Detailed information for compound 1549487

Basic information

Technical information
  • TDR Targets ID: 1549487
  • Name: 1-[(4-methoxyphenyl)methyl]-5-oxo-N-(2-phenyl ethyl)pyrrolidine-3-carboxamide
  • MW: 352.427 | Formula: C21H24N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.14 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CN1CC(CC1=O)C(=O)NCCc1ccccc1
  • InChi: 1S/C21H24N2O3/c1-26-19-9-7-17(8-10-19)14-23-15-18(13-20(23)24)21(25)22-12-11-16-5-3-2-4-6-16/h2-10,18H,11-15H2,1H3,(H,22,25)
  • InChiKey: BZTGARPHWAMEPX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[(4-methoxyphenyl)methyl]-5-oxo-N-(2-phenylethyl)-3-pyrrolidinecarboxamide
  • 5-keto-1-(4-methoxybenzyl)-N-(2-phenylethyl)pyrrolidine-3-carboxamide
  • MLS000521110
  • SMR000131519
  • EU-0097740

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0015 0.0389
Schistosoma mansoni endoplasmin 0.0018 0.0062 0.0065
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.1776 0.9627 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0098 0.0501 0.218
Echinococcus multilocularis multidrug resistance protein 1 0.0007 0.0006 0.0006
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0029 0.0123 0.0128
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.009 0.3528
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Plasmodium falciparum LCCL domain-containing protein 0.0297 0.1581 1
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0007 0.0006 0.0072
Trypanosoma cruzi Heat shock protein 83, putative 0.0018 0.0062 0.2364
Loa Loa (eye worm) heat shock protein 90 0.0018 0.0062 0.0274
Plasmodium falciparum perforin-like protein 4 0.0165 0.0864 0.5461
Plasmodium falciparum perforin-like protein 3 0.0165 0.0864 0.5461
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.1693 0.9175 0.9175
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0199 0.8039
Schistosoma mansoni endoplasmin 0.0018 0.0062 0.0065
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0006 0.0006
Schistosoma mansoni chromobox protein 0.0038 0.0173 0.0179
Brugia malayi polk-prov protein 0.0023 0.0094 0.0593
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0025
Loa Loa (eye worm) hypothetical protein 0.0098 0.0501 0.22
Schistosoma mansoni flap endonuclease-1 0.0013 0.0036 0.0037
Brugia malayi chromobox protein homolog 3 0.0021 0.0082 0.0518
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0029 0.0123 0.0128
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0029 0.0123 0.0128
Loa Loa (eye worm) hypothetical protein 0.0043 0.0199 0.0873
Entamoeba histolytica P-glycoprotein-2 0.0007 0.0006 0.0254
Trypanosoma cruzi DNA repair protein, putative 0.0018 0.0065 0.2453
Loa Loa (eye worm) hypothetical protein 0.0017 0.0057 0.025
Onchocerca volvulus Phospholipase A2 homolog 0.0148 0.077 0.3365
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0173 0.7015
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0032 0.0143 0.5712
Brugia malayi Phospholipase A2 family protein 0.0148 0.077 0.4867
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0014 0.0043 0.1549
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0015 0.0389
Trichomonas vaginalis ABC transporter, putative 0.0007 0.0006 0.0254
Schistosoma mansoni Replicative DNA helicase 0.021 0.111 0.1153
Trichomonas vaginalis heat shock protein, putative 0.0018 0.0062 0.254
Trypanosoma cruzi hypothetical protein, conserved 0.0009 0.0015 0.0389
Plasmodium falciparum heat shock protein 90 0.0018 0.0062 0.0395
Onchocerca volvulus 0.0017 0.0057 0.0226
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Trypanosoma brucei heat shock protein 90, putative 0.0018 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0148 0.077 0.3382
Schistosoma mansoni multidrug resistance protein 0.0007 0.0006 0.0006
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Toxoplasma gondii perforin-like protein PLP1 0.0165 0.0864 1
Toxoplasma gondii heat shock protein 75, putative 0.0007 0.0006 0.0066
Trypanosoma cruzi polo-like protein kinase, putative 0.0051 0.0246 1
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0007 0.0006 0.0254
Plasmodium falciparum endoplasmin, putative 0.0011 0.0025 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.1956
Schistosoma mansoni multidrug resistance protein 0.0007 0.0006 0.0006
Plasmodium falciparum perforin-like protein 2 0.0165 0.0864 0.5461
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0094 0.3666
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Giardia lamblia Heat shock protein HSP 90-alpha 0.0018 0.0062 0.2056
Echinococcus multilocularis heat shock protein 90 0.0018 0.0062 0.0065
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0007 0.0006 0.0006
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Onchocerca volvulus 0.0297 0.1581 0.694
Leishmania major DNA polymerase eta, putative 0.0043 0.0199 0.8039
Trichomonas vaginalis flap endonuclease-1, putative 0.0014 0.0043 0.1762
Schistosoma mansoni DNA polymerase IV / kappa 0.0009 0.0015 0.0016
Toxoplasma gondii Hsp90 domain-containing protein 0.0007 0.0006 0.0066
Echinococcus granulosus RUN 0.0297 0.1581 0.1643
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Plasmodium falciparum heat shock protein 90, putative 0.0007 0.0006 0.0036
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Onchocerca volvulus 0.0297 0.1581 0.694
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0013 0.0035 0.04
Echinococcus multilocularis endoplasmin 0.0014 0.0043 0.0045
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Plasmodium vivax multidomain scavenger receptor, putative 0.0297 0.1581 1
Schistosoma mansoni heat shock protein 0.0007 0.0006 0.0006
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.3329
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative 0.0007 0.0006 0.0024
Echinococcus multilocularis flap endonuclease 1 0.0014 0.0043 0.0045
Leishmania major p-glycoprotein 0.0007 0.0006 0.0024
Leishmania major DNA damage repair protein, putative 0.0009 0.0015 0.0389
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0032 0.0143 0.0137
Echinococcus granulosus dna polymerase eta 0.0043 0.0199 0.0206
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0006 0.0006
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0082 0.036
Brugia malayi Heterochromatin protein 1 0.0038 0.0173 0.1091
Trypanosoma cruzi heat shock protein 85, putative 0.0014 0.0043 0.1549
Trichomonas vaginalis endoplasmin, putative 0.0011 0.0025 0.1028
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0007 0.0006 0.0027
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0007 0.0006 0.0006
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0018 0.0065 0.2453
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0007 0.0006 0.0254
Mycobacterium ulcerans heat shock protein 90 0.0014 0.0043 0.0254
Brugia malayi ImpB/MucB/SamB family protein 0.0043 0.0199 0.1257
Trichomonas vaginalis abcb9, putative 0.0007 0.0006 0.0254
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Plasmodium vivax heat shock protein, putative 0.0007 0.0006 0.0036
Entamoeba histolytica heat shock protein 90, putative 0.0018 0.0062 0.254
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Leishmania major DNA polymerase kappa, putative 0.0032 0.0143 0.5712
Loa Loa (eye worm) hypothetical protein 0.0297 0.1581 0.6947
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0082 0.3329
Plasmodium vivax perforin-like protein 1 0.0165 0.0864 0.5461
Entamoeba histolytica heat shock protein 90, putative 0.0018 0.0062 0.254
Schistosoma mansoni heat shock protein 0.0018 0.0062 0.0065
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0051 0.0246 0.0255
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0014 0.0043 0.1568
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0091 0.3686
Trypanosoma cruzi DNA damage repair protein, putative 0.0009 0.0015 0.0389
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Echinococcus granulosus heat shock protein 90 0.0014 0.0043 0.0045
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Brugia malayi Flap endonuclease-1 0.0014 0.0043 0.0274
Mycobacterium ulcerans recombinase A 0.0059 0.0286 0.2471
Giardia lamblia Flap structure-specific endonuclease 0.0014 0.0043 0.1227
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Chlamydia trachomatis hypothetical protein 0.0165 0.0864 0.7765
Echinococcus multilocularis multidrug resistance protein 1 0.0007 0.0006 0.0006
Giardia lamblia DINP protein human, muc B family 0.0032 0.0143 0.5539
Brugia malayi Endoplasmin precursor 0.0018 0.0062 0.0395
Echinococcus multilocularis Polycystic kidney disease protein 0.0297 0.1581 0.1643
Brugia malayi Hsp90 protein 0.0007 0.0006 0.0036
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0051 0.0246 1
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0202 0.1708
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0014 0.0043 0.0502
Trichomonas vaginalis ABC transporter, putative 0.0007 0.0006 0.0254
Echinococcus granulosus multidrug resistance protein 1 0.0007 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0297 0.1581 0.1643
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Giardia lamblia Heat shock protein HSP 90-alpha 0.0014 0.0043 0.1207
Trypanosoma brucei hypothetical protein, conserved 0.0009 0.0015 0.0389
Schistosoma mansoni hypothetical protein 0.0092 0.0468 0.0486
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Chlamydia trachomatis replicative DNA helicase 0.021 0.111 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0007 0.0006 0.0254
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.0007 0.0006 0.0006
Trypanosoma cruzi heat shock protein 90, putative 0.001 0.0023 0.0723
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0051 0.0246 0.0255
Loa Loa (eye worm) hypothetical protein 0.0297 0.1581 0.6947
Trichomonas vaginalis heat shock protein, putative 0.0011 0.0025 0.1028
Onchocerca volvulus 0.0007 0.0006 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0105 0.4257
Toxoplasma gondii heat shock protein HSP90 0.0018 0.0062 0.0723
Leishmania major DNA polymerase eta, putative 0.0023 0.009 0.3528
Plasmodium falciparum perforin-like protein 1 0.0165 0.0864 0.5461
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trypanosoma cruzi heat shock protein 85, putative 0.0018 0.0062 0.2364
Plasmodium vivax heat shock protein 86, putative 0.0018 0.0062 0.0395
Chlamydia trachomatis recombinase RecA 0.0059 0.0286 0.2531
Loa Loa (eye worm) flap endonuclease-1 0.0014 0.0043 0.019
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0009 0.0015 0.0174
Echinococcus multilocularis ATP binding cassette sub family B 0.0007 0.0006 0.0006
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0007 0.0006 0.0231
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0059 0.0286 0.2275
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0007 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.1492 0.8082 0.8395
Trichomonas vaginalis CAMK family protein kinase 0.0025 0.0105 0.4257
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0094 0.3682
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Schistosoma mansoni lipoxygenase 0.1776 0.9627 1
Treponema pallidum replicative DNA helicase (dnaB) 0.021 0.111 1
Brugia malayi ImpB/MucB/SamB family protein 0.0029 0.0123 0.078
Plasmodium vivax DNA repair protein REV1, putative 0.0009 0.0015 0.0095
Leishmania major DNA polymerase kappa, putative 0.0009 0.0015 0.0389
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0007 0.0006 0.0254
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Loa Loa (eye worm) multidrug resistance protein 3 0.0007 0.0006 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0094 0.3666
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.021 0.111 0.3238
Echinococcus granulosus heat shock protein 0.0018 0.0062 0.0065
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0246 0.0255
Schistosoma mansoni chromobox protein 0.0038 0.0173 0.0179
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0023 0.0091 0.0374
Giardia lamblia Kinase, PLK 0.0051 0.0246 1
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0059 0.0286 0.0737
Entamoeba histolytica serine/threonine protein kinase, putative 0.0051 0.0246 1
Trypanosoma cruzi heat shock protein 85, putative 0.0018 0.0062 0.2364
Loa Loa (eye worm) doublecortin family protein 0.0297 0.1581 0.6947
Echinococcus granulosus lipoxygenase domain containing protein 0.0297 0.1581 0.1643
Echinococcus granulosus geminin 0.0092 0.0468 0.0486
Trichomonas vaginalis ABC transporter, putative 0.0007 0.0006 0.0254
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0091 0.3686
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Plasmodium vivax flap endonuclease 1, putative 0.0014 0.0043 0.0274
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0007 0.0006 0.0254
Schistosoma mansoni loxhd1 0.0297 0.1581 0.1643
Echinococcus granulosus heat shock protein 90 0.0018 0.0062 0.0065
Plasmodium vivax perforin-like protein 3 0.0165 0.0864 0.5461
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0094 0.3682
Echinococcus granulosus arachidonate 5 lipoxygenase 0.1776 0.9627 1
Trypanosoma brucei Heat shock protein 83, putative 0.0018 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0425 0.2276 1
Echinococcus granulosus flap endonuclease 1 0.0014 0.0043 0.0045
Plasmodium falciparum perforin-like protein 5 0.0165 0.0864 0.5461
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0021 0.0082 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Plasmodium vivax heat shock protein 90, putative 0.0007 0.0006 0.0036
Echinococcus multilocularis heat shock protein 90 0.0014 0.0043 0.0045
Trypanosoma brucei unspecified product 0.002 0.0075 0.2869
Trypanosoma cruzi DNA damage repair protein, putative 0.0009 0.0015 0.0389
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0043 0.1743
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trypanosoma cruzi polo-like protein kinase, putative 0.0051 0.0246 1
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0007 0.0006 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0202 0.8218
Echinococcus multilocularis macrophage expressed protein 0.1492 0.8082 0.8395
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0043 0.1743
Trichomonas vaginalis heat shock protein, putative 0.0014 0.0043 0.1743
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0143 0.5712
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0202 0.8218
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0048 0.1956
Echinococcus multilocularis geminin 0.0092 0.0468 0.0486
Trichomonas vaginalis chromobox protein, putative 0.0038 0.0173 0.7015
Toxoplasma gondii heat shock protein 90, putative 0.0018 0.0062 0.0723
Echinococcus multilocularis chromobox protein 1 0.0038 0.0173 0.0179
Schistosoma mansoni kinase 0.0026 0.0108 0.0113
Schistosoma mansoni multidrug resistance protein 0.0007 0.0006 0.0006
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0014 0.0043 0.0045
Entamoeba histolytica P-glycoprotein 5, putative 0.0007 0.0006 0.0254
Echinococcus granulosus endoplasmin 0.0014 0.0043 0.0045
Entamoeba histolytica P-glycoprotein-5 0.0007 0.0006 0.0254
Giardia lamblia Grp94/Hsp90 0.0014 0.0043 0.1207
Schistosoma mansoni rab6-interacting 0.0297 0.1581 0.1643
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0027
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0007 0.0006 0.0006
Echinococcus granulosus dna polymerase kappa 0.0043 0.0202 0.021
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0007 0.0006 0.0006
Brugia malayi hypothetical protein 0.0297 0.1581 1
Brugia malayi Doublecortin family protein 0.0297 0.1581 1
Echinococcus multilocularis dna polymerase eta 0.0043 0.0199 0.0206
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Toxoplasma gondii MAC/Perforin domain-containing protein 0.0165 0.0864 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0051 0.0246 0.1555
Schistosoma mansoni rab6-interacting 0.0297 0.1581 0.1643
Schistosoma mansoni terminal deoxycytidyl transferase 0.0029 0.0123 0.0128
Brugia malayi N-terminal motif family protein 0.0098 0.0501 0.3167
Treponema pallidum recombinase A 0.0059 0.0286 0.2275
Onchocerca volvulus Phospholipase A2 homolog 0.0425 0.2276 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0014 0.0043 0.1568
Echinococcus multilocularis heat shock protein 0.0018 0.0062 0.0065
Schistosoma mansoni hypothetical protein 0.0092 0.0468 0.0486
Trichomonas vaginalis abcb9, putative 0.0007 0.0006 0.0254
Schistosoma mansoni lipoxygenase 0.1242 0.672 0.698
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0023 0.009 0.1047
Trichomonas vaginalis heat shock protein, putative 0.0007 0.0006 0.0231
Trypanosoma brucei DNA polymerase IV, putative 0.004 0.0183 0.7363
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Entamoeba histolytica P-glyco protein 6, putative 0.0007 0.0006 0.0254
Schistosoma mansoni heat shock protein 0.0018 0.0062 0.0065
Echinococcus multilocularis RUN 0.0297 0.1581 0.1643
Loa Loa (eye worm) heterochromatin protein 1 0.0038 0.0173 0.0758
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0051 0.0246 0.108
Entamoeba histolytica P-glycoprotein-2, putative 0.0007 0.0006 0.0254
Plasmodium vivax perforin-like protein 4 0.0165 0.0864 0.5461
Plasmodium falciparum heat shock protein 90, putative 0.0007 0.0006 0.0036
Trypanosoma brucei chrX additional, unordered contigs 0.0009 0.0015 0.0389
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Trypanosoma brucei unspecified product 0.002 0.0075 0.2869
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Mycobacterium leprae Conserved hypothetical protein 0.062 0.334 1
Echinococcus granulosus chromobox protein 1 0.0038 0.0173 0.0179
Plasmodium vivax multidrug resistance protein 1, putative 0.0007 0.0006 0.0039
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0014 0.0043 0.1568
Mycobacterium tuberculosis Conserved hypothetical protein 0.0029 0.0123 0.0117
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Plasmodium falciparum multidrug resistance protein 1 0.0007 0.0006 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0202 0.8176
Entamoeba histolytica P-glycoprotein-2 0.0007 0.0006 0.0254
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Echinococcus granulosus macrophage expressed protein 0.1492 0.8082 0.8395
Echinococcus granulosus lipoxygenase domain containing protein 0.0297 0.1581 0.1643
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0007 0.0006 0.0006
Echinococcus multilocularis lipoxygenase domain containing protein 0.0297 0.1581 0.1643
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0014 0.0043 0.0037
Trypanosoma brucei polo-like protein kinase 0.0051 0.0246 1
Trichomonas vaginalis abcb9, putative 0.0007 0.0006 0.0254
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0007 0.0006 0.0254
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0202 0.1708
Trypanosoma cruzi heat shock protein 85, putative 0.0018 0.0062 0.2364
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0007 0.0006 0.0072
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0007 0.0006 0.0006
Plasmodium vivax perforin-like protein 5 0.0165 0.0864 0.5461
Loa Loa (eye worm) twinkle helicase 0.006 0.0293 0.1288
Plasmodium falciparum DNA repair protein REV1, putative 0.0009 0.0015 0.0095
Entamoeba histolytica P-glycoprotein-1 0.0007 0.0006 0.0254
Trypanosoma cruzi DNA repair protein, putative 0.0018 0.0065 0.2453
Mycobacterium ulcerans replicative DNA helicase DnaB 0.021 0.111 1
Trichomonas vaginalis CAMK family protein kinase 0.0051 0.0246 1
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0202 0.021
Plasmodium vivax perforin-like protein 2 0.0165 0.0864 0.5461
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0202 0.8176
Echinococcus granulosus chromobox protein 1 0.0038 0.0173 0.0179
Brugia malayi multidrug resistance protein 3 0.0007 0.0006 0.0039
Brugia malayi hypothetical protein 0.0297 0.1581 1
Brugia malayi ABC transporter family protein 0.0007 0.0006 0.0039
Schistosoma mansoni smdr2 0.0007 0.0006 0.0006
Trichomonas vaginalis taga, putative 0.0007 0.0006 0.0254
Trypanosoma cruzi heat shock protein 90, putative 0.0018 0.0062 0.2364
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0007 0.0006 0.0254
Echinococcus multilocularis chromobox protein 1 0.0038 0.0173 0.0179
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Trypanosoma cruzi heat shock protein 90, putative 0.0014 0.0043 0.1549
Plasmodium falciparum flap endonuclease 1 0.0014 0.0043 0.0274
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0007 0.0006 0.0006
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Onchocerca volvulus Serine\/threonine kinase homolog 0.0051 0.0246 0.1058
Echinococcus granulosus Polycystic kidney disease protein 0.0297 0.1581 0.1643
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0007 0.0006 0.0254
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0202 0.8176
Trypanosoma brucei DNA damage repair protein, putative 0.0009 0.0015 0.0389
Schistosoma mansoni polycystin 1-related 0.0297 0.1581 0.1643
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0029 0.0123 0.0542
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0007 0.0006 0.0006
Trypanosoma brucei heat shock protein, putative 0.0018 0.0062 0.2364
Entamoeba histolytica Flap nuclease, putative 0.0014 0.0043 0.1762
Trypanosoma brucei DNA polymerase eta, putative 0.0043 0.0199 0.8039
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0007 0.0006 0.0254
Entamoeba histolytica deoxycytidyl transferase, putative 0.0029 0.0123 0.5017
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0027
Leishmania major heat shock protein 83-1 0.0018 0.0062 0.2364
Trypanosoma brucei heat shock protein 90, putative 0.0018 0.0062 0.2364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0412
Plasmodium vivax endoplasmin, putative 0.0018 0.0062 0.0395
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0007 0.0006 0.0006
Trypanosoma brucei DNA damage repair protein, putative 0.0009 0.0015 0.0389
Loa Loa (eye worm) heat shock protein 75 0.0007 0.0006 0.0025
Trichomonas vaginalis ABC transporter, putative 0.0007 0.0006 0.0254
Echinococcus multilocularis lipoxygenase domain containing protein 0.0297 0.1581 0.1643
Schistosoma mansoni DNA polymerase eta 0.0043 0.0199 0.0206
Loa Loa (eye worm) endoplasmin 0.0018 0.0062 0.0274
Brugia malayi heat shock protein 90 0.0018 0.0062 0.0395
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.021 0.111 1
Trypanosoma brucei unspecified product 0.004 0.0183 0.7363
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0094 0.3682

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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