Detailed information for compound 1543248

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 417.462 | Formula: C17H15N5O4S2
  • H donors: 3 H acceptors: 5 LogP: 1.86 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)NC(=O)C)CSc1nnc(s1)NC(=O)c1ccco1
  • InChi: 1S/C17H15N5O4S2/c1-10(23)18-11-4-2-5-12(8-11)19-14(24)9-27-17-22-21-16(28-17)20-15(25)13-6-3-7-26-13/h2-8H,9H2,1H3,(H,18,23)(H,19,24)(H,20,21,25)
  • InChiKey: NKBWHTMLJCRGSC-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Photinus pyralis Luciferin 4-monooxygenase Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-coA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Onchocerca volvulus Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain fatty-acid CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi AMP-binding enzyme family protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania braziliensis 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium yoelii peroxisomal-coenzyme a synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium falciparum acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania infantum 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium berghei acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans acyl-CoA synthetase Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania mexicana 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania donovani 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Plasmodium knowlesi acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans fatty-acid-CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Get druggable targets OG5_126609 All targets in OG5_126609
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Entamoeba histolytica acyl-CoA synthetase, putative Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126609 All targets in OG5_126609
Leishmania major 4-coumarate:coa ligase-like protein Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Get druggable targets OG5_126609 All targets in OG5_126609
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 558 aa 20.4 %
Theileria parva long-chain fatty acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 507 aa 23.5 %
Leishmania infantum long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 544 aa 21.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 494 aa 23.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 4, putative Luciferin 4-monooxygenase   550 aa 497 aa 23.7 %
Trypanosoma brucei fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Trypanosoma cruzi fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 495 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.4 %
Onchocerca volvulus Lysine-specific histone demethylase 1A homolog Luciferin 4-monooxygenase   550 aa 550 aa 22.5 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 502 aa 24.9 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 466 aa 21.7 %
Mycobacterium ulcerans non-ribosomal peptide synthetase Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trypanosoma congolense fatty acyl CoA synthetase 2, putative Luciferin 4-monooxygenase   550 aa 500 aa 22.4 %
Leishmania donovani long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 500 aa 23.4 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 531 aa 19.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD32 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 442 aa 23.5 %
Leishmania mexicana long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 483 aa 23.8 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 524 aa 24.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 21.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Mycobacterium leprae FATTY-ACID-CoA LIGASE FADD26 (FATTY-ACID-COA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 533 aa 22.7 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.5 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Cryptosporidium parvum acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 25.7 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 550 aa 20.9 %
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 535 aa 23.2 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein Luciferin 4-monooxygenase   550 aa 476 aa 22.5 %
Entamoeba histolytica acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 446 aa 22.0 %
Candida albicans similar to S. cerevisiae FAA4 (YMR246W) long-chain fatty acid--CoA synthetase Luciferin 4-monooxygenase   550 aa 478 aa 23.4 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 497 aa 19.3 %
Leishmania major long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 23.2 %
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) Luciferin 4-monooxygenase   550 aa 509 aa 22.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 541 aa 22.4 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 24.4 %
Leishmania braziliensis long chain fatty Acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 496 aa 22.8 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 517 aa 24.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 452 aa 26.1 %
Onchocerca volvulus Luciferin 4-monooxygenase   550 aa 487 aa 23.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD34 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 537 aa 20.9 %
Mycobacterium ulcerans putative fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 576 aa 20.8 %
Mycobacterium tuberculosis Probable acyl-CoA ligase FadD31 (acyl-CoA synthetase) (acyl-CoA synthase) Luciferin 4-monooxygenase   550 aa 592 aa 20.4 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 492 aa 23.6 %
Trichomonas vaginalis AMP dependent CoA ligase, putative Luciferin 4-monooxygenase   550 aa 527 aa 25.0 %
Neospora caninum Short-chain dehydrogenase/reductase SDR, related Luciferin 4-monooxygenase   550 aa 518 aa 19.1 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 484 aa 26.0 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 463 aa 23.5 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase, FadD11 Luciferin 4-monooxygenase   550 aa 492 aa 24.6 %
Dictyostelium discoideum AMP-dependent synthetase and ligase domain-containing protein Luciferin 4-monooxygenase   550 aa 545 aa 24.9 %
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 461 aa 22.3 %
Trichomonas vaginalis AMP dependent ligase, putative Luciferin 4-monooxygenase   550 aa 445 aa 26.1 %
Loa Loa (eye worm) AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 489 aa 23.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 18.3 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF Luciferin 4-monooxygenase   550 aa 558 aa 20.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 542 aa 22.1 %
Babesia bovis long-chain acyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 445 aa 21.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 577 aa 22.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 494 aa 24.3 %
Dictyostelium discoideum acetyl-CoA ligase Luciferin 4-monooxygenase   550 aa 549 aa 22.2 %
Leishmania braziliensis long-chain-fatty-acid-CoA ligase, putative Luciferin 4-monooxygenase   550 aa 504 aa 25.6 %
Schistosoma mansoni FAA1 Long-chain-fatty-acid--CoA ligase 1 Luciferin 4-monooxygenase   550 aa 494 aa 26.3 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 482 aa 24.7 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Schistosoma japonicum ko:K01897 long-chain fatty-acid-CoA ligase [EC6.2.1.3], putative Luciferin 4-monooxygenase   550 aa 466 aa 27.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 539 aa 19.1 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Onchocerca volvulus Matrilysin homolog Luciferin 4-monooxygenase   550 aa 466 aa 24.2 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD32 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase). Also shown to have acyl-ACP ligase activity. Luciferin 4-monooxygenase   550 aa 487 aa 22.4 %
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 Luciferin 4-monooxygenase   550 aa 493 aa 22.1 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 459 aa 27.0 %
Mycobacterium leprae Probable long-chain-fatty-acid-CoA ligase FadD15 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 484 aa 23.3 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 493 aa 20.7 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 480 aa 21.5 %
Trichomonas vaginalis long-chain-fatty-acid CoA ligase, putative Luciferin 4-monooxygenase   550 aa 490 aa 23.3 %
Echinococcus granulosus long chain fatty acid transport protein 4 Luciferin 4-monooxygenase   550 aa 476 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD24 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 526 aa 21.9 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 582 aa 22.3 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD21 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 586 aa 24.4 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 541 aa 21.6 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 543 aa 24.5 %
Echinococcus multilocularis long chain fatty acid coenzyme A ligase 1 Luciferin 4-monooxygenase   550 aa 443 aa 26.4 %
Neospora caninum acetyl-coenzyme a synthetase, putative Luciferin 4-monooxygenase   550 aa 549 aa 20.9 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD26 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 560 aa 21.4 %
Toxoplasma gondii propionate-CoA ligase Luciferin 4-monooxygenase   550 aa 550 aa 21.1 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD28 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 484 aa 20.5 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD23 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 542 aa 23.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 499 aa 19.2 %
Mycobacterium leprae PROBABLE FATTY-ACID--CoA LIGASE FADD21 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) Luciferin 4-monooxygenase   550 aa 565 aa 22.8 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 462 aa 23.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD29 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 617 aa 22.2 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD11 Luciferin 4-monooxygenase   550 aa 498 aa 23.5 %
Brugia malayi AMP-binding enzyme family protein Luciferin 4-monooxygenase   550 aa 497 aa 24.7 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 530 aa 23.8 %
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE Luciferin 4-monooxygenase   550 aa 502 aa 22.5 %
Cryptosporidium parvum acetyl-coenzyme A synthetase Luciferin 4-monooxygenase   550 aa 545 aa 22.8 %
Echinococcus granulosus long chain fatty acid coenzyme A ligase 5 Luciferin 4-monooxygenase   550 aa 458 aa 25.8 %
Cryptosporidium hominis acetyl-CoenzymeA synthetase (acetate--coa ligase) (acyl-activating enzyme) Luciferin 4-monooxygenase   550 aa 549 aa 22.6 %
Cryptosporidium parvum putative long chain fatty acyl CoA synthetase having a signal peptide Luciferin 4-monooxygenase   550 aa 472 aa 24.8 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 505 aa 28.1 %
Schistosoma japonicum ko:K08745 solute carrier family 27 (fatty acid transporter), member 1, putative Luciferin 4-monooxygenase   550 aa 501 aa 24.6 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 535 aa 22.6 %
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase Luciferin 4-monooxygenase   550 aa 509 aa 21.8 %
Candida albicans similar to S. cerevisiae ACS2 (YLR153C) acetyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 539 aa 22.1 %
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 Luciferin 4-monooxygenase   550 aa 463 aa 21.8 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 522 aa 19.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 507 aa 20.9 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 576 aa 19.8 %
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD28 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 504 aa 22.6 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 554 aa 22.9 %
Trypanosoma brucei gambiense fatty acyl CoA synthetase 3 Luciferin 4-monooxygenase   550 aa 491 aa 23.6 %
Babesia bovis fatty acyl-CoA synthetase family protein Luciferin 4-monooxygenase   550 aa 461 aa 23.4 %
Trypanosoma cruzi fatty acyl CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 480 aa 25.2 %
Candida albicans similar to S. cerevisiae FAT1 (YBR041W) fatty acid transporter and very long-chain fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 496 aa 24.2 %
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase Luciferin 4-monooxygenase   550 aa 536 aa 24.4 %
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative Luciferin 4-monooxygenase   550 aa 476 aa 20.8 %
Trichomonas vaginalis antibiotic synthetase, putative Luciferin 4-monooxygenase   550 aa 581 aa 21.2 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 476 aa 23.5 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 601 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 603 aa 22.6 %
Leishmania mexicana acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 559 aa 20.6 %
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 480 aa 22.5 %
Leishmania braziliensis acetyl-CoA synthetase, putative Luciferin 4-monooxygenase   550 aa 596 aa 21.1 %
Toxoplasma gondii type I fatty acid synthase, putative Luciferin 4-monooxygenase   550 aa 514 aa 19.8 %
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD29 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) Luciferin 4-monooxygenase   550 aa 529 aa 22.3 %
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase FadD15 Luciferin 4-monooxygenase   550 aa 482 aa 24.3 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 478 aa 21.1 %
Dictyostelium discoideum hypothetical protein Luciferin 4-monooxygenase   550 aa 538 aa 21.8 %
Trichomonas vaginalis AMP dependent ligase/synthetase, putative Luciferin 4-monooxygenase   550 aa 526 aa 22.4 %
Cryptosporidium hominis acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 460 aa 26.1 %
Mycobacterium ulcerans acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 593 aa 22.1 %
Dictyostelium discoideum fatty acyl-CoA synthetase Luciferin 4-monooxygenase   550 aa 501 aa 24.4 %
Mycobacterium tuberculosis Probable fatty-acid-AMP ligase FadD25 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) Luciferin 4-monooxygenase   550 aa 475 aa 21.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus potassium channel subfamily K 8 0.002 0.0011 0.0011
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Trypanosoma brucei calcium-activated potassium channel, putative 0.002 0.0011 0.0295
Echinococcus multilocularis calcium activated potassium channel variant 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 21 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.0032 0.0183 0.0243
Brugia malayi hypothetical protein 0.002 0.0011 0.0042
Mycobacterium tuberculosis Possible transmembrane cation transporter 0.002 0.0011 0.0794
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0146 0.0146
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.0295
Loa Loa (eye worm) uncoordinated protein 58 0.002 0.0011 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 5 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0065 0.1723
Schistosoma mansoni importin beta-1 0.0029 0.0146 0.0146
Loa Loa (eye worm) TWK-7 protein 0.002 0.0011 0.0015
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0534
Schistosoma mansoni chromobox protein 0.0069 0.0741 0.0741
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0183 0.0702
Plasmodium falciparum importin beta, putative 0.0029 0.0146 1
Leishmania major DNA polymerase eta, putative 0.0031 0.0179 0.4775
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1495 0.1982
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0065 0.0248
Leishmania major DNA polymerase eta, putative 0.0045 0.0375 1
Echinococcus multilocularis snurportin 1 0.031 0.4303 0.4303
Echinococcus multilocularis chromobox protein 1 0.0069 0.0741 0.0741
Brugia malayi Twik (KCNK-like) family of potasium channels, alpha subunit 40 0.002 0.0011 0.0042
Entamoeba histolytica hypothetical protein 0.0024 0.0065 0.4635
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0183 0.0243
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0045 0.0375 0.0497
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.3718
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39B 0.002 0.0011 0.0042
Loa Loa (eye worm) large conductance calcium-activated potassium channel alpha subunit ai 0.002 0.0011 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 19. C. elegans unc-58 ortholog 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0166 0.0221
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0032 0.127
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0179 0.4775
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0179 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0533 0.2042
Entamoeba histolytica calcium-gated potassium channel protein, putative 0.002 0.0011 0.0794
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.3718
Mycobacterium ulcerans hypothetical protein 0.0029 0.0139 0.0534
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0334 0.1281
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0043
Echinococcus granulosus dna polymerase eta 0.0045 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Brugia malayi RNA, U transporter 1 0.0083 0.0938 0.3597
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0864
Loa Loa (eye worm) potassium voltage-gated channel subfamily Q member 5 0.002 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trypanosoma cruzi calcium-activated potassium channel, putative 0.002 0.0011 0.0295
Leishmania major importin beta-1 subunit, putative 0.0024 0.0065 0.1723
Mycobacterium ulcerans ion transport protein 0.002 0.0011 0.0042
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0029 0.0139 0.0534
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0029 0.0139 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.0295
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.053 0.7546 0.7546
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.002 0.0011 0.0295
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Schistosoma mansoni chromobox protein 0.0069 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0205 0.2749 0.3643
Plasmodium falciparum acyl-CoA synthetase 0.0021 0.0032 0.1578
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0011 0.0042
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0021 0.0032 0.5
Trypanosoma cruzi calcium-activated potassium channel, putative 0.002 0.0011 0.0295
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.1192 0.4571
Giardia lamblia Hypothetical protein 0.002 0.0011 0.3416
Plasmodium vivax importin-beta 2, putative 0.0029 0.0146 1
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0146 0.8029
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1495 0.1982
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0011 0.0011
Brugia malayi chromobox protein homolog 3 0.0039 0.0291 0.1114
Mycobacterium ulcerans glutaminase 0.0196 0.2608 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.0534
Echinococcus multilocularis dna polymerase eta 0.0045 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Echinococcus granulosus chromobox protein 1 0.0069 0.0741 0.0741
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 7 0.002 0.0011 0.0042
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0864
Echinococcus multilocularis Two pore potassium channel protein sup 9 0.002 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.053 0.7546 1
Schistosoma mansoni calcium-activated potassium channel 0.053 0.7546 0.7546
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.031 0.4303 0.4303
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0043
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0065 0.0248
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.1582
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0146 0.3892
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.0375 1
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0741 0.0982
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0375 0.1437
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0533 0.0706
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0741 0.2841
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0021 0.0032 0.0124
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0533 0.0533
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.002 0.0011 0.0042
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0146 0.0193
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0032 0.0124
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Echinococcus granulosus TWiK family of potassium channels protein 7 0.002 0.0011 0.0011
Entamoeba histolytica Ran family GTPase 0.0021 0.0032 0.2325
Loa Loa (eye worm) TWK-28 protein 0.002 0.0011 0.0015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0011 0.0042
Mycobacterium ulcerans transmembrane cation transporter 0.002 0.0011 0.0042
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0183 0.0183
Loa Loa (eye worm) glutaminase 2 0.0196 0.2608 0.3457
Trypanosoma cruzi ion transport protein, putative 0.002 0.0011 0.0295
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0011 0.0042
Echinococcus multilocularis GPCR, family 2 0.0032 0.0183 0.0183
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0032 0.0864
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0043
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0291 0.865
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.1192 0.158
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.01 0.1192 0.158
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0183 0.0702
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0043
Schistosoma mansoni glutaminase 0.0196 0.2608 0.2608
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0139 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0139 0.5
Brugia malayi glutaminase DH11.1 0.0196 0.2608 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0146 0.0559
Leishmania major calcium/potassium channel (CAKC), putative 0.002 0.0011 0.0295
Schistosoma mansoni DNA polymerase eta 0.0045 0.0375 0.0375
Trypanosoma brucei DNA polymerase eta, putative 0.0045 0.0375 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0334 0.1281
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 35 0.002 0.0011 0.0042
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0029 0.0139 1
Leishmania major GTP-binding protein, putative 0.0021 0.0032 0.0864
Entamoeba histolytica acyl-coA synthetase, putative 0.0029 0.0139 1
Echinococcus multilocularis potassium channel subfamily K 8 0.002 0.0011 0.0011
Echinococcus multilocularis twik family of potassium channels 0.002 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0032 0.0183 0.0183
Schistosoma mansoni microtubule-associated protein tau 0.0696 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0183 0.0183
Trichomonas vaginalis glutaminase, putative 0.0196 0.2608 1
Schistosoma mansoni calcium-activated potassium channel 0.002 0.0011 0.0011
Trypanosoma cruzi ion transport protein, putative 0.002 0.0011 0.0295
Echinococcus granulosus Two pore potassium channel protein sup 9 0.002 0.0011 0.0011
Leishmania major ion transport protein-like protein 0.002 0.0011 0.0295
Echinococcus granulosus small conductance calcium activated potassium 0.053 0.7546 0.7546
Echinococcus granulosus potassium channel subfamily K 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0185
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 24 0.002 0.0011 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0291 0.1114
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0533 0.0533
Echinococcus multilocularis chromobox protein 1 0.0069 0.0741 0.0741
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.4303 0.5703
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.0534
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0029 0.0139 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0029 0.0139 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0065 0.0248
Loa Loa (eye worm) hypothetical protein 0.0039 0.0291 0.0385
Echinococcus multilocularis potassium channel subfamily K 0.002 0.0011 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0029 0.0139 0.0534
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.1081
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0146 0.3892
Echinococcus granulosus twik family of potassium channels 0.002 0.0011 0.0011
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0029 0.0139 0.0534
Echinococcus granulosus chromobox protein 1 0.0069 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Echinococcus multilocularis small conductance calcium activated potassium 0.053 0.7546 0.7546
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0334 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0533 0.0533
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0741 0.2841
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Echinococcus granulosus twik family of potassium channels 0.002 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.0295
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0185
Leishmania major potassium channel subunit-like protein 0.002 0.0011 0.0295
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0011 0.0042
Schistosoma mansoni ran 0.0021 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.1192 0.4571
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 38. C. elegans sup-9 ortholog 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0029 0.0139 0.0534
Loa Loa (eye worm) hypothetical protein 0.0068 0.0725 0.0961
Schistosoma mansoni calcium-activated potassium channel 0.0316 0.4382 0.4382
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 28 0.002 0.0011 0.0042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0533 0.0533
Trypanosoma cruzi calcium/potassium channel (CAKC), putative 0.002 0.0011 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0123 0.0471
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.1081
Schistosoma mansoni ran 0.0021 0.0032 0.0032
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0183 0.0183
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Echinococcus multilocularis microtubule associated protein 2 0.0696 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0533 0.0533
Echinococcus multilocularis twik family of potassium channels 0.002 0.0011 0.0011
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0032 0.0032
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 39A 0.002 0.0011 0.0042
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0032 0.1582
Loa Loa (eye worm) hypothetical protein 0.011 0.1349 0.1788
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trichomonas vaginalis ran, putative 0.0021 0.0032 0.0124
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0029 0.0139 0.0534
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0534
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 17 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0183 0.0183
Echinococcus granulosus snurportin 1 0.031 0.4303 0.4303
Loa Loa (eye worm) glutaminase 0.0196 0.2608 0.3457
Onchocerca volvulus 0.003 0.0166 0.481
Onchocerca volvulus 0.0029 0.0139 0.3969
Echinococcus multilocularis TWiK family of potassium channels protein 7 0.002 0.0011 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0011 0.0295
Echinococcus granulosus importin subunit beta 1 0.0029 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0021 0.0032 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0029 0.0139 0.0534
Loa Loa (eye worm) hypothetical protein 0.0194 0.2585 0.3426
Brugia malayi Heterochromatin protein 1 0.0069 0.0741 0.2841
Echinococcus multilocularis potassium channel subfamily K 8 0.002 0.0011 0.0011
Echinococcus granulosus potassium channel subfamily K 8 0.002 0.0011 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0725 0.2781
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 45 0.002 0.0011 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.1081
Trypanosoma brucei calcium/potassium channel (CAKC), putative 0.002 0.0011 0.0295
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0123 0.0471
Schistosoma mansoni twik family of potassium channels-related 0.002 0.0011 0.0011
Echinococcus granulosus calcium activated potassium channel variant 0.002 0.0011 0.0011
Leishmania major 4-coumarate:coa ligase-like protein 0.0029 0.0139 0.3718
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Loa Loa (eye worm) S-phase kinase-associated protein 1A 0.002 0.0011 0.0015
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 12 0.002 0.0011 0.0042
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.002 0.0015 0.1081
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.002 0.0011 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0291 0.1114
Brugia malayi MH2 domain containing protein 0.012 0.1495 0.5733
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0139 0.0185
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0021 0.0032 0.2321
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Brugia malayi hypothetical protein 0.002 0.0011 0.0042
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 13 0.002 0.0011 0.0042
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0015
Schistosoma mansoni hypothetical protein 0.0032 0.0183 0.0183
Echinococcus granulosus GPCR family 2 0.0032 0.0183 0.0183
Plasmodium vivax acyl-CoA synthetase, putative 0.0021 0.0032 0.1578
Schistosoma mansoni hypothetical protein 0.0068 0.0725 0.0725

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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