Detailed information for compound 1556506

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 456.624 | Formula: C23H28N4O2S2
  • H donors: 1 H acceptors: 2 LogP: 3.97 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CSc1nc2sc3c(c2c(=O)n1C)CCCC3)NCC(c1ccccc1)N(C)C
  • InChi: 1S/C23H28N4O2S2/c1-26(2)17(15-9-5-4-6-10-15)13-24-19(28)14-30-23-25-21-20(22(29)27(23)3)16-11-7-8-12-18(16)31-21/h4-6,9-10,17H,7-8,11-14H2,1-3H3,(H,24,28)
  • InChiKey: PGCZOFPLHDFVKB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens v-ets avian erythroblastosis virus E26 oncogene homolog Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni ets-related Get druggable targets OG5_131947 All targets in OG5_131947
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) fli-1 protein Get druggable targets OG5_131947 All targets in OG5_131947
Schistosoma japonicum ko:K09435 transcriptional regulator ERG, putative Get druggable targets OG5_131947 All targets in OG5_131947
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0236 0.1723
Brugia malayi Pre-SET motif family protein 0.0037 0.0421 0.0493
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0013 0.0042 0.004
Plasmodium vivax transportin, putative 0.0011 0.0021 0.0135
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0009
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0011 0.001 0.0012
Echinococcus granulosus histone lysine methyltransferase setb 0.0057 0.0747 0.0746
Schistosoma mansoni tsg101-related 0.0057 0.075 0.074
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.1323 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0292 0.0341
Schistosoma mansoni ets-related 0.0013 0.0042 0.0031
Loa Loa (eye worm) hypothetical protein 0.0057 0.0747 0.0746
Schistosoma mansoni pyruvate kinase 0.0033 0.0367 0.0357
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0008
Brugia malayi Ets-domain containing protein 0.0087 0.1225 0.1435
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0528 0.0527
Loa Loa (eye worm) D-ets-2 protein 0.0013 0.0042 0.004
Plasmodium vivax importin-beta 2, putative 0.006 0.0792 1
Echinococcus multilocularis importin subunit beta 1 0.006 0.0792 0.0791
Echinococcus multilocularis geminin 0.0504 0.7819 0.7819
Schistosoma mansoni gabp alpha 0.0087 0.1225 0.1216
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.1323 0.1322
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0421 0.042
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0012 0.0025 0.0117
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0057 0.0747 0.0746
Brugia malayi Fli-1 protein 0.0265 0.4044 0.4736
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.039 0.0389
Brugia malayi hypothetical protein 0.0011 0.001 0.0012
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0541 0.4043
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.004
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0792 1
Loa Loa (eye worm) hypothetical protein 0.0046 0.0574 0.0573
Trichomonas vaginalis hypothetical protein 0.0034 0.0372 0.0425
Echinococcus multilocularis nibrin 0.0011 0.001 0.0009
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0541 0.054
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.01
Schistosoma mansoni zinc finger protein 0.0025 0.0241 0.0231
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0541 0.4043
Brugia malayi PHD-finger family protein 0.0032 0.0343 0.0401
Loa Loa (eye worm) hypothetical protein 0.0023 0.0208 0.0207
Schistosoma mansoni elf1 0.0013 0.0042 0.0031
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0013 0.0042 0.0031
Echinococcus multilocularis protein quaking 0.0028 0.0277 0.0276
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0747 0.0738
Brugia malayi kap beta 3 protein 0.0011 0.0021 0.0024
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0236 0.2893
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0236 0.2893
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0367 0.5
Echinococcus multilocularis ets variant gene 4 0.0013 0.0042 0.004
Echinococcus multilocularis ETS transcription factor Elf 5 0.0013 0.0042 0.004
Brugia malayi DKFZp564C0469 protein 0.0011 0.001 0.0012
Schistosoma mansoni hypothetical protein 0.0018 0.0133 0.0123
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.004
Schistosoma mansoni importin-beta 2 0.0011 0.0021 0.0011
Schistosoma mansoni hypothetical protein 0.0504 0.7819 0.7817
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0367 0.0366
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.1323 0.155
Schistosoma mansoni cpg binding protein 0.0032 0.0354 0.0344
Echinococcus multilocularis cpg binding protein 0.0032 0.0354 0.0353
Brugia malayi Ets-domain containing protein 0.0013 0.0042 0.0049
Echinococcus multilocularis zinc finger protein 0.0025 0.0241 0.024
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0528 0.0527
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0023 0.01
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Echinococcus granulosus protein quaking 0.0028 0.0277 0.0276
Schistosoma mansoni tsg101-related 0.0057 0.075 0.074
Loa Loa (eye worm) glutaminase 2 0.0549 0.8539 0.8539
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0009
Schistosoma mansoni tsg101-related 0.0047 0.0583 0.0574
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0208 0.1506
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0367 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0421 0.0412
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0367 0.0419
Echinococcus granulosus importin 5 0.0011 0.0021 0.002
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0297 0.0296
Loa Loa (eye worm) hypothetical protein 0.0028 0.0277 0.0276
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1895 0.1894
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0297 0.0288
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0021 0.0135
Loa Loa (eye worm) hypothetical protein 0.0085 0.1193 0.1192
Plasmodium falciparum pyruvate kinase 0.0033 0.0367 0.4566
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1008 0.1007
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0575 0.0662
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.1323 0.1315
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0541 0.6788
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.1144 0.8636
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0367 0.2719
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0036 0.0042
Schistosoma mansoni hypothetical protein 0.0504 0.7819 0.7817
Echinococcus granulosus pyruvate kinase 0.0033 0.0367 0.0366
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0367 0.4566
Giardia lamblia Pyruvate kinase 0.0017 0.0111 0.0768
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0009
Loa Loa (eye worm) glutaminase 0.0549 0.8539 0.8539
Schistosoma mansoni pyruvate kinase 0.0017 0.0111 0.0101
Mycobacterium ulcerans glutaminase 0.0549 0.8539 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Echinococcus multilocularis pyruvate kinase 0.0033 0.0367 0.0366
Echinococcus multilocularis pyruvate kinase 0.0026 0.0256 0.0255
Echinococcus multilocularis replication factor c subunit 1 0.0011 0.001 0.0009
Echinococcus multilocularis transportin 1 0.0011 0.0021 0.002
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.1323 1
Trichomonas vaginalis hypothetical protein 0.0011 0.0021 0.0012
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0082 0.1144 0.8636
Echinococcus granulosus ETS transcription factor Elf 5 0.0013 0.0042 0.004
Onchocerca volvulus 0.0287 0.4379 1
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.0575 0.0662
Loa Loa (eye worm) kap beta 3 protein 0.0011 0.0021 0.002
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0541 0.6788
Loa Loa (eye worm) fli-1 protein 0.0265 0.4044 0.4043
Brugia malayi hypothetical protein 0.0011 0.001 0.0012
Schistosoma mansoni ran 0.0044 0.0541 0.0532
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0167 0.0157
Loa Loa (eye worm) hypothetical protein 0.0069 0.0932 0.0931
Echinococcus granulosus hypothetical protein 0.0028 0.0277 0.0276
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0367 0.0366
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.383 0.3829
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0167 0.0157
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Schistosoma mansoni hypothetical protein 0.0013 0.0042 0.0031
Brugia malayi MH2 domain containing protein 0.013 0.1895 0.2219
Plasmodium falciparum importin beta, putative 0.006 0.0792 1
Treponema pallidum DNA ligase (lig) 0.0011 0.001 0.5
Echinococcus granulosus transportin 1 0.0011 0.0021 0.002
Brugia malayi RNA, U transporter 1 0.0171 0.2547 0.2983
Echinococcus multilocularis tumor susceptibility gene 101 protein 0.0069 0.0932 0.0931
Echinococcus multilocularis pyruvate kinase 0.0033 0.0367 0.0366
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0367 0.0419
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0761 0.96
Schistosoma mansoni ets 0.0013 0.0042 0.0031
Trypanosoma brucei ISWI complex protein 0.0018 0.0133 0.0937
Schistosoma mansoni hypothetical protein 0.0406 0.6262 0.6258
Schistosoma mansoni pyruvate kinase 0.0033 0.0367 0.0357
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0023 0.01
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0208 0.0207
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0818 0.0809
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Brugia malayi hypothetical protein 0.0016 0.0096 0.0113
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0367 0.0817
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0612 0.0706
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0367 0.0419
Leishmania major hypothetical protein, conserved 0.0018 0.0133 0.0864
Echinococcus granulosus cpg binding protein 0.0032 0.0354 0.0353
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0367 0.043
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0023 0.0015
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.0011 0.001 0.5
Echinococcus granulosus GA binding protein alpha chain 0.0087 0.1225 0.1224
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Leishmania major pyruvate kinase 0.0033 0.0367 0.266
Echinococcus multilocularis GA binding protein alpha chain 0.0087 0.1225 0.1224
Brugia malayi transcription factor E74 isoform 0.0013 0.0042 0.0049
Loa Loa (eye worm) hypothetical protein 0.0049 0.062 0.0618
Schistosoma mansoni glutaminase 0.0549 0.8539 0.8538
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.6262 0.6261
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0042 0.004
Schistosoma mansoni hypothetical protein 0.0028 0.0277 0.0267
Echinococcus granulosus nibrin 0.0011 0.001 0.0009
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.011
Schistosoma mansoni cpg binding protein 0.0028 0.0292 0.0282
Brugia malayi Pax transcription activation domain interacting protein 0.0011 0.001 0.0012
Schistosoma mansoni importin beta-1 0.006 0.0792 0.0783
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0009
Loa Loa (eye worm) DNA-binding protein D-ETS-3 0.0013 0.0042 0.004
Schistosoma mansoni hypothetical protein 0.0642 1 1
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0087 0.1225 0.1224
Trypanosoma brucei Vps23 core domain containing protein, putative 0.0022 0.019 0.1368
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0236 0.2893
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0792 0.5956
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0541 0.4043
Plasmodium vivax SET domain protein, putative 0.0037 0.0421 0.5256
Giardia lamblia Pyruvate kinase 0.0033 0.0367 0.2719
Loa Loa (eye worm) hypothetical protein 0.0075 0.1024 0.1023
Schistosoma mansoni cpg binding protein 0.0032 0.0354 0.0344
Loa Loa (eye worm) importin-beta domain-containing protein 0.0011 0.0021 0.002
Loa Loa (eye worm) hypothetical protein 0.0025 0.0236 0.0235
Loa Loa (eye worm) hypothetical protein 0.0082 0.1144 0.1143
Brugia malayi Ets-domain containing protein 0.0087 0.1225 0.1435
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0023 0.0015
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0541 0.4043
Brugia malayi tumor suppressor. 0.0326 0.4998 0.5853
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0541 0.054
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0541 0.054
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Echinococcus granulosus protein C ets 2 0.0013 0.0042 0.004
Loa Loa (eye worm) hypothetical protein 0.0033 0.0367 0.0366
Echinococcus granulosus dnaJ subfamily B 0.0406 0.6262 0.6261
Echinococcus multilocularis importin 5 0.0011 0.0021 0.002
Echinococcus granulosus replication factor c subunit 1 0.0011 0.001 0.0009
Brugia malayi DNA-binding protein D-ETS-3 0.0013 0.0042 0.0049
Brugia malayi Bromodomain containing protein 0.0092 0.13 0.1523
Echinococcus granulosus translational activator gcn1 0.0011 0.0021 0.002
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.1323 0.1322
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.01
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0011 0.0018 0.0017
Schistosoma mansoni bromodomain containing protein 0.0078 0.1076 0.1067
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1323 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0167 0.0166
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0642 1 1
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.01
Schistosoma mansoni kinase 0.0048 0.0594 0.0585
Entamoeba histolytica HEAT repeat domain containing protein 0.0011 0.0021 0.0081
Leishmania major importin beta-1 subunit, putative 0.0049 0.0612 0.4542
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.011
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0167 0.0166
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0111 0.1289
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0178 0.0177
Entamoeba histolytica tumor susceptibility gene 101 protein, putative 0.0047 0.0583 0.4364
Brugia malayi hypothetical protein 0.0069 0.0932 0.1092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0421 0.0412
Entamoeba histolytica hypothetical protein 0.0049 0.0612 0.4585
Entamoeba histolytica Ran family GTPase 0.0044 0.0541 0.4043
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0367 0.043
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0612 0.0706
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.1323 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.1323 0.1322
Echinococcus granulosus geminin 0.0504 0.7819 0.7819
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0111 0.1289
Echinococcus granulosus tumor susceptibility gene 101 protein 0.0069 0.0932 0.0931
Plasmodium falciparum transportin 0.0011 0.0021 0.0135
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0541 0.0634
Echinococcus granulosus ETS transcription factor Elf 1 0.0013 0.0042 0.004
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Brugia malayi Pre-SET motif family protein 0.0252 0.383 0.4485
Echinococcus granulosus pyruvate kinase 0.0033 0.0367 0.0366
Schistosoma mansoni ran 0.0044 0.0541 0.0532
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0367 0.0366
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0042 0.004
Echinococcus multilocularis ewsr:fli fusion protein type 0.0013 0.0042 0.004
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0013 0.0042 0.004
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0367 0.2719
Leishmania major hypothetical protein, conserved 0.0022 0.019 0.1298
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0009
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.011
Leishmania major pyruvate kinase 0.0033 0.0367 0.266
Echinococcus multilocularis snurportin 1 0.0642 1 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0236 0.1723
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0421 0.5256
Schistosoma mansoni hypothetical protein 0.0025 0.0235 0.0225
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0367 0.2719
Brugia malayi Importin beta-1 subunit 0.006 0.0792 0.0928
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Echinococcus multilocularis pyruvate kinase 0.0017 0.0111 0.011
Echinococcus granulosus pyruvate kinase 0.0017 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0682 0.0681
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.1323 0.154
Trichomonas vaginalis glutaminase, putative 0.0549 0.8539 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Entamoeba histolytica hypothetical protein 0.0012 0.0023 0.01
Loa Loa (eye worm) hypothetical protein 0.0011 0.001 0.0009
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0367 0.2719
Toxoplasma gondii HEAT repeat-containing protein 0.0011 0.0021 0.0135
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1895 0.1894
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0367 0.0817
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0111 0.1289
Loa Loa (eye worm) ets-domain-containing protein 0.0013 0.0042 0.004
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0236 0.2893
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0012 0.0023 0.01
Leishmania major hypothetical protein, conserved 0.0025 0.0236 0.1656
Trichomonas vaginalis ran, putative 0.0044 0.0541 0.0623
Trypanosoma brucei Importin-beta N-terminal domain/HEAT-like repeat, putative 0.0011 0.0021 0.0081
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0792 0.5956
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0367 0.0817
Trypanosoma brucei polo-like protein kinase 0.0094 0.1323 1
Echinococcus granulosus ewsr:fli fusion protein type 0.0013 0.0042 0.004
Echinococcus granulosus importin subunit beta 1 0.006 0.0792 0.0791
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0011 0.0018 0.0017
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0612 0.4585
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0367 0.4566
Schistosoma mansoni hypothetical protein 0.0013 0.0042 0.0031
Echinococcus multilocularis ETS transcription factor Elf 2 0.0013 0.0042 0.004
Trypanosoma cruzi ISWI complex protein 0.0018 0.0133 0.0937
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0235 0.0234
Echinococcus granulosus ETS transcription factor Elf 2 0.0013 0.0042 0.004
Schistosoma mansoni zinc finger protein 0.0018 0.0133 0.0123
Schistosoma mansoni ets-related 0.0265 0.4044 0.4038
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1008 0.1007
Onchocerca volvulus 0.0028 0.0292 0.0644
Echinococcus granulosus ETS domain containing protein Elk 1 0.0013 0.0042 0.004
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0297 0.0296
Schistosoma mansoni hypothetical protein 0.0028 0.0277 0.0267
Brugia malayi hypothetical protein 0.0028 0.0277 0.0324
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0541 0.6788
Echinococcus multilocularis protein C ets 2 0.0013 0.0042 0.004
Brugia malayi hypothetical protein 0.0025 0.0236 0.0277
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0236 0.1723
Onchocerca volvulus 0.0037 0.0421 0.0941
Echinococcus granulosus zinc finger protein 0.0025 0.0241 0.024
Echinococcus multilocularis translational activator gcn1 0.0011 0.0021 0.002
Echinococcus multilocularis ETS transcription factor Elf 1 0.0013 0.0042 0.004
Giardia lamblia Kinase, PLK 0.0094 0.1323 1
Brugia malayi topoisomerase 0.0011 0.001 0.0012
Trypanosoma cruzi ISWI complex protein 0.0018 0.0133 0.0937
Chlamydia trachomatis pyruvate kinase 0.0033 0.0367 1
Leishmania major GTP-binding protein, putative 0.0044 0.0541 0.3994
Trichomonas vaginalis set domain proteins, putative 0.0287 0.4379 0.5123
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.1323 0.3006
Trypanosoma cruzi Vps23 core domain containing protein, putative 0.0022 0.019 0.1368
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0277 0.0324
Brugia malayi Bromodomain containing protein 0.0046 0.0573 0.0671
Loa Loa (eye worm) tumor suppressor 0.0326 0.4998 0.4997
Brugia malayi glutaminase DH11.1 0.0549 0.8539 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0057 0.0747 0.0738
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0612 0.0706
Loa Loa (eye worm) hypothetical protein 0.006 0.0792 0.0791
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0292 0.029

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) > 59.642 uM PUBCHEM_BIOASSAY: Luminescence-based cell-based high throughput dose response assay for activators of the GAA850 frataxin (FXN) promoter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540364, AID588328, AID588350, AID588351] ChEMBL. No reference
EC50 (functional) > 59.642 uM PUBCHEM_BIOASSAY: Counterscreen for activators of the GAA850 frataxin promoter: luminescence-based cell-based high throughput dose response assay to identify activators of the GAA30 frataxin promoter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540364, AID588328, AID588350, AID588351] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 3.5481 uM PubChem BioAssay. qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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