Detailed information for compound 1523245

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.819 | Formula: C16H15ClN2O4S
  • H donors: 2 H acceptors: 2 LogP: 2.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1sccc1C(=O)N)Cc1cc(Cl)c2c(c1)OCCCO2
  • InChi: 1S/C16H15ClN2O4S/c17-11-6-9(7-12-14(11)23-4-1-3-22-12)8-13(20)19-16-10(15(18)21)2-5-24-16/h2,5-7H,1,3-4,8H2,(H2,18,21)(H,19,20)
  • InChiKey: HVXMILNLTYLOGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Stress-activated protein kinase jnk-1 Get druggable targets OG5_129677 All targets in OG5_129677
Echinococcus multilocularis c Jun NH2 terminal kinase Get druggable targets OG5_129677 All targets in OG5_129677
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum ko:K04440 c-Jun N-terminal kinase, putative Get druggable targets OG5_129677 All targets in OG5_129677
Echinococcus granulosus c-Jun N-terminal kinases Get druggable targets OG5_129677 All targets in OG5_129677
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi conserved hypotetical protein 0.0016 0.0058 0.0058
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0283 0.0283
Entamoeba histolytica thymidine kinase, putative 0.0132 0.1501 0.1227
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0283 0.0283
Echinococcus multilocularis thymidine kinase 0.0166 0.1925 0.1877
Brugia malayi tRNA-specific adenosine deaminase 2 0.004 0.0353 0.0353
Onchocerca volvulus Putative deoxycytidylate deaminase 0.004 0.0353 0.0353
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Brugia malayi hypothetical protein 0.0037 0.0313 0.0313
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0037 0.032 0.0264
Echinococcus granulosus tumor protein p63 0.0344 0.4134 0.41
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0082 0.0082
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0082 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0283 0.0283
Giardia lamblia Thymidine kinase 0.0132 0.1501 0.122
Trypanosoma cruzi thymidine kinase, putative 0.0132 0.1501 0.1191
Brugia malayi Stress-activated protein kinase jnk-1 0.0278 0.3316 0.3316
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0283 0.0283
Echinococcus granulosus thymidine kinase 0.0166 0.1925 0.1877
Echinococcus multilocularis acetylcholinesterase 0.0023 0.014 0.0083
Onchocerca volvulus 0.0016 0.0058 0.0058
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0082 0.0248
Echinococcus granulosus thymidine kinase 0.0166 0.1925 0.1877
Onchocerca volvulus 0.004 0.0353 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0283 0.069
Echinococcus multilocularis tRNA specific adenosine deaminase 2 0.004 0.0353 0.0296
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0283 0.0853
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0058 0.0058
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0283 0.069
Echinococcus multilocularis thymidine kinase 0.0166 0.1925 0.1877
Schistosoma mansoni zinc finger protein 0.0016 0.0058 0.0175
Trypanosoma brucei cytidine deaminase 0.0816 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0058 0.0058
Brugia malayi dCMP deaminase 0.004 0.0353 0.0353
Entamoeba histolytica cytidine/deoxycytidylate deaminase family protein 0.004 0.0353 0.0041
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0283 0.0283
Brugia malayi ecdysteroid receptor 0.0034 0.0283 0.0283
Mycobacterium tuberculosis Hypothetical protein 0.0048 0.0455 0.0106
Echinococcus granulosus deoxycytidylate deaminase 0.004 0.0353 0.0296
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Brugia malayi hypothetical protein 0.0016 0.0058 0.0058
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0058 0.0058
Loa Loa (eye worm) dCMP deaminase 0.004 0.0353 0.0904
Loa Loa (eye worm) acetylcholinesterase 1 0.0023 0.014 0.0253
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0283 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0283 0.0283
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0517 0.1409
Brugia malayi steroid hormone receptor 0.0034 0.0283 0.0283
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0058 0.0175
Schistosoma mansoni cytidine/deoxycytidylate deaminase-related 0.004 0.0353 0.1064
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Onchocerca volvulus 0.0101 0.1114 0.1114
Brugia malayi hypothetical protein 0.0018 0.0082 0.0082
Echinococcus granulosus acetylcholinesterase 0.0023 0.014 0.0083
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0517 0.1409
Schistosoma mansoni coup transcription factor 0.0034 0.0283 0.0853
Schistosoma mansoni nuclear receptor 0.0016 0.0058 0.0175
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0283 0.0226
Brugia malayi Carboxylesterase family protein 0.0023 0.014 0.014
Onchocerca volvulus 0.005 0.0483 0.0483
Echinococcus multilocularis acetylcholinesterase 0.0023 0.014 0.0083
Loa Loa (eye worm) deoxynucleoside kinase 0.0037 0.032 0.0805
Brugia malayi thymidylate synthase 0.0101 0.1114 0.1114
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0283 0.0226
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0037 0.032 0.0966
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0058 0.0175
Echinococcus multilocularis tumor protein p63 0.0344 0.4134 0.41
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0283 0.069
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0278 0.3316 1
Trypanosoma cruzi cytidine deaminase-like protein 0.0816 1 1
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0483 0.1458
Echinococcus granulosus carboxylesterase 5A 0.0023 0.014 0.0083
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0283 0.0283
Leishmania major cytidine deaminase-like protein 0.0816 1 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0283 0.0283
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.014 0.0423
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0283 0.069
Loa Loa (eye worm) thymidylate synthase 0.0101 0.1114 0.3241
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0058 0.0058
Brugia malayi ecdysone receptor 0.0016 0.0058 0.0058
Leishmania major thymidine kinase, putative 0.0132 0.1501 0.1191
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.3359
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0283 0.0226
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0058 0.0058
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0283 0.0283
Echinococcus multilocularis expressed protein 0.0089 0.0961 0.0908
Brugia malayi nuclear receptor NHR-88 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0253
Trypanosoma cruzi thymidine kinase, putative 0.0132 0.1501 0.1191
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0082 0.0074
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0283 0.0226
Echinococcus granulosus expressed protein 0.0089 0.0961 0.0908
Wolbachia endosymbiont of Brugia malayi pyrimidine deaminase and reductase 0.004 0.0353 1
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Echinococcus granulosus acetylcholinesterase 0.0023 0.014 0.0083
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0253
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0082 0.0248
Trichomonas vaginalis cytidine deaminase, putative 0.0816 1 1
Brugia malayi Carboxylesterase family protein 0.0023 0.014 0.014
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0283 0.0853
Entamoeba histolytica hypothetical protein, conserved 0.004 0.0353 0.0041
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0283 0.0853
Brugia malayi TAR-binding protein 0.0053 0.0517 0.0517
Echinococcus granulosus thymidylate synthase 0.0101 0.1114 0.1062
Brugia malayi hypothetical protein 0.0048 0.0455 0.0455
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0283 0.0226
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0283 0.0226
Trichomonas vaginalis cytidine deaminase, putative 0.0816 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0283 0.0283
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0101 0.1114 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0082 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Echinococcus granulosus c-Jun N-terminal kinases 0.0278 0.3316 0.3277
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Echinococcus multilocularis survival motor neuron protein 1 0.0056 0.0557 0.0501
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0082 0.0082
Mycobacterium ulcerans cytidine/deoxycytidylate deaminase 0.004 0.0353 0.0037
Trichomonas vaginalis thymidine kinase, putative 0.0132 0.1501 0.122
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0058 0.0175
Schistosoma mansoni hypothetical protein 0.0037 0.0313 0.0943
Treponema pallidum deoxycytidylate deaminase 0.004 0.0353 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0283 0.0283
Schistosoma mansoni retinoic acid receptor RXR 0.0135 0.1531 0.4616
Giardia lamblia Cytidine deaminase 0.0816 1 1
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0283 0.0853
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0283 0.069
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0283 0.0283
Loa Loa (eye worm) carboxylesterase 0.0023 0.014 0.0253
Onchocerca volvulus 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Echinococcus multilocularis carboxylesterase 5A 0.0023 0.014 0.0083
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0283 0.0226
Trichomonas vaginalis thymidine kinase, putative 0.0132 0.1501 0.122
Echinococcus granulosus tRNA specific adenosine deaminase 2 0.004 0.0353 0.0296
Onchocerca volvulus 0.0016 0.0058 0.0058
Schistosoma mansoni nuclear receptor 0.0016 0.0058 0.0175
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0101 0.1114 0.0789
Echinococcus multilocularis cytidine deaminase 0.0816 1 1
Onchocerca volvulus 0.0816 1 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0283 0.0853
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0037 0.032 0.0264
Brugia malayi RNA binding protein 0.0053 0.0517 0.0517
Echinococcus granulosus cytidine deaminase 0.0816 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Loa Loa (eye worm) hypothetical protein 0.005 0.0483 0.1305
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0283 0.0226
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0101 0.1114 0.0823
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0313 0.0943
Brugia malayi Cytidine and deoxycytidylate deaminase zinc-binding region family protein 0.004 0.0353 0.0353
Loa Loa (eye worm) RNA binding protein 0.0053 0.0517 0.1409
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0058 0.0058
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0517 0.0462
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0816 1 1
Mycobacterium ulcerans cytidine deaminase 0.0816 1 1
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Echinococcus multilocularis deoxycytidylate deaminase 0.004 0.0353 0.0296
Mycobacterium ulcerans thymidylate synthase 0.0101 0.1114 0.0823
Brugia malayi tailless protein 0.0016 0.0058 0.0058
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Echinococcus multilocularis thymidylate synthase 0.0101 0.1114 0.1062
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Trichomonas vaginalis thymidine kinase, putative 0.0132 0.1501 0.122
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0166 0.1925 0.1877
Brugia malayi hypothetical protein 0.0016 0.0058 0.0058
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0283 0.0226
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Schistosoma mansoni dCTP deaminase 0.004 0.0353 0.1064
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0283 0.0283
Trypanosoma brucei thymidine kinase 0.0132 0.1501 0.1191
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Brugia malayi nuclear receptor NHR-88 0.0016 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0283 0.069
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0048 0.0455 0.0106
Entamoeba histolytica cytidine deaminase, putative 0.0816 1 1
Mycobacterium leprae possible cytidine/deoxycytidylate deaminase 0.004 0.0353 0.0037
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0283 0.0283
Giardia lamblia Cytosine deaminase, putative 0.004 0.0353 0.0033
Echinococcus multilocularis transfer RNA-Ile 0.0166 0.1925 0.1877
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3316 1
Schistosoma mansoni cytidine/deoxycytidylate deaminase-related 0.004 0.0353 0.1064
Brugia malayi nuclear hormone receptor 0.0016 0.0058 0.0058
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0117 0.1306 0.1255
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0058 0.0175
Schistosoma mansoni thymidine kinase 0.0166 0.1925 0.5803
Echinococcus multilocularis cytidine and deoxycytidylate deaminase 0.004 0.0353 0.0296
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0135 0.1531 0.1481
Echinococcus granulosus survival motor neuron protein 1 0.0056 0.0557 0.0501
Loa Loa (eye worm) hypothetical protein 0.004 0.0353 0.0904
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0283 0.0283
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0058 0.0175
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0313 0.0256
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0455 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0283 0.069
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0278 0.3316 0.3277
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0283 0.0283
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0283 0.0853
Loa Loa (eye worm) tRNA-specific adenosine deaminase 2 0.004 0.0353 0.0904
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0283 0.069
Schistosoma mansoni deoxycytidylate deaminase 0.004 0.0353 0.1064
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0283 0.0853
Trichomonas vaginalis riboflavin-specific deaminase, putative 0.004 0.0353 0.0033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0283 0.0226
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0283 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Echinococcus granulosus tar DNA binding protein 0.0053 0.0517 0.0462
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0058 0.0058
Brugia malayi nuclear receptor RXR 0.0018 0.0082 0.0082
Onchocerca volvulus 0.0816 1 1
Echinococcus granulosus cytidine and deoxycytidylate deaminase 0.004 0.0353 0.0296
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0517 0.0517
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0283 0.0853
Brugia malayi nuclear hormone receptor 0.0034 0.0283 0.0283
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0816 1 1
Brugia malayi nuclear receptor NHR-67 0.0016 0.0058 0.0058
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0283 0.0853
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0283 0.0853
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0816 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0557 0.153
Brugia malayi hypothetical protein 0.0056 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Mycobacterium ulcerans bifunctional riboflavin biosynthesis protein RibG 0.004 0.0353 0.0037
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0283 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0283 0.0283
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0313 0.0256
Brugia malayi Deoxynucleoside kinase family protein 0.0037 0.032 0.032
Brugia malayi hypothetical protein 0.0018 0.0082 0.0082
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Brugia malayi nuclear receptor RXR 0.0016 0.0058 0.0058
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0283 0.0853
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0816 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Chlamydia trachomatis bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase 0.004 0.0353 0.5

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.9 uM Inhibition of JNK1 by TR-FRET assay ChEMBL. 21458276

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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