Detailed information for compound 150656

Basic information

Technical information
  • TDR Targets ID: 150656
  • Name: N-(4-methoxyphenyl)-N-methyl-4-pyridin-4-ylpy rimidin-2-amine
  • MW: 292.335 | Formula: C17H16N4O
  • H donors: 0 H acceptors: 3 LogP: 2.78 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N(c1nccc(n1)c1ccncc1)C
  • InChi: 1S/C17H16N4O/c1-21(14-3-5-15(22-2)6-4-14)17-19-12-9-16(20-17)13-7-10-18-11-8-13/h3-12H,1-2H3
  • InChiKey: FVQOIMDMTCTKJK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-methoxyphenyl)-N-methyl-4-(4-pyridyl)pyrimidin-2-amine
  • N-(4-methoxyphenyl)-N-methyl-4-(4-pyridyl)-2-pyrimidinamine
  • N-(4-methoxyphenyl)-N-methyl-4-pyridin-4-yl-pyrimidin-2-amine
  • (4-methoxyphenyl)-methyl-[4-(4-pyridyl)pyrimidin-2-yl]amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus granulosus allatostatin A receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0563 0.0562
Brugia malayi G protein-coupled receptor 0.0007 0.0058 0.0059
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0619 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0157 0.3949 0.3917
Toxoplasma gondii hypothetical protein 0.0027 0.0563 0.053
Schistosoma mansoni neuropeptide receptor 0.0007 0.0058 0.0006
Plasmodium falciparum LCCL domain-containing protein 0.0011 0.0161 0.2123
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0007 0.0052 0.005
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0563 0.0562
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0007 0.0058 0.0058
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0007 0.0058 0.0006
Echinococcus multilocularis orexin receptor type 2 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0157 0.3949 0.4068
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.9703 1
Plasmodium falciparum transporter, putative 0.0027 0.0563 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus multilocularis sex peptide receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) solute carrier family 6 member 4 0.0157 0.3949 0.4068
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0007 0.0058 0.0059
Onchocerca volvulus 0.0011 0.0161 0.0279
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0055
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0029 0.0619 0.0588
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.0563 0.0514
Onchocerca volvulus 0.0007 0.0058 0.0014
Giardia lamblia Kinase, CMGC MAPK 0.0029 0.0619 0.5
Brugia malayi CXXC zinc finger family protein 0.0016 0.0293 0.0302
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.0579
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis serotonin receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0052 0.0052
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0058 0.0056
Onchocerca volvulus 0.0007 0.0058 0.0014
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0161 0.0159
Echinococcus granulosus tachykinin peptides receptor 99D 0.0007 0.0058 0.0056
Toxoplasma gondii fructose-bisphospatase II 0.0378 0.9703 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0027 0.0563 0.0562
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0007 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) norepinephrine transporter 0.0157 0.3949 0.4068
Echinococcus multilocularis mitogen activated protein kinase 3 0.0029 0.0619 0.0618
Schistosoma mansoni growth hormone secretagogue receptor 0.0007 0.0058 0.0006
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0058 0.0056
Echinococcus granulosus dro:myosuppressin receptor 0.0007 0.0058 0.0056
Schistosoma mansoni cpg binding protein 0.0016 0.0293 0.0242
Brugia malayi Melatonin receptor type 1A 0.0007 0.0058 0.0059
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus multilocularis neuropeptide s receptor 0.0007 0.0058 0.0056
Brugia malayi hypothetical protein 0.0007 0.0052 0.0054
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0157 0.3949 0.4069
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0027 0.0563 0.0562
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0563 0.0562
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Schistosoma mansoni microtubule-associated protein tau 0.0389 1 1
Echinococcus granulosus serotonin receptor 0.0007 0.0058 0.0056
Brugia malayi Dopamine receptor 0.0007 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0563 0.0514
Brugia malayi Cytochrome P450 family protein 0.0023 0.0463 0.0477
Echinococcus granulosus lipoxygenase domain containing protein 0.0011 0.0161 0.0159
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0007 0.0058 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0058 0.0056
Brugia malayi Serotonin receptor 0.0007 0.0058 0.0059
Onchocerca volvulus 0.0007 0.0058 0.0014
Onchocerca volvulus 0.0007 0.0058 0.0014
Onchocerca volvulus 0.0027 0.0563 0.1312
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0007 0.0058 0.0056
Plasmodium falciparum amino acid transporter, putative 0.0027 0.0563 1
Loa Loa (eye worm) intermediate filament protein 0.0015 0.0267 0.0274
Brugia malayi G protein-coupled receptor F59B2.13 0.0007 0.0058 0.0059
Echinococcus multilocularis g-protein coupled receptor 0.0007 0.0058 0.0056
Schistosoma mansoni hypothetical protein 0.0007 0.0058 0.0006
Schistosoma mansoni hypothetical protein 0.0231 0.5875 0.5853
Schistosoma mansoni cpg binding protein 0.0017 0.0317 0.0266
Echinococcus granulosus somatostatin receptor 0.0007 0.0058 0.0056
Brugia malayi RE15519p 0.0007 0.0058 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Schistosoma mansoni hypothetical protein 0.0011 0.0161 0.0109
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni fructose-16-bisphosphatase-related 0.0378 0.9703 0.9702
Echinococcus granulosus neuropeptide receptor 0.0007 0.0058 0.0056
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0563 0.0514
Brugia malayi neuropeptide F receptor 0.0007 0.0058 0.0059
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0058 0.0006
Brugia malayi Dopamine receptor protein 2 0.0007 0.0058 0.0059
Brugia malayi aspartic protease BmAsp-2, identical 0.0007 0.0052 0.0054
Loa Loa (eye worm) hypothetical protein 0.0007 0.0052 0.0052
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0058 0.0006
Brugia malayi Dopamine receptor protein 1 0.0007 0.0058 0.0059
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0067 0.1602 0.1601
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0058 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0007 0.0058 0.0059
Echinococcus granulosus fructose 16 bisphosphatase 1 0.0378 0.9703 0.9703
Plasmodium vivax multidomain scavenger receptor, putative 0.0011 0.0161 0.2123
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0058 0.0058
Brugia malayi putative neuropeptide receptor NPR1 0.0007 0.0058 0.0059
Trypanosoma brucei sedoheptulose-1,7-bisphosphatase 0.0141 0.3528 0.3202
Schistosoma mansoni neuropeptide receptor 0.0007 0.0058 0.0006
Echinococcus granulosus neuropeptide receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis neuropeptide receptor A26 0.0007 0.0058 0.0056
Loa Loa (eye worm) TYRA-2 protein 0.0007 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Treponema pallidum sodium- and chloride- dependent transporter 0.0157 0.3949 0.5
Echinococcus granulosus dnaJ subfamily B 0.0231 0.5875 0.5874
Brugia malayi putative neuropeptide receptor 0.0007 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Schistosoma mansoni cellular tumor antigen P53 0.0028 0.0597 0.0548
Loa Loa (eye worm) hypothetical protein 0.0157 0.3949 0.4068
Echinococcus granulosus fmrfamide receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0563 0.0514
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0007 0.0062 0.0061
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi fructose-1,6-bisphosphatase 0.0378 0.9703 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0016 0.0293 0.03
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0027 0.0563 0.0581
Loa Loa (eye worm) hypothetical protein 0.0015 0.0267 0.0274
Schistosoma mansoni histamine h1 receptor 0.0007 0.0058 0.0006
Echinococcus granulosus Polycystic kidney disease protein 0.0011 0.0161 0.0159
Echinococcus multilocularis cpg binding protein 0.0017 0.0317 0.0315
Onchocerca volvulus 0.0027 0.0563 0.1312
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Echinococcus multilocularis allatostatin A receptor 0.0007 0.0058 0.0056
Echinococcus granulosus cpg binding protein 0.0017 0.0317 0.0315
Onchocerca volvulus Neuropeptide F receptor homolog 0.0007 0.0058 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.0581
Brugia malayi Pepsin A precursor 0.0007 0.0052 0.0054
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0007 0.0058 0.0059
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0058 0.0056
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) serotonin transporter b 0.0157 0.3949 0.4068
Brugia malayi aspartic protease BmAsp-1, identical 0.0007 0.0052 0.0054
Echinococcus multilocularis musashi 0.0015 0.0267 0.0265
Onchocerca volvulus 0.0007 0.0058 0.0014
Echinococcus multilocularis RUN 0.0011 0.0161 0.0159
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0058 0.0056
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0007 0.0058 0.0059
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0058 0.0056
Echinococcus granulosus g protein coupled receptor 0.0007 0.0058 0.0056
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0027 0.0563 0.5
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Echinococcus multilocularis somatostatin receptor 0.0007 0.0058 0.0056
Schistosoma mansoni biogenic amine receptor 0.0007 0.0058 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus granulosus orexin receptor type 2 0.0007 0.0058 0.0056
Echinococcus multilocularis tumor protein p63 0.0191 0.4831 0.483
Loa Loa (eye worm) hypothetical protein 0.0007 0.0055 0.0055
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0463 0.0475
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0157 0.3949 0.3917
Echinococcus granulosus g protein coupled receptor 0.0007 0.0058 0.0056
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0563 0.0514
Toxoplasma gondii hypothetical protein 0.0027 0.0563 0.053
Echinococcus granulosus neuropeptides capa receptor 0.0007 0.0058 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Loa Loa (eye worm) hypothetical protein 0.0157 0.3949 0.4068
Brugia malayi G-protein coupled receptor 0.0007 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Echinococcus granulosus neuropeptide receptor A26 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Echinococcus multilocularis neuropeptides capa receptor 0.0007 0.0058 0.0056
Onchocerca volvulus 0.0007 0.0058 0.0014
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0007 0.0058 0.0056
Schistosoma mansoni lipoxygenase 0.0067 0.1602 0.1558
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0058 0.0056
Brugia malayi sulfakinin receptor protein 0.0007 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus multilocularis sodium and chloride dependent glycine 0.0027 0.0563 0.0562
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0058 0.0006
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0007 0.0058 0.0059
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0007 0.0058 0.0056
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0007 0.0058 0.0056
Brugia malayi Tachykinin-like peptides receptor 99D 0.0007 0.0058 0.0059
Echinococcus granulosus sodium and chloride dependent glycine 0.0027 0.0563 0.0562
Echinococcus multilocularis serotonin transporter 0.0157 0.3949 0.3948
Brugia malayi Eukaryotic aspartyl protease family protein 0.0007 0.0052 0.0054
Onchocerca volvulus 0.0007 0.0058 0.0014
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Schistosoma mansoni lipoxygenase 0.0047 0.1081 0.1035
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus granulosus biogenic amine 5HT receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0058 0.0056
Echinococcus granulosus lamin dm0 0.0015 0.0267 0.0265
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0007 0.0058 0.0006
Echinococcus granulosus serotonin transporter 0.0157 0.3949 0.3948
Brugia malayi AKH receptor 0.0007 0.0058 0.0059
Echinococcus granulosus intermediate filament protein 0.0015 0.0267 0.0265
Brugia malayi Intermediate filament tail domain containing protein 0.0015 0.0267 0.0275
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0619 1
Echinococcus multilocularis dnaJ subfamily B 0.0231 0.5875 0.5874
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0007 0.0058 0.0056
Trypanosoma cruzi fructose-1,6-bisphosphatase, cytosolic, putative 0.0378 0.9703 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0007 0.0058 0.0006
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0007 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Leishmania major 0.0378 0.9703 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0563 0.0514
Schistosoma mansoni rab6-interacting 0.0011 0.0161 0.0109
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0058 0.0006
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.0579
Schistosoma mansoni hypothetical protein 0.0007 0.0058 0.0006
Schistosoma mansoni amine GPCR 0.0007 0.0058 0.0006
Trypanosoma brucei fructose-1,6-bisphosphatase 0.0378 0.9703 1
Schistosoma mansoni cpg binding protein 0.0017 0.0317 0.0266
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni polycystin 1-related 0.0011 0.0161 0.0109
Onchocerca volvulus 0.0015 0.0267 0.0552
Schistosoma mansoni lamin 0.0015 0.0267 0.0216
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0007 0.0058 0.0006
Loa Loa (eye worm) hypothetical protein 0.0015 0.026 0.0266
Brugia malayi larval opioid receptor 0.0007 0.0058 0.0059
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0008 0.0083 0.0084
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0007 0.0058 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis serotonin receptor 0.0007 0.0058 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0058 0.0056
Schistosoma mansoni hypothetical protein 0.0007 0.0058 0.0006
Onchocerca volvulus 0.0007 0.0058 0.0014
Toxoplasma gondii sedoheptulose-1,7-bisphosphatase 0.0141 0.3528 0.3601
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.0007 0.0058 0.0056
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0007 0.0058 0.0006
Onchocerca volvulus 0.0007 0.0058 0.0014
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0027 0.0563 0.0514
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Schistosoma mansoni neuropeptide receptor 0.0007 0.0058 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0389 1 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.0581
Onchocerca volvulus 0.0011 0.0161 0.0279
Echinococcus granulosus neuropeptide s receptor 0.0007 0.0058 0.0056
Schistosoma mansoni amine GPCR 0.0007 0.0058 0.0006
Echinococcus multilocularis neuropeptide FF receptor 2 0.0007 0.0058 0.0056
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.0619 0.057
Loa Loa (eye worm) melatonin receptor type 1A 0.0007 0.0058 0.0058
Schistosoma mansoni amine GPCR 0.0007 0.0058 0.0006
Onchocerca volvulus 0.0027 0.0563 0.1312
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Onchocerca volvulus 0.0007 0.0058 0.0014
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0007 0.0058 0.0006
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0067 0.1602 0.1601
Echinococcus multilocularis mitogen activated protein kinase 0.0029 0.0619 0.0618
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0058 0.0056
Echinococcus multilocularis Polycystic kidney disease protein 0.0011 0.0161 0.0159
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0027 0.0563 0.0514
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0052 0.0052
Onchocerca volvulus 0.0007 0.0058 0.0014
Echinococcus granulosus alpha 1A adrenergic receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0007 0.0052 0.0052
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.0581
Schistosoma mansoni biogenic amine receptor 0.0007 0.0058 0.0006
Schistosoma mansoni rab6-interacting 0.0011 0.0161 0.0109
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0062 0.0062
Echinococcus granulosus sex peptide receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0007 0.0062 0.0061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0007 0.0058 0.0056
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0027 0.0563 0.0562
Echinococcus granulosus RUN 0.0011 0.0161 0.0159
Echinococcus multilocularis G-protein coupled receptor, putative 0.0007 0.0058 0.0056
Echinococcus granulosus g protein coupled receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) fructose-1,6-bisphosphatase 0.0378 0.9703 1
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.053
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0029 0.0619 0.0636
Onchocerca volvulus 0.0007 0.0058 0.0014
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0058 0.0058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0007 0.0058 0.0056
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Echinococcus multilocularis fructose 1,6 bisphosphatase 1 0.0378 0.9703 0.9703
Echinococcus granulosus G protein coupled receptor 139 0.0007 0.0058 0.0056
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Loa Loa (eye worm) aspartyl protease 6 0.0007 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.3528 0.3202
Echinococcus granulosus mitogen activated protein kinase 0.0029 0.0619 0.0618
Echinococcus multilocularis G protein coupled receptor 139 0.0007 0.0058 0.0056
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.053
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi Doublecortin family protein 0.0011 0.0161 0.0166
Schistosoma mansoni neuropeptide F-like receptor 0.0007 0.0058 0.0006
Schistosoma mansoni biogenic amine receptor 0.0007 0.0058 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0058 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0011 0.0161 0.0164
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0007 0.0052 0.005
Brugia malayi hypothetical protein 0.0011 0.0161 0.0166
Loa Loa (eye worm) G-protein coupled receptor 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni neuropeptide receptor 0.0007 0.0058 0.0006
Brugia malayi hypothetical protein 0.0027 0.0563 0.0581
Onchocerca volvulus 0.0007 0.0058 0.0014
Schistosoma mansoni amine GPCR 0.0007 0.0058 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Echinococcus granulosus peptide allatostatin:somatostatin 0.0007 0.0058 0.0056
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0007 0.0058 0.0056
Schistosoma mansoni adenoreceptor 0.0007 0.0058 0.0006
Onchocerca volvulus 0.0015 0.0267 0.0552
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0563 1
Schistosoma mansoni loxhd1 0.0011 0.0161 0.0109
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0619 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0597 0.0614
Echinococcus multilocularis dro:myosuppressin receptor 0.0007 0.0058 0.0056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0007 0.0058 0.0006
Toxoplasma gondii fructose-bisphospatase I 0.0141 0.3528 0.3601
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0027 0.0563 0.0514
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0161 0.0159
Brugia malayi ORL1-like opioid receptor 0.0007 0.0058 0.0059
Brugia malayi hypothetical protein 0.0007 0.0052 0.0054
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Echinococcus granulosus mitogen activated protein kinase 3 0.0029 0.0619 0.0618
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0007 0.0058 0.0006
Schistosoma mansoni hypothetical protein 0.0007 0.0058 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.0029 0.0619 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0007 0.0058 0.0006
Echinococcus multilocularis lamin dm0 0.0015 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Trypanosoma cruzi sedoheptulose-1,7-bisphosphatase, putative 0.0141 0.3528 0.3202
Onchocerca volvulus 0.0007 0.0058 0.0014
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0007 0.0058 0.0058
Echinococcus granulosus tumor protein p63 0.0191 0.4831 0.483
Brugia malayi neuropeptide F receptor 0.0007 0.0058 0.0059
Brugia malayi G-protein coupled receptor 0.0007 0.0058 0.0059
Echinococcus multilocularis neuropeptide Y receptor 0.0007 0.0058 0.0056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0007 0.0058 0.0056
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0027 0.0563 0.0562
Toxoplasma gondii histone lysine methyltransferase SET1 0.0031 0.067 0.064
Echinococcus granulosus 7TM GPCR rhodopsin 0.0007 0.0058 0.0056
Loa Loa (eye worm) neuropeptide F receptor 0.0007 0.0058 0.0058
Onchocerca volvulus 0.0007 0.0058 0.0014
Schistosoma mansoni sodium/chloride dependent transporter 0.0027 0.057 0.0521
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0007 0.0058 0.0006
Brugia malayi hypothetical protein 0.0007 0.0058 0.0059
Echinococcus granulosus tm gpcr rhodopsin 0.0007 0.0058 0.0056
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0027 0.0563 0.053
Plasmodium vivax amine transporter, putative 0.0027 0.0563 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.0011 0.0161 0.0159
Brugia malayi intermediate filament protein 0.0015 0.0267 0.0275
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0007 0.0058 0.0056
Echinococcus granulosus g-protein coupled receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Brugia malayi hypothetical protein 0.0011 0.0161 0.0166
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Schistosoma mansoni amine GPCR 0.0007 0.0058 0.0006
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0027 0.0563 0.0562
Echinococcus multilocularis neuropeptide receptor 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Onchocerca volvulus 0.0028 0.0597 0.1399
Onchocerca volvulus 0.0016 0.0293 0.0618
Schistosoma mansoni opsin-like receptor 0.0007 0.0058 0.0006
Schistosoma mansoni opsin-like receptor 0.0007 0.0058 0.0006
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0007 0.0058 0.0056
Echinococcus multilocularis lamin 0.0015 0.0267 0.0265
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0015 0.0267 0.0274
Schistosoma mansoni memapsin-2 (A01 family) 0.0173 0.4374 0.4345
Schistosoma mansoni sodium-dependent amino acid transporter 0.0027 0.0563 0.0514
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Onchocerca volvulus 0.0157 0.3949 1
Schistosoma mansoni opsin-like receptor 0.0007 0.0058 0.0006
Schistosoma mansoni myosin xvIII 0.0007 0.0058 0.0006
Schistosoma mansoni intermediate filament proteins 0.0015 0.0267 0.0216
Brugia malayi GnHR receptor homolog 0.0007 0.0058 0.0059
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0007 0.0058 0.0058
Brugia malayi MAP kinase sur-1 0.0029 0.0619 0.0638
Brugia malayi cytoplasmic intermediate filament protein 0.0008 0.0083 0.0086
Brugia malayi Serotonin receptor 0.0007 0.0058 0.0059
Echinococcus granulosus lamin 0.0015 0.0267 0.0265
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0007 0.0058 0.0006
Echinococcus granulosus hypothetical protein 0.0007 0.0058 0.0056
Echinococcus multilocularis g protein coupled receptor 0.0007 0.0058 0.0056
Echinococcus granulosus neuropeptide FF receptor 2 0.0007 0.0058 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0007 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0027 0.0563 0.0579
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0765 0.0717
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0007 0.0058 0.0056
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0007 0.0058 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.0007 0.0058 0.0056
Loa Loa (eye worm) doublecortin family protein 0.0011 0.0161 0.0164
Onchocerca volvulus 0.0007 0.0058 0.0014
Loa Loa (eye worm) hypothetical protein 0.0011 0.0161 0.0164
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0007 0.0058 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0007 0.0058 0.0006
Schistosoma mansoni lamin 0.0015 0.0267 0.0216
Brugia malayi follicle stimulating hormone receptor 0.0007 0.0058 0.0059
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0027 0.0563 0.0562
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0007 0.0058 0.0058
Echinococcus multilocularis fmrfamide receptor 0.0007 0.0058 0.0056
Onchocerca volvulus 0.0007 0.0058 0.0014

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 24 uM In vitro inhibition of histamine release from human basophils ChEMBL. 8410986
IC50 (functional) > 24 uM In vitro inhibition of histamine release from human basophils ChEMBL. 8410986

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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