TDR Targets

Basic information

Technical information

TDR Targets ID: 1525877
Name: 4-amino-N-butyl-8-(2,5-dimethoxyphenyl)cinnol ine-3-carboxamide
MW: 380.44 | Formula: C21H24N4O3
H donors: 2 H acceptors: 3 LogP: 3.48 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCNC(=O)c1nnc2c(c1N)cccc2c1cc(OC)ccc1OC
InChi: 1S/C21H24N4O3/c1-4-5-11-23-21(26)20-18(22)15-8-6-7-14(19(15)24-25-20)16-12-13(27-2)9-10-17(16)28-3/h6-10,12H,4-5,11H2,1-3H3,(H2,22,24)(H,23,26)
InChiKey: RINRTVBSMKHYQY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-amino-N-butyl-8-(2,5-dimethoxyphenyl)-3-cinnolinecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	gamma-aminobutyric acid (GABA) A receptor, alpha 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Brugia malayi	Neurotransmitter-gated ion-channel ligand binding domain containing protein	gamma-aminobutyric acid (GABA) A receptor, alpha 2	451 aa	393 aa	25.9 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0199	0.0749
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0101	0.0937	0.1472
Echinococcus granulosus	histone acetyltransferase MYST2	0.0101	0.0937	0.1472
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0105	0.0992	0.1564
Giardia lamblia	Giardia trophozoite antigen GTA-1	0.0026	0.0097	0.362
Loa Loa (eye worm)	hypothetical protein	0.048	0.5236	0.967
Brugia malayi	Shank2E	0.0026	0.0097	0.0064
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.0026	0.0097	0.0056
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0199	0.0749
Plasmodium vivax	hexose transporter	0.0105	0.0992	0.1932
Echinococcus multilocularis	Sterile alpha motif type	0.0026	0.0097	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0101	0.0937	0.1633
Loa Loa (eye worm)	jmjC domain-containing protein	0.0144	0.1427	0.2548
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0032	0.0164	0.0207
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.012	0.1155	0.1838
Schistosoma mansoni	sex comb on midleg homolog	0.0279	0.2959	0.2913
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0199	0.0749
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0101	0.0937	0.1472
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0031	0.0143	0.0165
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0168	0.7803
Brugia malayi	mbt repeat family protein	0.029	0.3087	0.5845
Schistosoma mansoni	hypothetical protein	0.0105	0.0992	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0168	0.6871
Onchocerca volvulus		0.0035	0.0199	0.019
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0156	0.0172
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0028	0.0119	0.0092
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0156	0.0177
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.017	0.1728	0.3464
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0199	0.0228
Trypanosoma cruzi	Kinesin-13 5, putative	0.0026	0.0097	0.4522
Brugia malayi	hypothetical protein	0.0161	0.1627	0.3023
Brugia malayi	hypothetical protein	0.0026	0.0097	0.0064
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0028	0.0119	0.0055
Schistosoma mansoni	polyhomeotic	0.0026	0.0097	0.0033
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0199	0.0749
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Echinococcus multilocularis	polyhomeotic protein 2	0.0026	0.0097	0.0056
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0448	0.4869	1
Onchocerca volvulus		0.0035	0.0199	0.019
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0026	0.0097	0.0064
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Onchocerca volvulus		0.0317	0.3387	0.6132
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0547	0.5999	1
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0026	0.0097	0.0033
Plasmodium falciparum	protein kinase 6	0.0448	0.4869	1
Loa Loa (eye worm)	hydrolase	0.0495	0.5412	1
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0101	0.0937	0.0879
Trichomonas vaginalis	cgi-62, putative	0.0026	0.0097	0.0688
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0156	0.0092
Trichomonas vaginalis	c2h2 zinc finger protein, putative	0.0026	0.0097	0.0688
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Plasmodium falciparum	mitogen-activated protein kinase 2	0.017	0.1728	0.3464
Schistosoma mansoni	sex comb on midleg homolog	0.0279	0.2959	0.2913
Mycobacterium ulcerans	epoxide hydrolase EphA	0.0161	0.1618	1
Onchocerca volvulus	Epoxide hydrolase 1 homolog	0.05	0.5462	1
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Plasmodium falciparum	hexose transporter	0.0105	0.0992	0.1932
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1627	0.2923
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.048	0.5236	0.9578
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0215	0.0486
Brugia malayi	jmjC domain containing protein	0.0027	0.01	0.0069
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.0091	0.005
Echinococcus multilocularis	chromobox protein 2	0.0207	0.2142	0.3501
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0168	0.6871
Schistosoma mansoni	Protein aveugle	0.0026	0.0097	0.0033
Leishmania major	glucose transporter, lmgt3	0.0033	0.0168	0.6871
Mycobacterium ulcerans	putative regulatory protein	0.0036	0.0201	0.0882
Echinococcus multilocularis	liprin alpha 2	0.0026	0.0097	0.0056
Echinococcus multilocularis	histone acetyltransferase myst3	0.0043	0.0282	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Trichomonas vaginalis	conserved hypothetical protein	0.0026	0.0097	0.0688
Brugia malayi	hypothetical protein	0.0026	0.0097	0.0064
Leishmania major	hypothetical protein, conserved	0.0035	0.0199	0.8942
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0199	0.0749
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0032	0.0164	0.0207
Plasmodium vivax	JmjC domain containing protein	0.0031	0.0143	0.0165
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0026	0.0097	0.0062
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.0026	0.0097	0.0056
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0026	0.0097	0.0056
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Echinococcus multilocularis	Sterile alpha motif SAM	0.0026	0.0097	0.0056
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0156	0.7525
Echinococcus granulosus	polyhomeotic protein 2	0.0026	0.0097	0.0056
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0199	0.087
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0215	0.0315
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0168	0.1423
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0034	0.0182	0.038
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0156	0.9253
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0215	0.0315
Toxoplasma gondii	PLU-1 family protein	0.0046	0.032	0.0823
Echinococcus granulosus	chromobox protein 2	0.0207	0.2142	0.3501
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0032	0.0164	0.032
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0199	0.0253
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0199	0.0749
Echinococcus multilocularis	lysine specific demethylase 5A	0.0081	0.072	0.1105
Trypanosoma cruzi	hexose transporter	0.0033	0.0168	0.7803
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0168	0.7803
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0156	0.0155
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0156	0.0155
Schistosoma mansoni	spingomyelin synthetase-related	0.0026	0.0097	0.0033
Brugia malayi	Cytochrome P450 family protein	0.0026	0.0091	0.0051
Schistosoma mansoni	phd finger protein	0.0043	0.0282	0.0219
Echinococcus granulosus	single minded 2	0.0036	0.0201	0.0231
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0215	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0097	0.0033
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0156	1
Toxoplasma gondii	ABC1 family protein	0.0035	0.0199	0.0435
Echinococcus granulosus	pdz domain containing protein	0.0026	0.0097	0.0056
Echinococcus granulosus	tumor suppressor p53 binding protein 1	0.0344	0.3691	0.6111
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0199	0.0136
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0032	0.0163	0.0192
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0168	0.7803
Echinococcus granulosus	lysine specific demethylase 5A	0.0098	0.0904	0.1416
Brugia malayi	beta-lactamase family protein	0.0035	0.0199	0.0261
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.0026	0.0097	0.2197
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0199	0.0749
Onchocerca volvulus		0.0036	0.0201	0.0193
Brugia malayi	hypoxia-induced factor 1	0.0149	0.1486	0.2749
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0199	0.0253
Echinococcus granulosus	histone acetyltransferase myst3	0.0043	0.0282	0.0367
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0168	0.1423
Brugia malayi	bHLH-PAS transcription factor	0.0036	0.0201	0.0265
Echinococcus granulosus	liprin alpha 2	0.0026	0.0097	0.0056
Brugia malayi	jmjC domain containing protein	0.0144	0.1427	0.2635
Brugia malayi	cask-interacting protein 2	0.0026	0.0097	0.0064
Mycobacterium tuberculosis	Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase)	0.0161	0.1618	0.6808
Echinococcus multilocularis	pdz domain containing protein	0.0026	0.0097	0.0056
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0199	0.0228
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0199	0.0136
Brugia malayi	Liprin-alpha 2	0.0026	0.0097	0.0064
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0098	0.0904	0.0846
Toxoplasma gondii	facilitative glucose transporter GT1	0.0105	0.0992	0.2985
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0026	0.0097	0.0056
Schistosoma mansoni	protein kinase	0.0032	0.0163	0.01
Plasmodium falciparum	protein kinase 7	0.0298	0.3174	0.6471
Brugia malayi	mbt repeat family protein	0.048	0.5236	1
Trichomonas vaginalis	CAMK family protein kinase	0.0032	0.0163	0.1374
Brugia malayi	CHD4 protein	0.0028	0.0119	0.0106
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0028	0.0119	0.0092
Schistosoma mansoni	glucose transport protein	0.0105	0.0992	0.0934
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0163	0.0185
Loa Loa (eye worm)	MBCTL1	0.0101	0.0937	0.1633
Entamoeba histolytica	protein kinase, putative	0.0032	0.0163	1
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0199	0.0261
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0199	0.0749
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0168	0.1423
Trypanosoma cruzi	Kinesin-13 5, putative	0.0026	0.0097	0.4522
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0156	0.0172
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Echinococcus multilocularis	liprin alpha 2	0.0026	0.0097	0.0056
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0547	0.5999	1
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0168	0.1423
Brugia malayi	Sphingomyelin synthase-related 1	0.0026	0.0097	0.0064
Loa Loa (eye worm)	CHromoDomain protein family member	0.0028	0.0119	0.0102
Echinococcus granulosus	polycomb protein SCMH1	0.0279	0.2959	0.4877
Schistosoma mansoni	jumonji domain containing protein	0.0027	0.01	0.0036
Trypanosoma cruzi	hypothetical protein	0.0026	0.0097	0.4522
Echinococcus multilocularis	polycomb protein SCMH1	0.0279	0.2959	0.4877
Trichomonas vaginalis	conserved hypothetical protein	0.0105	0.0992	1
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0101	0.0937	0.1472
Schistosoma mansoni	glucose transport protein	0.0105	0.0992	0.0934
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0064	0.0342
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0032	0.0164	0.032
Schistosoma mansoni	single-minded	0.0048	0.0343	0.0281
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0064	0.2979
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0199	0.0253
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0027	0.01	0.006
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0199	0.1749
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0215	1
Echinococcus granulosus	Sterile alpha motif type	0.0026	0.0097	0.0056
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0199	0.1749
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0026	0.0097	0.0033
Schistosoma mansoni	aryl hydrocarbon receptor	0.0048	0.0343	0.0281
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0026	0.0097	0.0056
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0098	0.0904	0.0846
Leishmania major	glucose transporter, lmgt2	0.0033	0.0168	0.6871
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0199	0.0253
Brugia malayi	beta-lactamase family protein	0.0035	0.0199	0.0261
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0027	0.01	0.006
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0032	0.0164	0.0207
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0199	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0089	0.0046
Echinococcus granulosus	Sterile alpha motif SAM	0.0026	0.0097	0.0056
Echinococcus multilocularis	calcium dependent protein kinase	0.003	0.0141	0.0129
Loa Loa (eye worm)	tnks protein	0.0026	0.0097	0.0062
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0032	0.0164	0.0207
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0168	0.6871
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0168	0.1423
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0199	0.0749
Schistosoma mansoni	glucose transport protein	0.0105	0.0992	0.0934
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0215	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0215	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0097	0.0033
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0032	0.0163	0.0185
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0101	0.0937	0.1689
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0199	0.087
Schistosoma mansoni	serine/threonine protein kinase	0.0032	0.0163	0.01
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0199	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0404	0.4376	0.7265
Toxoplasma gondii	protein kinase, putative	0.0298	0.3174	1
Loa Loa (eye worm)	mbt repeat family protein	0.029	0.3087	0.5652
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0199	0.9257
Brugia malayi	Sugar transporter family protein	0.0105	0.0992	0.1795
Entamoeba histolytica	protein kinase, putative	0.0032	0.0163	1
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0032	0.0164	0.0207
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0168	0.6871
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0168	0.6871
Schistosoma mansoni	protein kinase	0.0032	0.0163	0.01
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Brugia malayi	hydrolase, alpha/beta fold family protein	0.025	0.2635	0.497
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Echinococcus multilocularis	transfer RNA-Lys	0.0036	0.0201	0.0231
Giardia lamblia	Kinesin-13	0.0026	0.0097	0.362
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0156	0.0177
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0032	0.0164	0.0207
Echinococcus multilocularis	tumor suppressor p53 binding protein 1	0.0344	0.3691	0.6111
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0199	0.9257
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.012	0.1155	0.1838
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0199	0.1749
Echinococcus granulosus	liprin alpha 2	0.0026	0.0097	0.0056
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0199	0.0253
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0149	0.1486	0.2658
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0199	0.8942
Loa Loa (eye worm)	AIDA-1b	0.0026	0.0097	0.0062
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0199	0.087
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0097	0.0062
Brugia malayi	beta-lactamase	0.0035	0.0199	0.0261
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0404	0.4376	0.4339
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0168	0.1423
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0026	0.0097	0.0056
Schistosoma mansoni	DNAj-like protein	0.0026	0.0097	0.0033
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0032	0.0163	0.6561
Leishmania major	protein kinase, putative	0.0032	0.0163	0.6561
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Brugia malayi	coiled-coil like protein 1	0.0026	0.0097	0.0064
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0199	0.0749
Brugia malayi	Cam kinase protein 1	0.0032	0.0163	0.0192
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0064	0.2292
Schistosoma mansoni	protein kinase	0.0032	0.0163	0.01
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0032	0.0164	0.0207
Echinococcus granulosus	SAM and MBT domain containing protein	0.0404	0.4376	0.7265
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Plasmodium vivax	protein kinase, putative	0.0026	0.0097	0.0069
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.017	0.1728	0.5352
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0199	0.0253
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0227	0.2365	1
Schistosoma mansoni	hypothetical protein	0.0344	0.3691	0.365
Mycobacterium ulcerans	lipase LipD	0.0035	0.0199	0.087
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0064	0.5
Onchocerca volvulus		0.0035	0.0199	0.019
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0199	0.1749
Loa Loa (eye worm)	sugar transporter	0.0105	0.0992	0.1736
Trichomonas vaginalis	esterase, putative	0.0035	0.0199	0.1749
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0168	0.6871
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0156	0.0092
Schistosoma mansoni	chromobox protein	0.0207	0.2142	0.2091
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0156	0.1297
Schistosoma mansoni	Protein aveugle	0.0026	0.0097	0.0033
Echinococcus multilocularis	General substrate transporter	0.0091	0.0824	0.1281
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0199	1
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0032	0.0164	0.0207
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0199	0.1749
Brugia malayi	PAS domain containing protein	0.0048	0.0343	0.0539
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.0026	0.0097	0.2197
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0032	0.0164	0.0207
Brugia malayi	bicaudal-C	0.0026	0.0097	0.0064
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0168	0.6871
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0032	0.0163	0.0185
Echinococcus granulosus	General substrate transporter	0.0091	0.0824	0.1281
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0199	0.0281
Echinococcus granulosus	calcium dependent protein kinase	0.003	0.0141	0.0129
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0032	0.0163	0.0167
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0215	1
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0168	0.1423
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0105	0.0992	0.1564
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0032	0.0163	0.0167
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0032	0.0164	0.032
Toxoplasma gondii	hypothetical protein	0.0027	0.0102	0.0121
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0199	0.0253
Brugia malayi	AIDA-1b	0.0026	0.0097	0.0064
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0199	0.087
Leishmania major	glucose transporter, lmgt1	0.0033	0.0168	0.6871

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 7.82	Displacement of [3H]flunitrazepam from benzodiazepine binding site GABAA alpha2beta3gamma2 receptor expressed in Sf9 cells after 1 hr	ChEMBL.	21498079

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1783255

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1525877