Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Schistosoma mansoni | lamin | 0.0028 | 0.0049 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.0164 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | dehydrogenases, short chain protein 9 | 0.002 | 0.0017 | 0.0135 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0357 | 0.1267 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.002 | 0.0017 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0357 | 0.1267 | 0.1252 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Trichomonas vaginalis | estradiol 17 beta-dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0357 | 0.1267 | 0.1443 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 0.0049 | 0.0386 |
Entamoeba histolytica | short chain dehydrogenase family protein | 0.002 | 0.0017 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Wolbachia endosymbiont of Brugia malayi | Short-chain alcohol dehydrogenase family enzyme | 0.002 | 0.0017 | 0.5 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0357 | 0.1267 | 1 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Trypanosoma brucei | 3-keto-dihydrosphingosine reductase | 0.002 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | Retinol dehydrogenase 12 | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1267 | 1 |
Trypanosoma brucei | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Trypanosoma brucei | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Mycobacterium ulcerans | short chain dehydrogenase | 0.1436 | 0.5271 | 0.5263 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.0164 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0357 | 0.1267 | 0.1252 |
Trichomonas vaginalis | short-chain dehydrogenases/reductase, putative | 0.002 | 0.0017 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Giardia lamblia | Oxidoreductase, short chain dehydrogenase/reductase family | 0.002 | 0.0017 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0064 | 0.0181 | 0.0189 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 0.0049 | 0.0032 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.0164 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | Dehydrogenases, short chain protein 2 | 0.002 | 0.0017 | 0.0135 |
Mycobacterium ulcerans | oxidoreductase | 0.0357 | 0.1267 | 0.1252 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0357 | 0.1267 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase 3, putative | 0.002 | 0.0017 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1267 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Trypanosoma brucei | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Loa Loa (eye worm) | short chain dehydrogenase/reductase family oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0357 | 0.1267 | 1 |
Brugia malayi | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.0189 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0357 | 0.1267 | 0.1443 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0049 | 0.0386 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0357 | 0.1267 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.002 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1267 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0357 | 0.1267 | 1 |
Trypanosoma brucei | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Giardia lamblia | Reductase, putative | 0.002 | 0.0017 | 0.5 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Schistosoma mansoni | amine oxidase | 0.0357 | 0.1267 | 0.1252 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Onchocerca volvulus | 0.0028 | 0.0049 | 0.0255 | |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.1436 | 0.5271 | 0.6067 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2711 | 1 | 1 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 0.0049 | 0.0037 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2711 | 1 | 1 |
Brugia malayi | Dehydrogenases, short chain protein 30 | 0.002 | 0.0017 | 0.0135 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.002 | 0.0017 | 0.5 |
Brugia malayi | Hypothetical oxidoreductase F56D1.5 | 0.002 | 0.0017 | 0.0135 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase 2 | 0.002 | 0.0017 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0357 | 0.1267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1267 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.2354 | 0.8677 | 1 |
Onchocerca volvulus | 0.0357 | 0.1267 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.0164 |
Brugia malayi | dehydrogenases, short chain protein 2 | 0.002 | 0.0017 | 0.0135 |
Trypanosoma brucei | beta-D-hydroxybutyrate dehydrogenase | 0.002 | 0.0017 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 0.0049 | 0.0037 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0049 | 0.0386 |
Echinococcus multilocularis | 0.0357 | 0.1267 | 0.1252 | |
Brugia malayi | D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor | 0.002 | 0.0017 | 0.0135 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2711 | 1 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0357 | 0.1267 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0357 | 0.1267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0357 | 0.1267 | 0.1252 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Trichomonas vaginalis | hydroxyacyl dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0357 | 0.1267 | 1 |
Loa Loa (eye worm) | dehydrogenase | 0.002 | 0.0017 | 0.0135 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0064 | 0.0181 | 0.0164 |
Brugia malayi | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1267 | 1 |
Mycobacterium ulcerans | monoamine oxidase | 0.0357 | 0.1267 | 0.1252 |
Plasmodium vivax | hypothetical protein, conserved | 0.0357 | 0.1267 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0064 | 0.0181 | 0.1309 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0357 | 0.1267 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0017 | 0.0135 |
Entamoeba histolytica | estradiol 17-beta-dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Giardia lamblia | Hypothetical protein | 0.002 | 0.0017 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Entamoeba histolytica | short chain dehydrogenase family protein | 0.002 | 0.0017 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.2354 | 0.8677 | 1 |
Trichomonas vaginalis | steroid dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Giardia lamblia | Short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Entamoeba histolytica | oxidoreductase, short chain dehydrogenase/reductase family | 0.002 | 0.0017 | 0.5 |
Echinococcus multilocularis | lamin | 0.0028 | 0.0049 | 0.0032 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0049 | 0.0386 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0047 | 0.0371 |
Onchocerca volvulus | 0.0028 | 0.0049 | 0.0255 | |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 0.0049 | 0.0032 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.1309 |
Schistosoma mansoni | lamin | 0.0028 | 0.0049 | 0.0032 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0357 | 0.1267 | 0.1252 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0064 | 0.0181 | 0.0164 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0357 | 0.1267 | 0.1443 |
Echinococcus multilocularis | musashi | 0.0028 | 0.0049 | 0.0032 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2711 | 1 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0357 | 0.1267 | 1 |
Echinococcus granulosus | lamin | 0.0028 | 0.0049 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0357 | 0.1267 | 1 |
Brugia malayi | hypothetical protein | 0.0357 | 0.1267 | 1 |
Schistosoma mansoni | amine oxidase | 0.0357 | 0.1267 | 0.1252 |
Loa Loa (eye worm) | dehydrogenase | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Mycobacterium ulcerans | dehydrogenase | 0.0357 | 0.1267 | 0.1252 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | SWIRM domain containing protein | 0.0357 | 0.1267 | 1 |
Trypanosoma brucei | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Brugia malayi | intermediate filament protein | 0.0028 | 0.0049 | 0.0386 |
Entamoeba histolytica | hypothetical protein | 0.002 | 0.0017 | 0.5 |
Trichomonas vaginalis | short-chain dehydrogenase, putative | 0.002 | 0.0017 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.002 | 0.0017 | 0.0135 |
Trypanosoma brucei | 3-ketoacyl-CoA reductase, putative | 0.002 | 0.0017 | 0.5 |
Entamoeba histolytica | 3-ketodihydrosphingosine reductase protein, putative | 0.002 | 0.0017 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0357 | 0.1267 | 0.1443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.