TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 670.495 | Formula: C26H48I2N4
H donors: 0 H acceptors: 0 LogP: 9.58 Rotable bonds: 19
Rule of 5 violations (Lipinski): 2
SMILES: C[n+]1ccn(c1)CCCCCCCCCCCCCCCCCCn1cc[n+](c1)C.[I-].[I-]
InChi: 1S/C26H48N4.2HI/c1-27-21-23-29(25-27)19-17-15-13-11-9-7-5-3-4-6-8-10-12-14-16-18-20-30-24-22-28(2)26-30;;/h21-26H,3-20H2,1-2H3;2*1H/q+2;;/p-2
InChiKey: FHPIVWIONXZNLT-UHFFFAOYSA-L

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Uracil-DNA glycosylase	0.00391942	0.00827278	0.00827278
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0417915	0.306814	1
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Brugia malayi	Fibronectin type III domain containing protein	0.00944367	0.0518198	0.0518198
Schistosoma mansoni	sodium-dependent amino acid transporter	0.00808947	0.0411448	0.0904565
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.00846561	0.0441098	1
Schistosoma mansoni	neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule	0.00458017	0.0134814	0.0143329
Echinococcus multilocularis	neuroglian	0.0114556	0.0676793	0.182093
Brugia malayi	hypothetical protein	0.00846561	0.0441098	0.0441098
Schistosoma mansoni	septate junction protein	0.00458017	0.0134814	0.0143329
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.00458017	0.0134814	0.0143329
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.917263
Loa Loa (eye worm)	hypothetical protein	0.00944367	0.0518198	0.0518198
Schistosoma mansoni	amine oxidase	0.00846561	0.0441098	0.0986157
Echinococcus granulosus	mitogen activated protein kinase 11	0.0417915	0.306814	0.724444
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.111746	0.858257	1
Loa Loa (eye worm)	hypothetical protein	0.00944367	0.0518198	0.0518198
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.012012	0.0720653	0.170159
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.00808947	0.0411448	0.0971502
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.120212	0.924991	1
Brugia malayi	Prion-like-	0.00458017	0.0134814	0.0134814
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.917263
Plasmodium vivax	hypothetical protein, conserved	0.00808947	0.0411448	0.917263
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0476543	0.35303	0.35303
Loa Loa (eye worm)	hypothetical protein	0.012012	0.0720653	0.0720653
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.00808947	0.0411448	0.0971502
Onchocerca volvulus		0.116857	0.898547	0.975076
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.00808947	0.0411448	0.0904565
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Brugia malayi	amine oxidase, flavin-containing family protein	0.00846561	0.0441098	0.0441098
Loa Loa (eye worm)	norepinephrine transporter	0.0476543	0.35303	0.35303
Toxoplasma gondii	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.917263
Echinococcus multilocularis	roundabout 2	0.0140238	0.0879248	0.236565
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.00808947	0.0411448	0.0904565
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.00808947	0.0411448	0.0971502
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.00808947	0.0411448	0.0411448
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Onchocerca volvulus	Tyrosine kinase homolog	0.119727	0.92117	1
Echinococcus granulosus	mitogen activated protein kinase 14	0.0417915	0.306814	0.724444
Schistosoma mansoni	amine oxidase	0.00846561	0.0441098	0.0986157
Loa Loa (eye worm)	hypothetical protein	0.0476543	0.35303	0.35303
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.00944367	0.0518198	0.119832
Echinococcus multilocularis	sodium and chloride dependent glycine	0.00808947	0.0411448	0.110701
Loa Loa (eye worm)	hypothetical protein	0.00944367	0.0518198	0.0518198
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.00458017	0.0134814	0.0362721
Echinococcus granulosus	serotonin transporter	0.0476543	0.35303	0.833568
Mycobacterium tuberculosis	Probable oxidoreductase	0.0254197	0.177757	0.164155
Echinococcus multilocularis	sodium and chloride dependent glycine	0.00808947	0.0411448	0.110701
Echinococcus granulosus	sodium and chloride dependent glycine	0.00808947	0.0411448	0.0971502
Loa Loa (eye worm)	hypothetical protein	0.00846561	0.0441098	0.0441098
Echinococcus granulosus	peroxidasin	0.00458017	0.0134814	0.031832
Plasmodium vivax	hypothetical protein, conserved	0.00846561	0.0441098	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.00458017	0.0134814	0.031832
Echinococcus granulosus	neuroglian	0.0114556	0.0676793	0.159803
Loa Loa (eye worm)	hypothetical protein	0.0476543	0.35303	0.35303
Echinococcus granulosus	roundabout 2	0.00458017	0.0134814	0.031832
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.00458017	0.0134814	0.0362721
Leishmania major	UDP-galactopyranose mutase	0.00846561	0.0441098	0.12004
Onchocerca volvulus		0.00808947	0.0411448	0.0304767
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.00846561	0.0441098	1
Brugia malayi	Peroxidasin	0.00458017	0.0134814	0.0134814
Plasmodium falciparum	protoporphyrinogen oxidase	0.00846561	0.0441098	1
Echinococcus multilocularis	hemicentin 1	0.00458017	0.0134814	0.0362721
Echinococcus granulosus	uracil DNA glycosylase	0.00391942	0.00827278	0.0195335
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0476543	0.35303	0.948697
Loa Loa (eye worm)	hypothetical protein	0.00846561	0.0441098	0.0441098
Echinococcus granulosus	tyrosine protein kinase otk	0.00458017	0.0134814	0.031832
Loa Loa (eye worm)	hypothetical protein	0.0500194	0.371674	0.371674
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.0411448
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0417915	0.306814	0.825493
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.00846561	0.0441098	0.0986157
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.00846561	0.0441098	1
Mycobacterium ulcerans	dehydrogenase	0.00846561	0.0441098	0.0390928
Echinococcus multilocularis	protoporphyrinogen oxidase	0.00846561	0.0441098	0.118679
Loa Loa (eye worm)	hypothetical protein	0.0140238	0.0879248	0.0879248
Schistosoma mansoni	cell adhesion molecule	0.00458017	0.0134814	0.0143329
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0417915	0.306814	1
Echinococcus granulosus	lachesin	0.00458017	0.0134814	0.031832
Echinococcus multilocularis	neurotracting:lsamp:neurotrimin:obcam	0.00458017	0.0134814	0.0362721
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.00808947	0.0411448	0.110701
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.00846561	0.0441098	0.0986157
Onchocerca volvulus		0.0476543	0.35303	0.37408
Loa Loa (eye worm)	hypothetical protein	0.00846561	0.0441098	0.0441098
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.00808947	0.0411448	0.0904565
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.00808947	0.0411448	0.0904565
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0417915	0.306814	1
Loa Loa (eye worm)	hypothetical protein	0.00846561	0.0441098	0.0441098
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00944367	0.0518198	0.0518198
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.129727	1	1
Schistosoma mansoni	neuroglian	0.00458017	0.0134814	0.0143329
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Schistosoma mansoni	cell adhesion molecule	0.00458017	0.0134814	0.0143329
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.00808947	0.0411448	0.0904565
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Entamoeba histolytica	hypothetical protein, conserved	0.0500194	0.371674	1
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.00808947	0.0411448	0.110701
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.0411448
Echinococcus granulosus	lysine specific histone demethylase 1A	0.00846561	0.0441098	0.104151
Schistosoma mansoni	nephrin	0.0114556	0.0676793	0.163474
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0417915	0.306814	0.825493
Schistosoma mansoni	cell adhesion molecule	0.012012	0.0720653	0.175543
Schistosoma mansoni	cell adhesion molecule	0.00458017	0.0134814	0.0143329
Echinococcus granulosus	vesicular acetylcholine transporter	0.0126552	0.0771361	0.182132
Chlamydia trachomatis	protoporphyrinogen oxidase	0.00846561	0.0441098	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.00458017	0.0134814	0.0362721
Onchocerca volvulus	Vesicular acetylcholine transporter homolog	0.0126552	0.0771361	0.0701283
Plasmodium falciparum	transporter, putative	0.00808947	0.0411448	0.917263
Loa Loa (eye worm)	hypothetical protein	0.00944367	0.0518198	0.0518198
Echinococcus multilocularis	serotonin transporter	0.0476543	0.35303	0.949839
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.120212	0.924991	1
Loa Loa (eye worm)	hypothetical protein	0.00944367	0.0518198	0.0518198
Brugia malayi	vesicular acetylcholine transporter unc-17	0.0126552	0.0771361	0.0771361
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.00846561	0.0441098	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.00808947	0.0411448	0.0904565
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Echinococcus multilocularis	vesicular acetylcholine transporter	0.0126552	0.0771361	0.207537
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.0411448
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0417915	0.306814	0.825493
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.00458017	0.0134814	0.0362721
Echinococcus granulosus	neuroglian	0.00458017	0.0134814	0.031832
Loa Loa (eye worm)	hypothetical protein	0.0140238	0.0879248	0.0879248
Brugia malayi	P38 map kinase family protein 2	0.0417915	0.306814	0.306814
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0417915	0.306814	0.825493
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.0411448
Echinococcus granulosus	lysine specific histone demethylase 1A	0.00846561	0.0441098	0.104151
Loa Loa (eye worm)	hypothetical protein	0.0476543	0.35303	0.35303
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.00808947	0.0411448	0.0904565
Brugia malayi	hypothetical protein	0.00808947	0.0411448	0.0411448
Schistosoma mansoni	vesicular acetylcholine transporter	0.0126552	0.0771361	0.189497
Mycobacterium ulcerans	hypothetical protein	0.0500194	0.371674	0.396415
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.00808947	0.0411448	0.0971502
Plasmodium falciparum	amino acid transporter, putative	0.00808947	0.0411448	0.917263
Plasmodium vivax	amine transporter, putative	0.00808947	0.0411448	0.917263
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Schistosoma mansoni	nephrin	0.00458017	0.0134814	0.0143329
Toxoplasma gondii	histone lysine-specific demethylase	0.00846561	0.0441098	1
Mycobacterium leprae	PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO)	0.00846561	0.0441098	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Echinococcus multilocularis	Immunoglobulin	0.00944367	0.0518198	0.139423
Echinococcus granulosus	roundabout 2	0.00458017	0.0134814	0.031832
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.00846561	0.0441098	0.118679
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.00944367	0.0518198	0.139423
Schistosoma mansoni	sphingosine kinase A B	0.0500194	0.371674	1
Loa Loa (eye worm)	serotonin transporter b	0.0476543	0.35303	0.35303
Loa Loa (eye worm)	uracil-DNA glycosylase	0.00391942	0.00827278	0.00827278
Brugia malayi	hypothetical protein	0.00944367	0.0518198	0.0518198
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Plasmodium vivax	hypothetical protein, conserved	0.00846561	0.0441098	1
Echinococcus multilocularis	peroxidasin	0.00458017	0.0134814	0.0362721
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Trypanosoma cruzi	UDP-galactopyranose mutase	0.00846561	0.0441098	0.12004
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.00944367	0.0518198	0.119832
Schistosoma mansoni	septate junction protein	0.00458017	0.0134814	0.0143329
Schistosoma mansoni	sphingoid long chain base kinase	0.0500194	0.371674	1
Echinococcus multilocularis	sphingosine kinase 1	0.0500194	0.371674	1
Echinococcus granulosus	sphingosine kinase 1	0.0500194	0.371674	0.877589
Onchocerca volvulus		0.00808947	0.0411448	0.0304767
Toxoplasma gondii	hypothetical protein	0.00808947	0.0411448	0.917263
Trichomonas vaginalis	uracil DNA glycosylase, putative	0.00391942	0.00827278	0.5
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00458017	0.0134814	0.0134814
Echinococcus granulosus	contactin	0.00458017	0.0134814	0.031832
Schistosoma mansoni	sodium/chloride dependent transporter	0.0476543	0.35303	0.948697
Loa Loa (eye worm)	hypothetical protein	0.00846561	0.0441098	0.0441098
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0417915	0.306814	1
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0417915	0.306814	0.306814
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Echinococcus multilocularis	roundabout 2	0.00458017	0.0134814	0.0362721
Echinococcus multilocularis	uracil DNA glycosylase	0.00391942	0.00827278	0.0222582
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0476543	0.35303	0.35303
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.00846561	0.0441098	1
Loa Loa (eye worm)	hypothetical protein	0.00808947	0.0411448	0.0411448
Echinococcus granulosus	hemicentin 1	0.00458017	0.0134814	0.031832
Echinococcus multilocularis		0.00846561	0.0441098	0.118679
Schistosoma mansoni	titin	0.00458017	0.0134814	0.0143329
Onchocerca volvulus		0.00808947	0.0411448	0.0304767
Schistosoma mansoni	roundabout	0.00458017	0.0134814	0.0143329
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00458017	0.0134814	0.0134814
Echinococcus granulosus	Immunoglobulin	0.00944367	0.0518198	0.122356
Schistosoma mansoni	sodium/chloride dependent transporter	0.00808947	0.0411448	0.0904565
Mycobacterium ulcerans	protoporphyrinogen oxidase	0.00846561	0.0441098	0.0390928
Loa Loa (eye worm)	hypothetical protein	0.00846561	0.0441098	0.0441098
Brugia malayi	Serotonin receptor	0.045438	0.335559	0.335559
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.00808947	0.0411448	0.0411448
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Trypanosoma cruzi	UDP-galactopyranose mutase	0.00846561	0.0441098	0.12004
Echinococcus granulosus	twitchin	0.0116086	0.0688853	0.162651
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.00458017	0.0134814	0.0134814
Onchocerca volvulus		0.00846561	0.0441098	0.0337433
Echinococcus multilocularis	roundabout 2	0.00458017	0.0134814	0.0362721
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814
Echinococcus multilocularis	Immunoglobulin	0.00944367	0.0518198	0.139423
Loa Loa (eye worm)	hypothetical protein	0.00458017	0.0134814	0.0134814
Echinococcus multilocularis	lachesin	0.00458017	0.0134814	0.0362721
Mycobacterium ulcerans	short chain dehydrogenase	0.0254197	0.177757	0.184881
Treponema pallidum	sodium- and chloride- dependent transporter	0.0476543	0.35303	0.5
Mycobacterium ulcerans	monoamine oxidase	0.00846561	0.0441098	0.0390928
Echinococcus multilocularis	tyrosine protein kinase otk	0.00458017	0.0134814	0.0362721
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.00473317	0.0146874	0.0146874
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0565961	0.423517	1
Echinococcus multilocularis	hemicentin 1	0.00458017	0.0134814	0.0362721
Echinococcus granulosus	roundabout 2	0.0140238	0.0879248	0.207606
Schistosoma mansoni	vesicular amine transporter	0.00944439	0.0518255	0.119847
Echinococcus granulosus	defective proboscis extension response	0.00944367	0.0518198	0.122356
Brugia malayi	SWIRM domain containing protein	0.00846561	0.0441098	0.0441098
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.00808947	0.0411448	0.0904565
Schistosoma mansoni	sodium/chloride dependent transporter	0.00824246	0.0423508	0.0937753
Loa Loa (eye worm)	vesicular acetylcholine transporter unc-17	0.0126552	0.0771361	0.0771361
Echinococcus multilocularis	neuroglian	0.00458017	0.0134814	0.0362721
Echinococcus granulosus	sodium and chloride dependent glycine	0.00808947	0.0411448	0.0971502
Brugia malayi	Immunoglobulin I-set domain containing protein	0.129727	1	1
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.00808947	0.0411448	0.917263
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.00808947	0.0411448	0.110701
Schistosoma mansoni	tyrosine kinase	0.00543825	0.0202455	0.0329463
Toxoplasma gondii	hypothetical protein	0.00808947	0.0411448	0.917263
Loa Loa (eye worm)	hypothetical protein	0.00944367	0.0518198	0.0518198
Mycobacterium tuberculosis	Conserved protein	0.0500194	0.371674	0.40234
Mycobacterium ulcerans	oxidoreductase	0.00846561	0.0441098	0.0390928
Brugia malayi	Immunoglobulin I-set domain containing protein	0.00458017	0.0134814	0.0134814

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.0009 uM	Antiplasmodial activity against Plasmodium falciparum assessed as inhibition of parasite LDH activity after 72 hrs	ChEMBL.	21944972

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	21944972

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1923949

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1563472