TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 349.405 | Formula: C20H20FN5
H donors: 1 H acceptors: 2 LogP: 3.04 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CN(CCn1cnc(c1c1ccc2c(c1)cn[nH]2)c1ccc(cc1)F)C
InChi: 1S/C20H20FN5/c1-25(2)9-10-26-13-22-19(14-3-6-17(21)7-4-14)20(26)15-5-8-18-16(11-15)12-23-24-18/h3-8,11-13H,9-10H2,1-2H3,(H,23,24)
InChiKey: BMFRTFUXTDHARJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	Pim-1 proto-oncogene, serine/threonine kinase	Starlite/ChEMBL	References
Homo sapiens	Rho-associated, coiled-coil containing protein kinase 2	Starlite/ChEMBL	References
Homo sapiens	aurora kinase B	Starlite/ChEMBL	References
Homo sapiens	p21 protein (Cdc42/Rac)-activated kinase 4	Starlite/ChEMBL	References
Homo sapiens	Janus kinase 2	Starlite/ChEMBL	References
Homo sapiens	epidermal growth factor receptor	Starlite/ChEMBL	References
Homo sapiens	kinase insert domain receptor	Starlite/ChEMBL	References
Homo sapiens	glycogen synthase kinase 3 beta	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei gambiense	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Tyrosine-protein kinase transforming protein erbB, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	AGC/DMPK/ROCK protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	aurora B kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CMGC/GSK protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	Serine/threonine-protein kinase 12, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Neospora caninum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	IPR002219,Protein kinase C, phorbol ester/diacylglycerol binding,domain-containing	Get druggable targets OG5_131020	All targets in OG5_131020
Brugia malayi	Furin-like cysteine rich region family protein	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania braziliensis	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus multilocularis	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania mexicana	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine-protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania infantum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	IPR006212,Furin-like repeat;IPR009030,Growth factor, receptor,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Trypanosoma brucei	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	serine/threonine-protein kinase PAK 7	Get druggable targets OG5_131977	All targets in OG5_131977
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Brugia malayi	Protein kinase domain containing protein	Get druggable targets OG5_134863	All targets in OG5_134863
Leishmania donovani	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Rho-associated protein kinase 1, putative	Get druggable targets OG5_131020	All targets in OG5_131020
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Plasmodium knowlesi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	Immunoglobulin I-set domain containing protein	Get druggable targets OG5_130320	All targets in OG5_130320
Leishmania major	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	serine:threonine protein kinase 12 B	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	intracellular kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma cruzi	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	rho associated protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Loa Loa (eye worm)	TK/EGFR protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	ko:K05085 receptor tyrosine-protein kinase erbB-4, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium yoelii	putative protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania infantum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_131020	All targets in OG5_131020
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_127024	All targets in OG5_127024
Onchocerca volvulus		Get druggable targets OG5_130320	All targets in OG5_130320
Cryptosporidium parvum	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	Serine/threonine protein kinase required for induction of IME2 by Ime1p	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	ko:K04702 proto-oncogene serine/threonine-protein kinase Pim-1, putative	Get druggable targets OG5_134863	All targets in OG5_134863
Loa Loa (eye worm)	TK/KIN16 protein kinase	Get druggable targets OG5_130320	All targets in OG5_130320
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Onchocerca volvulus		Get druggable targets OG5_131020	All targets in OG5_131020
Candida albicans	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Trypanosoma brucei	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	protein kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Toxoplasma gondii	aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania major	glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270	Get druggable targets OG5_126888	All targets in OG5_126888
Entamoeba histolytica	serine/threonine protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	protein kinase (EC 2.7.1.-) p46XlEg22	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Plasmodium falciparum	glycogen synthase kinase 3	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium falciparum	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08850 aurora kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Leishmania braziliensis	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus	Tyrosine kinase homolog	Get druggable targets OG5_130320	All targets in OG5_130320
Echinococcus multilocularis		Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	rho-associated protein kinase 1	Get druggable targets OG5_131020	All targets in OG5_131020
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Candida albicans	likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu	Get druggable targets OG5_127024	All targets in OG5_127024
Brugia malayi	serine/threonine protein kinase 6	Get druggable targets OG5_127024	All targets in OG5_127024
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Neospora caninum	hypothetical protein	Get druggable targets OG5_127024	All targets in OG5_127024
Babesia bovis	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium berghei	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	serine/threonine kinase 12	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma congolense	aurora B kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Trypanosoma brucei gambiense	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Brugia malayi	Serine/threonine-protein kinase Pim-3	Get druggable targets OG5_134863	All targets in OG5_134863
Cryptosporidium parvum	protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	ko:K08822 glycogen synthase kinase 3 alpha, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	serine/threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Entamoeba histolytica	protein kinase domain containing protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-2 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Aurora kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Plasmodium yoelii	Protein kinase domain, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Loa Loa (eye worm)	CAMK/PIM protein kinase	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus granulosus	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	Receptor tyrosine-protein kinase erbB-4 precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Candida albicans	second truncated form of RIM11 Serine/threonine protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium knowlesi	serine/threonine protein kinase, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Theileria parva	glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Leishmania donovani	Aurora I-related kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Echinococcus multilocularis	epidermal growth factor receptor	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	Get druggable targets OG5_131977	All targets in OG5_131977
Echinococcus granulosus	glycogen synthase kinase 3 beta	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus granulosus	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Schistosoma mansoni	tyrosine kinase	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	Get druggable targets OG5_126888	All targets in OG5_126888
Onchocerca volvulus	Serine\/threonine protein kinase homolog	Get druggable targets OG5_134863	All targets in OG5_134863
Echinococcus multilocularis	protein kinase shaggy	Get druggable targets OG5_126888	All targets in OG5_126888
Schistosoma japonicum	IPR000494,EGF receptor, L domain,domain-containing	Get druggable targets OG5_128597	All targets in OG5_128597
Schistosoma japonicum	expressed protein	Get druggable targets OG5_128597	All targets in OG5_128597
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	hypothetical protein	Get druggable targets OG5_128597	All targets in OG5_128597
Trichomonas vaginalis	CMGC family protein kinase	Get druggable targets OG5_126888	All targets in OG5_126888
Loa Loa (eye worm)	AUR protein kinase	Get druggable targets OG5_127024	All targets in OG5_127024
Schistosoma japonicum	Epidermal growth factor receptor precursor, putative	Get druggable targets OG5_128597	All targets in OG5_128597
Leishmania mexicana	protein kinase, putative,glycogen synthase kinase, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Plasmodium vivax	glycogen synthase kinase 3, putative	Get druggable targets OG5_126888	All targets in OG5_126888
Giardia lamblia	Kinase, CMGC GSK	Get druggable targets OG5_126888	All targets in OG5_126888
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	Get druggable targets OG5_131977	All targets in OG5_131977
Echinococcus multilocularis	aurora kinase A	Get druggable targets OG5_127024	All targets in OG5_127024

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma brucei	mitogen-activated protein kinase 5	aurora kinase B	303 aa	299 aa	22.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0952	0.1936
Echinococcus granulosus	aurora kinase A	0.007	0.114	0.3101
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0026	0.0017
Echinococcus multilocularis	rho associated protein kinase	0.0178	0.3138	0.8659
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0026	0.0001
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0237	0.059
Brugia malayi	WH1 domain containing protein	0.0019	0.0192	0.0168
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0019	0.0192	0.0465
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0026	0.0001
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0185	0.3276	0.327
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0019	0.0192	0.0465
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0192	0.0168
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0237	0.059
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0042
Schistosoma mansoni	hypothetical protein	0.0019	0.0192	0.044
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0026	0.0001
Schistosoma mansoni	vesicular amine transporter	0.0011	0.0051	0.007
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0026	0.0002
Loa Loa (eye worm)	SRC-1	0.001	0.0025	0.0016
Giardia lamblia	Kinase, CMGC GSK	0.006	0.0952	0.7928
Trichomonas vaginalis	set domain proteins, putative	0.0231	0.4121	1
Entamoeba histolytica	protein kinase domain containing protein	0.006	0.0952	0.8359
Onchocerca volvulus		0.0231	0.4121	1
Loa Loa (eye worm)	AUR protein kinase	0.007	0.114	0.1132
Schistosoma mansoni	tyrosine kinase	0.0099	0.1686	0.4374
Brugia malayi	Serine/threonine-protein kinase Pim-3	0.0194	0.3443	0.3427
Trichomonas vaginalis	AGC family protein kinase	0.007	0.114	0.2412
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0382	0.0941
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0026	0.0001
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0026	0.0002
Entamoeba histolytica	protein kinase, putative	0.0021	0.0237	0.2077
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.007	0.114	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0026	0.0002
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0026	0.0002
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0237	0.0114
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0019	0.0192	0.0465
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0026	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0026	0.0017
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0026	0.0002
Echinococcus multilocularis	protein kinase shaggy	0.006	0.0952	0.258
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0042
Toxoplasma gondii	aurora kinase	0.007	0.114	1
Echinococcus multilocularis	tyrosine protein kinase shark	0.001	0.0025	0.000000062803
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.006	0.096	0.26
Echinococcus granulosus	histone lysine methyltransferase setb	0.0029	0.0382	0.0994
Schistosoma mansoni	tyrosine kinase	0.006	0.096	0.2461
Entamoeba histolytica	protein kinase domain containing protein	0.007	0.114	1
Onchocerca volvulus		0.0029	0.0382	0.0873
Schistosoma mansoni	tyrosine kinase	0.0096	0.1617	0.4191
Loa Loa (eye worm)	AUR protein kinase	0.007	0.114	0.1132
Schistosoma mansoni	tyrosine kinase	0.0096	0.1617	0.4191
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0026	0.0002
Schistosoma mansoni	glycogen synthase kinase 3-related (gsk3) (cmgc group III)	0.006	0.0952	0.2442
Onchocerca volvulus		0.001	0.0026	0.0002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0026	0.0002
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0026	0.0001
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0026	0.0002
Onchocerca volvulus		0.0175	0.3093	0.7491
Giardia lamblia	Aurora kinase	0.007	0.114	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.001	0.0025	0.0016
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0382	0.0374
Loa Loa (eye worm)	TK protein kinase	0.001	0.0025	0.0016
Echinococcus granulosus	glycogen synthase kinase 3 beta	0.006	0.0952	0.258
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0237	0.0114
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0021	0.0237	0.059
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0026	0.0002
Schistosoma mansoni	serine/threonine protein kinase	0.0178	0.3138	0.8195
Echinococcus multilocularis	PAK box P21 Rho binding	0.0019	0.0192	0.0465
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0026	0.0002
Brugia malayi	intracellular kinase	0.006	0.0952	0.093
Schistosoma mansoni	serine/threonine protein kinase	0.007	0.114	0.2935
Schistosoma mansoni	hypothetical protein	0.0215	0.3824	1
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0382	0.0941
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.006	0.096	0.26
Echinococcus granulosus	PAK box P21 Rho binding	0.0019	0.0192	0.0465
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0026	0.0001
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.007	0.114	1
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0026	0.0002
Echinococcus multilocularis	proto oncogene serine:threonine protein kinase	0.0194	0.3443	0.9508
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0026	0.0002
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Echinococcus granulosus	protein kinase shaggy	0.006	0.0952	0.258
Entamoeba histolytica	protein kinase domain containing protein	0.006	0.0952	0.8359
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0026	0.0017
Plasmodium falciparum	serine/threonine protein kinase, putative	0.007	0.114	1
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0051	0.0074
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0029	0.0382	0.0941
Entamoeba histolytica	hypothetical protein	0.0019	0.0192	0.1685
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0204	0.362	1
Schistosoma mansoni	nephrin	0.0014	0.0104	0.021
Entamoeba histolytica	protein kinase, putative	0.007	0.114	1
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Loa Loa (eye worm)	hypothetical protein	0.001	0.0025	0.0016
Brugia malayi	Pre-SET motif family protein	0.0203	0.3602	0.3586
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0026	0.0002
Brugia malayi	nuclear receptor NHR-88	0.001	0.0026	0.0001
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0026	0.0002
Brugia malayi	hypothetical protein	0.0011	0.0051	0.0027
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Entamoeba histolytica	protein kinase, putative	0.0021	0.0237	0.2077
Trichomonas vaginalis	AGC family protein kinase	0.007	0.114	0.2412
Schistosoma mansoni	hypothetical protein	0.0019	0.0192	0.044
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0026	0.0002
Brugia malayi	Furin-like cysteine rich region family protein	0.0183	0.323	0.3213
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0192	0.0183
Schistosoma mansoni	protein kinase	0.007	0.114	0.2935
Echinococcus multilocularis	roundabout 2	0.0018	0.0172	0.041
Echinococcus granulosus	defective proboscis extension response	0.0011	0.0051	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0026	0.0001
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0204	0.362	1
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0099	0.1686	0.4621
Schistosoma mansoni	tyrosine kinase	0.0099	0.1686	0.4374
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0203	0.3602	0.3596
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.006	0.0952	0.0945
Trypanosoma brucei	aurora B kinase	0.007	0.114	0.0651
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0042
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Toxoplasma gondii	cell-cycle-associated protein kinase GSK, putative	0.006	0.0952	0.753
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Leishmania major	protein kinase, putative	0.007	0.114	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0026	0.0001
Brugia malayi	Pre-SET motif family protein	0.0029	0.0382	0.0358
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0021	0.0237	0.059
Echinococcus granulosus	tyrosine protein kinase shark	0.001	0.0025	0.000000062803
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0015	0.0119	0.0263
Echinococcus granulosus	twitchin	0.0017	0.0149	0.0346
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.3443	0.3438
Schistosoma mansoni	protein kinase	0.0021	0.0237	0.0558
Brugia malayi	serine/threonine-protein kinase 6	0.007	0.114	0.1118
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0026	0.0002
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0026	0.0017
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0026	0.0017
Trichomonas vaginalis	AGC family protein kinase	0.007	0.114	0.2412
Schistosoma mansoni	serine/threonine protein kinase	0.0023	0.0261	0.0623
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0011	0.0051	0.007
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0028	0.0362	0.0939
Schistosoma mansoni	protein kinase	0.0019	0.0192	0.044
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0026	0.0002
Echinococcus granulosus	insulin receptor	0.006	0.096	0.26
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0042
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.007	0.114	0.3101
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0026	0.0002
Echinococcus multilocularis	Immunoglobulin	0.0011	0.0051	0.0074
Onchocerca volvulus		0.006	0.0952	0.2265
Echinococcus granulosus	proto oncogene serine:threonine protein kinase	0.0194	0.3443	0.9508
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0026	0.0002
Trichomonas vaginalis	CMGC family protein kinase	0.006	0.0952	0.1936
Schistosoma mansoni	tyrosine kinase	0.0183	0.323	0.8437
Schistosoma mansoni	tyrosine kinase	0.0023	0.0261	0.0623
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Loa Loa (eye worm)	CMGC/GSK protein kinase	0.006	0.0952	0.0945
Echinococcus granulosus	neuroglian	0.0014	0.0104	0.0222
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0011	0.0051	0.0074
Echinococcus granulosus	epidermal growth factor receptor	0.0099	0.1686	0.4621
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0051	0.0042
Echinococcus multilocularis	glycogen synthase kinase 3 beta	0.006	0.0952	0.258
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.007	0.114	1
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0026	0.0002
Trypanosoma cruzi	aurora B kinase, putative	0.007	0.114	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0026	0.0002
Brugia malayi	Protein kinase domain containing protein	0.006	0.096	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0119	0.011
Schistosoma mansoni	protein kinase	0.0021	0.0237	0.0558
Schistosoma mansoni	hypothetical protein	0.0019	0.0192	0.044
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0026	0.0002
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0223	0.3969	0.3964
Trypanosoma brucei	RNA helicase, putative	0.0215	0.3824	1
Entamoeba histolytica	protein kinase, putative	0.007	0.114	1
Onchocerca volvulus		0.0178	0.3138	0.76
Schistosoma mansoni	tyrosine kinase	0.006	0.096	0.2461
Schistosoma mansoni	tyrosine kinase	0.0096	0.1617	0.4191
Entamoeba histolytica	p21-activated kinase	0.0021	0.0237	0.2077
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0026	0.0001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0185	0.3276	0.326
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0029	0.0382	0.0994
Schistosoma mansoni	serine/threonine protein kinase	0.0194	0.3443	0.8998
Brugia malayi	Protein kinase domain	0.0021	0.0237	0.0213
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0026	0.0001
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0026	0.0001
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0019	0.0192	0.0183
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0026	0.0002
Echinococcus granulosus	epidermal growth factor receptor	0.0183	0.323	0.8915
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0026	0.0001
Plasmodium vivax	glycogen synthase kinase 3, putative	0.006	0.0952	0.753
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0026	0.0001
Onchocerca volvulus	Tyrosine kinase homolog	0.0173	0.3053	0.7394
Loa Loa (eye worm)	AUR protein kinase	0.007	0.114	0.1132
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Brugia malayi	Fibronectin type III domain containing protein	0.0011	0.0051	0.0027
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.007	0.114	1
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0026	0.0002
Entamoeba histolytica	protein kinase, putative	0.0021	0.0237	0.2077
Brugia malayi	serine/threonine kinase 12	0.007	0.114	0.1118
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0026	0.0002
Onchocerca volvulus	Serine\/threonine protein kinase homolog	0.0194	0.3443	0.8345
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0026	0.0017
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0012	0.0069	0.0124
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0026	0.0002
Schistosoma mansoni	coup transcription factor	0.001	0.0026	0.0002
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0026	0.0001
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0237	0.0114
Echinococcus multilocularis	neuroglian	0.0014	0.0104	0.0222
Echinococcus multilocularis		0.0056	0.0876	0.2367
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0026	0.0002
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0021	0.0237	0.059
Echinococcus granulosus	rho-associated protein kinase 1	0.0178	0.3138	0.8659
Onchocerca volvulus		0.0167	0.2931	0.7095
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0026	0.0017
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Brugia malayi	nuclear hormone receptor	0.001	0.0026	0.0001
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0026	0.0002
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0026	0.0002
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0026	0.0002
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0026	0.0001
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0026	0.0002
Giardia lamblia	Kinase, CMGC GSK	0.006	0.0952	0.7928
Schistosoma mansoni	protein kinase	0.0021	0.0237	0.0558
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0029	0.0382	0.0941
Echinococcus multilocularis	aurora kinase A	0.007	0.114	0.3101
Brugia malayi	P21-Rho-binding domain containing protein	0.0019	0.0192	0.0168
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Brugia malayi	serine/threonine protein kinase 6	0.007	0.114	0.1118
Schistosoma mansoni	tyrosine kinase	0.001	0.0025	0.000000059439
Brugia malayi	serine/threonine-protein kinase PAK 7	0.0223	0.3969	0.3954
Schistosoma mansoni	cell adhesion molecule	0.0015	0.0119	0.0248
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0029	0.0382	0.0994
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Echinococcus multilocularis	epidermal growth factor receptor	0.0099	0.1686	0.4621
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0019	0.0192	0.044
Echinococcus granulosus	roundabout 2	0.0018	0.0172	0.041
Entamoeba histolytica	protein kinase, putative	0.006	0.0952	0.8359
Trichomonas vaginalis	AGC family protein kinase	0.007	0.114	0.2412
Brugia malayi	ecdysteroid receptor	0.001	0.0026	0.0001
Loa Loa (eye worm)	CAMK/PIM protein kinase	0.0194	0.3443	0.3438
Echinococcus multilocularis	insulin receptor	0.006	0.096	0.26
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0237	0.0114
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0183	0.323	0.3224
Loa Loa (eye worm)	hypothetical protein	0.001	0.0026	0.0017
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.007	0.114	0.3101
Entamoeba histolytica	protein kinase , putative	0.007	0.114	1
Entamoeba histolytica	protein kinase, putative	0.0021	0.0237	0.2077
Echinococcus multilocularis	epidermal growth factor receptor	0.0183	0.323	0.8915
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0026	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0172	0.0164
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0026	0.0002
Echinococcus granulosus	Immunoglobulin	0.0011	0.0051	0.0074
Entamoeba histolytica	hypothetical protein	0.0019	0.0192	0.1685
Brugia malayi	Protein kinase domain containing protein	0.0194	0.3443	0.3427
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0021	0.0237	0.059
Loa Loa (eye worm)	TK/INSR protein kinase	0.006	0.096	0.0952
Trichomonas vaginalis	STE family protein kinase	0.0021	0.0237	0.0114
Loa Loa (eye worm)	TK/FER protein kinase	0.001	0.0025	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0172	0.0164
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0011	0.0051	0.007
Echinococcus multilocularis	PAK box P21 Rho binding	0.0021	0.0237	0.059
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0011	0.0051	0.0027
Schistosoma mansoni	tyrosine kinase	0.001	0.0033	0.0023
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.001	0.0025	0.0216
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0026	0.0002
Brugia malayi	steroid hormone receptor	0.001	0.0026	0.0001

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 0.067 uM	Inhibition of EGFR	ChEMBL.	21288717
Ki (binding)	> 1.45 uM	Inhibition of JAK2	ChEMBL.	21288717
Ki (binding)	> 3.75 uM	Inhibition of Pak4	ChEMBL.	21288717
Ki (binding)	> 4.9 uM	Inhibition of aurora 2	ChEMBL.	21288717
Ki (binding)	> 5.45 uM	Inhibition of GSK3-beta	ChEMBL.	21288717
Ki (binding)	> 6 uM	Inhibition of Rock2	ChEMBL.	21288717
Ki (binding)	> 8.75 uM	Inhibition of Pim1	ChEMBL.	21288717
Ki (binding)	> 8.88 uM	Inhibition of KDR	ChEMBL.	21288717

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1682557

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1506018