TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 270.306 | Formula: C14H10N2O2S
H donors: 2 H acceptors: 2 LogP: 2.18 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccs1)Nc1cccc2c1cc[nH]c2=O
InChi: 1S/C14H10N2O2S/c17-13-10-3-1-4-11(9(10)6-7-15-13)16-14(18)12-5-2-8-19-12/h1-8H,(H,15,17)(H,16,18)
InChiKey: WQPUCYVIJWZASX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Mus musculus	poly (ADP-ribose) polymerase family, member 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Neospora caninum	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2-A, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	ko:K00774 NAD ADP-ribosyltransferase [EC2.4.2.30], putative	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei gambiense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma brucei	poly(adp-ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma congolense	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	hypothetical protein	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 1, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Brugia malayi	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly adp ribose polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly ADP ribose polymerase 1	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	WGR domain containing protein	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus granulosus	poly (ADP ribose) polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma mansoni	poly [ADP-ribose] polymerase	Get druggable targets OG5_128423	All targets in OG5_128423
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	Get druggable targets OG5_128423	All targets in OG5_128423
Echinococcus multilocularis	poly (adp ribose) polymerase 2	Get druggable targets OG5_128423	All targets in OG5_128423
Schistosoma japonicum	Poly [ADP-ribose] polymerase 2, putative	Get druggable targets OG5_128423	All targets in OG5_128423

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0042	0.0027	0.018
Leishmania major	protein kinase, putative	0.0051	0.0068	0.3853
Echinococcus granulosus	Immunoglobulin	0.0082	0.0207	0.0235
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Trypanosoma cruzi	NEK family Serine/threonine-protein kinase, putative	0.0042	0.0028	0.0025
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0042	0.0027	0.0018
Entamoeba histolytica	protein kinase domain containing protein	0.0066	0.0135	0.0744
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	serine:threonine protein kinase 12 B	0.0066	0.0135	0.0148
Echinococcus multilocularis	roundabout 2	0.0086	0.0229	0.0261
Echinococcus granulosus	integrin linked protein kinase	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Brugia malayi	Plexin repeat family protein	0.0643	0.2771	0.2763
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	activated cdc42 kinase 1	0.0042	0.0027	0.0018
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0042	0.0027	0.0018
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0042	0.0027	0.0018
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0042	0.0027	0.0015
Trypanosoma cruzi	serine/threonine protein kinase, putative	0.0042	0.0028	0.0025
Brugia malayi	Tyrosine-protein kinase PR2	0.0042	0.0027	0.0015
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	semaphorin 5B	0.0274	0.1086	0.1289
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0042	0.0027	0.018
Echinococcus granulosus	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Brugia malayi	hypothetical protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase shark	0.0042	0.0027	0.0018
Echinococcus granulosus	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0042	0.0027	0.0018
Trypanosoma brucei	serine/threonine-protein kinase NRKB, putative	0.0042	0.0028	0.0025
Brugia malayi	Receptor family ligand binding region containing protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0042	0.0027	0.0018
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0086	0.0229	0.0218
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0042	0.0027	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Trichomonas vaginalis	CAMK family protein kinase	0.0042	0.0027	0.018
Entamoeba histolytica	poly(ADP-ribose) polymerase, putative	0.0167	0.0597	0.3914
Leishmania major	rac serine-threonine kinase, putative,protein kinase, putative	0.0042	0.0028	0.013
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0144	0.0494	0.0469
Loa Loa (eye worm)	hypothetical protein	0.012	0.0383	0.0372
Trypanosoma brucei	serine/threonine-protein kinase NrkA	0.0042	0.0028	0.0025
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0082	0.0207	0.0181
Echinococcus multilocularis	regulator of G protein signaling 7	0.0361	0.1483	0.1764
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1086	0.1076
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	rac serine:threonine kinase	0.0042	0.0028	0.002
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0167	0.0597	0.0572
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0042	0.0027	0.0015
Schistosoma mansoni	regulator of G protein signaling	0.0361	0.1483	0.146
Echinococcus multilocularis	axis inhibition protein axin	0.0361	0.1483	0.1764
Schistosoma mansoni	hypothetical protein	0.0274	0.1086	0.1062
Brugia malayi	Furin-like cysteine rich region family protein	0.0042	0.0027	0.0015
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.1866	0.8352	0.835
Echinococcus granulosus	natriuretic peptide receptor 1	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trypanosoma brucei	aurora B kinase	0.0066	0.0135	0.1901
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0051	0.0068	0.0733
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0042	0.0027	0.0018
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Entamoeba histolytica	hypothetical protein	0.0361	0.1483	1
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus multilocularis	epidermal growth factor receptor	0.0042	0.0027	0.0018
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0042	0.0027	0.0018
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	hypothetical protein	0.012	0.0383	0.0372
Echinococcus multilocularis	epidermal growth factor receptor	0.0042	0.0027	0.0018
Brugia malayi	serine/threonine-protein kinase 6	0.0066	0.0135	0.0124
Echinococcus multilocularis	protein kinase	0.0042	0.0027	0.0018
Schistosoma mansoni	hypothetical protein	0.0369	0.152	0.1498
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0042	0.0027	0.0018
Echinococcus granulosus	poly ADP ribose polymerase 1	0.0167	0.0597	0.0702
Brugia malayi	hypothetical protein	0.0361	0.1483	0.1473
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	3-phosphoinositide dependent protein kinase-1, putative	0.0042	0.0028	0.019
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	exocyst complex component 2	0.012	0.0383	0.0446
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0042	0.0027	0.0018
Echinococcus granulosus	G protein coupled receptor kinase 1	0.1346	0.5979	0.7155
Schistosoma mansoni	hypothetical protein	0.0274	0.1086	0.1062
Echinococcus granulosus	tyrosine protein kinase	0.0042	0.0027	0.0018
Trypanosoma brucei	Serine/threonine-protein kinase NEK21, putative	0.0042	0.0028	0.0025
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0051	0.0068	0.0068
Entamoeba histolytica	hypothetical protein	0.012	0.0383	0.2449
Echinococcus granulosus	transcription factor collier	0.012	0.0383	0.0446
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0042	0.0028	0.0025
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	epidermal growth factor receptor	0.0042	0.0027	0.0018
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0042	0.0027	0.0018
Entamoeba histolytica	protein kinase, putative	0.0066	0.0135	0.0744
Echinococcus granulosus	insulin receptor	0.0042	0.0027	0.0018
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0082	0.0207	0.0181
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0028	0.0001
Trypanosoma cruzi	Protein kinase B	0.0042	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0229	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus granulosus	neuroglian	0.0082	0.0207	0.0235
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.012	0.0383	0.2585
Echinococcus granulosus	protein kinase	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	activated cdc42 kinase 1	0.0042	0.0027	0.0018
Echinococcus multilocularis	aurora kinase A	0.0066	0.0135	0.0148
Schistosoma mansoni	serine/threonine-protein kinase	0.0042	0.0028	0.0001
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK/FAK protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Trypanosoma cruzi	NIMA-related kinase, putative	0.0042	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Toxoplasma gondii	calcium dependent protein kinase CDPK7	0.0042	0.0028	0.0025
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0361	0.1483	0.1764
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus granulosus	poly adp ribose polymerase 2	0.0167	0.0597	0.0702
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Loa Loa (eye worm)	TK/ABL protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.012	0.0383	0.2585
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Brugia malayi	ephrin receptor 1 precursor	0.0042	0.0027	0.0015
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0042	0.0027	0.0015
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	activated cdc42 kinase 1	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Brugia malayi	A-kinase anchor protein 10, precursor	0.0361	0.1483	0.1473
Echinococcus granulosus	raf serine:threonine protein kinase	0.0042	0.0027	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus granulosus	c src tyrosine kinase	0.0042	0.0027	0.0018
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Schistosoma mansoni	hypothetical protein	0.012	0.0383	0.0358
Echinococcus multilocularis	transcription factor collier	0.012	0.0383	0.0446
Schistosoma mansoni	serine/threonine protein kinase	0.0066	0.0135	0.0109
Brugia malayi	Guanylyl cyclase protein 23	0.0042	0.0027	0.0015
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0042	0.0027	0.0018
Echinococcus multilocularis	poly (ADP ribose) polymerase 1	0.0167	0.0597	0.0702
Echinococcus granulosus	regulator of G protein signaling 7	0.0361	0.1483	0.1764
Brugia malayi	plexin A	0.0763	0.332	0.3312
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0042	0.0028	0.0025
Brugia malayi	hypothetical protein	0.0086	0.0229	0.0218
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1086	0.1076
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0051	0.0068	0.0733
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0051	0.0068	0.0733
Schistosoma mansoni	regulator of G protein signaling	0.0361	0.1483	0.146
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0135	0.0911
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	regulator of G protein signaling	0.0361	0.1483	0.1764
Brugia malayi	hypothetical protein	0.0361	0.1483	0.1473
Schistosoma mansoni	semaphorin 5-related	0.0274	0.1086	0.1062
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK/ALK protein kinase	0.0273	0.1082	0.1072
Echinococcus multilocularis	axis inhibition protein axin	0.0361	0.1483	0.1764
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0042	0.0027	0.0018
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0123	0.0399	0.0388
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	protein-tyrosine kinase	0.0042	0.0027	0.0015
Entamoeba histolytica	hypothetical protein	0.0361	0.1483	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Plasmodium vivax	serine/threonine protein kinase 6, putative	0.0066	0.0135	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	SRC-1	0.0042	0.0027	0.0015
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0042	0.0028	0.013
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0361	0.1483	0.1473
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0051	0.0068	0.0068
Schistosoma mansoni	plexin	0.0643	0.2771	0.2752
Trichomonas vaginalis	STE family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.012	0.0383	0.2585
Echinococcus granulosus	receptor type guanylyl cyclase	0.0042	0.0027	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0042	0.0027	0.0018
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0042	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Schistosoma mansoni	fibrocystin l	0.012	0.0383	0.0358
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.1866	0.8352	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.1866	0.8352	1
Entamoeba histolytica	protein kinase domain containing protein	0.0051	0.0068	0.0287
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0042	0.0027	0.0018
Brugia malayi	SRC-1	0.0042	0.0027	0.0015
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0082	0.0207	0.0235
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0047	0.0049	0.0044
Trypanosoma brucei	NEK family Serine/threonine-protein kinase, putative	0.0042	0.0028	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0047	0.005	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Brugia malayi	integrin-linked kinase	0.0042	0.0027	0.0015
Schistosoma mansoni	axis inhibition protein axin	0.0361	0.1483	0.146
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	IPT/TIG domain containing protein	0.012	0.0383	0.0372
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	protein kinase	0.0042	0.0027	0.0018
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0042	0.0027	0.018
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0167	0.0597	1
Leishmania major	folate/biopterin transporter, putative	0.0042	0.0028	0.013
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Brugia malayi	serine/threonine kinase 12	0.0066	0.0135	0.0124
Echinococcus granulosus	tyrosine protein kinase pr2	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Toxoplasma gondii	poly(ADP-ribose) polymerase catalytic domain-containing protein	0.0167	0.0597	1
Brugia malayi	WGR domain containing protein	0.0167	0.0597	0.0586
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Echinococcus multilocularis	Immunoglobulin	0.0082	0.0207	0.0235
Plasmodium falciparum	protein kinase, putative	0.0051	0.0068	0.3853
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus granulosus	epidermal growth factor receptor	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0369	0.152	0.151
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Schistosoma mansoni	cell adhesion molecule	0.0086	0.0229	0.0203
Loa Loa (eye worm)	TK/CSK protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0207	0.0196
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.1483	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	beta adrenergic receptor kinase	0.1707	0.7627	0.9131
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK/Met protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Brugia malayi	regulator of G-protein signaling rgs-7	0.0361	0.1483	0.1473
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Brugia malayi	PXA domain containing protein	0.0361	0.1483	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	regulator of G protein signaling 5, rgs5, putative	0.0361	0.1483	1
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0042	0.0027	0.0015
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0047	0.005	0.0047
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0229	0.0218
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	serine:threonine protein kinase 12 B	0.0066	0.0135	0.0148
Trypanosoma brucei	protein kinase, putative	0.0051	0.0068	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0207	0.0196
Entamoeba histolytica	hypothetical protein	0.0047	0.005	0.0163
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	twitchin	0.0091	0.0249	0.0285
Echinococcus granulosus	tyrosine kinase	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Plasmodium falciparum	calcium-dependent protein kinase 7	0.0042	0.0028	0.013
Schistosoma mansoni	serine/threonine protein kinase	0.1707	0.7627	0.7621
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0028	0.001
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0051	0.0068	0.0068
Schistosoma mansoni	serine/threonine protein kinase	0.1707	0.7627	0.7621
Echinococcus multilocularis	exocyst complex component 2	0.012	0.0383	0.0446
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	PXA domain-containing protein	0.0361	0.1483	0.1473
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus multilocularis	poly (adp ribose) polymerase 2	0.0167	0.0597	0.0702
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Plasmodium vivax	calcium-dependent protein kinase 7, putative	0.0042	0.0028	0.013
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0028	0.001
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.1483	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1483	0.1473
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0361	0.1483	0.146
Echinococcus multilocularis	hypothetical protein	0.0274	0.1086	0.1289
Echinococcus granulosus	ephrin type A receptor 4 A	0.0042	0.0027	0.0018
Trypanosoma cruzi	NIMA-related kinase, putative	0.0042	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Leishmania major	protein kinase, putative	0.0042	0.0028	0.013
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0042	0.0027	0.0018
Schistosoma mansoni	z-protein (S1r protein)	0.0361	0.1483	0.146
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0135	0.0911
Schistosoma mansoni	protein kinase	0.0051	0.0068	0.0042
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Entamoeba histolytica	tyrosin kinase, putative	0.0162	0.0575	0.3764
Entamoeba histolytica	p21-activated kinase	0.0042	0.0028	0.001
Echinococcus multilocularis	c src tyrosine kinase	0.0042	0.0027	0.0018
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0094	0.0266	0.0305
Loa Loa (eye worm)	hypothetical protein	0.012	0.0383	0.0372
Loa Loa (eye worm)	AUR protein kinase	0.0066	0.0135	0.0124
Echinococcus granulosus	poly (ADP ribose) polymerase	0.0047	0.005	0.0047
Schistosoma mansoni	voltage-gated potassium channel	0.0042	0.0028	0.0001
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0042	0.0027	0.0018
Brugia malayi	PXA domain containing protein	0.0361	0.1483	0.1473
Schistosoma mansoni	hypothetical protein	0.012	0.0383	0.0358
Echinococcus granulosus	axis inhibition protein axin	0.0361	0.1483	0.1764
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0135	0.0911
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0042	0.0028	0.0025
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0361	0.1483	0.1473
Echinococcus multilocularis	tyrosine protein kinase	0.0042	0.0027	0.0018
Brugia malayi	Fibronectin type III domain containing protein	0.0086	0.0229	0.0218
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0094	0.0266	0.0254
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Echinococcus multilocularis	semaphorin 5B	0.0274	0.1086	0.1289
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	insulin receptor	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	sema domain-containing protein	0.0274	0.1086	0.1076
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1483	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0207	0.0196
Echinococcus granulosus	kinase suppressor of Ras 1	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0643	0.2771	0.2763
Trypanosoma cruzi	poly(ADP-ribose) polymerase, putative	0.0167	0.0597	1
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0082	0.0207	0.0235
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Schistosoma mansoni	regulator of G protein signaling	0.0361	0.1483	0.146
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.1866	0.8352	0.835
Trichomonas vaginalis	ribosomal protein S6 kinase, 90kD, polypeptide, putative	0.0042	0.0028	0.019
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Entamoeba histolytica	hypothetical protein	0.012	0.0383	0.2449
Loa Loa (eye worm)	TK/DDR protein kinase	0.0042	0.0027	0.0015
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0042	0.0027	0.0015
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0042	0.0027	0.0018
Trypanosoma cruzi	aurora B kinase, putative	0.0066	0.0135	0.1901
Echinococcus multilocularis	expressed protein	0.0361	0.1483	0.1764
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0123	0.0399	0.0388
Schistosoma mansoni	protein kinase	0.0066	0.0135	0.0109
Echinococcus multilocularis	plexin a4	0.0763	0.332	0.3966
Leishmania major	protein kinase, putative	0.0066	0.0135	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0042	0.0028	0.0001
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Brugia malayi	hypothetical protein	0.0274	0.1086	0.1076
Loa Loa (eye worm)	hypothetical protein	0.012	0.0383	0.0372
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0028	0.001
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0042	0.0027	0.0018
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0042	0.0027	0.0018
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Brugia malayi	DNA-binding protein LAG-1	0.012	0.0383	0.0372
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0042	0.0027	0.0018
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0042	0.0027	0.0018
Echinococcus multilocularis	regulator of G protein signaling 3	0.0361	0.1483	0.1764
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0042	0.0027	0.0018
Echinococcus granulosus	Regulator of G protein signaling 20	0.0361	0.1483	0.1764
Loa Loa (eye worm)	TK/INSR protein kinase	0.0042	0.0027	0.0015
Toxoplasma gondii	protein kinase domain-containing protein	0.0042	0.0028	0.0025
Echinococcus granulosus	regulator of G protein signaling 3	0.0361	0.1483	0.1764
Brugia malayi	WGR domain containing protein	0.0167	0.0597	0.0586
Echinococcus multilocularis	integrin linked protein kinase	0.0042	0.0027	0.0018
Loa Loa (eye worm)	plexin A	0.0763	0.332	0.3312
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0207	0.0196
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Echinococcus granulosus	serine/threonine protein kinase	0.0042	0.0028	0.002
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	poly (ADP ribose) polymerase	0.007	0.0153	0.017
Leishmania major	protein kinase, putative	0.0042	0.0028	0.013
Schistosoma mansoni	poly [ADP-ribose] polymerase	0.0167	0.0597	0.0572
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0042	0.0027	0.0018
Brugia malayi	Tyrosine-protein kinase abl-1	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Entamoeba histolytica	serine/threonine- protein kinase 6 , putative	0.0066	0.0135	0.0744
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0042	0.0027	0.018
Entamoeba histolytica	serine/threonine protein kinase 6, putative	0.0066	0.0135	0.0744
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0042	0.0027	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Entamoeba histolytica	hypothetical protein	0.012	0.0383	0.2449
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0361	0.1483	0.146
Loa Loa (eye worm)	TK/EPH protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0167	0.0597	0.0586
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Entamoeba histolytica	protein kinase , putative	0.0066	0.0135	0.0744
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0361	0.1483	0.1764
Brugia malayi	SH2 domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0028	0.0017
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1086	0.1076
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0028	0.001
Loa Loa (eye worm)	TK/ROR protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK/FER protein kinase	0.0042	0.0027	0.0015
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.1866	0.8352	0.835
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	tyrosine kinase	0.0042	0.0027	0.0018
Echinococcus multilocularis	FL cytokine receptor	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	defective proboscis extension response	0.0082	0.0207	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Schistosoma mansoni	axis inhibition protein axin	0.0361	0.1483	0.146
Trypanosoma brucei	poly(adp-ribose) polymerase	0.0167	0.0597	1
Echinococcus multilocularis	protein tyrosine kinase	0.0042	0.0027	0.0018
Giardia lamblia	Aurora kinase	0.0066	0.0135	1
Entamoeba histolytica	hypothetical protein	0.0361	0.1483	1
Trypanosoma cruzi	Serine/threonine-protein kinase NEK17, putative	0.0042	0.0028	0.0025
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	expressed protein	0.0361	0.1483	0.1764
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0229	0.0218
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Loa Loa (eye worm)	serine/threonine protein kinase	0.0042	0.0027	0.0015
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0042	0.0028	0.0017
Echinococcus granulosus	tyrosine kinase	0.0042	0.0027	0.0018
Trypanosoma cruzi	Serine/threonine-protein kinase NEK21, putative	0.0042	0.0028	0.0025
Brugia malayi	Sema domain containing protein	0.0274	0.1086	0.1076
Plasmodium falciparum	serine/threonine protein kinase, putative	0.0066	0.0135	1
Brugia malayi	regulator of G-protein signaling egl-10	0.0361	0.1483	0.1473
Echinococcus granulosus	tyrosine protein kinase Blk	0.0042	0.0027	0.0018
Schistosoma mansoni	regulator of G protein signaling	0.0361	0.1483	0.146
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.1483	1
Echinococcus multilocularis	heat shock protein 70	0.0042	0.0027	0.0018
Brugia malayi	serine/threonine protein kinase 6	0.0066	0.0135	0.0124
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0042	0.0027	0.0018
Echinococcus multilocularis	activin receptor type	0.0051	0.0068	0.0068
Entamoeba histolytica	protein kinase domain containing protein	0.0162	0.0575	0.3764
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1483	0.1473
Schistosoma mansoni	protein kinase	0.0051	0.0068	0.0042
Loa Loa (eye worm)	sema domain-containing protein	0.0274	0.1086	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0047	0.0049	0.0044
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0207	0.0196
Schistosoma mansoni	regulator of G protein signaling	0.0361	0.1483	0.146
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0042	0.0028	0.0025
Trichomonas vaginalis	AGC family protein kinase	0.0066	0.0135	0.0911
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus granulosus	tyrosine protein kinase Srms	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1483	0.1473
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1483	0.1473
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0042	0.0027	0.0018
Entamoeba histolytica	serine/threonine- protein kinase 6, putative	0.0066	0.0135	0.0744
Brugia malayi	Probable exocyst complex component Sec5	0.012	0.0383	0.0372
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	roundabout 2	0.0086	0.0229	0.0261
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0042	0.0027	0.0015
Leishmania major	serine/threonine-protein kinase a, putative	0.0042	0.0028	0.013
Trichomonas vaginalis	protein kinase atn1, putative	0.0042	0.0027	0.018
Trichomonas vaginalis	TK family protein kinase	0.0042	0.0027	0.018
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Trichomonas vaginalis	conserved hypothetical protein	0.012	0.0383	0.2585
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	protein tyrosine kinase	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0042	0.0027	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0027	0.018
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0028	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.1483	1
Brugia malayi	hypothetical protein	0.0274	0.1086	0.1076
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0042	0.0028	0.001
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0207	0.0196
Brugia malayi	hypothetical protein	0.0042	0.0027	0.0015
Brugia malayi	Protein kinase domain containing protein	0.0273	0.1082	0.1072
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Loa Loa (eye worm)	AUR protein kinase	0.0066	0.0135	0.0124
Echinococcus multilocularis	regulator of G protein signaling 3	0.0361	0.1483	0.1764
Echinococcus granulosus	tyrosine kinase	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1086	0.1076
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0361	0.1483	0.1473
Echinococcus multilocularis	transfer RNA-Thr	0.0042	0.0027	0.0018
Schistosoma mansoni	vesicular amine transporter	0.0084	0.0219	0.0193
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1086	0.1076
Trypanosoma brucei	protein kinase, putative	0.0042	0.0028	0.0025
Brugia malayi	hypothetical protein	0.0042	0.0027	0.0015
Echinococcus granulosus	tyrosine protein kinase csk	0.0042	0.0027	0.0018
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.1707	0.7627	0.7624
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0042	0.0027	0.0018
Echinococcus granulosus	regulator of G protein signaling 3	0.0361	0.1483	0.1764
Echinococcus granulosus	aurora kinase A	0.0066	0.0135	0.0148
Loa Loa (eye worm)	RGS-3 protein	0.0361	0.1483	0.1473
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.012	0.0383	0.2585
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Echinococcus granulosus	plexin a4	0.0763	0.332	0.3966
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	WGR domain containing protein	0.0094	0.0266	0.0305
Brugia malayi	Raf kinase	0.0042	0.0027	0.0015
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.1483	1
Entamoeba histolytica	hypothetical protein	0.0042	0.0028	0.001
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0042	0.0027	0.0015
Entamoeba histolytica	cell surface protease gp63, putative	0.012	0.0383	0.2449
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0042	0.0027	0.0018
Echinococcus granulosus	tyrosine protein kinase shark	0.0042	0.0027	0.0018
Schistosoma mansoni	ephrin receptor	0.0047	0.0049	0.0022
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0042	0.0027	0.0018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0027	0.0015
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0051	0.0068	0.0733
Loa Loa (eye worm)	hypothetical protein	0.0361	0.1483	0.1473
Loa Loa (eye worm)	AUR protein kinase	0.0066	0.0135	0.0124
Brugia malayi	Sema domain containing protein	0.0274	0.1086	0.1076
Loa Loa (eye worm)	hypothetical protein	0.0274	0.1086	0.1076
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.1346	0.5979	0.7155
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0361	0.1483	0.146
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0042	0.0027	0.0018
Echinococcus granulosus	tyrosine protein kinase HCK	0.0042	0.0027	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0204	0.0764	0.0753
Trypanosoma cruzi	serine/threonine-protein kinase NRKB, putative	0.0042	0.0028	0.0025
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0361	0.1483	0.1764
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Echinococcus multilocularis	tyrosine kinase	0.0042	0.0027	0.0018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0042	0.0027	0.0018
Echinococcus granulosus	semaphorin 1A	0.0274	0.1086	0.1289
Toxoplasma gondii	aurora kinase	0.0066	0.0135	0.1901
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Schistosoma mansoni	nephrin	0.0086	0.0229	0.0203
Echinococcus multilocularis	regulator of G protein signaling 7	0.0361	0.1483	0.1764
Echinococcus granulosus	regulator of G protein signaling 7	0.0361	0.1483	0.1764
Echinococcus multilocularis	neuroglian	0.0082	0.0207	0.0235
Brugia malayi	Protein kinase domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	activin receptor type	0.0051	0.0068	0.0068
Entamoeba histolytica	protein kinase, putative	0.0066	0.0135	0.0744
Onchocerca volvulus		0.0643	0.2771	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	Clan MA, family M8, leishmanolysin-like metallopeptidase	0.012	0.0383	0.2585
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0042	0.0027	0.0018
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Loa Loa (eye worm)	TK/ACK protein kinase	0.0042	0.0027	0.0015
Brugia malayi	SH2 domain containing protein	0.0042	0.0027	0.0015
Echinococcus granulosus	beta-adrenergic receptor kinase	0.1707	0.7627	0.9131
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	conserved hypothetical protein	0.0361	0.1483	1
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Onchocerca volvulus		0.0274	0.1086	0.386
Entamoeba histolytica	hypothetical protein	0.012	0.0383	0.2449
Trichomonas vaginalis	TKL family protein kinase	0.0042	0.0027	0.018
Trichomonas vaginalis	AGC family protein kinase	0.0042	0.0028	0.019
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0042	0.0027	0.0018
Echinococcus multilocularis	Immunoglobulin	0.0082	0.0207	0.0235
Brugia malayi	C-terminal src kinase protein 1	0.0042	0.0027	0.0015
Entamoeba histolytica	protein kinase, putative	0.0042	0.0028	0.001
Loa Loa (eye worm)	poly(ADP-ribose) polymerase	0.012	0.0381	0.037
Echinococcus granulosus	axis inhibition protein axin	0.0361	0.1483	0.1764
Schistosoma mansoni	plexin	0.0369	0.152	0.1498
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0042	0.0027	0.0015
Loa Loa (eye worm)	TK protein kinase	0.0042	0.0027	0.0015
Entamoeba histolytica	hypothetical protein	0.0042	0.0028	0.001
Schistosoma mansoni	protein kinase	0.0051	0.0068	0.0042

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 7 uM	Inhibition of recombinant full length mouse PARP-2 after 10 mins using [3H]NAD+ by solution-phase assay	ChEMBL.	21417348
IC50 (binding)	= 22.4 uM	Inhibition of full length human PARP-1 after 10 mins by FlashPlate scintillation proximity assay	ChEMBL.	21417348

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1767058

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1510204