Detailed information for compound 1562284

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 409.544 | Formula: C23H27N3O2S
  • H donors: 1 H acceptors: 2 LogP: 4.63 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(CCNC(=O)c1sc(nc1c1ccccc1)c1ccc(cc1)OC)CC
  • InChi: 1S/C23H27N3O2S/c1-4-26(5-2)16-15-24-22(27)21-20(17-9-7-6-8-10-17)25-23(29-21)18-11-13-19(28-3)14-12-18/h6-14H,4-5,15-16H2,1-3H3,(H,24,27)
  • InChiKey: JRYZYBGDRAPBMS-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0984 0.1103
Trichomonas vaginalis set domain proteins, putative 0.0239 0.2867 0.9079
Entamoeba histolytica hypothetical protein 0.007 0.0725 0.5277
Entamoeba histolytica Ran family GTPase 0.0042 0.0365 0.1875
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1225 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0458 0.0607
Echinococcus granulosus lamin 0.0027 0.0179 0.0206
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0458 0.1409
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0149 0.2248
Onchocerca volvulus Glucosylceramidase homolog 0.0171 0.2003 0.6788
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.023 0.0593
Loa Loa (eye worm) hypothetical protein 0.003 0.0216 0.0286
Loa Loa (eye worm) hypothetical protein 0.0027 0.0179 0.0237
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0216 0.0216
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3141 1
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.113 0.3561
Brugia malayi phosphofructokinase 0.011 0.1225 0.3866
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0306 0.0469
Brugia malayi MH1 domain containing protein 0.0016 0.0035 0.0053
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0167 0.1134
Loa Loa (eye worm) hypothetical protein 0.0057 0.0556 0.0737
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1225 0.1623
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0968 0.1282
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0041
Loa Loa (eye worm) Smad1 0.0016 0.0035 0.0046
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0167 0.1134
Schistosoma mansoni flap endonuclease-1 0.0024 0.0135 0.012
Loa Loa (eye worm) hypothetical protein 0.0034 0.0261 0.0345
Loa Loa (eye worm) inositol-1 0.0037 0.0306 0.0406
Trichomonas vaginalis ran, putative 0.0042 0.0365 0.0667
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0216 0.0216
Echinococcus multilocularis inositol monophosphatase 1 0.0037 0.0306 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3141 1
Echinococcus multilocularis survival motor neuron protein 1 0.0239 0.2862 0.2862
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0031
Plasmodium vivax SET domain protein, putative 0.003 0.0216 0.3511
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.023 0.166
Loa Loa (eye worm) hypothetical protein 0.0239 0.2862 0.3791
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0167 0.2581
Echinococcus granulosus snurportin 1 0.0608 0.7549 0.8706
Brugia malayi 6-phosphofructokinase 0.011 0.1225 0.3866
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0035 0.0035
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0556 0.4394
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0216 0.0214
Echinococcus granulosus Smad4 0.0016 0.0035 0.004
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0556 1
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0209 0.3392
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0167 0.0167
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0179 0.0514
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0608 0.7549 1
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1225 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0035 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0209 0.3392
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0968 0.1084
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.023 0.023
Plasmodium falciparum importin beta, putative 0.0057 0.0556 1
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0031 0.023 0.3162
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1225 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0968 0.1116
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0209 0.3392
Brugia malayi follicle stimulating hormone receptor 0.0236 0.283 0.9005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0236 0.283 0.3749
Echinococcus granulosus lamin dm0 0.0027 0.0179 0.0206
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0209 0.0143
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0031 0.0036
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0209 0.2145
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0365 0.6363
Plasmodium vivax importin-beta 2, putative 0.0057 0.0556 1
Brugia malayi intermediate filament protein 0.0027 0.0179 0.0514
Loa Loa (eye worm) hypothetical protein 0.0102 0.113 0.1497
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.023 0.166
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0091 0.0984 0.1135
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3141 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.023 0.0304
Onchocerca volvulus 0.0042 0.0362 0.0681
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0031 0.0031
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3141 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0035 0.0046
Echinococcus granulosus intermediate filament protein 0.0027 0.0179 0.0206
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0209 0.0143
Schistosoma mansoni intermediate filament proteins 0.0027 0.0179 0.0171
Loa Loa (eye worm) transcription factor SMAD2 0.0233 0.2794 0.3701
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1225 0.3559
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0419 0.0849
Loa Loa (eye worm) hypothetical protein 0.032 0.3896 0.5161
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0419 0.0849
Loa Loa (eye worm) hypothetical protein 0.0049 0.0458 0.0607
Brugia malayi MH1 domain containing protein 0.0016 0.0035 0.0053
Leishmania major hypothetical protein, conserved 0.0025 0.0149 0.0988
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0744 0.9272 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0216 0.3511
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0005
Schistosoma mansoni ran 0.0042 0.0365 0.0387
Loa Loa (eye worm) hypothetical protein 0.0149 0.1728 0.2289
Schistosoma mansoni hypothetical protein 0.0049 0.0451 0.0486
Brugia malayi hypothetical protein 0.0025 0.0149 0.042
Brugia malayi hypothetical protein 0.0149 0.1728 0.5475
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0031 0.0041
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1225 0.1292
Echinococcus granulosus inositol monophosphatase 1 0.0037 0.0306 0.0353
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3141 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0261 0.0776
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0202 0.0232
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0149 0.0988
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0037 0.0306 0.524
Brugia malayi MH2 domain containing protein 0.0233 0.2794 0.8889
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1225 0.1382
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0031 0.0042
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0362 0.0383
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0209 0.0143
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0744 0.9272 1
Schistosoma mansoni smad 0.0016 0.0035 0.0005
Entamoeba histolytica hypothetical protein 0.0046 0.0419 0.2386
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1225 1
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0149 0.2248
Echinococcus granulosus microtubule associated protein 2 0.0696 0.8671 1
Brugia malayi hypothetical protein 0.0016 0.0037 0.0061
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0365 0.6363
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Trichomonas vaginalis glucosylceramidase, putative 0.0261 0.3141 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0149 0.0988
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0035 0.0005
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0451 0.1386
Brugia malayi Smad1 0.0016 0.0035 0.0053
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0035 0.0046
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1225 1
Brugia malayi hypothetical protein 0.0102 0.113 0.3561
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0035 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0209 0.3392
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0419 0.325
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Onchocerca volvulus 0.0031 0.023 0.0189
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.2303
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1225 0.3559
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0365 0.2796
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.8671 0.8671
Leishmania major importin beta-1 subunit, putative 0.0046 0.0419 0.325
Schistosoma mansoni inositol monophosphatase 0.0037 0.0306 0.0319
Echinococcus multilocularis Smad4 0.0016 0.0035 0.0035
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0037 0.0306 0.0085
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0179 0.0237
Schistosoma mansoni lamin 0.0027 0.0179 0.0171
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0216 0.0214
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0209 0.0143
Entamoeba histolytica hypothetical protein 0.007 0.0725 0.5277
Schistosoma mansoni hypothetical protein 0.0608 0.7549 0.8702
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0034 0.0261 0.0266
Brugia malayi hypothetical protein 0.007 0.0725 0.2265
Echinococcus multilocularis smad 0.0016 0.0035 0.0035
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.023 0.166
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1225 0.3163
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0209 0.0143
Onchocerca volvulus 0.0102 0.113 0.354
Brugia malayi Pre-SET motif family protein 0.003 0.0216 0.0632
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0365 0.2796
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0031 0.0042
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0744 0.9272 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0037 0.0306 0.1318
Echinococcus granulosus GPCR family 2 0.0016 0.0031 0.0036
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.023 0.3777
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1225 0.1623
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0365 0.0421
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0031 0.0036
Echinococcus granulosus flap endonuclease 1 0.0026 0.0167 0.0192
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.023 0.0677
Schistosoma mansoni transcription factor LCR-F1 0.007 0.0725 0.0804
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0149 0.0988
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1225 0.3559
Echinococcus multilocularis geminin 0.0502 0.6205 0.6205
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0365 1
Schistosoma mansoni hypothetical protein 0.0502 0.6205 0.7146
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0031 0.023 0.3777
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0365 0.1111
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0968 0.1084
Leishmania major GTP-binding protein, putative 0.0042 0.0365 0.2796
Brugia malayi RNA, U transporter 1 0.0162 0.1889 0.599
Loa Loa (eye worm) MH2 domain-containing protein 0.0233 0.2794 0.3701
Schistosoma mansoni inositol monophosphatase 0.0037 0.0306 0.0319
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Echinococcus multilocularis lamin dm0 0.0027 0.0179 0.0179
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0149 0.2248
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0261 0.3141 0.416
Entamoeba histolytica hypothetical protein 0.007 0.0725 0.5277
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0031 0.023 0.3777
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1225 1
Brugia malayi MH2 domain containing protein 0.0016 0.0035 0.0053
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0031 0.023 0.166
Schistosoma mansoni survival motor neuron protein 0.0049 0.0451 0.0486
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0037 0.0306 0.0469
Onchocerca volvulus 0.0049 0.0451 0.1013
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0031 0.0031
Echinococcus granulosus geminin 0.0502 0.6205 0.7157
Schistosoma mansoni lamin 0.0027 0.0179 0.0171
Echinococcus multilocularis snurportin 1 0.0608 0.7549 0.7549
Loa Loa (eye worm) hypothetical protein 0.0027 0.0172 0.0228
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0283 0.3421 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0209 0.0143
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0031 0.0031
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0031
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0091 0.0984 0.0984
Echinococcus granulosus survival motor neuron protein 1 0.0239 0.2862 0.33
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0209 0.3392
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0984 0.1103
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Entamoeba histolytica hypothetical protein 0.007 0.0725 0.5277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0216 0.0214
Onchocerca volvulus 0.0239 0.2867 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0149 0.2248
Schistosoma mansoni hypothetical protein 0.0502 0.6205 0.7146
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0031 0.023 0.0265
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0419 0.0849
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0556 0.0556
Brugia malayi MH2 domain containing protein 0.0016 0.0035 0.0053
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0035 0.0035
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0167 0.1134
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0209 0.0402
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.021 0.2499 0.331
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0968 0.1084
Trichomonas vaginalis inositol monophosphatase, putative 0.0037 0.0306 0.0469
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0968 0.304
Schistosoma mansoni importin beta-1 0.0057 0.0556 0.0608
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0365 0.0484
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.212 0.6569
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0179 0.0237
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0031 0.023 0.0211
Trichomonas vaginalis glucosylceramidase, putative 0.0171 0.2003 0.6176
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0216 0.0249
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.0725 0.0837
Echinococcus granulosus importin subunit beta 1 0.0057 0.0556 0.0641
Brugia malayi Flap endonuclease-1 0.0026 0.0167 0.0476
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0167 0.2581
Onchocerca volvulus 0.0149 0.1728 0.5763
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1225 0.1074
Echinococcus multilocularis GPCR, family 2 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0102 0.113 0.354
Loa Loa (eye worm) hypothetical protein 0.0025 0.0149 0.0198
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0005
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0036
Echinococcus multilocularis lamin 0.0027 0.0179 0.0179
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0458 0.1409
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.2303
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0031 0.0041
Brugia malayi 6-phosphofructokinase 0.011 0.1225 0.3866
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0031 0.0031
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0031 0.023 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0968 0.0968
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0744 0.9272 1
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0167 0.0221
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1225 0.3559
Brugia malayi hypothetical protein 0.0123 0.1392 0.44
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0031 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0102 0.113 0.1497
Schistosoma mansoni smad1 5 8 and 0.0016 0.0035 0.0005
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1225 0.1101
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.0725 0.0725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0968 0.0968
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0209 0.3392
Echinococcus granulosus smad 0.0016 0.0035 0.004
Brugia malayi Importin beta-1 subunit 0.0057 0.0556 0.1722
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1225 0.1225
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0018 0.0024
Brugia malayi Pre-SET motif family protein 0.021 0.2499 0.7944
Brugia malayi isocitrate dehydrogenase 0.0016 0.0031 0.0042
Echinococcus multilocularis musashi 0.0027 0.0179 0.0179
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0365 0.0365
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0031 0.0041
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1225 0.1413
Schistosoma mansoni Smad4 0.0016 0.0035 0.0005
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.2303
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0556 0.4394
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0033 0.0257 0.0244
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.8671 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0365 0.2796
Loa Loa (eye worm) phosphofructokinase 0.011 0.1225 0.1623
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0365 0.6363
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0283 0.3421 1
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0209 0.0143
Plasmodium falciparum flap endonuclease 1 0.0026 0.0167 0.2581
Schistosoma mansoni ran 0.0042 0.0365 0.0387
Brugia malayi Inositol-1 0.0037 0.0306 0.0922
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0261 0.3141 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0968 0.1116
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0037 0.0306 0.2303
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0209 0.3392
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1225 0.1382
Brugia malayi hypothetical protein 0.0239 0.2862 0.9106
Schistosoma mansoni hypothetical protein 0.007 0.0725 0.0804
Trichomonas vaginalis glucosylceramidase, putative 0.018 0.212 0.6569

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 7.7 uM Antimalarial malarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human A positive erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 24 hrs ChEMBL. 21570837
Inhibition (functional) Antimalarial malarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human A positive erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation at 19.3 ug/ml after 24 hrs ChEMBL. 21570837

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum 21570837

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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