Detailed information for compound 1531559

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 380.442 | Formula: C24H20N4O
  • H donors: 1 H acceptors: 1 LogP: 7.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(ccc1/N=N/c1c(O)ccc2c1cccc2)/N=N/c1ccccc1C
  • InChi: 1S/C24H20N4O/c1-16-7-3-6-10-21(16)26-25-19-12-13-22(17(2)15-19)27-28-24-20-9-5-4-8-18(20)11-14-23(24)29/h3-15,29H,1-2H3/b26-25+,28-27+
  • InChiKey: RCTGMCJBQGBLKT-PAMTUDGESA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.00000000033566
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.00000000033566
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0104 0.0118
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0435 0.1583
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0466 0.1565
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0317 0.0547
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0317 0.1018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0703 0.2866
Brugia malayi ecdysteroid receptor 0.0012 0.0104 0.0222
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0044 0.0728 0.2845
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.9748
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0023 0.0317 0.0317
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0013 0.0131 0.0131
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0584 0.0662
Mycobacterium ulcerans class a beta-lactamase, BlaC 0.0152 0.2787 0.4416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0104 0.0104
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0024 0.0343 0.0732
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.0327 0.6126 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0012 0.0104 0.004
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.1145
Giardia lamblia DINP protein human, muc B family 0.0044 0.0728 1
Echinococcus granulosus leucine aminopeptidase protein 0.0121 0.2192 0.2192
Echinococcus granulosus mixed lineage leukemia protein mll 0.001 0.0065 0.0065
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0145 0.0197
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0104 0.0104
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0104 0.0104
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0584 0.0584
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0026 0.00000000033566
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0317 0.1054
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0317 0.0547
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0044 0.0728 0.0728
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0104 0.0222
Chlamydia trachomatis cytosol aminopeptidase 0.0121 0.2192 0.5
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0317 0.0838
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0014 0.0145 0.0236
Brugia malayi hypothetical protein 0.0029 0.0435 0.0927
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0343 0.0343
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0065 0.0065
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0104 0.0118
Plasmodium falciparum M17 leucyl aminopeptidase 0.0121 0.2192 0.3422
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0104 0.0222
Echinococcus multilocularis neuropeptide receptor A26 0.0531 1 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0023 0.0317 0.0675
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0121 0.2192 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0044 0.0728 0.0728
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0044 0.0728 0.1318
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0104 0.0118
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0026 0.00000000033566
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0104 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0728 0.2986
Trypanosoma brucei beta lactamase 0.0073 0.1277 0.5528
Trypanosoma brucei unspecified product 0.0031 0.0466 0.1565
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.9748
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0466 0.1565
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0104 0.0118
Leishmania major hypothetical protein, conserved 0.0029 0.0435 0.1414
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.1145
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0104 0.0104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0103 0.0103
Brugia malayi steroid hormone receptor 0.0012 0.0104 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0728 0.2986
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0104 0.0222
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0728 0.0974
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0023 0.0317 0.0287
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.0435 0.1617
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0545 0.0545
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0121 0.2192 0.1887
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0317 0.0675
Entamoeba histolytica deoxycytidyl transferase, putative 0.0044 0.0728 1
Trypanosoma brucei unspecified product 0.0031 0.0466 0.1565
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Schistosoma mansoni DNA helicase recq5 0.0023 0.0317 0.0359
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0044 0.0728 0.1551
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0104 0.0222
Echinococcus granulosus cpg binding protein 0.0035 0.0547 0.0547
Mycobacterium ulcerans DNA polymerase IV 0.0044 0.0728 0.0974
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0104 0.0222
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0024 0.0343 0.0732
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.01 0.0214
Giardia lamblia Sgs1 DNA helicase, putative 0.0023 0.0317 0.2945
Schistosoma mansoni DNA helicase recq1 0.0023 0.0317 0.0359
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0023 0.0317 0.0317
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0024 0.0343 0.0343
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0104 0.0222
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0104 0.0104
Echinococcus granulosus dna polymerase kappa 0.0044 0.0728 0.0728
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0104 0.0104
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0104 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0104 0.0118
Schistosoma mansoni hypothetical protein 0.0043 0.0712 0.0806
Loa Loa (eye worm) hypothetical protein 0.0023 0.0317 0.0675
Schistosoma mansoni leucine aminopeptidase 0.0024 0.0343 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0104 0.0222
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0584 0.0584
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0065 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0584 0.1246
Echinococcus granulosus bloom syndrome protein 0.0023 0.0317 0.0317
Mycobacterium tuberculosis Probable conserved lipoprotein LpqF 0.0073 0.1277 0.1017
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0013 0.0131 0.0131
Brugia malayi polk-prov protein 0.0014 0.0145 0.031
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0024 0.0343 0.0732
Trichomonas vaginalis set domain proteins, putative 0.0287 0.5352 1
Schistosoma mansoni cpg binding protein 0.0033 0.0511 0.0579
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.00000000033566
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0024 0.0343 0.0732
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0023 0.0317 0.0838
Onchocerca volvulus 0.0033 0.0511 0.0776
Brugia malayi ImpB/MucB/SamB family protein 0.0074 0.1285 0.274
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.0435 0.0562
Brugia malayi nuclear receptor NHR-88 0.0012 0.0104 0.0222
Brugia malayi cytosol aminopeptidase 0.0024 0.0343 0.0732
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.0327 0.6126 1
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0317 0.3498
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0104 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0466 0.1565
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0145 0.0197
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0104 0.0222
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0145 0.0236
Loa Loa (eye worm) hypothetical protein 0.0014 0.0145 0.031
Echinococcus multilocularis dna polymerase kappa 0.0044 0.0728 0.0728
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0104 0.0118
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0511 0.1091
Schistosoma mansoni hypothetical protein 0.0013 0.0131 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0104 0.0222
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Brugia malayi hypothetical protein 0.0019 0.0239 0.051
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.0327 0.6126 1
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0121 0.2192 0.2713
Brugia malayi Pre-SET motif family protein 0.0037 0.0584 0.1246
Onchocerca volvulus 0.0287 0.5352 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0584 0.0584
Brugia malayi CXXC zinc finger family protein 0.0033 0.0511 0.1091
Toxoplasma gondii leucyl aminopeptidase LAP 0.0121 0.2192 1
Brugia malayi Pre-SET motif family protein 0.0252 0.469 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0023 0.0317 0.0317
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0343 0.0968
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0104 0.0222
Treponema pallidum hypothetical protein 0.0327 0.6126 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0584 0.2331
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0104 0.0222
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0104 0.0104
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.00000000033566
Echinococcus granulosus neuropeptide receptor A26 0.0531 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0104 0.0222
Mycobacterium leprae PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC 0.0327 0.6126 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Schistosoma mansoni hypothetical protein 0.0469 0.8832 1
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0096 0.0108
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0121 0.2192 0.5
Schistosoma mansoni DNA polymerase eta 0.0074 0.1285 0.1455
Echinococcus multilocularis neuropeptide s receptor 0.0531 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.1241 0.1405
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0317 0.1054
Echinococcus multilocularis leucine aminopeptidase protein 0.0121 0.2192 0.2192
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0104 0.0222
Echinococcus granulosus dnaJ subfamily B 0.0469 0.8832 0.8832
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.1099 0.4785
Trypanosoma brucei DNA polymerase eta, putative 0.0074 0.1285 0.5568
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.9748
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0104 0.0118
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0317 0.0675
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0104 0.0222
Mycobacterium ulcerans leucyl aminopeptidase 0.0121 0.2192 0.3422
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0728 0.2986
Loa Loa (eye worm) RecQ helicase 0.0023 0.0317 0.0675
Leishmania major DNA polymerase eta, putative 0.0043 0.0703 0.2723
Loa Loa (eye worm) hypothetical protein 0.0029 0.0435 0.0927
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0317 0.0317
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.0435 0.1414
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0104 0.0222
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0103 0.0103
Schistosoma mansoni mixed-lineage leukemia protein mll 0.001 0.0065 0.0073
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0104 0.0222
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0104 0.0222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0104 0.0222
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0104 0.0104
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0728 0.2845
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0435 0.0484
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0104 0.0104
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0343 0.0343
Echinococcus multilocularis dnaJ subfamily B 0.0469 0.8832 0.8832
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0012 0.0104 0.0014
Leishmania major DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Echinococcus granulosus dna polymerase eta 0.0074 0.1285 0.1285
Mycobacterium ulcerans lipoprotein LpqF 0.0073 0.1277 0.1892
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.0968
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0121 0.2192 1
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0728 0.2845
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.00000000033566
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0317 0.0675
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0104 0.0118
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0121 0.2192 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.001 0.0065 0.0065
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0023 0.0317 0.0317
Schistosoma mansoni terminal deoxycytidyl transferase 0.0044 0.0728 0.0824
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Plasmodium vivax SET domain protein, putative 0.0037 0.0584 0.081
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0145 0.0197
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0121 0.2192 0.3476
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0023 0.0317 0.0287
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0104 0.0104
Echinococcus multilocularis dna polymerase eta 0.0074 0.1285 0.1285
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0104 0.0104
Onchocerca volvulus 0.0037 0.0584 0.0915
Entamoeba histolytica recQ family DNA helicase 0.0012 0.0104 0.0133
Schistosoma mansoni coup transcription factor 0.0012 0.0104 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0104 0.0222
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0026 0.00000000033566
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.0968
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.469 1
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0024 0.0343 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0104 0.0222
Echinococcus granulosus leucyl aminopeptidase 0.0024 0.0343 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0145 0.0197
Trypanosoma brucei DNA polymerase IV, putative 0.0044 0.0728 0.2845
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.0968
Leishmania major DNA polymerase eta, putative 0.0074 0.1285 0.5568
Brugia malayi hypothetical protein 0.0043 0.0712 0.1518
Schistosoma mansoni cpg binding protein 0.0035 0.0547 0.062
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0712 0.0712
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0343 0.0343
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0584 0.0662
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0104 0.0104
Trypanosoma cruzi DNA polymerase eta, putative 0.0074 0.1285 0.5655
Trichomonas vaginalis DNA polymerase eta, putative 0.0044 0.0728 0.1318
Trypanosoma brucei unspecified product 0.0044 0.0728 0.2845
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0104 0.0118
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0104 0.0118
Loa Loa (eye worm) hypothetical protein 0.0074 0.1285 0.274
Echinococcus multilocularis cpg binding protein 0.0035 0.0547 0.0547
Brugia malayi nuclear hormone receptor 0.0012 0.0104 0.0222
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0024 0.0343 0.0732
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0104 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0104 0.0222
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0044 0.0728 0.0824
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0145 0.0164
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Mycobacterium tuberculosis Class a beta-lactamase BlaC 0.0152 0.2787 0.3814
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.0327 0.6126 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0104 0.0222
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0584 0.0662
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0104 0.0222
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0712 0.0712
Entamoeba histolytica hypothetical protein 0.0043 0.0712 0.9748
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0728 0.1551
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0104 0.0222
Trypanosoma cruzi DNA polymerase kappa, putative 0.0044 0.0728 0.2986
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0121 0.2192 1
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0317 0.0547
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.0968
Schistosoma mansoni cpg binding protein 0.0035 0.0547 0.062
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.0435 0.1583
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0103 0.0219
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0024 0.0343 0.0968
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0728 0.2845
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0145 0.0082
Schistosoma mansoni blooms syndrome DNA helicase 0.0012 0.0104 0.0118
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0104 0.0104
Echinococcus multilocularis leucyl aminopeptidase 0.0024 0.0343 0.0343
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0104 0.0104
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0703 0.2895
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0584 0.0662
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0712 0.0806
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0104 0.0104
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.0435 0.0484
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0104 0.0104

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 18.8322 uM PubChem BioAssay: Tox21. qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 21.3138 uM PubChem BioAssay: Tox21. qHTS assay to identify small molecule agonists of the NFkB signaling pathway. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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