Detailed information for compound 1549203

Basic information

Technical information
  • TDR Targets ID: 1549203
  • Name: N'-(4-chlorobenzoyl)naphthalene-1-carbohydraz ide
  • MW: 324.761 | Formula: C18H13ClN2O2
  • H donors: 2 H acceptors: 2 LogP: 4.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C(=O)NNC(=O)c1cccc2c1cccc2
  • InChi: 1S/C18H13ClN2O2/c19-14-10-8-13(9-11-14)17(22)20-21-18(23)16-7-3-5-12-4-1-2-6-15(12)16/h1-11H,(H,20,22)(H,21,23)
  • InChiKey: HANJMTYCXZQLLL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N'-[(4-chlorophenyl)-oxomethyl]-1-naphthalenecarbohydrazide
  • N'-(4-chlorophenyl)carbonylnaphthalene-1-carbohydrazide
  • NSC88177
  • ZINC00568822

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.0341 0.0323 0.2628
Schistosoma mansoni hypothetical protein 0.0037 0.0017 0.0138
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Loa Loa (eye worm) hypothetical protein 0.0123 0.0104 0.0104
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0022 0.5953
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0965
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1244 0.123 0.2386
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0965
Loa Loa (eye worm) hypothetical protein 0.0238 0.0219 0.0219
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0036 0.0016 0.5697
Schistosoma mansoni survival motor neuron protein 0.0049 0.0029 0.0234
Loa Loa (eye worm) hypothetical protein 0.004 0.002 0.002
Brugia malayi Cell death protein 3 precursor 0.0083 0.0064 0.0064
Brugia malayi hypothetical protein 0.0152 0.0133 0.0133
Echinococcus multilocularis lamin 0.0027 0.0007 0.0014
Echinococcus multilocularis carnitine O palmitoyltransferase 1, liver 0.515 0.5157 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0241 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0073 0.059
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0023 0.6227
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0028 0.0055
Onchocerca volvulus 0.1244 0.123 1
Leishmania major carnitine palmitoyltransferase-like protein 0.2436 0.2429 0.471
Trichomonas vaginalis ran, putative 0.0042 0.0022 0.0923
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0027 0.1101
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0048 0.0028 1
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0241 1
Plasmodium falciparum importin beta, putative 0.0057 0.0037 1
Echinococcus multilocularis choline O acetyltransferase 0.1244 0.123 0.2386
Loa Loa (eye worm) hypothetical protein 0.0036 0.0016 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0028 1
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0219 0.0425
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0045 0.0367
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0006 0.1503
Schistosoma mansoni ran 0.0042 0.0022 0.0181
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.5992
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0028
Trypanosoma cruzi metacaspase, putative 0.0043 0.0023 0.0045
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.2436 0.2429 0.2429
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Schistosoma mansoni ran 0.0042 0.0022 0.0181
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0241 1
Schistosoma mansoni hypothetical protein 0.004 0.002 0.0165
Echinococcus granulosus lamin dm0 0.0027 0.0007 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0028 1
Echinococcus multilocularis carnitine O palmitoyltransferase 2 0.2436 0.2429 0.471
Schistosoma mansoni importin beta-1 0.0057 0.0037 0.0304
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0073 0.0073
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0023 0.0045
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0219 0.0425
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0037 1
Trypanosoma cruzi hypothetical protein, conserved 0.1244 0.123 0.2386
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0048 0.0028 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0016 0.0016
Mycobacterium ulcerans hypothetical protein 0.0048 0.0028 1
Brugia malayi intermediate filament protein 0.0027 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0068 0.0048 0.0394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0073 0.0141
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0095
Onchocerca volvulus 0.004 0.002 0.0106
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0241 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.008 0.008
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0027 0.0052
Echinococcus granulosus geminin 0.0341 0.0323 0.0627
Onchocerca volvulus Huntingtin homolog 0.0123 0.0104 0.079
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0023
Echinococcus granulosus carnitine O palmitoyltransferase 2 0.2436 0.2429 0.471
Echinococcus multilocularis musashi 0.0027 0.0007 0.0014
Brugia malayi Choline O-acetyltransferase 0.1244 0.123 0.123
Trypanosoma cruzi hypothetical protein, conserved 0.1244 0.123 0.2386
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.1244 0.123 0.2386
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0043 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0123 0.0104 0.0104
Trypanosoma cruzi carnitine O-palmitoyltransferase II, putative 0.2436 0.2429 0.471
Echinococcus multilocularis caspase 0.0114 0.0094 0.0183
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0028 0.5
Schistosoma mansoni hypothetical protein 0.0341 0.0323 0.2628
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0014 0.5002
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0965
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.0151 0.1178
Trypanosoma cruzi metacaspase, putative 0.0043 0.0023 0.0045
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0006 0.0011
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0037 0.0073
Echinococcus multilocularis lamin dm0 0.0027 0.0007 0.0014
Echinococcus granulosus caspase 2 0.0083 0.0064 0.0123
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.5992
Loa Loa (eye worm) hypothetical protein 0.0025 0.0006 0.0006
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0027 0.1101
Onchocerca volvulus Cell death protein 3 homolog 0.0083 0.0064 0.046
Echinococcus granulosus apoptotic protease activating factor 1 0.004 0.002 0.0039
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0022 0.0043
Echinococcus granulosus choline O acetyltransferase 0.1244 0.123 0.2386
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0043 0.0023 0.0189
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0028
Onchocerca volvulus 0.0048 0.0028 0.0172
Brugia malayi TAR-binding protein 0.0065 0.0045 0.0045
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Onchocerca volvulus 0.1244 0.123 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0022 0.0092
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0241 1
Onchocerca volvulus Huntingtin homolog 0.0123 0.0104 0.079
Echinococcus granulosus carnitine O palmitoyltransferase 1 liver 0.515 0.5157 1
Brugia malayi hypothetical protein 0.0025 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.9969 1 1
Brugia malayi hypothetical protein 0.0123 0.0104 0.0104
Brugia malayi RNA, U transporter 1 0.0162 0.0143 0.0143
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0022 0.5953
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Leishmania major importin beta-1 subunit, putative 0.0046 0.0027 0.0052
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.5992
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0048 0.0028 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0048 0.0028 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0017 0.0033
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Echinococcus granulosus lamin 0.0027 0.0007 0.0014
Echinococcus granulosus importin subunit beta 1 0.0057 0.0037 0.0073
Entamoeba histolytica acyl-CoA synthetase, putative 0.0048 0.0028 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0014 0.5002
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0029 0.0029
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0028 0.0028
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0048 0.0028 1
Loa Loa (eye worm) hypothetical protein 0.01 0.008 0.008
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0012 0.0012
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0022 0.0043
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0022 0.0043
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0037 0.0154
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0045 0.0367
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0007 0.0007
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0023 0.0023
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0048 0.0048
Brugia malayi Choline/Carnitine o-acyltransferase family protein 0.1244 0.123 0.123
Trypanosoma brucei metacaspase 0.0043 0.0023 0.0096
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0095
Loa Loa (eye worm) hypothetical protein 0.0083 0.0064 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0161 0.666
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1647 0.1635 0.3171
Loa Loa (eye worm) carnitine O-palmitoyltransferase I isoform 0.1244 0.123 0.123
Trichomonas vaginalis glucosylceramidase, putative 0.026 0.0241 1
Leishmania major GTP-binding protein, putative 0.0042 0.0022 0.0043
Echinococcus granulosus tar DNA binding protein 0.0065 0.0045 0.0087
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0045 0.0367
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0006 0.1503
Onchocerca volvulus 0.0152 0.0133 0.1027
Echinococcus multilocularis apoptotic protease activating factor 1 0.004 0.002 0.0039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0073 0.0141
Entamoeba histolytica hypothetical protein 0.0037 0.0017 0.5992
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0006 0.1503
Loa Loa (eye worm) hypothetical protein 0.0036 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Schistosoma mansoni choline o-acyltransferase 0.1244 0.123 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Echinococcus granulosus GPCR family 2 0.0031 0.0012 0.0023
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0095
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0022 0.5953
Plasmodium falciparum metacaspase 1 0.0043 0.0023 0.6227
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.1244 0.123 0.123
Trypanosoma brucei metacaspase MCA3 0.0043 0.0023 0.0096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0023
Echinococcus granulosus tumor protein p63 0.0329 0.031 0.0602
Loa Loa (eye worm) choline O-acetyltransferase 0.1244 0.123 0.123
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0073 0.0141
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0609 0.0592 0.0592
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0073 0.059
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Trypanosoma cruzi metacaspase, putative 0.0043 0.0023 0.0045
Schistosoma mansoni lamin 0.0027 0.0007 0.006
Brugia malayi hypothetical protein 0.0238 0.0219 0.0219
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0023 0.6227
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0 0.5
Schistosoma mansoni lamin 0.0027 0.0007 0.006
Schistosoma mansoni hypothetical protein 0.0609 0.0592 0.4814
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0006 0.1503
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0036 0.0016 0.5
Brugia malayi Choline O-acetyltransferase 0.1244 0.123 0.123
Brugia malayi Importin beta-1 subunit 0.0057 0.0037 0.0037
Schistosoma mansoni caspase-7 (C14 family) 0.0083 0.0064 0.0517
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Echinococcus granulosus caspase 3 0.0071 0.0051 0.0099
Trypanosoma brucei metacaspase MCA2 0.0043 0.0023 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0016 0.0016
Plasmodium vivax metacaspase 1, putative 0.0043 0.0023 0.6227
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0012 0.0023
Echinococcus granulosus caspase 8 0.0043 0.0023 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0014 0.5002
Trypanosoma cruzi carnitine/choline acetyltransferase, putative 0.1244 0.123 0.2386
Plasmodium vivax acyl-CoA synthetase, putative 0.0036 0.0016 0.4324
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0073 0.0073
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0048 0.0028 1
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.515 0.5157 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0022 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0028 0.0055
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0034 0.0014 0.5002
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0006 0.0023
Trypanosoma cruzi choline/carnitine O-acetyltransferase, putative 0.1244 0.123 0.2386
Echinococcus multilocularis geminin 0.0341 0.0323 0.0627
Loa Loa (eye worm) hypothetical protein 0.0068 0.0048 0.0048
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.1244 0.123 0.5065
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0017 0.0033
Trypanosoma cruzi hypothetical protein, conserved 0.1244 0.123 0.2386
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0045 0.0367
Echinococcus multilocularis GPCR, family 2 0.0031 0.0012 0.0023
Trypanosoma brucei carnitine O-palmitoyltransferase II, putative 0.2436 0.2429 1
Echinococcus granulosus caspase 0.0114 0.0094 0.0183
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.0161 0.666
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0965
Schistosoma mansoni caspase-3 (C14 family) 0.0114 0.0094 0.0767
Entamoeba histolytica acyl-coA synthetase, putative 0.0048 0.0028 1
Onchocerca volvulus 0.0049 0.0029 0.0176
Trypanosoma brucei Metacaspase-4 0.0043 0.0023 0.0096
Plasmodium falciparum metacaspase-like protein 0.0043 0.0023 0.6227
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Brugia malayi AMP-binding enzyme family protein 0.0048 0.0028 0.0028
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0045 0.0045
Schistosoma mansoni intermediate filament proteins 0.0027 0.0007 0.006
Entamoeba histolytica hypothetical protein 0.0046 0.0027 0.9356
Leishmania major 4-coumarate:coa ligase-like protein 0.0048 0.0028 0.0055
Plasmodium vivax importin-beta 2, putative 0.0057 0.0037 1
Entamoeba histolytica Ran family GTPase 0.0042 0.0022 0.7843
Loa Loa (eye worm) hypothetical protein 0.0152 0.0133 0.0133
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0045 0.0045
Loa Loa (eye worm) choline/Carnitine O-acyltransferase 0.2436 0.2429 0.2429
Schistosoma mansoni hypothetical protein 0.0049 0.0029 0.0234
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0045 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0028 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0114 0.0094 0.0183
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.026 0.0241 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0965
Echinococcus granulosus snurportin 1 0.0609 0.0592 0.1149
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.008 0.008
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0012 0.0012
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0028 0.0231
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0012 0.0023
Trypanosoma brucei hypothetical protein, conserved 0.1244 0.123 0.5065
Mycobacterium ulcerans acyl-CoA synthetase 0.0048 0.0028 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0048 0.0028 0.5
Schistosoma mansoni caspase-7 (C14 family) 0.0114 0.0094 0.0767
Loa Loa (eye worm) hypothetical protein 0.0036 0.0016 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0006 0.0011
Echinococcus multilocularis caspase 3 0.0071 0.0051 0.0099
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0043 0.0023 0.0965
Trypanosoma cruzi carnitine O-acetyltransferase, putative 0.1244 0.123 0.2386
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0043 0.0023 0.6227
Echinococcus granulosus intermediate filament protein 0.0027 0.0007 0.0014
Onchocerca volvulus 0.0048 0.0028 0.0172
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0022 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0045 0.0367
Trypanosoma cruzi metacaspase, putative 0.0043 0.0023 0.0045
Leishmania major carnitine/choline acetyltransferase, putative 0.1244 0.123 0.2386
Echinococcus multilocularis caspase 2 0.0083 0.0064 0.0123
Trypanosoma cruzi hypothetical protein, conserved 0.1244 0.123 0.2386
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0 0.5
Brugia malayi RNA binding protein 0.0065 0.0045 0.0045
Echinococcus multilocularis caspase 8 0.0043 0.0023 0.0045
Trypanosoma brucei carnitine O-palmitoyltransferase, putative 0.1244 0.123 0.5065
Echinococcus multilocularis snurportin 1 0.0609 0.0592 0.1149
Schistosoma mansoni choline o-acyltransferase 0.1244 0.123 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0012 0.0012
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0073 0.0141
Leishmania major choline/Carnitine o-acyltransferase-like protein 0.515 0.5157 1
Plasmodium falciparum acyl-CoA synthetase 0.0036 0.0016 0.4324
Loa Loa (eye worm) hypothetical protein 0.0057 0.0037 0.0037
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.515 0.5157 1
Trypanosoma brucei metacaspase 5, putative 0.0043 0.0023 0.0096
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0023 0.6227
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0036 0.0016 0.5697
Leishmania major metacaspase, putative 0.0043 0.0023 0.0045
Trypanosoma cruzi choline/carnitine O-acyltransferase, putative 0.1244 0.123 0.2386
Echinococcus multilocularis tumor protein p63 0.0329 0.031 0.0602
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0022 0.0043
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0045 0.0087
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.026 0.0241 0.0241
Leishmania major hypothetical protein, conserved 0.0025 0.0006 0.0011
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0027 0.1101
Brugia malayi hypothetical protein 0.004 0.002 0.002
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.0151 0.6277
Onchocerca volvulus 0.1244 0.123 1
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0095
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0114 0.0094 0.0183
Brugia malayi hypothetical protein 0.0037 0.0017 0.0017
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0007 0.0007
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0017 0.0138
Onchocerca volvulus 0.1244 0.123 1
Trypanosoma brucei carnitine O-acetyltransferase, putative 0.1244 0.123 0.5065
Loa Loa (eye worm) RNA binding protein 0.0065 0.0045 0.0045
Trypanosoma cruzi metacaspase 5, putative 0.0043 0.0023 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0073 0.059
Loa Loa (eye worm) hypothetical protein 0.0048 0.0028 0.0028
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0037 0.0154
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0023 0.0965

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 1 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.