0168
Plasmodium falciparum casein kinase 2, alpha subunit 0.0079 0.0526 0.3445
Trichomonas vaginalis ap endonuclease, putative 0.004 0.021 0.1303
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0407 0.0748
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.021 0.1303
Plasmodium vivax unspecified product 0.0079 0.0526 0.3445
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0509 0.3664
Trypanosoma brucei phosphoglycerate kinase 0.0065 0.0407 0.0748
Echinococcus granulosus dna polymerase eta 0.0046 0.0258 0.0808
Trichomonas vaginalis esterase, putative 0.0077 0.0509 0.3664
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0048 0.0065
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Schistosoma mansoni replication factor A 1 rfa1 0.0072 0.0464 0.0458
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0079 0.0526 0.3445
Trypanosoma brucei DNA repair and recombination helicase protein PIF7 0.0027 0.0104 0.0122
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0001 0.0003
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0077 0.0503 0.1593
Schistosoma mansoni phosphoglycerate kinase 0.0176 0.1312 0.1306
Loa Loa (eye worm) matrixin family protein 0.0051 0.0295 0.1026
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0509 0.1209
Loa Loa (eye worm) hypothetical protein 0.0053 0.0314 0.1089
Schistosoma mansoni lamin 0.0027 0.0104 0.0097
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.021 0.034
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0491 0.1552
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0072 0.0464 0.3312
Schistosoma mansoni intermediate filament proteins 0.0027 0.0104 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0168
Echinococcus multilocularis tumor protein p63 0.0343 0.2663 0.4073
Onchocerca volvulus Matrilysin homolog 0.0021 0.0053 0.0017
Schistosoma mansoni hypothetical protein 0.0028 0.0113 0.0107
Onchocerca volvulus 0.003 0.0125 0.027
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0065 0.0407 0.0748
Onchocerca volvulus Ribonuclease H1 homolog 0.0022 0.0058 0.0034
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0048 0.0168
Brugia malayi hypothetical protein 0.0075 0.0491 0.1704
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0587 0.1119
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.0021
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0104 0.0122
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0104 0.036
Plasmodium falciparum casein kinase II beta chain 0.0042 0.0226 0.0942
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0142 0.1031 0.3579
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0135
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0509 0.3301
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0065
Echinococcus multilocularis geminin 0.0329 0.2551 0.3901
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0509 0.1209
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0147 0.0211
Echinococcus multilocularis replication protein A 70 kDa DNA binding 0.0072 0.0464 0.0702
Brugia malayi RNase H family protein 0.0022 0.0058 0.0202
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0042 0.0226 0.0627
Onchocerca volvulus Peroxidasin homolog 0.004 0.0207 0.056
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0258 0.0441
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0337 0.1169
Toxoplasma gondii hypothetical protein 0.01 0.0691 0.5161
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0006 0.0021
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0509 0.1209
Brugia malayi ecdysteroid receptor 0.002 0.0048 0.0168
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0104 0.036
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0123
Echinococcus multilocularis dna polymerase eta 0.0046 0.0258 0.0387
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0048 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0048 0.0135
Brugia malayi beta-lactamase family protein 0.0077 0.0509 0.1767
Brugia malayi RNase H family protein 0.0022 0.0058 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Mycobacterium tuberculosis Conserved protein 0.0077 0.0509 0.1209
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1109 0.1691
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0168
Toxoplasma gondii CMGC kinase, CK2 family 0.0079 0.0526 0.3876
Brugia malayi Hemopexin family protein 0.003 0.0125 0.0433
Loa Loa (eye worm) replication factor A 73 kDa subunit 0.0072 0.0464 0.1612
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0176 0.1312 1
Brugia malayi Phosphoglycerate kinase 0.0176 0.1312 0.4554
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0048 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0509 0.3664
Echinococcus granulosus transcription factor Dp 1 0.0082 0.0547 0.1733
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0188 0.0651
Echinococcus multilocularis dnaJ subfamily B 0.04 0.3128 0.4786
Schistosoma mansoni ap endonuclease 0.004 0.021 0.0204
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0001 0.0003
Onchocerca volvulus Matrilysin homolog 0.0047 0.0261 0.0752
Toxoplasma gondii histone lysine methyltransferase SET1 0.0106 0.0743 0.5566
Echinococcus multilocularis musashi 0.0027 0.0104 0.0149
Loa Loa (eye worm) glutamate receptor 0.0017 0.002 0.0071
Brugia malayi Animal haem peroxidase family protein 0.004 0.0207 0.0719
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0509 0.1209
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.1031 0.2033
Brugia malayi Phosphoglycerate kinase 0.0065 0.0407 0.1414
Brugia malayi replication factor A 73 kDa subunit 0.0072 0.0464 0.1612
Echinococcus granulosus dna polymerase kappa 0.002 0.0045 0.0123
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0113 0.0107
Onchocerca volvulus Putative replication factor A 73 kDa subunit 0.0064 0.0403 0.1253
Brugia malayi jmjC domain containing protein 0.0093 0.0638 0.2214
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.0065
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.021 0.0652
Echinococcus multilocularis lamin dm0 0.0027 0.0104 0.0149
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0048 0.0135
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0048 0.0065
Mycobacterium ulcerans beta-lactamase 0.0077 0.0509 0.1873
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0168
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0142 0.1031 0.1025
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0369 0.288 1
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0097 0.0109
Echinococcus granulosus peroxidasin 0.004 0.0207 0.0643
Toxoplasma gondii ck2 beta subunit 0.0042 0.0226 0.1538
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0176 0.1312 0.3301
Mycobacterium ulcerans phosphoglycerate kinase 0.0176 0.1312 0.5114
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0273 0.0949
Brugia malayi Animal haem peroxidase family protein 0.004 0.0207 0.0719
Plasmodium vivax casein kinase II beta chain, putative 0.0042 0.0226 0.0942
Trypanosoma brucei phosphoglycerate kinase 0.0176 0.1312 0.2613
Echinococcus multilocularis cpg binding protein 0.0059 0.0362 0.0546
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0618 0.4894 1
Echinococcus granulosus muscleblind protein 0.0151 0.1109 0.3534
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0638 0.0968
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0071 0.0065
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0023 0.0054
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0048 0.0042
Plasmodium falciparum replication protein A1, large subunit 0.0034 0.0161 0.0402
Schistosoma mansoni cellular tumor antigen P53 0.005 0.029 0.0284
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.021 0.043
Echinococcus multilocularis ATP dependent DNA helicase PIF1 0.0027 0.0104 0.0149
Brugia malayi MH2 domain containing protein 0.0121 0.0861 0.299
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.021 0.0728
Trypanosoma cruzi DNA repair and recombination helicase protein PIF6, putative 0.0027 0.0104 0.0122
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0509 0.1209
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0491 0.0485
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0039 0.02 0.0694
Trichomonas vaginalis ap endonuclease, putative 0.004 0.021 0.1303
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0176 0.1312 0.4499
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0188 0.0581
Echinococcus granulosus tumor protein p63 0.0343 0.2663 0.851
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0048 0.0042
Schistosoma mansoni cpg binding protein 0.0059 0.0362 0.0357
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0509 0.3425
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0048 0.0065
Entamoeba histolytica protein kinase domain containing protein 0.0079 0.0526 0.3799
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0359 0.1245
Brugia malayi Csnk2b protein 0.0042 0.0226 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0509 0.0957
Brugia malayi Matrixin family protein 0.0021 0.0053 0.0185
Echinococcus granulosus ribonuclease H1 0.0022 0.0058 0.0166
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0369 0.288 1
Mycobacterium ulcerans hypothetical protein 0.0077 0.0509 0.1873
Onchocerca volvulus 0.004 0.0207 0.056
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0036 0.0176 0.026
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0006 0.0021
Schistosoma mansoni hypothetical protein 0.0027 0.0104 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0168
Schistosoma mansoni phosphoglucomutase 0.0022 0.0058 0.0052
Brugia malayi hypothetical protein 0.004 0.0207 0.0719
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0113 0.0658
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0049 0.0281 0.0275
Schistosoma mansoni metabotropic glutamate receptor 0.0036 0.0176 0.017
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0042 0.0226 0.1432
Echinococcus granulosus metabotropic glutamate receptor 5 0.0053 0.0314 0.0985
Loa Loa (eye worm) hypothetical protein 0.0033 0.015 0.0519
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0142 0.1031 0.2033
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0042 0.0226 0.0374
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0058 0.0028
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0509 0.1873
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Onchocerca volvulus 0.0077 0.0509 0.1626
Loa Loa (eye worm) hypothetical protein 0.0176 0.1312 0.4554
Loa Loa (eye worm) matrix metalloproteinase 0.0021 0.0053 0.0185
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.021 0.0544
Giardia lamblia Phosphoglycerate kinase 0.0176 0.1312 1
Loa Loa (eye worm) beta-lactamase 0.0077 0.0509 0.1767
Echinococcus multilocularis dna polymerase kappa 0.002 0.0045 0.0059
Brugia malayi Matrixin family protein 0.0021 0.0053 0.0185
Entamoeba histolytica hypothetical protein, conserved 0.0027 0.0104 0.0466
Mycobacterium tuberculosis Conserved hypothetical protein 0.0325 0.2522 0.6454
Plasmodium falciparum casein kinase II beta chain 0.0042 0.0226 0.0942
Giardia lamblia Casein kinase II beta chain 0.0042 0.0226 0.1432
Mycobacterium leprae Probable lipase LipE 0.0077 0.0509 0.3425
Brugia malayi Matrixin family protein 0.0021 0.0053 0.0185
Brugia malayi metabotropic glutamate receptor type 2 0.0021 0.0053 0.0185
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0142 0.1031 0.7783
Brugia malayi RNA binding protein 0.0136 0.0984 0.3418
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0509 0.0957
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0048 0.0168
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Mycobacterium ulcerans hydrolase 0.0026 0.0091 0.0185
Trypanosoma cruzi ribonuclease H1, putative 0.0022 0.0058 0.0028
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0188 0.0181
Brugia malayi RNase H family protein 0.0022 0.0058 0.0202
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0045 0.0038
Echinococcus granulosus intermediate filament protein 0.0027 0.0104 0.0312
Leishmania major ribonuclease H1, putative 0.0022 0.0058 0.0028
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0407 0.0748
Onchocerca volvulus Chorion peroxidase homolog 0.004 0.0207 0.056
Loa Loa (eye worm) Csnk2b protein 0.0042 0.0226 0.0785
Mycobacterium tuberculosis Conserved protein 0.0077 0.0509 0.1209
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0072 0.0464 0.3312
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0048 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0168
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0207 0.0719
Entamoeba histolytica replication factor A protein 1, putative 0.0031 0.0133 0.0695
Echinococcus granulosus tar DNA binding protein 0.0136 0.0984 0.3133
Brugia malayi Animal haem peroxidase family protein 0.004 0.0207 0.0719
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Leishmania major DNA polymerase eta, putative 0.0046 0.0258 0.0441
Brugia malayi Peroxidasin 0.004 0.0207 0.0719
Echinococcus granulosus lamin dm0 0.0027 0.0104 0.0312
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0104 0.036
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0048 0.0135
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Leishmania major phosphoglycerate kinase C, glycosomal 0.0176 0.1312 0.2613
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0042 0.0226 0.0374
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0042
Chlamydia trachomatis phosphoglycerate kinase 0.0176 0.1312 0.5
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0176 0.1312 1
Entamoeba histolytica DNA repair and recombination protein, putative 0.0027 0.0104 0.0466
Echinococcus multilocularis casein kinase ii subunit alpha 0.0079 0.0526 0.0797
Loa Loa (eye worm) RNA binding protein 0.0136 0.0984 0.3418
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0176 0.1312 0.2613
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0087 0.0587 0.1119
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0273 0.0949
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0509 0.1767
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0509 0.0503
Onchocerca volvulus 0.0027 0.0104 0.0195
Echinococcus granulosus jumonji domain containing protein 0.004 0.0203 0.0632
Trypanosoma brucei unspecified product 0.0026 0.0097 0.0109
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0065 0.0407 0.0748
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0638 0.2023
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0292 0.2254 0.4557
Brugia malayi beta-lactamase family protein 0.0077 0.0509 0.1767
Echinococcus multilocularis ribonuclease H1 0.0022 0.0058 0.008
Brugia malayi Animal haem peroxidase family protein 0.004 0.0207 0.0719
Loa Loa (eye worm) hypothetical protein 0.0077 0.0509 0.1767
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.036
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.021 0.0728
Brugia malayi intermediate filament protein 0.0027 0.0104 0.036
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0162 0.0238
Leishmania major PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative 0.0027 0.0104 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0087 0.0587 0.1119
Trypanosoma brucei ingi protein (ORF1) 0.0026 0.0097 0.0109
Loa Loa (eye worm) glutamate receptor 0.0043 0.0233 0.0808
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.021 0.1209
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0026 0.0091 0.0314
Schistosoma mansoni cpg binding protein 0.0059 0.0362 0.0357
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0203 0.0302
Schistosoma mansoni nuclear hormone receptor 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0077 0.0509 0.1767
Brugia malayi beta-lactamase 0.0077 0.0509 0.1767
Schistosoma mansoni hypothetical protein 0.0214 0.1622 0.1617
Brugia malayi F/Y-rich N-terminus family protein 0.0026 0.0097 0.0335
Onchocerca volvulus Peroxidase homolog 0.004 0.0207 0.056
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0104 0.0122
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Schistosoma mansoni peroxidasin 0.004 0.0207 0.0201
Entamoeba histolytica hypothetical protein 0.0075 0.0491 0.3521
Echinococcus granulosus replication protein A 70 kDa DNA binding 0.0072 0.0464 0.1467
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Schistosoma mansoni hypothetical protein 0.04 0.3128 0.3124
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.005 0.0288 0.0282
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0045 0.0155
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.2254 0.4557
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0053 0.0314 0.0472
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0021 0.0053 0.0047
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0509 0.161
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0048 0.0168
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0068 0.0435 0.3085
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0042 0.0226 0.0374
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0258 0.0898
Schistosoma mansoni coup transcription factor 0.002 0.0048 0.0042
Echinococcus granulosus geminin 0.0329 0.2551 0.815
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.021 0.0805
Entamoeba histolytica casein kinase, putative 0.0079 0.0526 0.3799
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0042 0.0226 0.1432
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Brugia malayi Bromodomain containing protein 0.0028 0.0113 0.0393
Mycobacterium ulcerans lipase LipD 0.0077 0.0509 0.1873
Echinococcus multilocularis peregrin 0.0028 0.0113 0.0164
Loa Loa (eye worm) hypothetical protein 0.0048 0.0273 0.0949
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0048 0.0042
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0136 0.0984 0.3418
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0483 0.0477
Echinococcus multilocularis lamin 0.0027 0.0104 0.0149
Trypanosoma brucei DNA repair and recombination helicase protein PIF6 0.0027 0.0104 0.0122
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0819 0.6529 1
Leishmania major DNA polymerase eta, putative 0.0033 0.0147 0.0211
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0176 0.1312 0.2613
Trypanosoma brucei phosphoglycerate kinase 0.0176 0.1312 0.2613
Schistosoma mansoni DNA polymerase eta 0.0046 0.0258 0.0252
Brugia malayi CXXC zinc finger family protein 0.0056 0.0337 0.1169
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.021 0.0312
Entamoeba histolytica hypothetical protein 0.0075 0.0491 0.3521
Schistosoma mansoni peroxidasin 0.004 0.0207 0.0201
Brugia malayi nuclear receptor NHR-88 0.002 0.0048 0.0168
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0207 0.0719
Trypanosoma brucei Casein kinase II 0.0079 0.0526 0.0993
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0176 0.1312 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0509 0.0503
Brugia malayi PHD-finger family protein 0.0028 0.0113 0.0393
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0741 0.1437
Echinococcus granulosus dnaJ subfamily B 0.04 0.3128 1
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0369 0.288 1
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0984 0.0979
Schistosoma mansoni metabotropic glutamate receptor 0.0021 0.0053 0.0047
Loa Loa (eye worm) hypothetical protein 0.0077 0.0509 0.1767
Brugia malayi TAR-binding protein 0.0136 0.0984 0.3418
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.1031 0.2033
Schistosoma mansoni phosphoglycerate kinase 0.0176 0.1312 0.1306
Loa Loa (eye worm) hypothetical protein 0.0151 0.1109 0.3852
Echinococcus granulosus casein kinase ii subunit beta 0.0042 0.0226 0.0704
Onchocerca volvulus 0.0056 0.0337 0.1018
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0509 0.0957
Toxoplasma gondii replication factor-a protein 1 (rpa1) subfamily protein 0.0034 0.0161 0.1034
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0045 0.0059
Mycobacterium tuberculosis Conserved protein 0.0077 0.0509 0.1209
Brugia malayi Metabotropic glutamate receptor precursor. 0.0043 0.0233 0.0808
Brugia malayi Casein kinase II, alpha chain 0.0079 0.0526 0.1826
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0048 0.0065
Schistosoma mansoni hypothetical protein 0.0075 0.0491 0.0485
Trypanosoma cruzi casein kinase II, putative 0.0079 0.0526 0.0993
Echinococcus multilocularis transcription factor Dp 1 0.0082 0.0547 0.0829
Onchocerca volvulus 0.004 0.0207 0.056
Echinococcus multilocularis peroxidasin 0.004 0.0207 0.0308
Loa Loa (eye worm) animal heme peroxidase 0.004 0.0207 0.0719
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0147 0.092
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0079 0.0526 0.1826
Wolbachia endosymbiont of Brugia malayi extracellular metallopeptidase 0.0365 0.2845 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0042 0.0226 0.0627
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0369 0.288 0.2875
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0185
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0042 0.0226 0.1432
Echinococcus granulosus phosphoglycerate kinase 1 0.0176 0.1312 0.4181
Trypanosoma cruzi DNA repair and recombination helicase protein PIF7, putative 0.0027 0.0104 0.0122
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0026 0.0091 0.012
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0048 0.0168
Toxoplasma gondii exonuclease III APE 0.004 0.021 0.1411
Leishmania major replication factor A, 51kDa subunit, putative 0.0034 0.0161 0.0241
Onchocerca volvulus 0.005 0.029 0.0852
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0491 0.0743
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0369 0.288 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0047 0.0261 0.0752
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Plasmodium vivax casein kinase II beta chain, putative 0.0042 0.0226 0.0942
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0142 0.1031 0.3282
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0048 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0091 0.0314
Schistosoma mansoni polycystin 1-related 0.0032 0.0143 0.0137
Entamoeba histolytica phosphoglycerate kinase, putative 0.0176 0.1312 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0618 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0113 0.0393
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0113 0.0393
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0048 0.0168
Echinococcus multilocularis muscleblind protein 0.0151 0.1109 0.1691
Giardia lamblia Rrm3p helicase 0.0027 0.0104 0.0466
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0861 0.299
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0119 0.0846 0.084
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Leishmania major casein kinase II, putative 0.0079 0.0526 0.0993
Brugia malayi Matrixin family protein 0.0051 0.0295 0.1026
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0048 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0048 0.0042
Trypanosoma brucei RNA helicase, putative 0.0214 0.1622 0.3253
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0097 0.0109
Onchocerca volvulus Peroxidase homolog 0.004 0.0207 0.056
Echinococcus multilocularis phosphoglycerate kinase 1 0.0176 0.1312 0.2001
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0113 0.0658
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.0346
Trypanosoma brucei Replication factor A protein 1 0.0034 0.0161 0.0241
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Loa Loa (eye worm) blistered cuticle protein 3 0.004 0.0207 0.0719
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0042 0.0226 0.1538
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0113 0.0164
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0048 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0048 0.0168
Trypanosoma brucei phosphoglycerate kinase, putative 0.0065 0.0407 0.0748
Loa Loa (eye worm) hypothetical protein 0.005 0.029 0.1005
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0048 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0048 0.0168
Brugia malayi Animal haem peroxidase family protein 0.004 0.0207 0.0719
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0188 0.0181
Trypanosoma cruzi Replication factor A protein 1 0.0034 0.0161 0.0241
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Trypanosoma brucei ribonuclease H1 0.0022 0.0058 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.021 0.034
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0087 0.0587 0.1119
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0113 0.0343
Brugia malayi nuclear hormone receptor 0.002 0.0048 0.0168
Plasmodium vivax replication protein A1, large subunit, putative 0.0034 0.0161 0.0402
Brugia malayi Muscleblind-like protein 0.0151 0.1109 0.3852
Loa Loa (eye worm) hypothetical protein 0.0077 0.0509 0.1767
Mycobacterium ulcerans hypothetical protein 0.0325 0.2522 1
Onchocerca volvulus 0.0021 0.0053 0.0017
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0142 0.1031 0.3579
Schistosoma mansoni hypothetical protein 0.0329 0.2551 0.2546
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Schistosoma mansoni protein kinase 0.0079 0.0526 0.052
Echinococcus granulosus lamin 0.0027 0.0104 0.0312
Leishmania major phosphoglycerate kinase B, cytosolic 0.0176 0.1312 0.2613
Schistosoma mansoni phosphoglucomutase 0.0022 0.0058 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0026 0.0097 0.0109
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0176 0.1312 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Trichomonas vaginalis replication factor A 1, rfa1, putative 0.0034 0.0161 0.0921
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0509 0.3664
Loa Loa (eye worm) hypothetical protein 0.0049 0.0278 0.0965
Leishmania major mitochondrial DNA polymerase beta 0.0618 0.4894 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0185
Schistosoma mansoni thyroid hormone receptor 0.002 0.0048 0.0042
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0493 0.3884 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0273 0.0949
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0509 0.1873
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0407 0.0748
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0048 0.0065
Onchocerca volvulus Peroxidasin homolog 0.004 0.0207 0.056
Schistosoma mansoni cpg binding protein 0.0056 0.0337 0.0331
Giardia lamblia PHD finger protein 15 0.0028 0.0113 0.0541
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0509 0.1209
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0045 0.0038
Schistosoma mansoni lamin 0.0027 0.0104 0.0097
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0861 0.299
Treponema pallidum phosphoglycerate kinase 0.0176 0.1312 1
Schistosoma mansoni hypothetical protein 0.003 0.0125 0.0119
Echinococcus multilocularis casein kinase ii subunit beta 0.0042 0.0226 0.0337
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0227 0.1722 0.1717
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0048 0.0168
Giardia lamblia Ribonuclease H 0.0022 0.0058 0.0106
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.021 0.034
Schistosoma mansoni ap endonuclease 0.004 0.021 0.0204
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0142 0.1031 0.2033
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0292 0.2254 0.4557
Onchocerca volvulus 0.0077 0.0509 0.1626
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0168
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0168
Echinococcus granulosus ATP dependent DNA helicase PIF1 0.0027 0.0104 0.0312
Brugia malayi Protein kinase domain containing protein 0.0369 0.288 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0048 0.0168
Echinococcus granulosus cpg binding protein 0.0059 0.0362 0.1141
Brugia malayi steroid hormone receptor 0.002 0.0048 0.0168
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0023 0.008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0023 0.0026
Giardia lamblia Kinase, CMGC CK2 0.0079 0.0526 0.3799
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.021 0.1303
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0509 0.3664
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.021 0.034
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0984 0.0979
Loa Loa (eye worm) hypothetical protein 0.0077 0.0509 0.1767
Echinococcus granulosus casein kinase ii subunit alpha 0.0079 0.0526 0.1665
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Entamoeba histolytica hypothetical protein 0.0075 0.0491 0.3521
Leishmania major hypothetical protein, conserved 0.0077 0.0509 0.0957
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Entamoeba histolytica hypothetical protein 0.0075 0.0491 0.3521
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0258 0.0441
Loa Loa (eye worm) hypothetical protein 0.0046 0.0258 0.0898
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0984 0.0979
Plasmodium falciparum phosphoglycerate kinase 0.0176 0.1312 1
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0065 0.0407 0.0748
Schistosoma mansoni hypothetical protein 0.0033 0.015 0.0144
Onchocerca volvulus Dual oxidase homolog 0.004 0.0207 0.056
Trichomonas vaginalis CMGC family protein kinase 0.0079 0.0526 0.3799
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Brugia malayi Blistered cuticle protein 3 0.004 0.0207 0.0719
Schistosoma mansoni tar DNA-binding protein 0.0136 0.0984 0.0979
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0509 0.1767
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0509 0.1209
Schistosoma mansoni phosphoglucomutase 0.0022 0.0058 0.0052
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0369 0.288 0.9205
Onchocerca volvulus 0.004 0.0207 0.056
Schistosoma mansoni casein kinase II beta subunit 0.0042 0.0226 0.022
Echinococcus granulosus metabotropic glutamate receptor 2 0.0036 0.0176 0.0544
Brugia malayi RNA recognition motif domain containing protein 0.0136 0.0984 0.3418
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0142 0.1031 0.1571
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.021 0.0666
Echinococcus multilocularis tar DNA binding protein 0.0136 0.0984 0.15
Schistosoma mansoni hypothetical protein 0.0329 0.2551 0.2546
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0509 0.0771
Loa Loa (eye worm) hypothetical protein 0.004 0.0207 0.0719
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0048 0.0168
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.015 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0104 0.0466
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0048 0.0168
Onchocerca volvulus Alhambra homolog 0.0028 0.0113 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0168
Loa Loa (eye worm) hypothetical protein 0.0077 0.0509 0.1767
Loa Loa (eye worm) hypothetical protein 0.0021 0.0053 0.0185
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0048 0.0065
Onchocerca volvulus 0.0077 0.0509 0.1626
Loa Loa (eye worm) hypothetical protein 0.0151 0.1109 0.3852
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0176 0.1312 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0077 0.0503 0.0762
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0048 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0048 0.0168
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0509 0.3664
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0369 0.288 0.4405
Onchocerca volvulus 0.0027 0.0104 0.0195
Loa Loa (eye worm) matrixin family protein 0.0047 0.0261 0.0907
Echinococcus granulosus peregrin 0.0028 0.0113 0.0343
Toxoplasma gondii ribonuclease HI protein 0.0022 0.0058 0.0229
Loa Loa (eye worm) TAR-binding protein 0.0136 0.0984 0.3418
Trichomonas vaginalis ribonuclease H1, putative 0.0022 0.0058 0.0106
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0618 0.4894 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0042 0.0226 0.1432
Echinococcus granulosus FTZ F1 alpha 0.002 0.0048 0.0135
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0048 0.0168

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 120 nM Binding constant of the compound containing a pseudophenylalanineresidue ChEMBL. 8064799
Ki (binding) = 0.12 uM Inhibition of bacterial collagenase from corynebacterium rathaii ChEMBL. 8064799
Ki (binding) = 0.18 uM Inhibition of bacterial collagenase from corynebacterium rathaii ChEMBL. 8064799
koff (ADMET) = 2 s-1 Compound was evaluated for the dissociation rate constant ChEMBL. 8064799
kon (ADMET) = 1.6 M-1 s-1 Compound was evaluated for the association rate constant ChEMBL. 8064799

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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