Detailed information for compound 1564094

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 327.381 | Formula: C17H21N5O2
  • H donors: 0 H acceptors: 3 LogP: 1.98 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(c1nc2c(n1C)c(=O)n(c(=O)n2C)C)CCc1ccccc1
  • InChi: 1S/C17H21N5O2/c1-19(11-10-12-8-6-5-7-9-12)16-18-14-13(20(16)2)15(23)22(4)17(24)21(14)3/h5-9H,10-11H2,1-4H3
  • InChiKey: DHDMBCFMVUOZMM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase B 520 aa 462 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Echinococcus granulosus lysyl tRNA synthetase 0.0069 0.0448 0.0735
Brugia malayi Sugar transporter family protein 0.0309 0.2293 0.6427
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0052 0.0115
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0093 0.0631 0.275
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0072 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0267 0.0438
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0108 0.0749 0.1129
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0352 0.0773
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.345 0.5659
Plasmodium falciparum calcium-dependent protein kinase 2 0.0095 0.0646 0.0646
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.0237
Plasmodium falciparum calcium-dependent protein kinase 3 0.0095 0.0646 0.0646
Echinococcus granulosus glycyl tRNA synthetase 0.0017 0.0052 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0093 0.0631 0.1034
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0236
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.0112 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0072 0.0158
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0496 0.6628
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0267 0.0438
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0072 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Toxoplasma gondii protein kinase, putative 0.0874 0.6629 1
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0069 0.0448 0.5783
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0161 0.0513
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0072 0.0118
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0072 0.0158
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.0112 0.0288
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Brugia malayi CXXC zinc finger family protein 0.0057 0.0352 0.0986
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0095 0.0645 0.1808
Echinococcus granulosus neuropeptide s receptor 0.046 0.345 0.5659
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0098 0.067 0.1472
Toxoplasma gondii facilitative glucose transporter GT1 0.0309 0.2293 0.3459
Mycobacterium ulcerans integral membrane transport protein 0.0044 0.0252 0.0819
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0017 0.0052 0.0078
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0026 0.0042
Onchocerca volvulus 0.0044 0.0252 0.3049
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0015 0.0036 0.0481
Leishmania major glucose transporter/membrane transporter D2, putative 0.0096 0.0655 0.8744
Echinococcus granulosus FTZ F1 alpha 0.002 0.0072 0.0118
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0059 0.0368 0.1361
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0095 0.0646 0.0646
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0072 0.0201
Schistosoma mansoni amine oxidase 0.0025 0.0112 0.0183
Trichomonas vaginalis conserved hypothetical protein 0.0309 0.2293 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Toxoplasma gondii sugar transporter ST1 0.0044 0.0252 0.038
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.0112 0.0183
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0017 0.0052 0.0113
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0072 0.0118
Leishmania major UDP-galactopyranose mutase 0.0025 0.0112 0.1493
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.05 0.3756 0.3756
Onchocerca volvulus 0.0044 0.0252 0.3049
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0377 0.1294
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0267 0.0438
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.0112 0.0112
Schistosoma mansoni transient receptor potential channel 0.0191 0.1387 0.2276
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0053 0.0326 0.0717
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Schistosoma mansoni cpg binding protein 0.0057 0.0352 0.0577
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0377 0.1397
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0072 0.0201
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus calcium dependent protein kinase 0.0089 0.06 0.0985
Loa Loa (eye worm) hypothetical protein 0.0182 0.1313 0.2886
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0044 0.0252 0.0885
Trypanosoma cruzi hexose transporter, putative 0.0052 0.0321 0.3994
Echinococcus granulosus synaptic vesicle 2 protein 0.0044 0.0252 0.0413
Toxoplasma gondii glycyl-tRNA synthetase 0.0017 0.0052 0.0078
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.074 0.1116
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0026 0.0042
Trypanosoma brucei glucose transporter 2A 0.0096 0.0655 0.8744
Echinococcus granulosus dnaJ subfamily B 0.0805 0.6096 1
Plasmodium vivax importin-beta 2, putative 0.0057 0.0352 0.0352
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0072 0.0118
Trypanosoma cruzi glucose transporter, putative 0.0044 0.0252 0.303
Onchocerca volvulus 0.0025 0.0112 0.0677
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0252 0.0706
Trichomonas vaginalis sugar transport protein, putative 0.0044 0.0252 0.1099
Echinococcus granulosus Sugar transporter ERD6 protein 0.0044 0.0252 0.0413
Schistosoma mansoni cpg binding protein 0.006 0.0376 0.0618
Loa Loa (eye worm) hypothetical protein 0.0093 0.0631 0.1386
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0071
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0095 0.0646 0.0974
Schistosoma mansoni glucose transport protein 0.0309 0.2293 0.3762
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0326 0.0717
Schistosoma mansoni hypothetical protein 0.0102 0.0704 0.1156
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Chlamydia trachomatis lysine--tRNA ligase 0.0069 0.0448 1
Onchocerca volvulus 0.0044 0.0252 0.3049
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0017 0.0052 0.0064
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Schistosoma mansoni hypothetical protein 0.0097 0.0663 0.1087
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0655 0.868
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0237 0.0237
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0017 0.0052 0.0799
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0072 0.0118
Trichomonas vaginalis helicase, putative 0.0013 0.0016 0.0071
Plasmodium falciparum threonine--tRNA ligase 0.0017 0.0052 0.0052
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0072 0.0118
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0177 0.0291
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0061 0.0383 0.1669
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Trichomonas vaginalis ran, putative 0.0042 0.0237 0.1035
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0044 0.0252 0.0252
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0655 0.2854
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0377 0.0618
Trypanosoma cruzi hexose transporter 0.0096 0.0655 0.868
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0044 0.0252 0.0413
Loa Loa (eye worm) hypothetical protein 0.0026 0.0115 0.0253
Echinococcus multilocularis General substrate transporter 0.0266 0.1959 0.3214
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0072 0.0118
Onchocerca volvulus 0.0044 0.0252 0.3049
Schistosoma mansoni hypothetical protein 0.0167 0.1199 0.1967
Echinococcus granulosus GPCR family 2 0.0047 0.0282 0.0463
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Plasmodium vivax lysine--tRNA ligase, putative 0.0069 0.0448 0.0448
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0044 0.0252 0.0819
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.027 0.1176
Echinococcus multilocularis transient receptor potential gamma protein 0.0289 0.2139 0.3509
Brugia malayi SWIRM domain containing protein 0.0025 0.0112 0.0313
Echinococcus granulosus short transient receptor potential channel 6 0.0191 0.1387 0.2276
Schistosoma mansoni transient receptor potential channel 4 0.0289 0.2139 0.3509
Plasmodium falciparum protein kinase 7 0.0874 0.6629 0.6629
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0603 0.455 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0377 0.1294
Trichomonas vaginalis glucose transporter, putative 0.0096 0.0655 0.2854
Brugia malayi hypothetical protein 0.0025 0.0112 0.0313
Brugia malayi Calcitonin receptor-like protein seb-1 0.015 0.1068 0.2994
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0015 0.0036 0.0054
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0095 0.0645 0.1418
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0072 0.0158
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0069 0.0448 0.5986
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0108 0.0749 1
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0326 0.0717
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0095 0.0646 0.0974
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.0112 0.0183
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0112 0.0112
Schistosoma mansoni hypothetical protein 0.0034 0.0177 0.0291
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0072 0.0201
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0072 0.0118
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0093 0.0631 0.1767
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0161 0.2153
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0237 0.3169
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0072 0.0118
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0161 0.0264
Loa Loa (eye worm) hypothetical protein 0.0108 0.0744 0.1635
Echinococcus multilocularis lamin 0.0053 0.0326 0.0535
Loa Loa (eye worm) hypothetical protein 0.0093 0.0631 0.1386
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0072 0.0118
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0352 0.47
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0072 0.0118
Plasmodium falciparum proline--tRNA ligase 0.0108 0.0749 0.0749
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0047 0.0282 0.0463
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0072 0.0158
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0289 0.2139 0.4701
Echinococcus multilocularis snurportin 1 0.0603 0.455 0.7464
Plasmodium vivax calcium-dependent protein kinase, putative 0.0095 0.0646 0.0646
Echinococcus multilocularis transient receptor potential ion channel A 0.028 0.2065 0.3388
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0093 0.0631 0.1767
Loa Loa (eye worm) sugar transporter 0.0044 0.0252 0.0554
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi glycyl-tRNA synthetase 0.0017 0.0052 0.0145
Onchocerca volvulus Putative transporter 0.0044 0.0252 0.3049
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0252 0.0554
Echinococcus granulosus lamin 0.0053 0.0326 0.0535
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0038 0.021 0.0463
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0448 0.0735
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0267 0.0438
Echinococcus multilocularis musashi 0.0053 0.0326 0.0535
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0161 0.0354
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0645 0.2814
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0309 0.2293 0.3762
Echinococcus multilocularis synaptic vesicle 2 protein 0.0044 0.0252 0.0413
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0097 0.0663 0.1857
Leishmania major threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0689
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.2671 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Plasmodium vivax proline--tRNA ligase, putative 0.0108 0.0749 0.0749
Trichomonas vaginalis sugar transporter, putative 0.0096 0.0655 0.2854
Echinococcus multilocularis glycyl tRNA synthetase 0.0017 0.0052 0.0085
Trichomonas vaginalis conserved hypothetical protein 0.0096 0.0655 0.2854
Brugia malayi hypothetical protein 0.0044 0.0252 0.0706
Trichomonas vaginalis myo-inositol transporter, putative 0.0044 0.0252 0.1099
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0161 0.1756
Schistosoma mansoni glucose transport protein 0.0309 0.2293 0.3762
Brugia malayi RNA, U transporter 1 0.0161 0.1152 0.3228
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0017 0.0052 0.0113
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0137 0.0383
Leishmania major glucose transporter, lmgt1 0.0096 0.0655 0.8744
Entamoeba histolytica protein kinase, putative 0.0095 0.0645 1
Loa Loa (eye worm) major facilitator superfamily transporter 0.0044 0.0252 0.0554
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0072 0.0201
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0095 0.0645 0.8619
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni hypothetical protein 0.0309 0.2293 0.3762
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0017 0.0045 0.0607
Schistosoma mansoni lamin 0.0053 0.0326 0.0535
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0069 0.0448 0.6932
Loa Loa (eye worm) sugar transporter 0.0309 0.2293 0.504
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Brugia malayi Transient-receptor-potential like protein 0.0108 0.0744 0.2085
Trichomonas vaginalis sugar transporter, putative 0.0096 0.0655 0.2854
Brugia malayi latrophilin 2 splice variant baaae 0.0102 0.0704 0.1974
Brugia malayi intermediate filament protein 0.0053 0.0326 0.0914
Entamoeba histolytica hypothetical protein 0.0046 0.027 0.4181
Echinococcus multilocularis calcium dependent protein kinase 0.0089 0.06 0.0985
Leishmania major hypothetical protein, conserved 0.0075 0.0496 0.6628
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.0112 0.0112
Echinococcus granulosus short transient receptor potential channel 6 0.0191 0.1387 0.2276
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.2477 1
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0072 0.0201
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0267 0.0749
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0029 0.0138 0.0209
Schistosoma mansoni transient receptor potential channel 0.0191 0.1387 0.2276
Echinococcus granulosus intermediate filament protein 0.0053 0.0326 0.0535
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0496 0.0496
Echinococcus multilocularis short transient receptor potential channel 6 0.0191 0.1387 0.2276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0047 0.0282 0.062
Entamoeba histolytica hypothetical protein 0.0069 0.0448 0.6945
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0267 0.0438
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0072 0.0118
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0072 0.0201
Echinococcus multilocularis calcium activated potassium channel 0.0016 0.0037 0.0061
Schistosoma mansoni glucose transporter 0.0044 0.0252 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0072 0.0201
Onchocerca volvulus 0.0057 0.0352 0.4738
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0047 0.0282 0.0463
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Onchocerca volvulus 0.0044 0.0252 0.3049
Chlamydia trachomatis proline--tRNA ligase 0.0033 0.017 0.2978
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0026 0.0042
Trypanosoma brucei sugar transporter, putative 0.0044 0.0252 0.3365
Chlamydia trachomatis protoporphyrinogen oxidase 0.0025 0.0112 0.1519
Schistosoma mansoni ran 0.0042 0.0237 0.0389
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0161 0.0264
Leishmania major glucose transporter, lmgt2 0.0096 0.0655 0.8744
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0072 0.0118
Plasmodium falciparum lysine--tRNA ligase 0.0069 0.0448 0.0448
Schistosoma mansoni cpg binding protein 0.006 0.0376 0.0618
Mycobacterium ulcerans oxidoreductase 0.0025 0.0112 0.0288
Schistosoma mansoni thyroid hormone receptor 0.002 0.0072 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0044 0.0252 0.0885
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0112 0.0313
Loa Loa (eye worm) hypothetical protein 0.0476 0.3569 0.7843
Echinococcus granulosus TRP transient receptor potential channel 0.0108 0.0744 0.1221
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0093 0.0631 1
Plasmodium vivax glycine--tRNA ligase, putative 0.0017 0.0052 0.0052
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0496 0.0496
Echinococcus multilocularis GPCR, family 2 0.0047 0.0282 0.0463
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0093 0.0631 0.1034
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) pigment dispersing factor receptor c 0.015 0.1068 0.2348
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.027 0.1176
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Echinococcus multilocularis cpg binding protein 0.006 0.0376 0.0618
Plasmodium falciparum importin beta, putative 0.0057 0.0352 0.0352
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0072 0.0118
Brugia malayi nuclear receptor NHR-88 0.002 0.0072 0.0201
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0799
Echinococcus granulosus snurportin 1 0.0603 0.455 0.7464
Giardia lamblia Prolyl-tRNA synthetase 0.0093 0.0631 1
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0225
Brugia malayi lysyl-tRNA synthetase 0.0069 0.0448 0.1256
Trypanosoma brucei THT1 - hexose transporter, putative 0.0096 0.0655 0.8744
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni hypothetical protein 0.0805 0.6096 1
Toxoplasma gondii sugar transporter ST2 0.0044 0.0252 0.038
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Trichomonas vaginalis glucose transporter, putative 0.0044 0.0252 0.1099
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0377 0.1294
Brugia malayi hypothetical protein 0.0044 0.0252 0.0706
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0218
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0072 0.0118
Brugia malayi Sugar transporter family protein 0.0044 0.0252 0.0706
Brugia malayi Sugar transporter family protein 0.0044 0.0252 0.0706
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0377 0.0618
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0095 0.0645 0.1059
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0108 0.0749 1
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.0112 0.0112
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0044 0.0252 0.0413
Echinococcus granulosus calcium activated potassium channel 0.0016 0.0037 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0052 0.0086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0107 0.0236
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0102 0.0704 0.1548
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Schistosoma mansoni coup transcription factor 0.002 0.0072 0.0118
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0072 0.0201
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.0112 0.1274
Plasmodium falciparum calcium-dependent protein kinase 1 0.0095 0.0646 0.0646
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0161 0.1756
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0749 1
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0161 0.0452
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.0112 0.0183
Onchocerca volvulus 0.0044 0.0252 0.3049
Echinococcus multilocularis solute carrier family 22 0.0044 0.0252 0.0413
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0157
Schistosoma mansoni nuclear hormone receptor 0.002 0.0072 0.0118
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0059 0.0368 0.1361
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Echinococcus granulosus General substrate transporter 0.0266 0.1959 0.3214
Echinococcus multilocularis dnaJ subfamily B 0.0805 0.6096 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0072 0.0201
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0496 0.0749
Trypanosoma cruzi sugar transporter, putative 0.0044 0.0252 0.303
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0749 1
Schistosoma mansoni hypothetical protein 0.0047 0.0282 0.0463
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0157
Plasmodium falciparum hexose transporter 0.0309 0.2293 0.2293
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0267 0.0438
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0017 0.0052 0.0145
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0016 0.0071
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0093 0.0631 0.1034
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0161 0.0243
Echinococcus granulosus solute carrier family 22 0.0044 0.0252 0.0413
Brugia malayi hypothetical protein 0.0075 0.0496 0.1391
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0052 0.0086
Echinococcus multilocularis geminin 0.0167 0.1199 0.1967
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0072 0.0118
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0095 0.0646 0.0646
Entamoeba histolytica Ran family GTPase 0.0042 0.0237 0.3677
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.005 0.0141
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0095 0.0646 0.0974
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0115 0.0189
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi hypothetical protein 0.0049 0.0291 0.0816
Trichomonas vaginalis importin beta-1, putative 0.0046 0.027 0.1176
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0115 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0052 0.0319 0.07
Plasmodium vivax hexose transporter 0.0309 0.2293 0.2293
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0017 0.0052 0.0059
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0377 0.0569
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.05 0.3756 0.5666
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0237 0.0389
Onchocerca volvulus 0.0053 0.0326 0.4306
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Schistosoma mansoni amine oxidase 0.0025 0.0112 0.0183
Plasmodium vivax CDK-related protein kinase 6, putative 0.1313 1 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0496 0.0496
Giardia lamblia Hexose transporter 0.0044 0.0252 0.346
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus granulosus survival motor neuron protein 1 0.0476 0.3569 0.5854
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0026 0.0042
Giardia lamblia Lysyl-tRNA synthetase 0.0069 0.0448 0.6849
Schistosoma mansoni lamin 0.0053 0.0326 0.0535
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0072 0.0201
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0072 0.0201
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0108 0.0749 1
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0044 0.0252 0.0819
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0161 0.0264
Leishmania major protein kinase, putative 0.0095 0.0645 0.8619
Echinococcus multilocularis 0.0025 0.0112 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi Importin beta-1 subunit 0.0057 0.0352 0.0986
Echinococcus granulosus lamin dm0 0.0053 0.0326 0.0535
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0161 0.2153
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0093 0.0631 0.1034
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Plasmodium vivax threonine--tRNA ligase, putative 0.0017 0.0052 0.0052
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0161 0.2153
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0237 0.2824
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0177 0.0291
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0267 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0069 0.0448 0.1954
Loa Loa (eye worm) hypothetical protein 0.0075 0.0496 0.1091
Leishmania major hypothetical protein, conserved 0.0044 0.0252 0.3365
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0352 0.0531
Onchocerca volvulus 0.0097 0.0663 1
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0017 0.0052 0.0145
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Toxoplasma gondii lysine-tRNA ligase 0.0069 0.0448 0.0676
Schistosoma mansoni thyroid hormone receptor 0.002 0.0072 0.0118
Echinococcus granulosus importin subunit beta 1 0.0057 0.0352 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0096 0.0655 0.2854
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0838 0.1375
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0017 0.0052 0.0262
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0496 0.6458
Mycobacterium ulcerans dehydrogenase 0.0025 0.0112 0.0288
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0352 0.47
Echinococcus multilocularis lamin dm0 0.0053 0.0326 0.0535
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0044 0.0252 0.3365
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0161 0.0264
Schistosoma mansoni protein kinase 0.0095 0.0645 0.1059
Loa Loa (eye worm) hypothetical protein 0.0075 0.0497 0.1092
Echinococcus granulosus transient receptor potential ion channel A 0.028 0.2065 0.3388
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0448 0.1564
Schistosoma mansoni lysyl-tRNA synthetase 0.0069 0.0448 0.0735
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Brugia malayi major facilitator superfamily protein 0.0044 0.0252 0.0706
Leishmania major hypothetical protein, conserved 0.0015 0.0036 0.0481
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0112 0.031
Echinococcus granulosus neuropeptide receptor A26 0.046 0.345 0.5659
Schistosoma mansoni hypothetical protein 0.0603 0.455 0.7464
Schistosoma mansoni glucose transport protein 0.0309 0.2293 0.3762
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.015 0.1068 0.2994
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0033 0.017 0.0507
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0112 0.031
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0377 0.0618
Plasmodium falciparum mitogen-activated protein kinase 2 0.05 0.3756 0.3756
Brugia malayi steroid hormone receptor 0.002 0.0072 0.0201
Mycobacterium ulcerans sugar transporter 0.0044 0.0252 0.0819
Loa Loa (eye worm) hypothetical protein 0.0047 0.0282 0.062
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0252 0.0706
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Onchocerca volvulus 0.0053 0.0326 0.4306
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0309 0.2293 0.3762
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0072 0.0201
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0112 0.1063
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0161 0.0161
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0069 0.0448 0.1564
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.027 0.328
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0112 0.0183
Plasmodium vivax sugar transporter, putative 0.0044 0.0252 0.0252
Loa Loa (eye worm) hypothetical protein 0.0095 0.0645 0.1418
Brugia malayi hypothetical protein 0.0476 0.3569 1
Toxoplasma gondii transporter, major facilitator family protein 0.0044 0.0252 0.038
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0047 0.0282 0.079
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0072 0.0118
Trypanosoma brucei THT1 - hexose transporter, putative 0.0096 0.0655 0.8744
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0072 0.0201
Schistosoma mansoni hypothetical protein 0.0167 0.1199 0.1967
Trypanosoma cruzi hexose transporter, putative 0.0044 0.0252 0.303
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0072 0.0158
Echinococcus multilocularis survival motor neuron protein 1 0.0476 0.3569 0.5854
Loa Loa (eye worm) hypothetical protein 0.015 0.1068 0.2348
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0326 0.0914
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0017 0.0052 0.0689
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.0521
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0093 0.0631 0.9772
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Onchocerca volvulus 0.0044 0.0252 0.3049
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0026 0.0042
Onchocerca volvulus 0.0044 0.0252 0.3049
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0496 0.6458
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.0665
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0047 0.0282 0.0463
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Onchocerca volvulus 0.0044 0.0252 0.3049
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.2671 1
Echinococcus multilocularis neuropeptide s receptor 0.046 0.345 0.5659
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0044 0.0252 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Brugia malayi major facilitator superfamily protein 0.0044 0.0252 0.0706
Entamoeba histolytica protein kinase, putative 0.0095 0.0645 1
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0655 0.868
Loa Loa (eye worm) hypothetical protein 0.002 0.0072 0.0158
Loa Loa (eye worm) hypothetical protein 0.0069 0.0448 0.0985
Loa Loa (eye worm) hypothetical protein 0.0025 0.0112 0.0246
Schistosoma mansoni importin beta-1 0.0057 0.0352 0.0577
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trypanosoma brucei THT1 - hexose transporter, putative 0.0096 0.0655 0.8744
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0237 0.3207
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0072 0.0158
Brugia malayi Major Facilitator Superfamily protein 0.0044 0.0252 0.0706
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0016 0.0071
Toxoplasma gondii sugar transporter ST3 0.0044 0.0252 0.038
Leishmania major myo-inositol/proton symporter (MIT) 0.0044 0.0252 0.3365
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0016 0.0071
Brugia malayi ecdysteroid receptor 0.002 0.0072 0.0201
Leishmania major glucose transporter, lmgt3 0.0096 0.0655 0.8744
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0072 0.0118
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0108 0.0744 0.1221
Trypanosoma brucei glucose transporter 1E 0.0096 0.0655 0.8744
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0267 0.0438
Brugia malayi hypothetical protein 0.0044 0.0252 0.0706
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0352 0.0577
Leishmania major importin beta-1 subunit, putative 0.0046 0.027 0.3603
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0017 0.0052 0.0085
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0112 0.0183
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.0113
Brugia malayi isocitrate dehydrogenase 0.0032 0.0161 0.0452
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0252 0.1099
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.0112 0.0169
Echinococcus granulosus cpg binding protein 0.006 0.0376 0.0618
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0095 0.0646 0.0646
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0072 0.0158
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0377 0.5036
Echinococcus granulosus geminin 0.0167 0.1199 0.1967
Plasmodium falciparum calcium-dependent protein kinase 5 0.0095 0.0646 0.0646
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0095 0.0645 0.1418
Mycobacterium ulcerans monoamine oxidase 0.0025 0.0112 0.0288
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0377 0.0618
Echinococcus multilocularis short transient receptor potential channel 6 0.0191 0.1387 0.2276
Trichomonas vaginalis sugar transporter, putative 0.0044 0.0252 0.1099
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0655 0.868
Leishmania major lysyl-tRNA synthetase, putative 0.0069 0.0448 0.5986
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0072 0.0118
Schistosoma mansoni transient receptor potential channel 0.0289 0.2139 0.3509
Onchocerca volvulus 0.0044 0.0252 0.3049
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0059 0.0368 0.5587
Onchocerca volvulus 0.0044 0.0252 0.3049
Schistosoma mansoni ran 0.0042 0.0237 0.0389
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0112 0.1063
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0218
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0072 0.0118
Leishmania major hypothetical protein, conserved 0.0015 0.0036 0.0481
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0047 0.0282 0.0463
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0112 0.0112
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Brugia malayi Latrophilin receptor protein 2 0.0047 0.0282 0.079
Treponema pallidum prolyl-tRNA synthetase 0.0033 0.017 1
Schistosoma mansoni protein kinase 0.0095 0.0645 0.1059
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0095 0.0645 0.1059
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0161 0.0161
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0017 0.0052 0.0689
Giardia lamblia Sugar-proton symporter 0.0044 0.0252 0.346
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Schistosoma mansoni protein kinase 0.0095 0.0645 0.1059
Brugia malayi nuclear hormone receptor 0.002 0.0072 0.0201
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0645 0.1059
Trichomonas vaginalis glucose transporter, putative 0.0096 0.0655 0.2854
Echinococcus granulosus Threonyl tRNA synthetase C 0.0017 0.0052 0.0085
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0237 0.0389
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0036 0.0157
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Brugia malayi Cam kinase protein 1 0.0095 0.0645 0.1808
Loa Loa (eye worm) hypothetical protein 0.0057 0.0352 0.0773
Plasmodium falciparum calcium-dependent protein kinase 4 0.0095 0.0646 0.0646
Leishmania major GTP-binding protein, putative 0.0042 0.0237 0.3169
Echinococcus multilocularis lysyl tRNA synthetase 0.0069 0.0448 0.0735
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0137 0.03
Trypanosoma brucei glucose transporter, putative 0.0096 0.0655 0.8744
Onchocerca volvulus 0.0044 0.0252 0.3049
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0072 0.0201
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0072 0.0201
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0072 0.0158
Schistosoma mansoni survival motor neuron protein 0.0097 0.0663 0.1087
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0072 0.0201
Schistosoma mansoni intermediate filament proteins 0.0053 0.0326 0.0535
Echinococcus granulosus transient receptor potential gamma protein 0.0289 0.2139 0.3509
Loa Loa (eye worm) hypothetical protein 0.0044 0.0252 0.0554
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0237 0.0358
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0072 0.0118
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0161 0.0243
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0237 0.2824
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0112 0.0112
Schistosoma mansoni sugar transporter 0.0044 0.0252 0.0413
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0017 0.0052 0.0059
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0072 0.0118
Schistosoma mansoni glycyl-tRNA synthetase 0.0017 0.0052 0.0085

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 16.8 uM Inhibition of human recombinant MAOB using kynuramine as substrate by fluorescence assay ChEMBL. 22055712
IC50 (binding) = 107 uM Inhibition of human recombinant MAOA using kynuramine as substrate by fluorescence assay ChEMBL. 22055712

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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