Detailed information for compound 1505812

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 299.272 | Formula: C17H11F2NO2
  • H donors: 1 H acceptors: 2 LogP: 3.84 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1cccn1c1cc(F)c(c(c1)F)O)c1ccccc1
  • InChi: 1S/C17H11F2NO2/c18-13-9-12(10-14(19)17(13)22)20-8-4-7-15(20)16(21)11-5-2-1-3-6-11/h1-10,22H
  • InChiKey: JIEFSNXCHIBURK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 329 aa 19.8 %
Onchocerca volvulus Aldose reductase   316 aa 314 aa 37.3 %
Onchocerca volvulus Aldose reductase   316 aa 321 aa 40.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   316 aa 277 aa 37.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   316 aa 320 aa 40.3 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   316 aa 320 aa 19.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 330 aa 18.8 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   316 aa 295 aa 21.4 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   316 aa 296 aa 26.7 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   316 aa 335 aa 24.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   316 aa 281 aa 29.2 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   316 aa 320 aa 19.4 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   316 aa 309 aa 26.9 %
Leishmania braziliensis aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   316 aa 267 aa 27.3 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   316 aa 334 aa 24.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.4393
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0035 0.0186 0.0252
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.04 0.0297
Onchocerca volvulus 0.0052 0.0582 0.113
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0035 0.0186 0.0252
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0582 0.0551
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.04 0.284
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0186 0.0252
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0468 0.0634
Onchocerca volvulus Bile acid receptor homolog 0.0186 0.3689 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0468 0.0634
Entamoeba histolytica 3-oxo-5-alpha-steroid 4-dehydrogenase domain-containing protein 0.0044 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Schistosoma mansoni carbonic anhydrase-related 0.006 0.0759 0.0798
Trichomonas vaginalis spcc417.12 protein, putative 0.0052 0.0582 1
Onchocerca volvulus 0.0052 0.0582 0.113
Loa Loa (eye worm) oxidoreductase 0.0038 0.0257 0.0099
Onchocerca volvulus 0.0038 0.0257 0.0203
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.006 0.0759 0.0798
Brugia malayi Carboxylesterase family protein 0.0052 0.0582 0.0551
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0582 0.0551
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Onchocerca volvulus 0.0038 0.0257 0.0203
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.04 0.284
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0257 0.0099
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0582 0.0551
Brugia malayi ecdysteroid receptor 0.0186 0.3689 0.4872
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.04 0.4393
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.4393
Schistosoma mansoni thyroid hormone receptor 0.016 0.3083 0.4028
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0263 0.5464 1
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0345 0.7378 1
Plasmodium vivax 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0297
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0257 0.0099
Brugia malayi Carboxylesterase family protein 0.0052 0.0582 0.0551
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0052 0.0582 0.0333
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0263 0.5464 0.7339
Echinococcus multilocularis carbonic anhydrase 0.006 0.0759 0.1029
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0052 0.0582 0.0333
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0186 0.0252
Leishmania major 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein 0.0044 0.04 0.0274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0035 0.0186 0.0252
Leishmania major carbonic anhydrase-like protein 0.0263 0.5464 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0566 0.0529
Entamoeba histolytica steroid 5-alpha reductase, putative 0.0044 0.04 1
Echinococcus multilocularis carboxylesterase 5A 0.0052 0.0582 0.0788
Loa Loa (eye worm) oxidoreductase 0.0038 0.0257 0.0099
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0263 0.5464 0.7339
Echinococcus granulosus BC026374 protein S09 family 0.0052 0.0582 0.0788
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0052 0.0582 0.0788
Onchocerca volvulus 0.0038 0.0257 0.0203
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0468 0.0392
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.006 0.0759 0.0798
Echinococcus multilocularis aldo keto reductase 0.0038 0.0257 0.0348
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.04 0.4393
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0345 0.7378 1
Loa Loa (eye worm) hypothetical protein 0.0186 0.3689 0.4872
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Schistosoma mansoni carbonic anhydrase-related 0.006 0.0759 0.0798
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.0274
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.2267 0.3073
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0035 0.0186 0.0252
Schistosoma mansoni pol-related 0.0038 0.0257 0.0099
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0052 0.0582 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0468 0.0392
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0257 0.0099
Echinococcus granulosus aldo keto reductase 0.0038 0.0257 0.0348
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0468 0.0392
Echinococcus multilocularis acetylcholinesterase 0.0052 0.0582 0.0788
Brugia malayi 3-oxo-5-alpha-steroid 4-dehydrogenase 1 0.0044 0.04 0.0297
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Schistosoma mansoni hypothetical protein 0.0179 0.352 0.4636
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Trypanosoma brucei carbonic anhydrase-like protein 0.0263 0.5464 1
Schistosoma mansoni BC026374 protein (S09 family) 0.0052 0.0582 0.0551
Echinococcus multilocularis acetylcholinesterase 0.0052 0.0582 0.0788
Loa Loa (eye worm) carboxylesterase 0.0052 0.0582 0.0551
Schistosoma mansoni synaptic glycoprotein sc2 related 0.0044 0.04 0.0297
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0035 0.0186 0.0252
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0263 0.5464 1
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0345 0.7378 1
Echinococcus multilocularis FTZ F1 alpha 0.0035 0.0186 0.0252
Onchocerca volvulus 0.0052 0.0582 0.113
Brugia malayi hypothetical protein 0.0052 0.0582 0.0551
Loa Loa (eye worm) oxidoreductase 0.0038 0.0257 0.0099
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0263 0.5464 0.7339
Entamoeba histolytica trans-2,3-enoyl-CoA reductase, putative 0.0044 0.04 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0035 0.0186 0.0252
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0263 0.5464 0.7339
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Echinococcus multilocularis geminin 0.0179 0.352 0.4771
Loa Loa (eye worm) hypothetical protein 0.006 0.0759 0.0798
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0035 0.0186 0.0252
Echinococcus granulosus hypothetical protein 0.0038 0.0257 0.0348
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Echinococcus granulosus acetylcholinesterase 0.0052 0.0582 0.0788
Loa Loa (eye worm) oxidoreductase 0.0038 0.0257 0.0099
Entamoeba histolytica hypothetical protein 0.0044 0.04 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.006 0.0759 0.0798
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0566 0.0529
Echinococcus granulosus acetylcholinesterase 0.0052 0.0582 0.0788
Echinococcus multilocularis aldo keto reductase 0.0038 0.0257 0.0348
Echinococcus granulosus para nitrobenzyl esterase 0.0052 0.0582 0.0788
Schistosoma mansoni neuroligin 3 (S09 family) 0.0052 0.0582 0.0551
Brugia malayi Synaptic glycoprotein SC2 0.0044 0.04 0.0297
Schistosoma mansoni aldo-keto reductase 0.0038 0.0257 0.0099
Echinococcus granulosus ecdysone induced protein 78C 0.0035 0.0186 0.0252
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0035 0.0186 0.0252
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Loa Loa (eye worm) carboxylesterase 0.0052 0.0582 0.0551
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Brugia malayi Carboxylesterase family protein 0.0052 0.0582 0.0551
Brugia malayi Carboxylesterase family protein 0.0052 0.0582 0.0551
Echinococcus granulosus carbonic anhydrase 0.006 0.0759 0.1029
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.0274
Onchocerca volvulus 0.0038 0.0257 0.0203
Echinococcus granulosus carboxylesterase 5A 0.0052 0.0582 0.0788
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0035 0.0186 0.0252
Trypanosoma cruzi 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.0274
Plasmodium falciparum carbonic anhydrase 0.006 0.0759 1
Echinococcus granulosus carbonic anhydrase II 0.0263 0.5464 0.7406
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0297
Loa Loa (eye worm) hypothetical protein 0.0038 0.0257 0.0099
Echinococcus granulosus 3 oxo 5 alpha steroid 4 dehydrogenase C terminal 0.0044 0.04 0.0542
Echinococcus multilocularis ecdysone induced protein 78C 0.0035 0.0186 0.0252
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Schistosoma mansoni aldo-keto reductase 0.0038 0.0257 0.0099
Loa Loa (eye worm) carbonic anhydrase 3 0.0263 0.5464 0.7339
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0468 0.0634
Loa Loa (eye worm) oxidoreductase 0.0038 0.0257 0.0099
Echinococcus multilocularis para nitrobenzyl esterase 0.0052 0.0582 0.0788
Echinococcus multilocularis 3 oxo 5 alpha steroid 4 dehydrogenase, C terminal 0.0044 0.04 0.0542
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.2267 0.3073
Schistosoma mansoni hypothetical protein 0.006 0.0759 0.0798
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0566 0.0529
Echinococcus multilocularis carbonic anhydrase II 0.0263 0.5464 0.7406
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Echinococcus multilocularis thyroid hormone receptor alpha 0.016 0.3083 0.4178
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0345 0.7378 1
Brugia malayi Carboxylesterase family protein 0.0052 0.0582 0.0551
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Echinococcus multilocularis synaptic glycoprotein sc2 0.0044 0.04 0.0542
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0188 0.0003
Onchocerca volvulus 0.0044 0.04 0.061
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.4393
Echinococcus multilocularis BC026374 protein (S09 family) 0.0052 0.0582 0.0788
Echinococcus multilocularis carbonic anhydrase 0.006 0.0759 0.1029
Onchocerca volvulus 0.0052 0.0582 0.113
Schistosoma mansoni carbonic anhydrase-related 0.006 0.0759 0.0798
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.4393
Giardia lamblia Synaptic glycoprotein SC2 0.0044 0.04 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.006 0.0759 0.0798
Trypanosoma brucei 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative 0.0044 0.04 0.0274
Toxoplasma gondii hypothetical protein 0.006 0.0759 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0468 0.0634
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0257 1
Trichomonas vaginalis 3-oxo-5-alpha-steroid 4-dehydrogenase, putative 0.0044 0.04 0.4393
Echinococcus granulosus geminin 0.0179 0.352 0.4771
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Echinococcus granulosus carbonic anhydrase 0.006 0.0759 0.1029
Echinococcus granulosus synaptic glycoprotein sc2 0.0044 0.04 0.0542
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0035 0.0186 0.0252
Loa Loa (eye worm) acetylcholinesterase 1 0.0052 0.0582 0.0551
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0035 0.0186 0.0252
Brugia malayi Carboxylesterase family protein 0.0052 0.0582 0.0551
Echinococcus multilocularis carbonic anhydrase 0.006 0.0759 0.1029
Echinococcus granulosus neuroligin 0.0052 0.0582 0.0788
Echinococcus multilocularis neuroligin 0.0052 0.0582 0.0788
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0052 0.0582 0.0788
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Loa Loa (eye worm) carboxylesterase 0.0052 0.0582 0.0551
Schistosoma mansoni hypothetical protein 0.0035 0.0188 0.0003
Schistosoma mansoni hypothetical protein 0.0179 0.352 0.4636
Trichomonas vaginalis synaptic glycoprotein sc2, putative 0.0044 0.04 0.4393
Loa Loa (eye worm) hypothetical protein 0.006 0.0759 0.0798
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0257 0.0099
Onchocerca volvulus 0.0038 0.0257 0.0203
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.006 0.0759 0.0798
Echinococcus granulosus FTZ F1 alpha 0.0035 0.0186 0.0252
Loa Loa (eye worm) hypothetical protein 0.0052 0.0566 0.0529
Onchocerca volvulus 0.0038 0.0257 0.0203
Echinococcus granulosus aldo keto reductase 0.0038 0.0257 0.0348
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Toxoplasma gondii 3-oxo-5-alpha-steroid 4-dehydrogenase 0.0044 0.04 0.284
Plasmodium vivax polyprenol reductase, putative 0.0044 0.04 0.5
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0263 0.5464 0.7339
Mycobacterium ulcerans hypothetical protein 0.0044 0.04 0.0146
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0468 0.0392
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0052 0.0582 0.0551
Echinococcus granulosus carbonic anhydrase 0.006 0.0759 0.1029
Loa Loa (eye worm) hypothetical protein 0.0035 0.0188 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0345 0.7378 1
Echinococcus granulosus aldo keto reductase 0.0038 0.0257 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.04 0.4393
Onchocerca volvulus 0.0052 0.0582 0.113
Schistosoma mansoni carbonic anhydrase 0.006 0.0759 0.0798
Schistosoma mansoni acetylcholinesterase 0.0052 0.0582 0.0551
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0468 0.0392
Schistosoma mansoni thyroid hormone receptor 0.016 0.3083 0.4028
Loa Loa (eye worm) hypothetical protein 0.0044 0.04 0.0297
Loa Loa (eye worm) hypothetical protein 0.006 0.0759 0.0798
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.006 0.0759 0.0798
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0257 0.0348
Echinococcus multilocularis aldo keto reductase 0.0038 0.0257 0.0348
Echinococcus multilocularis aldo keto reductase 0.0038 0.0257 0.0348
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0257 0.0348
Schistosoma mansoni hypothetical protein 0.0125 0.2267 0.2894
Loa Loa (eye worm) hypothetical protein 0.0052 0.0582 0.0551
Schistosoma mansoni gliotactin 0.0052 0.0582 0.0551

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.06 uM Inhibition of rat lens ALR2 ChEMBL. 21288726

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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