Detailed information for compound 1503389

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 426.53 | Formula: C26H22N2O2S
  • H donors: 2 H acceptors: 3 LogP: 5.01 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1c2ccccc2nc(c1[S+](C)[O-])c1ccccc1)NC1(CC1)c1ccccc1
  • InChi: 1S/C26H22N2O2S/c1-31(30)24-22(25(29)28-26(16-17-26)19-12-6-3-7-13-19)20-14-8-9-15-21(20)27-23(24)18-10-4-2-5-11-18/h2-15H,16-17H2,1H3,(H,28,29)
  • InChiKey: WFRQHOUKNHUVJY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens tachykinin receptor 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
Echinococcus multilocularis tachykinin peptides receptor 99D Get druggable targets OG5_131969 All targets in OG5_131969
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Plasmodium falciparum thioredoxin reductase 0.0016 0.0078 0.025
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0078 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0384 0.0384
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Echinococcus multilocularis somatostatin receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Mycobacterium tuberculosis Putative conserved ATPase 0.0051 0.043 0.143
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1309 0.1309
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0334 0.4314
Echinococcus granulosus slit 2 protein 0.0009 0.0002 0.0002
Trichomonas vaginalis proteasome-activating nucleotidase, putative 0.002 0.0119 0.1537
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) vesicle-fusing ATPase 0.005 0.042 0.139
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1008 1 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0082 0.0272
Echinococcus multilocularis fat cadherin tumor suppressor 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0018 0.007
Echinococcus multilocularis g-protein coupled receptor 0.0009 0.0008 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0272 0.0272
Brugia malayi hypothetical protein 0.0036 0.0272 0.1158
Schistosoma mansoni notch 0.0009 0.0002 0.0002
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.0891 0.0891
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Echinococcus granulosus protein kinase 0.0122 0.114 0.114
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.0793
Schistosoma mansoni opsin-like receptor 0.0009 0.0008 0.0008
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0091 0.0329
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0081 0.0731 0.0731
Echinococcus multilocularis G protein coupled receptor 139 0.0009 0.0008 0.0008
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0018 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0541 0.0541
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0012 0.0036 0.0036
Schistosoma mansoni notch 0.0009 0.0002 0.0002
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0009 0.0008 0.0027
Schistosoma mansoni histamine h1 receptor 0.0009 0.0008 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0298
Brugia malayi Temporarily assigned gene name protein 59 0.0051 0.0424 0.1808
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0009 0.0008 0.0008
Schistosoma mansoni neuropeptide receptor 0.0009 0.0008 0.0008
Onchocerca volvulus Ceramide kinase 1 homolog 0.0012 0.0036 0.0202
Brugia malayi CXXC zinc finger family protein 0.0029 0.0207 0.0877
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Echinococcus granulosus expressed conserved protein 0.0092 0.0831 0.0831
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0018 0.007
Brugia malayi Tachykinin-like peptides receptor 99D 0.0009 0.0008 0.0027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0018 0.0018
Schistosoma mansoni adenoreceptor 0.0009 0.0008 0.0008
Schistosoma mansoni sphingosine kinase A B 0.0309 0.3007 0.3007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0009 0.0008 0.0008
Brugia malayi AKH receptor 0.0009 0.0008 0.0027
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0072 0.0233
Echinococcus granulosus dnaJ subfamily B 0.0414 0.4053 0.4053
Echinococcus granulosus g protein coupled receptor 0.0009 0.0008 0.0008
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0078 0.025
Brugia malayi Protein kinase domain containing protein 0.0052 0.0439 0.1874
Echinococcus granulosus Diacylglycerol kinase theta 0.0012 0.0036 0.0036
Schistosoma mansoni notch 0.0009 0.0002 0.0002
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0439 0.0439
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0384 0.5008
Loa Loa (eye worm) hypothetical protein 0.0042 0.0334 0.1106
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0115
Schistosoma mansoni opsin-like receptor 0.0009 0.0008 0.0008
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0334 0.0334
Echinococcus multilocularis sphingosine kinase 1 0.0309 0.3007 0.3007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Brugia malayi larval opioid receptor 0.0009 0.0008 0.0027
Echinococcus granulosus Diacylglycerol kinase zeta 0.0012 0.0036 0.0036
Brugia malayi putative neuropeptide receptor NPR1 0.0009 0.0008 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0384 0.0384
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi Dopamine receptor protein 2 0.0009 0.0008 0.0027
Toxoplasma gondii cell division protein CDC48CY 0.0086 0.0775 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0078 0.0987
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0424 0.5578
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0008 0.0008
Echinococcus granulosus sphingosine kinase 1 0.0309 0.3007 0.3007
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0334 0.0334
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni myosin xvIII 0.0009 0.0008 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.0012
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0072 0.0072
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) VCP protein 0.0036 0.0271 0.0896
Echinococcus multilocularis serotonin receptor 0.0009 0.0008 0.0008
Echinococcus granulosus neurogenic locus notch protein 4 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi Eye-specific diacylglycerol kinase 0.0012 0.0036 0.0148
Plasmodium vivax cell division cycle protein 48 homologue, putative 0.0081 0.0731 0.4153
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0009 0.0008 0.0021
Echinococcus granulosus hypothetical protein 0.0009 0.0008 0.0008
Brugia malayi RE15519p 0.0009 0.0008 0.0027
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0036 0.0471
Loa Loa (eye worm) hypothetical protein 0.0023 0.0151 0.0495
Echinococcus granulosus 7TM GPCR rhodopsin 0.0009 0.0008 0.0008
Echinococcus multilocularis neurogenic locus notch protein 4 0.0009 0.0002 0.0002
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0906 0.0906
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0151 0.1646
Schistosoma mansoni laminin gamma-3 chain 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni protein kinase 0.0173 0.1648 0.1648
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0541 0.0541
Onchocerca volvulus Peroxidase homolog 0.0027 0.0182 0.1055
Echinococcus multilocularis lipoxygenase domain containing protein 0.0179 0.1708 0.1708
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0008 0.0008
Brugia malayi TAR-binding protein 0.0062 0.0541 0.231
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0078 0.025
Mycobacterium tuberculosis Diacylglycerol kinase 0.0012 0.0036 0.0121
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Leishmania major trypanothione reductase 0.0047 0.0384 0.5008
Entamoeba histolytica cdc48-like protein, putative 0.0081 0.0731 0.2336
Onchocerca volvulus 0.0029 0.0207 0.1199
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Loa Loa (eye worm) hypothetical protein 0.0023 0.0151 0.0495
Brugia malayi nuclear hormone receptor 0.001 0.0018 0.007
Echinococcus granulosus tar DNA binding protein 0.0062 0.0541 0.0541
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0052 0.0439 0.1455
Echinococcus granulosus notch 0.0009 0.0002 0.0002
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0008 0.0008
Schistosoma mansoni loxhd1 0.0179 0.1708 0.1708
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0009 0.0008 0.0021
Brugia malayi hypothetical protein 0.0179 0.1708 0.7314
Echinococcus granulosus protein jagged 2 0.0009 0.0002 0.0002
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0018 0.0096
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0008 0.0008
Treponema pallidum NADH oxidase 0.0016 0.0078 1
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Schistosoma mansoni coup transcription factor 0.001 0.0018 0.0018
Echinococcus granulosus protein jagged 1 0.0009 0.0002 0.0002
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0086 0.0775 0.0775
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0012 0.0036 0.0036
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0072 0.051
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis neuropeptide FF receptor 2 0.0009 0.0008 0.0008
Echinococcus granulosus somatostatin receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis protein dispatched 1 0.0048 0.0393 0.0393
Schistosoma mansoni notch 0.0009 0.0002 0.0002
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.0793
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Toxoplasma gondii cell division protein CDC48AP 0.0051 0.043 0.5538
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0162 0.1539 0.1539
Echinococcus granulosus dro:myosuppressin receptor 0.0009 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.0686 0.6775 0.6775
Onchocerca volvulus 0.0009 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0018
Echinococcus multilocularis slit 2 protein 0.0009 0.0002 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0018 0.0018
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0018 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.007
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0008 0.0008
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0051 0.0424 0.0424
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0018 0.0054
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0036 0.0471
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0018 0.0054
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0002 0.0002
Echinococcus multilocularis orexin receptor type 2 0.0009 0.0008 0.0008
Echinococcus granulosus Polycystic kidney disease protein 0.0179 0.1708 0.1708
Brugia malayi G protein-coupled receptor F59B2.13 0.0009 0.0008 0.0027
Echinococcus multilocularis 0.0122 0.114 0.114
Toxoplasma gondii diacylglycerol kinase, putative 0.0012 0.0036 0.0447
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0072 0.0212
Plasmodium falciparum glutathione reductase 0.0016 0.0078 0.025
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0182 0.0772
Schistosoma mansoni amine GPCR 0.0009 0.0008 0.0008
Trypanosoma brucei Valosin-containing protein 0.0081 0.0731 1
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0384 0.1277
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0008
Onchocerca volvulus 0.0009 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni neuropeptide receptor 0.0009 0.0008 0.0008
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0018 0.0018
Brugia malayi neuropeptide F receptor 0.0009 0.0008 0.0027
Onchocerca volvulus 0.0009 0.0008 0.0036
Echinococcus granulosus allatostatin A receptor 0.0009 0.0008 0.0008
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0078 1
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0008
Entamoeba histolytica transitional endoplasmic reticulum ATPase, putative 0.0081 0.0731 0.2336
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0012 0.0036 0.0471
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0018 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0018 0.007
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0151 0.0501
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0009 0.0008 0.0027
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0008 0.0008
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.051
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0183 0.1748 0.581
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.0793
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0002 0.0002
Echinococcus granulosus neuropeptide receptor A26 0.0009 0.0008 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0009 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0018 0.007
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus multilocularis protein patched 0.0042 0.0334 0.0334
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0151 0.1646
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0052 0.0439 0.0439
Schistosoma mansoni peroxidasin 0.0027 0.0182 0.0182
Schistosoma mansoni serine/threonine protein kinase 0.0052 0.0439 0.0439
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0984 0.3271
Schistosoma mansoni alpha-1 adrenergic receptor 0.0009 0.0008 0.0008
Echinococcus granulosus Vam6:Vps39 protein 0.0051 0.0424 0.0424
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0078 0.101
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus granulosus transitional endoplasmic reticulum atpase 0.0086 0.0775 0.0775
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Schistosoma mansoni cpg binding protein 0.0029 0.0207 0.0207
Schistosoma mansoni polycystin 1-related 0.0179 0.1708 0.1708
Loa Loa (eye worm) hypothetical protein 0.0179 0.1708 0.5676
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0984 0.3271
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0272 0.0272
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0541 0.1793
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Trichomonas vaginalis spermatogenesis associated factor, putative 0.0086 0.0775 1
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Onchocerca volvulus 0.0009 0.0008 0.0036
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.1103 0.3667
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0091 0.0304
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0366 0.358 0.358
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0009 0.0008 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0018 0.0054
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0009 0.0008 0.0027
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0182 0.1055
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0151 0.0385
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0151 0.0501
Schistosoma mansoni growth hormone secretagogue receptor 0.0009 0.0008 0.0008
Echinococcus granulosus cpg binding protein 0.0031 0.0223 0.0223
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0122 0.114 0.3788
Brugia malayi Melatonin receptor type 1A 0.0009 0.0008 0.0027
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0008 0.0008
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0009 0.0008 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0182 0.0772
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0018
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus granulosus delta-like protein 1 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi G-protein coupled receptor 0.0009 0.0008 0.0027
Schistosoma mansoni hypothetical protein 0.004 0.0319 0.0319
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0008 0.0021
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0207 0.0681
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0151 0.0501
Brugia malayi Doublecortin family protein 0.0179 0.1708 0.7314
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) glutathione reductase 0.0047 0.0384 0.1271
Schistosoma mansoni serine/threonine protein kinase 0.0183 0.1748 0.1748
Schistosoma mansoni nuclear hormone receptor 0.001 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0036 0.0036
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0009 0.0008 0.0008
Brugia malayi valosin containing protein 0.005 0.042 0.1791
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0009 0.0008 0.0008
Onchocerca volvulus 0.0051 0.0424 0.2472
Echinococcus granulosus neuropeptide FF receptor 2 0.0009 0.0008 0.0008
Brugia malayi sulfakinin receptor protein 0.0009 0.0008 0.0027
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0183 0.1748 0.1748
Echinococcus multilocularis fmrfamide receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Schistosoma mansoni protein kinase 0.0122 0.114 0.114
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0009 0.0008 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0172 0.1632 0.1632
Echinococcus granulosus neuropeptide receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0052 0.0439 0.0439
Loa Loa (eye worm) hypothetical protein 0.0172 0.1632 0.5425
Brugia malayi hypothetical protein 0.0051 0.0424 0.1808
Brugia malayi putative neuropeptide receptor 0.0009 0.0008 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0018 0.0054
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0151 0.0638
Schistosoma mansoni notch 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni vam6/vps39 related 0.0051 0.0424 0.0424
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0018 0.0054
Echinococcus granulosus g protein coupled receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0018 0.007
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0051 0.0424 0.0424
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0012 0.0036 0.0036
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0162 0.1539 0.6589
Onchocerca volvulus Neuropeptide F receptor homolog 0.0009 0.0008 0.0036
Onchocerca volvulus 0.0027 0.0182 0.1055
Schistosoma mansoni cell division control protein 48 aaa family protein 0.0036 0.0271 0.0271
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0298
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Brugia malayi follicle stimulating hormone receptor 0.0242 0.2334 1
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0115
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0424 0.5578
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0086 0.0775 0.0775
Loa Loa (eye worm) hypothetical protein 0.0097 0.0891 0.2957
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Mycobacterium ulcerans ATPase 0.0051 0.043 0.143
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0009 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0031 0.0223 0.0223
Onchocerca volvulus 0.0009 0.0008 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0151 0.0501
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0384 0.208
Loa Loa (eye worm) hypothetical protein 0.0051 0.0424 0.1403
Schistosoma mansoni hypothetical protein 0.0051 0.0424 0.0424
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0984 0.3271
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Plasmodium falciparum thioredoxin reductase 0.0047 0.0384 0.208
Schistosoma mansoni biogenic amine (5HT) receptor 0.0009 0.0008 0.0008
Echinococcus granulosus lipoxygenase domain containing protein 0.0179 0.1708 0.1708
Echinococcus multilocularis transitional endoplasmic reticulum atpase 0.0036 0.0271 0.0271
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.0891 0.2875
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.0151 0.0495
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0091 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0151 0.0501
Echinococcus granulosus neural cadherin 0.0009 0.0002 0.0002
Plasmodium falciparum LCCL domain-containing protein 0.0179 0.1708 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0298
Onchocerca volvulus 0.0023 0.0151 0.0872
Brugia malayi Protein kinase domain containing protein 0.0162 0.1539 0.6589
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0008 0.0008
Schistosoma mansoni neuropeptide receptor 0.0009 0.0008 0.0008
Brugia malayi Ceramide kinase 0.0012 0.0036 0.0148
Brugia malayi steroid hormone receptor 0.001 0.0018 0.007
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0009 0.0008 0.0008
Loa Loa (eye worm) ceramide kinase 0.0012 0.0036 0.0115
Schistosoma mansoni microtubule-associated protein tau 0.0698 0.6895 0.6895
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis neuropeptides capa receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0091 0.0304
Schistosoma mansoni amine GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0162 0.1539 0.5114
Loa Loa (eye worm) hypothetical protein 0.0179 0.1708 0.5676
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0384 0.1271
Loa Loa (eye worm) hypothetical protein 0.0051 0.0424 0.1403
Mycobacterium ulcerans hypothetical protein 0.0309 0.3007 1
Echinococcus multilocularis serotonin receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1309 0.1309
Trypanosoma cruzi Valosin-containing protein, putative 0.0081 0.0731 1
Schistosoma mansoni biogenic amine receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0018 0.0054
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus 7tm_1 domain containing protein 0.0009 0.0008 0.0008
Brugia malayi diacylglycerol kinase 0.0012 0.0036 0.0148
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0078 0.026
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0151 0.0501
Echinococcus granulosus lipoxygenase domain containing protein 0.0179 0.1708 0.1708
Echinococcus granulosus neurogenic locus notch protein 0.0009 0.0002 0.0002
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0009 0.0008 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Schistosoma mansoni septate junction protein 0.0009 0.0002 0.0002
Schistosoma mansoni rap gtpase-activating protein 0.0051 0.0424 0.0424
Echinococcus multilocularis dro:myosuppressin receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0008 0.0008
Schistosoma mansoni cell polarity protein 0.0009 0.0002 0.0002
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0072 0.03
Mycobacterium ulcerans diacylglycerol kinase 0.0012 0.0036 0.0121
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0072 0.0905
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0018 0.007
Onchocerca volvulus 0.0009 0.0008 0.0036
Brugia malayi Thioredoxin reductase 0.0047 0.0384 0.1638
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0082 0.0272
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.4053 0.4053
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0018 0.0096
Loa Loa (eye worm) diacylglycerol kinase 2 0.0012 0.0036 0.0115
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Plasmodium vivax cell division cycle ATPase, putative 0.0031 0.0227 0.114
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0009 0.0008 0.0021
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0018
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0078 0.1782
Onchocerca volvulus 0.0009 0.0008 0.0036
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) G-protein coupled receptor 0.0009 0.0008 0.0021
Loa Loa (eye worm) melatonin receptor type 1A 0.0009 0.0008 0.0021
Echinococcus multilocularis protein jagged 1 0.0009 0.0002 0.0002
Echinococcus granulosus peroxidasin 0.0027 0.0182 0.0182
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Schistosoma mansoni rab6-interacting 0.0179 0.1708 0.1708
Echinococcus granulosus biogenic amine 5HT receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0008 0.0008
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0151 0.0501
Mycobacterium ulcerans hypothetical protein 0.0023 0.0151 0.0501
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0009 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0036 0.0272 0.0272
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0035 0.0142
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Brugia malayi G protein-coupled receptor 0.0009 0.0008 0.0027
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0072 0.051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0008 0.0021
Onchocerca volvulus 0.0027 0.0182 0.1055
Onchocerca volvulus 0.0012 0.0036 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0036 0.0471
Mycobacterium tuberculosis Conserved protein 0.0309 0.3007 1
Brugia malayi Serotonin receptor 0.0009 0.0008 0.0027
Brugia malayi ecdysteroid receptor 0.001 0.0018 0.007
Echinococcus granulosus FTZ F1 alpha 0.001 0.0018 0.0018
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0151 0.1367
Loa Loa (eye worm) neuropeptide F receptor 0.0009 0.0008 0.0021
Echinococcus multilocularis neural cadherin 0.0009 0.0002 0.0002
Onchocerca volvulus 0.0009 0.0008 0.0036
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Mycobacterium tuberculosis Probable reductase 0.0107 0.0984 0.3271
Leishmania major Transitional endoplasmic reticulum ATPase, putative,valosin-containing protein homolog 0.0081 0.0731 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.051
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0008 0.0008
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0072 0.0072
Echinococcus multilocularis G-protein coupled receptor, putative 0.0009 0.0008 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Echinococcus multilocularis lipoxygenase domain containing protein 0.0179 0.1708 0.1708
Onchocerca volvulus 0.0179 0.1708 1
Brugia malayi ORL1-like opioid receptor 0.0009 0.0008 0.0027
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0009 0.0008 0.0008
Toxoplasma gondii transitional endoplasmic reticulum ATPase, putative 0.0051 0.043 0.5538
Brugia malayi probable protein kinase 0.0173 0.1648 0.7056
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0008 0.0008
Schistosoma mansoni biogenic amine receptor 0.0009 0.0008 0.0008
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.0891 0.3809
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0162 0.1539 0.9009
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0009 0.0008 0.0008
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0984 0.892
Echinococcus granulosus ceramide kinase 0.0012 0.0036 0.0036
Echinococcus multilocularis microtubule associated protein 2 0.0698 0.6895 0.6895
Echinococcus multilocularis sex peptide receptor 0.0009 0.0008 0.0008
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0078 0.025
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0012 0.0036 0.0036
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0334 0.1106
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0078 0.0987
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.1103 0.3667
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0012 0.0036 0.0447
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0078 0.026
Onchocerca volvulus 0.0009 0.0008 0.0036
Loa Loa (eye worm) TYRA-2 protein 0.0009 0.0008 0.0021
Toxoplasma gondii thioredoxin reductase 0.0047 0.0384 0.4945
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0052 0.0439 0.0439
Brugia malayi hypothetical protein 0.0027 0.0182 0.0772
Trichomonas vaginalis 26S protease regulatory subunit S10b, putative 0.002 0.0119 0.1537
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0009 0.0002 0.0002
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.0006
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0151 0.0385
Brugia malayi Blistered cuticle protein 3 0.0027 0.0182 0.0772
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0162 0.1539 0.1539
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Onchocerca volvulus 0.0009 0.0008 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0018 0.0018
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0182 0.0599
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0182 0.0599
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0541 0.1793
Schistosoma mansoni patched 1 0.0042 0.0334 0.0334
Schistosoma mansoni rab6-interacting 0.0179 0.1708 0.1708
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0182 0.0772
Brugia malayi G-protein coupled receptor 0.0009 0.0008 0.0027
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0009 0.0008 0.0036
Onchocerca volvulus 0.0009 0.0008 0.0036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0008 0.0008
Giardia lamblia AAA family ATPase 0.0051 0.043 1
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0012 0.0036 0.0036
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0078 0.026
Plasmodium falciparum cell division cycle protein 48 homologue, putative 0.0081 0.0731 0.4153
Schistosoma mansoni diacylglycerol kinase theta 0.0012 0.0036 0.0036
Echinococcus multilocularis RUN 0.0179 0.1708 0.1708
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0151 0.0385
Schistosoma mansoni notch 0.0009 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.001 0.0018 0.0054
Onchocerca volvulus 0.001 0.0018 0.0096
Schistosoma mansoni hypothetical protein 0.004 0.0319 0.0319
Entamoeba histolytica hypothetical protein, conserved 0.0309 0.3007 1
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0182 0.0599
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0072 0.0072
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0182 0.0772
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0072 0.0239
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0541 0.0541
Echinococcus multilocularis expressed conserved protein 0.0092 0.0831 0.0831
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0541 0.0541
Schistosoma mansoni hypothetical protein 0.0179 0.1708 0.1708
Plasmodium vivax multidomain scavenger receptor, putative 0.0179 0.1708 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0984 0.3271
Echinococcus granulosus alpha 1A adrenergic receptor 0.0009 0.0008 0.0008
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0182 0.1055
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0012 0.0036 0.0115
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0242 0.2334 0.7761
Brugia malayi vesicle-fusing ATPase 0.005 0.042 0.1791
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0051 0.0424 0.5578
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Echinococcus multilocularis peroxidasin 0.0027 0.0182 0.0182
Echinococcus multilocularis Diacylglycerol kinase theta 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0309 0.3007 1
Brugia malayi Dopamine receptor protein 1 0.0009 0.0008 0.0027
Brugia malayi neuropeptide F receptor 0.0009 0.0008 0.0027
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0051 0.0428 0.1419
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0009 0.0008 0.0008
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0078 0.0602
Trypanosoma brucei trypanothione reductase 0.0047 0.0384 0.5008
Echinococcus granulosus g protein coupled receptor 0.0009 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0009 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0541 0.0541
Plasmodium vivax glutathione reductase, putative 0.0047 0.0384 0.208
Schistosoma mansoni amine GPCR 0.0009 0.0008 0.0008
Echinococcus multilocularis protein jagged 2 0.0009 0.0002 0.0002
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0078 0.0602
Schistosoma mansoni neuropeptide f receptor 76f 0.0009 0.0008 0.0008
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0984 0.3271
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0082 0.0272
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0012 0.0036 0.0447
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0072 0.0072
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0078 0.101
Trichomonas vaginalis bmru protein, putative 0.0012 0.0036 0.0471
Brugia malayi GnHR receptor homolog 0.0009 0.0008 0.0027
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0298
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0466 0.6009
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0009 0.0008 0.0008
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0541 0.231
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.1103 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0151 0.0501
Echinococcus multilocularis protein jagged 1 0.0009 0.0002 0.0002
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0151 0.1646
Echinococcus granulosus g-protein coupled receptor 0.0009 0.0008 0.0008
Schistosoma mansoni opsin-like receptor 0.0009 0.0008 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0018 0.0018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Echinococcus granulosus neuropeptides capa receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0182 0.0599
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0078 0.026
Loa Loa (eye worm) hypothetical protein 0.0018 0.0091 0.0298
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0008 0.0008
Echinococcus granulosus neuropeptide receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0018 0.0054
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0009 0.0008 0.0008
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.1103 0.3667
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0012 0.0036 0.0471
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Brugia malayi glutathione reductase 0.0047 0.0384 0.1638
Schistosoma mansoni slit 0.0009 0.0002 0.0002
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0162 0.1539 0.5114
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.0891 0.0891
Brugia malayi isocitrate dehydrogenase 0.0016 0.0072 0.03
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0002 0.0002
Brugia malayi hypothetical protein 0.0179 0.1708 0.7314
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0602
Brugia malayi transitional endoplasmic reticulum ATPase TER94, putative 0.0036 0.0271 0.1154
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0009 0.0008 0.0008
Onchocerca volvulus Peroxidase homolog 0.0027 0.0182 0.1055
Echinococcus granulosus RUN 0.0179 0.1708 0.1708
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0035 0.0142
Brugia malayi nuclear receptor NHR-88 0.001 0.0018 0.007
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0018 0.0018
Loa Loa (eye worm) RNA binding protein 0.0062 0.0541 0.1793
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0009 0.0008 0.0008
Loa Loa (eye worm) doublecortin family protein 0.0179 0.1708 0.5676
Schistosoma mansoni neuropeptide receptor 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus multilocularis notch 0.0009 0.0002 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0018 0.0018
Schistosoma mansoni cpg binding protein 0.0031 0.0223 0.0223
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Brugia malayi Diacylglycerol kinase protein 2 0.0012 0.0036 0.0148
Brugia malayi hypothetical protein 0.0012 0.0036 0.0148
Echinococcus granulosus G protein coupled receptor 139 0.0009 0.0008 0.0008
Brugia malayi diacylglycerol kinase 0.0012 0.0036 0.0148
Onchocerca volvulus Transitional endoplasmic reticulum ATPase homolog 0.0086 0.0775 0.453
Schistosoma mansoni hypothetical protein 0.0009 0.0002 0.0002
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0334 0.0334
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0272 0.0272
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.007
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0008 0.0008
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0036 0.0471
Schistosoma mansoni peroxidasin 0.0027 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0115
Echinococcus multilocularis g protein coupled receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis neuropeptide receptor 0.0009 0.0008 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.0027 0.0182 0.0599
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0532 0.0532
Echinococcus granulosus rhodopsin orphan GPCR 0.0009 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0018 0.007
Brugia malayi RNA binding protein 0.0062 0.0541 0.231
Trichomonas vaginalis bmru protein, putative 0.0012 0.0036 0.0471
Echinococcus granulosus tachykinin peptides receptor 99D 0.0366 0.358 0.358
Echinococcus granulosus fmrfamide receptor 0.0009 0.0008 0.0008
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0009 0.0008 0.0008
Onchocerca volvulus 0.0179 0.1708 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0009 0.0008 0.0008
Onchocerca volvulus 0.0009 0.0008 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0009 0.0008 0.0027
Brugia malayi Serotonin receptor 0.0009 0.0008 0.0027
Entamoeba histolytica hypothetical protein 0.0036 0.0272 0.0793
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0072 0.0212
Onchocerca volvulus 0.0009 0.0008 0.0036
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0078 0.0602
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.0013
Schistosoma mansoni biogenic amine receptor 0.0009 0.0008 0.0008
Echinococcus granulosus peptide allatostatin:somatostatin 0.0009 0.0008 0.0008
Plasmodium falciparum glutathione reductase 0.0047 0.0384 0.208
Onchocerca volvulus 0.0009 0.0008 0.0036
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0091 0.0329
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0018 0.0018
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0182 0.0599
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0151 0.1367
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0009 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.1008 1 1
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0072 0.0905
Onchocerca volvulus 0.0027 0.0182 0.1055
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0182 0.0772
Echinococcus multilocularis neuropeptide s receptor 0.0009 0.0008 0.0008
Echinococcus granulosus neurogenic locus protein delta 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0018 0.007
Echinococcus granulosus protein jagged 1 0.0009 0.0002 0.0002
Trichomonas vaginalis diacylglycerol kinase, putative 0.0012 0.0036 0.0471
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0072 0.051
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0439 0.0439
Echinococcus granulosus orexin receptor type 2 0.0009 0.0008 0.0008
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Schistosoma mansoni sphingoid long chain base kinase 0.0309 0.3007 0.3007
Echinococcus multilocularis ceramide kinase 0.0012 0.0036 0.0036
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0018 0.0018
Echinococcus multilocularis allatostatin A receptor 0.0009 0.0008 0.0008
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0009 0.0008 0.0008
Echinococcus granulosus neuropeptide Y receptor 0.0009 0.0008 0.0008
Echinococcus multilocularis Polycystic kidney disease protein 0.0179 0.1708 0.1708
Echinococcus granulosus serotonin receptor 0.0009 0.0008 0.0008
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0078 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0018 0.007
Onchocerca volvulus 0.0009 0.0008 0.0036
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0182 0.1055
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0078 0.025
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0151 0.0638
Schistosoma mansoni hypothetical protein 0.004 0.0319 0.0319
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0183 0.1748 0.1748
Schistosoma mansoni hypothetical protein 0.004 0.0319 0.0319
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0009 0.0008 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0541 0.0541
Echinococcus multilocularis neurogenic locus notch protein 0.0009 0.0002 0.0002
Brugia malayi hypothetical protein 0.0009 0.0008 0.0027
Echinococcus granulosus microtubule associated protein 2 0.0698 0.6895 0.6895
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0018 0.0018
Brugia malayi CHE-14 protein 0.0042 0.0334 0.1425
Onchocerca volvulus 0.0009 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0051 0.0424 0.1403
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0082 0.0272
Schistosoma mansoni serine/threonine protein kinase 0.0162 0.1539 0.1539
Echinococcus multilocularis neuropeptide receptor A26 0.0009 0.0008 0.0008
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0009 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0009 0.0008 0.0008
Trichomonas vaginalis sphingosine kinase, putative 0.0012 0.0036 0.0471
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0018 0.007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0009 0.0008 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0009 0.0008 0.0008
Echinococcus granulosus tm gpcr rhodopsin 0.0009 0.0008 0.0008
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0052 0.0439 0.0439
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0151 0.0501
Echinococcus multilocularis neurogenic locus protein delta 0.0009 0.0002 0.0002
Schistosoma mansoni thyroid hormone receptor 0.001 0.0018 0.0018
Brugia malayi map kinase activated protein kinase protein 2 0.0183 0.1748 0.7486
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0051 0.0424 0.0424
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0009 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0414 0.4053 0.4053
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0018 0.0096
Schistosoma mansoni protein kinase 0.0052 0.0439 0.0439
Echinococcus multilocularis fibropellin Ia 0.0009 0.0002 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0018 0.007
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0151 0.0638
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0018 0.0018
Echinococcus granulosus protein jagged 2 0.0009 0.0002 0.0002
Echinococcus multilocularis cpg binding protein 0.0031 0.0223 0.0223
Echinococcus granulosus fibropellin Ia 0.0009 0.0002 0.0002
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0051 0.0424 0.0424
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0018 0.0018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0078 0.0327
Loa Loa (eye worm) hypothetical protein 0.0009 0.0008 0.0021
Brugia malayi Dopamine receptor 0.0009 0.0008 0.0027
Echinococcus granulosus neuropeptide s receptor 0.0009 0.0008 0.0008
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0018 0.0018
Echinococcus granulosus sex peptide receptor 0.0009 0.0008 0.0008
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0078 0.0602
Loa Loa (eye worm) hypothetical protein 0.005 0.042 0.139
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0182 0.1055
Brugia malayi Peroxidasin 0.0027 0.0182 0.0772
Onchocerca volvulus 0.0009 0.0008 0.0036

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 16 nM Antagonist activity at human NK3 receptor expressed in CHO cells assessed as inhibition of senktide-induced calcium flux by FLIPR assay ChEMBL. 21320776

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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