Detailed information for compound 1523245

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 366.819 | Formula: C16H15ClN2O4S
  • H donors: 2 H acceptors: 2 LogP: 2.84 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1sccc1C(=O)N)Cc1cc(Cl)c2c(c1)OCCCO2
  • InChi: 1S/C16H15ClN2O4S/c17-11-6-9(7-12-14(11)23-4-1-3-22-12)8-13(20)19-16-10(15(18)21)2-5-24-16/h2,5-7H,1,3-4,8H2,(H2,18,21)(H,19,20)
  • InChiKey: HVXMILNLTYLOGD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 8 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis c Jun NH2 terminal kinase Get druggable targets OG5_129677 All targets in OG5_129677
Brugia malayi Stress-activated protein kinase jnk-1 Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
Echinococcus granulosus c-Jun N-terminal kinases Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum ko:K04440 c-Jun N-terminal kinase, putative Get druggable targets OG5_129677 All targets in OG5_129677
Schistosoma japonicum IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing Get druggable targets OG5_129677 All targets in OG5_129677
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase Get druggable targets OG5_129677 All targets in OG5_129677
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tRNA specific adenosine deaminase 2 0.004 0.0353 0.0296
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0101 0.1114 1
Brugia malayi Carboxylesterase family protein 0.0023 0.014 0.014
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Giardia lamblia Thymidine kinase 0.0132 0.1501 0.122
Brugia malayi tailless protein 0.0016 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0034 0.0283 0.069
Brugia malayi conserved hypotetical protein 0.0016 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0253
Onchocerca volvulus 0.0816 1 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0034 0.0283 0.0226
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0058 0.0058
Schistosoma mansoni nuclear receptor nhr-48 0.0016 0.0058 0.0175
Schistosoma mansoni cytidine/deoxycytidylate deaminase-related 0.004 0.0353 0.1064
Echinococcus multilocularis cytidine deaminase 0.0816 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0058 0.0058
Schistosoma mansoni thymidine kinase 0.0166 0.1925 0.5803
Loa Loa (eye worm) carboxylesterase 0.0023 0.014 0.0253
Echinococcus multilocularis cytidine and deoxycytidylate deaminase 0.004 0.0353 0.0296
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0053 0.0517 0.1409
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0048 0.0455 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0283 0.0283
Brugia malayi orphan nuclear receptor NR2E1 0.0016 0.0058 0.0058
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0101 0.1114 0.0823
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0283 0.0853
Brugia malayi nuclear hormone receptor family member odr-7 0.0016 0.0058 0.0058
Toxoplasma gondii cytidine and deoxycytidylate deaminase zinc-binding region domain-containing protein 0.0816 1 1
Trypanosoma cruzi thymidine kinase, putative 0.0132 0.1501 0.1191
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.3359
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0018 0.0082 0.0024
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0034 0.0283 0.0853
Schistosoma mansoni deoxycytidylate deaminase 0.004 0.0353 0.1064
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0016 0.0058 0.0175
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Onchocerca volvulus 0.0816 1 1
Echinococcus granulosus ecdysone induced protein 78C 0.0034 0.0283 0.0226
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0034 0.0283 0.069
Brugia malayi RNA binding protein 0.0053 0.0517 0.0517
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0034 0.0283 0.0853
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0135 0.1531 0.1481
Echinococcus granulosus tar DNA binding protein 0.0053 0.0517 0.0462
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.3316 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Brugia malayi RNA recognition motif domain containing protein 0.0053 0.0517 0.0517
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Onchocerca volvulus 0.0101 0.1114 0.1114
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0037 0.032 0.0264
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Leishmania major cytidine deaminase-like protein 0.0816 1 1
Entamoeba histolytica hypothetical protein, conserved 0.004 0.0353 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0455 0.0139
Echinococcus multilocularis thyroid hormone receptor alpha 0.0034 0.0283 0.0226
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Echinococcus multilocularis thymidine kinase 0.0166 0.1925 0.1877
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0082 0.0082
Loa Loa (eye worm) deoxynucleoside kinase 0.0037 0.032 0.0805
Echinococcus multilocularis tRNA specific adenosine deaminase 2 0.004 0.0353 0.0296
Schistosoma mansoni steroid hormone receptor ad4bp 0.0034 0.0283 0.0853
Loa Loa (eye worm) hypothetical protein 0.0056 0.0557 0.153
Mycobacterium leprae possible cytidine/deoxycytidylate deaminase 0.004 0.0353 0.0037
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0034 0.0283 0.0853
Schistosoma mansoni cytidine/deoxycytidylate deaminase-related 0.004 0.0353 0.1064
Onchocerca volvulus Bile acid receptor homolog 0.0034 0.0283 0.0283
Brugia malayi ecdysteroid receptor 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Entamoeba histolytica thymidine kinase, putative 0.0132 0.1501 0.1227
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0278 0.3316 1
Brugia malayi nuclear receptor NHR-67 0.0016 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Echinococcus multilocularis acetylcholinesterase 0.0023 0.014 0.0083
Brugia malayi nuclear receptor NHR-88 0.0034 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Entamoeba histolytica cytidine deaminase, putative 0.0816 1 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0016 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Brugia malayi ecdysone receptor 0.0016 0.0058 0.0058
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Loa Loa (eye worm) steroid hormone receptor 0.0034 0.0283 0.069
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0082 0.0082
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0034 0.0283 0.069
Echinococcus granulosus cytidine and deoxycytidylate deaminase 0.004 0.0353 0.0296
Schistosoma mansoni nuclear receptor 0.0016 0.0058 0.0175
Echinococcus granulosus FTZ F1 alpha 0.0034 0.0283 0.0226
Echinococcus multilocularis survival motor neuron protein 1 0.0056 0.0557 0.0501
Schistosoma mansoni nuclear receptor 0.0016 0.0058 0.0175
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0034 0.0283 0.0283
Brugia malayi Cytidine and deoxycytidylate deaminase zinc-binding region family protein 0.004 0.0353 0.0353
Echinococcus granulosus c-Jun N-terminal kinases 0.0278 0.3316 0.3277
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0101 0.1114 0.0789
Loa Loa (eye worm) hypothetical protein 0.0023 0.014 0.0253
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Echinococcus granulosus thymidine kinase 0.0166 0.1925 0.1877
Wolbachia endosymbiont of Brugia malayi pyrimidine deaminase and reductase 0.004 0.0353 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0034 0.0283 0.0226
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0034 0.0283 0.0226
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0117 0.1306 0.1255
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Trichomonas vaginalis thymidine kinase, putative 0.0132 0.1501 0.122
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Echinococcus granulosus deoxycytidylate deaminase 0.004 0.0353 0.0296
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0016 0.0058 0.0058
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0283 0.0283
Echinococcus multilocularis tumor protein p63 0.0344 0.4134 0.41
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0034 0.0283 0.0853
Brugia malayi TAR-binding protein 0.0053 0.0517 0.0517
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0313 0.0943
Mycobacterium tuberculosis Hypothetical protein 0.0048 0.0455 0.0106
Loa Loa (eye worm) hypothetical protein 0.005 0.0483 0.1305
Brugia malayi hypothetical protein 0.0056 0.0557 0.0557
Trichomonas vaginalis thymidine kinase, putative 0.0132 0.1501 0.122
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0283 0.0853
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0483 0.1458
Onchocerca volvulus Protein ultraspiracle homolog 0.0034 0.0283 0.0283
Schistosoma mansoni zinc finger protein 0.0016 0.0058 0.0175
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0283 0.0853
Brugia malayi Nuclear hormone receptor E75 0.0016 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0016 0.0058 0.0175
Onchocerca volvulus 0.0016 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Brugia malayi hypothetical protein 0.0037 0.0313 0.0313
Brugia malayi hypothetical protein 0.0018 0.0082 0.0082
Loa Loa (eye worm) thymidylate synthase 0.0101 0.1114 0.3241
Mycobacterium tuberculosis Probable cytidine deaminase Cdd (cytidine aminohydrolase) (cytidine nucleoside deaminase) 0.0816 1 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0313 0.0256
Onchocerca volvulus 0.004 0.0353 0.0353
Chlamydia trachomatis bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino) uracil reductase 0.004 0.0353 0.5
Giardia lamblia Cytosine deaminase, putative 0.004 0.0353 0.0033
Echinococcus granulosus acetylcholinesterase 0.0023 0.014 0.0083
Brugia malayi hypothetical protein 0.0018 0.0082 0.0082
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0283 0.0283
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 1
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0058 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0018 0.0082 0.0074
Trichomonas vaginalis riboflavin-specific deaminase, putative 0.004 0.0353 0.0033
Trypanosoma cruzi thymidine kinase, putative 0.0132 0.1501 0.1191
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0037 0.032 0.0966
Mycobacterium ulcerans thymidylate synthase 0.0101 0.1114 0.0823
Echinococcus multilocularis thymidine kinase 0.0166 0.1925 0.1877
Loa Loa (eye worm) TAR-binding protein 0.0053 0.0517 0.1409
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0034 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Echinococcus multilocularis transfer RNA-Ile 0.0166 0.1925 0.1877
Brugia malayi nuclear hormone receptor family member nhr-6 0.0016 0.0058 0.0058
Brugia malayi nuclear hormone receptor 0.0016 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0034 0.0283 0.069
Onchocerca volvulus 0.005 0.0483 0.0483
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0278 0.3316 0.3277
Mycobacterium ulcerans bifunctional riboflavin biosynthesis protein RibG 0.004 0.0353 0.0037
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0016 0.0058 0.0175
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0034 0.0283 0.069
Brugia malayi Steroid receptor seven-up type 2 0.0034 0.0283 0.0283
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0034 0.0283 0.0283
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Schistosoma mansoni hypothetical protein 0.0037 0.0313 0.0943
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0283 0.0226
Echinococcus multilocularis ecdysone induced protein 78C 0.0034 0.0283 0.0226
Giardia lamblia Cytidine deaminase 0.0816 1 1
Trichomonas vaginalis thymidine kinase, putative 0.0132 0.1501 0.122
Schistosoma mansoni tar DNA-binding protein 0.0053 0.0517 0.1559
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0034 0.0283 0.0283
Schistosoma mansoni thyroid hormone receptor 0.0034 0.0283 0.0853
Brugia malayi thymidylate synthase 0.0101 0.1114 0.1114
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0283 0.0283
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0018 0.0082 0.0248
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0034 0.0283 0.0226
Echinococcus multilocularis FTZ F1 alpha 0.0034 0.0283 0.0226
Echinococcus granulosus cytidine deaminase 0.0816 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Echinococcus multilocularis tar DNA binding protein 0.0053 0.0517 0.0462
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Trypanosoma brucei thymidine kinase 0.0132 0.1501 0.1191
Brugia malayi nuclear hormone receptor 0.0034 0.0283 0.0283
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0034 0.0283 0.069
Brugia malayi hypothetical protein 0.0016 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Mycobacterium ulcerans cytidine/deoxycytidylate deaminase 0.004 0.0353 0.0037
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0101 0.1114 0.0789
Leishmania major thymidine kinase, putative 0.0132 0.1501 0.1191
Brugia malayi hypothetical protein 0.0048 0.0455 0.0455
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Echinococcus granulosus thymidylate synthase 0.0101 0.1114 0.1062
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.0166 0.1925 0.1877
Echinococcus granulosus survival motor neuron protein 1 0.0056 0.0557 0.0501
Brugia malayi Deoxynucleoside kinase family protein 0.0037 0.032 0.032
Trichomonas vaginalis cytidine deaminase, putative 0.0816 1 1
Trypanosoma cruzi cytidine deaminase-like protein 0.0816 1 1
Treponema pallidum deoxycytidylate deaminase 0.004 0.0353 0.5
Echinococcus multilocularis deoxycytidylate deaminase 0.004 0.0353 0.0296
Echinococcus multilocularis expressed protein 0.0089 0.0961 0.0908
Schistosoma mansoni RAR-like nuclear receptor 0.0034 0.0283 0.0853
Brugia malayi tRNA-specific adenosine deaminase 2 0.004 0.0353 0.0353
Loa Loa (eye worm) dCMP deaminase 0.004 0.0353 0.0904
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0034 0.0283 0.0853
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0313 0.0256
Trypanosoma cruzi cytidine deaminase-like protein, putative 0.0816 1 1
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0037 0.032 0.0264
Brugia malayi steroid hormone receptor 0.0034 0.0283 0.0283
Brugia malayi Stress-activated protein kinase jnk-1 0.0278 0.3316 0.3316
Entamoeba histolytica cytidine/deoxycytidylate deaminase family protein 0.004 0.0353 0.0041
Brugia malayi dCMP deaminase 0.004 0.0353 0.0353
Mycobacterium ulcerans cytidine deaminase 0.0816 1 1
Onchocerca volvulus Putative deoxycytidylate deaminase 0.004 0.0353 0.0353
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0082 0.0248
Echinococcus granulosus acetylcholinesterase 0.0023 0.014 0.0083
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Brugia malayi Carboxylesterase family protein 0.0023 0.014 0.014
Echinococcus multilocularis carboxylesterase 5A 0.0023 0.014 0.0083
Brugia malayi photoreceptor-specific nuclear receptor 0.0034 0.0283 0.0283
Loa Loa (eye worm) acetylcholinesterase 1 0.0023 0.014 0.0253
Loa Loa (eye worm) hypothetical protein 0.0034 0.0283 0.069
Echinococcus granulosus thymidine kinase 0.0166 0.1925 0.1877
Trypanosoma brucei cytidine deaminase 0.0816 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0034 0.0283 0.0226
Onchocerca volvulus 0.0034 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0034 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0034 0.0283 0.0283
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0023 0.014 0.0423
Loa Loa (eye worm) RNA binding protein 0.0053 0.0517 0.1409
Echinococcus granulosus tumor protein p63 0.0344 0.4134 0.41
Mycobacterium leprae PROBABLE CYTIDINE DEAMINASE CDD (CYTIDINE AMINOHYDROLASE) (CYTIDINE NUCLEOSIDE DEAMINASE) 0.0816 1 1
Brugia malayi nuclear receptor RXR 0.0018 0.0082 0.0082
Echinococcus granulosus carboxylesterase 5A 0.0023 0.014 0.0083
Brugia malayi nuclear receptor RXR 0.0016 0.0058 0.0058
Onchocerca volvulus 0.0016 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0034 0.0283 0.069
Echinococcus granulosus expressed protein 0.0089 0.0961 0.0908
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0034 0.0283 0.0226
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0037 0.032 0.0008
Schistosoma mansoni dCTP deaminase 0.004 0.0353 0.1064
Brugia malayi nuclear receptor NHR-88 0.0016 0.0058 0.0058
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0034 0.0283 0.0226
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0034 0.0283 0.0283
Schistosoma mansoni coup transcription factor 0.0034 0.0283 0.0853
Brugia malayi hypothetical protein 0.0016 0.0058 0.0058
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0034 0.0283 0.0226
Loa Loa (eye worm) tRNA-specific adenosine deaminase 2 0.004 0.0353 0.0904
Schistosoma mansoni retinoic acid receptor RXR 0.0135 0.1531 0.4616
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0034 0.0283 0.0283
Entamoeba histolytica hypothetical protein 0.0037 0.032 0.0008
Echinococcus multilocularis acetylcholinesterase 0.0023 0.014 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0034 0.0283 0.0283
Trichomonas vaginalis cytidine deaminase, putative 0.0816 1 1
Echinococcus multilocularis thymidylate synthase 0.0101 0.1114 0.1062
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0074
Loa Loa (eye worm) hypothetical protein 0.004 0.0353 0.0904
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0018 0.0082 0.0024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.9 uM Inhibition of JNK1 by TR-FRET assay ChEMBL. 21458276

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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