TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 449.651 | Formula: C27H35N3OS
H donors: 1 H acceptors: 1 LogP: 8.21 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1SC1CCCCC1)c1nc2n(c1NC1CCCCC1)ccc(c2)C
InChi: 1S/C27H35N3OS/c1-19-15-16-30-25(17-19)29-26(27(30)28-21-9-5-3-6-10-21)20-13-14-23(31-2)24(18-20)32-22-11-7-4-8-12-22/h13-18,21-22,28H,3-12H2,1-2H3
InChiKey: LZVBIRGNVGSWNZ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0242	0.169
Entamoeba histolytica	hypothetical protein	0.0158	0.0924	0.5934
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.001	0.0029	0.0204
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.001	0.0029	0.0078
Brugia malayi	hypothetical protein	0.0006	0.0004	0.0027
Trichomonas vaginalis	thymidine kinase, putative	0.0261	0.155	1
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0069
Plasmodium falciparum	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0242	0.1433	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0029	0.0204
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0029	0.0078
Onchocerca volvulus		0.001	0.0029	0.1855
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0113	0.0291
Onchocerca volvulus		0.0007	0.001	0.0444
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0007	0.001	0.0069
Mycobacterium tuberculosis	Probable oxidoreductase	0.0097	0.0555	0.1477
Loa Loa (eye worm)	hypothetical protein	0.01	0.0571	0.3983
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0226	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0113	0.0786
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0113	0.0275
Schistosoma mansoni	hypothetical protein	0.0041	0.0217	0.1514
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0226	0.1579
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0069
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0242	0.169
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.001	0.0029	0.0204
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.001	0.0069
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.0021	0.0021
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.001	0.0029	0.0078
Schistosoma mansoni	hypothetical protein	0.0041	0.0217	0.1514
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0029	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0007	0.001	0.0069
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0029	0.0204
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0113	0.0275
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0113	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0242	0.0242
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0076	0.0204
Trichomonas vaginalis	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0242	0.1433	0.9239
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0007	0.001	0.0069
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.001	0.0029	0.0029
Mycobacterium tuberculosis	Probable dehydrogenase	0.0087	0.0496	0.1318
Echinococcus multilocularis	Niemann Pick C1 protein	0.01	0.0571	0.0571
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.001	0.0029	0.0204
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0013	0.0048	0.0117
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0113	0.0275
Echinococcus granulosus	thioredoxin glutathione reductase	0.0039	0.0202	0.0541
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0113	0.0786
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Plasmodium vivax	acyl-CoA synthetase, putative	0.0018	0.0076	0.0504
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0016
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.001	0.0029	0.0078
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.001	0.0029	0.0204
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0013	0.0048	0.0245
Entamoeba histolytica	hypothetical protein	0.0158	0.0924	0.5934
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0263	0.0263
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0013	0.0048	0.0332
Brugia malayi	photoreceptor-specific nuclear receptor	0.001	0.0029	0.0204
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0013	0.0048	0.0332
Trypanosoma cruzi	trypanothione reductase, putative	0.0038	0.0199	0.1228
Loa Loa (eye worm)	patched family protein	0.0006	0.0004	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0113	0.0786
Brugia malayi	F/Y-rich N-terminus family protein	0.0009	0.002	0.0141
Schistosoma mansoni	retinoic acid receptor RXR	0.001	0.0029	0.0204
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0113	0.0275
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0007	0.001	0.0016
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0242	0.1433	0.9237
Brugia malayi	Patched protein homolog 1	0.0006	0.0004	0.0027
Chlamydia trachomatis	deoxycytidine triphosphate deaminase	0.0084	0.0476	0.3093
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.0141	0.0981
Loa Loa (eye worm)	dUTP diphosphatase	0.0242	0.1433	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0113	0.0666
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus granulosus	cpg binding protein	0.003	0.015	0.0403
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0087	0.0496	0.1318
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0087	0.0496	0.1318
Brugia malayi	nuclear receptor NHR-88	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.001	0.0029	0.0078
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0076	0.0529
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0013	0.0048	0.0245
Toxoplasma gondii	propionate-CoA ligase	0.0007	0.001	0.0042
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0113	0.0786
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.007	0.0177
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.058	0.4048
Loa Loa (eye worm)	patched family protein	0.0006	0.0004	0.0027
Onchocerca volvulus		0.0024	0.0113	0.7955
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0016
Echinococcus granulosus	Niemann Pick C1 protein	0.01	0.0571	0.1527
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.001	0.0029	0.0204
Plasmodium falciparum	acetyl-CoA synthetase, putative	0.0007	0.001	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0076	0.0529
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0039	0.0202	0.0202
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0029	0.0204
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0007	0.001	0.0072
Echinococcus multilocularis	thymidine phosphorylase	0.0622	0.3736	0.3736
Mycobacterium ulcerans	deoxycytidine triphosphate deaminase	0.0084	0.0476	0.1251
Loa Loa (eye worm)	histone methyltransferase	0.0009	0.0021	0.0146
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0242	0.0648
Trypanosoma cruzi	trypanothione reductase, putative	0.0013	0.0048	0.0245
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0069
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.001	0.0029	0.0204
Treponema pallidum	deoxyuridine 5'-triphosphate nucleotidohydrolase (dut)	0.0242	0.1433	1
Echinococcus multilocularis	mixed lineage leukemia protein mll	0.0007	0.001	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.001	0.0029	0.0204
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0242	0.169
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.007	0.0177
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Brugia malayi	CXXC zinc finger family protein	0.0029	0.0141	0.0981
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0007	0.001	0.0028
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0113	0.0786
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0113	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0076	0.0529
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.0199	0.139
Trypanosoma brucei	thymidine kinase	0.0261	0.155	1
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0007	0.001	0.0016
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0007	0.001	0.0016
Onchocerca volvulus	Protein ultraspiracle homolog	0.001	0.0029	0.1855
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0007	0.001	0.0027
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0013	0.0048	0.0101
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Loa Loa (eye worm)	oxidoreductase	0.0007	0.001	0.0069
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.001	0.0029	0.0204
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0038	0.0199	0.0523
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.083	0.083
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.001	0.0029	0.1855
Echinococcus granulosus	dUTP pyrophosphatase	0.0242	0.1433	0.3835
Brugia malayi	Nuclear hormone receptor-like 1	0.001	0.0029	0.0204
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.001	0.0029	0.0204
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0013	0.0048	0.0048
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0029	0.0204
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Loa Loa (eye worm)	steroid hormone receptor	0.001	0.0029	0.0204
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Echinococcus granulosus	mixed lineage leukemia protein mll	0.0007	0.001	0.0028
Onchocerca volvulus		0.0007	0.001	0.0444
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0113	0.1005
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0013	0.0048	0.0101
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0013	0.0048	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0076	0.0529
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0007	0.001	0.0069
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0013	0.0048	0.0127
Toxoplasma gondii	thioredoxin reductase	0.0038	0.0199	0.1366
Brugia malayi	hypothetical protein	0.0006	0.0004	0.0027
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Brugia malayi	ecdysteroid receptor	0.001	0.0029	0.0204
Wolbachia endosymbiont of Brugia malayi	deoxycytidine triphosphate deaminase	0.0084	0.0476	0.3093
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0113	0.0275
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0013	0.0048	0.0245
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.083	0.222
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0176	0.1031	1
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Echinococcus granulosus	thymidine phosphorylase	0.0622	0.3736	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Brugia malayi	steroid hormone receptor	0.001	0.0029	0.0204
Brugia malayi	Myosin head containing protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0029	0.0029
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0097	0.0555	0.1477
Leishmania major	trypanothione reductase	0.0038	0.0199	0.1228
Mycobacterium ulcerans	thymidine phosphorylase	0.0622	0.3736	1
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Plasmodium falciparum	glutathione reductase	0.0013	0.0048	0.0306
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0076	0.0192
Mycobacterium tuberculosis	Probable deoxycytidine triphosphate deaminase Dcd (dCTP deaminase)	0.0084	0.0476	0.1265
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.001	0.0029	0.0204
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.001	0.0026	0.0183
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0087	0.0496	0.1318
Brugia malayi	Patched related family protein 4	0.0006	0.0004	0.0027
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.001	0.0029	0.0204
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.001	0.0029	0.0204
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0113	0.0786
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0113	0.0275
Toxoplasma gondii	Acetyl-coenzyme A synthetase 2, putative	0.0007	0.001	0.0042
Echinococcus multilocularis	dUTP pyrophosphatase	0.0242	0.1433	0.1433
Schistosoma mansoni	thyroid hormone receptor	0.001	0.0029	0.0204
Onchocerca volvulus	Bile acid receptor homolog	0.001	0.0029	0.1855
Brugia malayi	hypothetical protein	0.0006	0.0004	0.0027
Entamoeba histolytica	hypothetical protein	0.0242	0.1433	0.9237
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.001	0.0022
Schistosoma mansoni	hypothetical protein	0.0041	0.0217	0.1514
Entamoeba histolytica	deoxycytidine triphosphate deaminase, putative	0.0084	0.0476	0.3026
Plasmodium vivax	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0242	0.1433	1
Plasmodium falciparum	thioredoxin reductase	0.0038	0.0199	0.1366
Leishmania major	thymidine kinase, putative	0.0261	0.155	1
Echinococcus multilocularis	thyroid hormone receptor alpha	0.001	0.0029	0.0029
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.001	0.0029	0.0204
Trichomonas vaginalis	antibiotic synthetase, putative	0.0007	0.001	0.0022
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0007	0.001	0.0016
Trypanosoma brucei	trypanothione reductase	0.0038	0.0199	0.1228
Brugia malayi	Thioredoxin reductase	0.0038	0.0199	0.139
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0113	0.0666
Onchocerca volvulus		0.0029	0.0141	1
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0226	0.0605
Echinococcus multilocularis	cpg binding protein	0.003	0.015	0.015
Giardia lamblia	Thymidine kinase	0.0261	0.155	1
Echinococcus multilocularis	FTZ F1 alpha	0.001	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Plasmodium falciparum	thioredoxin reductase	0.0013	0.0048	0.0306
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0029	0.0204
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0048	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Plasmodium vivax	acetyl-CoA synthetase, putative	0.0007	0.001	0.0042
Brugia malayi	CHE-14 protein	0.0043	0.0226	0.1579
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.001	0.0029	0.0204
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0016
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0013	0.0048	0.0306
Brugia malayi	glutathione reductase	0.0038	0.0199	0.139
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.001	0.0029	0.0204
Schistosoma mansoni	cpg binding protein	0.0029	0.0141	0.0981
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0113	0.0666
Loa Loa (eye worm)	patched family protein	0.0006	0.0004	0.0027
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0242	0.1433	0.9237
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0007	0.001	0.0016
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0113	0.0666
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0013	0.0048	0.0306
Mycobacterium leprae	PROBABLE DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE DCD (DCTP DEAMINASE)	0.0084	0.0476	0.4565
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0176	0.1031	0.274
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0054	0.0295	0.2041
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0007	0.001	0.0016
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0226	0.0226
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0024	0.0113	0.1005
Entamoeba histolytica	thymidine kinase, putative	0.0261	0.155	1
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0007	0.001	0.0016
Brugia malayi	nuclear hormone receptor	0.001	0.0029	0.0204
Echinococcus granulosus	neuropeptide receptor A26	0.0486	0.2909	0.7787
Trichomonas vaginalis	thymidine kinase, putative	0.0261	0.155	1
Echinococcus multilocularis	expressed conserved protein	0.0094	0.0534	0.0534
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0087	0.0496	0.4761
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0013	0.0048	0.0306
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0013	0.0048	0.0245
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.007	0.0177
Brugia malayi	Patched related family protein 12	0.0006	0.0004	0.0027
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.001	0.0029	0.0204
Schistosoma mansoni	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0242	0.1433	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.001	0.0029	0.0029
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	ecdysone induced protein 78C	0.001	0.0029	0.0029
Entamoeba histolytica	hypothetical protein	0.0084	0.0476	0.3026
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Trichomonas vaginalis	mercuric reductase, putative	0.0013	0.0048	0.0266
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.001	0.0029	0.0204
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0007	0.001	0.0016
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0242	0.1433	0.9237
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0242	0.0648
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.001	0.0026	0.0183
Schistosoma mansoni	RAR-like nuclear receptor	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	neuropeptide s receptor	0.0486	0.2909	0.2909
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0113	0.0275
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0048	0.0245
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.001	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Mycobacterium ulcerans	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0084	0.0476	0.1251
Schistosoma mansoni	cpg binding protein	0.003	0.015	0.105
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0097	0.0555	0.1477
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Mycobacterium tuberculosis	Probable reductase	0.0087	0.0496	0.1318
Brugia malayi	hypothetical protein	0.0006	0.0004	0.0027
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0018	0.0076	0.0177
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.01	0.0571	0.364
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial precursor, putative	0.0242	0.1433	0.9237
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.001	0.0029	0.0204
Brugia malayi	Steroid receptor seven-up type 2	0.001	0.0029	0.0204
Loa Loa (eye worm)	patched family protein	0.0006	0.0004	0.0027
Schistosoma mansoni	cpg binding protein	0.003	0.015	0.105
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0013	0.0048	0.0245
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0007	0.001	0.001
Entamoeba histolytica	hypothetical protein	0.0242	0.1433	0.9237
Brugia malayi	Niemann-Pick C1 protein precursor	0.01	0.0571	0.3983
Schistosoma mansoni	coup transcription factor	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	protein patched	0.0043	0.0226	0.0226
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.001	0.0029	0.0204
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0013	0.0048	0.0306
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0242	0.169
Onchocerca volvulus		0.0007	0.001	0.0444
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0017	0.007	0.0177
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.0021	0.0056
Schistosoma mansoni	hypothetical protein	0.0041	0.0217	0.1514
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0242	0.1433	0.9237
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0097	0.0555	0.5339
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0087	0.0496	0.1318
Brugia malayi	protein C24B5.3	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Brugia malayi	dUTP diphosphatase	0.0242	0.1433	1
Toxoplasma gondii	NADPH-glutathione reductase	0.0013	0.0048	0.0306
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.001	0.0029	0.0029
Plasmodium vivax	glutathione reductase, putative	0.0038	0.0199	0.1366
Trypanosoma cruzi	thymidine kinase, putative	0.0261	0.155	1
Chlamydia trachomatis	deoxyuridine 5'-triphosphate nucleotidohydrolase	0.0242	0.1433	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.001	0.0029	0.0204
Schistosoma mansoni	acetyl-CoA synthetase	0.0007	0.001	0.0069
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0069
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0176	0.1031	0.2752
Brugia malayi	Patched related family protein 10	0.0006	0.0004	0.0027
Brugia malayi	AMP-binding enzyme family protein	0.0007	0.001	0.0069
Schistosoma mansoni	steroid hormone receptor ad4bp	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	patched family protein	0.0006	0.0004	0.0027
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0242	0.0242
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0013	0.0048	0.0101
Wolbachia endosymbiont of Brugia malayi	dUTPase	0.0242	0.1433	1
Echinococcus granulosus	expressed conserved protein	0.0094	0.0534	0.1429
Trypanosoma cruzi	thymidine kinase, putative	0.0261	0.155	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0242	0.169
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein	0.0242	0.1433	0.9237
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Echinococcus granulosus	FTZ F1 alpha	0.001	0.0029	0.0078
Brugia malayi	protein C24B5.3	0.0006	0.0004	0.0027
Onchocerca volvulus		0.0007	0.001	0.0444
Toxoplasma gondii	deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	0.0242	0.1433	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.001	0.0029	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0076	0.0529
Echinococcus multilocularis	neuropeptide receptor A26	0.0486	0.2909	0.2909
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.001	0.0029	0.0204
Toxoplasma gondii	AMP-binding enzyme domain-containing protein	0.0007	0.001	0.0042
Brugia malayi	Patched family protein	0.0006	0.0004	0.0027
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0007	0.001	0.001
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0013	0.0048	0.0245
Plasmodium falciparum	acyl-CoA synthetase	0.0018	0.0076	0.0504
Plasmodium falciparum	glutathione reductase	0.0038	0.0199	0.1366
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0226	0.1423
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0226	0.0605
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0622	0.3736	1
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0284	0.1985
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0061	0.0335	0.2336
Entamoeba histolytica	deoxyuridine 5-triphosphate nucleotidohydrolase, putative	0.0084	0.0476	0.3026
Echinococcus granulosus	neuropeptide s receptor	0.0486	0.2909	0.7787
Echinococcus granulosus	ecdysone induced protein 78C	0.001	0.0029	0.0078
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0113	0.0666
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Loa Loa (eye worm)	glutathione reductase	0.0038	0.0199	0.139
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0013	0.0048	0.0245
Loa Loa (eye worm)	hypothetical protein	0.0006	0.0004	0.0027
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0113	0.0291
Trichomonas vaginalis	thymidine kinase, putative	0.0261	0.155	1
Schistosoma mansoni	patched 1	0.0043	0.0226	0.1579
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.001	0.0029	0.0078
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.0199	0.1366
Trichomonas vaginalis	glutathione reductase, putative	0.0013	0.0048	0.0266

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1734336

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1545646