Detailed information for compound 1527301

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 345.34 | Formula: C14H14F3N3O2S
  • H donors: 0 H acceptors: 3 LogP: 2.64 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCC(CC1)c1onc(n1)c1cccs1)CC(F)(F)F
  • InChi: 1S/C14H14F3N3O2S/c15-14(16,17)8-11(21)20-5-3-9(4-6-20)13-18-12(19-22-13)10-2-1-7-23-10/h1-2,7,9H,3-6,8H2
  • InChiKey: PURMOEJLBLWEGB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0283 0.3566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0081 0.1656
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0283 0.1924
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0081 0.0081
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0192 0.13
Echinococcus granulosus dna polymerase kappa 0.0019 0.0346 0.0346
Brugia malayi nuclear receptor NHR-88 0.001 0.0118 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0805 0.5543
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0118 0.1209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Echinococcus granulosus cathepsin L 0.0008 0.0081 0.0081
Onchocerca volvulus 0.0028 0.0579 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0817 0.0817
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Brugia malayi steroid hormone receptor 0.001 0.0118 0.1209
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1448 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.13
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.1488
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0346 0.2302
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0081 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0346 0.2362
Brugia malayi ecdysteroid receptor 0.001 0.0118 0.1209
Echinococcus granulosus cysteine protease 0.0008 0.0081 0.0081
Echinococcus granulosus cathepsin l1 0.0016 0.0283 0.0283
Loa Loa (eye worm) cysteine protease 0.0016 0.0283 0.2892
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0346 0.354
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0192 0.147
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0192 0.0255
Plasmodium falciparum thioredoxin reductase 0.0013 0.0192 0.0255
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0977 0.6709
Trypanosoma cruzi trypanothione reductase, putative 0.0013 0.0192 0.13
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0579 0.5929
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0013 0.0192 0.0255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0283 0.0283
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0016 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Onchocerca volvulus 0.0016 0.0283 0.3566
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.2244 0.3042
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0283 0.0385
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Onchocerca volvulus 0.0016 0.0283 0.3566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.1311 0.905
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Loa Loa (eye worm) fibroinase 0.0016 0.0283 0.2892
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.2892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Plasmodium vivax vivapain-3 0.0008 0.0081 0.011
Schistosoma mansoni thyroid hormone receptor 0.001 0.0118 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0016 0.0078
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0192 0.0192
Mycobacterium tuberculosis Probable reductase 0.0085 0.2005 0.2688
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.7606
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0283 0.2892
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0977 0.6735
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.186
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0118 0.1209
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.2005 0.2688
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0346 0.2362
Leishmania major cathepsin L-like protease 0.0063 0.1448 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0346 0.2302
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0088 0.0088
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.2892
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0197 0.1266
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.2244 0.0484
Plasmodium vivax glutathione reductase, putative 0.0037 0.0805 0.1154
Trypanosoma cruzi cysteine protease, putative 0.0008 0.0081 0.053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0081 0.0833
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0346 0.0227
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0197 0.1266
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0118 0.0118
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0005 0.0005 0.005
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.2892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0013 0.0192 0.13
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0118 0.1209
Plasmodium falciparum thioredoxin reductase 0.0037 0.0805 0.114
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.005
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0013 0.0192 0.0255
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0346 0.2302
Brugia malayi Thioredoxin reductase 0.0037 0.0805 0.8239
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0805 0.1154
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0346 0.354
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0346 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0044 0.0044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0118 0.1209
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0118 0.0118
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.2892
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0118 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.13
Plasmodium vivax vivapain-2 0.0016 0.0283 0.0401
Onchocerca volvulus 0.0016 0.0283 0.3566
Toxoplasma gondii cathepsin CPL 0.0016 0.0283 0.2221
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0118 0.1209
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0013 0.0192 0.1232
Loa Loa (eye worm) hypothetical protein 0.0006 0.0016 0.0165
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0118 0.1209
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0118 0.0118
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0192 0.0271
Trypanosoma brucei trypanothione reductase 0.0037 0.0805 0.5508
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.2892
Echinococcus multilocularis cysteine protease 0.0016 0.0283 0.0283
Leishmania major cathepsin L-like protease 0.0063 0.1448 1
Trypanosoma brucei unspecified product 0.0013 0.0197 0.1266
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0008 0.0081 0.0081
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0118 0.1209
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0346 0.2362
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0044 0.0044
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0192 0.147
Plasmodium falciparum glutathione reductase 0.0013 0.0192 0.0255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0118 0.1209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Plasmodium vivax vivapain-1 0.0008 0.0081 0.011
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0817 0.0817
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0008 0.0081 0.1656
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0283 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0192 0.197
Brugia malayi cathepsin L-like precursor 0.0011 0.0145 0.1488
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.2244 0.3042
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.2005 0.2688
Onchocerca volvulus 0.0011 0.0145 0.0592
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0118 0.0118
Echinococcus multilocularis cpg binding protein 0.003 0.062 0.062
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.005
Echinococcus granulosus dna polymerase eta 0.0044 0.0977 0.0977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0118 0.1209
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0402 1 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0013 0.0192 0.1232
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0118 0.1209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0009 0.0106 0.1088
Onchocerca volvulus 0.0016 0.0283 0.3566
Entamoeba histolytica cysteine protease, putative 0.0016 0.0283 0.7606
Loa Loa (eye worm) ctsf protein 0.0016 0.0283 0.2892
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0118 0.1209
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.186
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0118 0.0118
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0009 0.0106 0.1088
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0647 0.445
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0192 0.5
Schistosoma mansoni cpg binding protein 0.003 0.062 0.062
Brugia malayi Cathepsin L-like precursor 0.0011 0.0145 0.1488
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0346 0.0476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.1488
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0283 0.0283
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0192 0.5349
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.13
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0283 0.0283
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0118 0.0118
Plasmodium vivax vivapain-2 0.0016 0.0283 0.0401
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0013 0.0192 0.1232
Onchocerca volvulus 0.0016 0.0283 0.3566
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0346 0.2302
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0081 0.053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0118 0.1209
Leishmania major DNA polymerase eta, putative 0.0044 0.0977 0.6709
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0118 0.1209
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0192 0.5
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0346 0.0476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0081 0.0456
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1377 0.1377
Echinococcus granulosus cpg binding protein 0.003 0.062 0.062
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0283 0.3566
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0118 0.1209
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0283 0.0283
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.186
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0283 0.0283
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0008 0.0081 0.053
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0118 0.1209
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0283 0.0283
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.2005 0.2688
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0197 0.1266
Brugia malayi cathepsin F-like cysteine proteinase 0.0005 0.0005 0.005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.2005 0.2688
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0192 0.5161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.13
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.028 0.6936 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0192 0.1232
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0283 0.8003
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0805 0.8239
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.1232
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0145 0.3676
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0118 0.0118
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0346 0.2362
Schistosoma mansoni cpg binding protein 0.0028 0.0579 0.0579
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0805 0.0908
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0088 0.0899
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0145 0.0145
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0118 0.0118
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0044 0.0044
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.111 0.7656
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0118 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0283 0.2892
Brugia malayi polk-prov protein 0.0006 0.0016 0.0165
Loa Loa (eye worm) hypothetical protein 0.0005 0.0005 0.005
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0192 0.5161
Echinococcus granulosus FTZ F1 alpha 0.001 0.0118 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0016 0.0016
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0005 0.0005 0.005
Onchocerca volvulus 0.0016 0.0283 0.3566
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0283 0.2892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma cruzi hypothetical protein, conserved 0.0006 0.0016 0.0078
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0192 0.5
Loa Loa (eye worm) glutathione reductase 0.0037 0.0805 0.8239
Trypanosoma brucei unspecified product 0.0019 0.0346 0.2302
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1448 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0346 0.0346
Giardia lamblia DINP protein human, muc B family 0.0019 0.0346 1
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0145 0.1488
Trypanosoma cruzi DNA damage repair protein, putative 0.0006 0.0016 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0192 0.0255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0044 0.0044
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0283 0.0283
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0346 0.0346
Schistosoma mansoni nuclear hormone receptor 0.001 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0346 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Trypanosoma cruzi cysteine peptidase, putative 0.0008 0.0081 0.053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0192 0.0192
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0118 0.0118
Echinococcus granulosus cathepsin l1 0.0011 0.0145 0.0145
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.186
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0085 0.087
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0118 0.0118
Brugia malayi CXXC zinc finger family protein 0.0028 0.0579 0.5929
Loa Loa (eye worm) hypothetical protein 0.0016 0.0283 0.2892
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.028 0.6936 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0977 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0346 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0145 0.1488
Echinococcus multilocularis cysteine protease 0.0016 0.0283 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.028 0.6936 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.1448 1
Schistosoma mansoni DNA polymerase eta 0.0044 0.0977 0.0977
Brugia malayi Papain family cysteine protease containing protein 0.0008 0.0081 0.0833
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.028 0.6936 1
Echinococcus multilocularis dnaJ subfamily B 0.0402 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0118 0.1209
Treponema pallidum hypothetical protein 0.028 0.6936 1
Toxoplasma gondii thioredoxin reductase 0.0037 0.0805 0.6575
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.13
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0118 0.0118
Trypanosoma cruzi cysteine proteinase, putative 0.0008 0.0081 0.053
Schistosoma mansoni coup transcription factor 0.001 0.0118 0.0118
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0118 0.0118
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0283 0.0385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0118 0.1209
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.2244 0.3042
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0016 0.0016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0118 0.1209
Brugia malayi Cathepsin L-like precursor 0.0016 0.0283 0.2892
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.2005 0.2688
Plasmodium vivax unspecified product 0.0008 0.0081 0.011
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0118 0.1209
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0013 0.0192 0.0255
Trypanosoma brucei unspecified product 0.0013 0.0197 0.1266
Schistosoma mansoni cathepsin s 0.0005 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0145 0.3676
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0118 0.0118
Schistosoma mansoni thyroid hormone receptor 0.001 0.0118 0.0118
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0118 0.1209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0283 0.8003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0118 0.0118
Echinococcus granulosus cathepsin L cysteine protease 0.0008 0.0081 0.0081
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0118 0.0118
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0013 0.0192 0.1232
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0283 0.7606
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0118 0.1209
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0346 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0118 0.0118
Brugia malayi Cathepsin L-like precursor 0.0005 0.0005 0.005
Leishmania major cathepsin L-like protease 0.0063 0.1448 1
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0145 0.242
Leishmania major cathepsin L-like protease 0.0016 0.0283 0.186
Echinococcus multilocularis cathepsin L 0.0008 0.0081 0.0081
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0647 0.5261
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0977 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0283 0.8003
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.1448 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0013 0.0192 0.1232
Onchocerca volvulus 0.0016 0.0283 0.3566
Brugia malayi glutathione reductase 0.0037 0.0805 0.8239
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0118 0.1209
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.1216 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0118 0.0118
Schistosoma mansoni cpg binding protein 0.003 0.062 0.062
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0192 0.0271
Echinococcus multilocularis dna polymerase eta 0.0044 0.0977 0.0977
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0008 0.0081 0.0094
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0118 0.0118
Brugia malayi Cathepsin L-like precursor 0.0011 0.0145 0.1488
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.028 0.6936 1
Brugia malayi nuclear hormone receptor 0.001 0.0118 0.1209
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0283 0.3566
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0283 0.8003
Leishmania major trypanothione reductase 0.0037 0.0805 0.5508
Leishmania major DNA polymerase eta, putative 0.0031 0.0647 0.4407
Plasmodium falciparum glutathione reductase 0.0037 0.0805 0.114
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.1232
Loa Loa (eye worm) hypothetical protein 0.001 0.0118 0.1209
Leishmania major DNA polymerase kappa, putative 0.0019 0.0346 0.2302
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0118 0.1209
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0118 0.0118
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0013 0.0192 0.13
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.1448 1
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0283 0.186
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0088 0.0088
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0346 0.0227
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0008 0.0081 0.0456
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0192 0.0192

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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