Detailed information for compound 157872

Basic information

Technical information
  • TDR Targets ID: 157872
  • Name: (E)-N-[(5,7-difluoronaphthalen-1-yl)methyl]-N ,6,6-trimethylhept-2-en-4-yn-1-amine
  • MW: 327.411 | Formula: C21H23F2N
  • H donors: 0 H acceptors: 0 LogP: 5.79 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(Cc1cccc2c1cc(F)cc2F)C/C=C/C#CC(C)(C)C
  • InChi: 1S/C21H23F2N/c1-21(2,3)11-6-5-7-12-24(4)15-16-9-8-10-18-19(16)13-17(22)14-20(18)23/h5,7-10,13-14H,12,15H2,1-4H3/b7-5+
  • InChiKey: PTLOIFXSUBVRLG-FNORWQNLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (E)-N-[(5,7-difluoro-1-naphthyl)methyl]-N,6,6-trimethyl-hept-2-en-4-yn-1-amine
  • (E)-N-[(5,7-difluoro-1-naphthyl)methyl]-N,6,6-trimethyl-1-hept-2-en-4-ynamine
  • (E)-N-[(5,7-difluoronaphthalen-1-yl)methyl]-N,6,6-trimethyl-hept-2-en-4-yn-1-amine
  • (5,7-difluoro-1-naphthyl)methyl-[(E)-6,6-dimethylhept-2-en-4-ynyl]-methyl-amine
  • (E)-N-[(5,7-difluoro-1-naphthyl)methyl]-N,6,6-trimethylhept-2-en-4-yn-1-amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0205 0.0601
Brugia malayi Death domain containing protein 0.0086 0.0912 0.3113
Echinococcus granulosus netrin receptor unc 5 0.0086 0.0912 0.1073
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0075 0.1952
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0037 0.0044
Onchocerca volvulus 0.0051 0.051 0.1722
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0256 0.2901 1
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0435 0.1501
Onchocerca volvulus 0.0053 0.0525 0.1774
Schistosoma mansoni ankyrin 23/unc44 0.0086 0.0912 0.106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0357
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0029 0.0253 0.0283
Echinococcus multilocularis ATP binding cassette sub family B 0.001 0.0032 0.0032
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0256 0.2901 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0053 0.0525 0.1774
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0032 1
Schistosoma mansoni hypothetical protein 0.0043 0.0417 0.0476
Onchocerca volvulus 0.0029 0.0245 0.0805
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0036 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0036 0.0079
Echinococcus multilocularis netrin receptor unc 5 0.0086 0.0912 0.0912
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0036 0.0079
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0029 0.0253 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0036 0.0079
Echinococcus granulosus lipoxygenase domain containing protein 0.0077 0.0809 0.0952
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0036 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.013 0.1261
Onchocerca volvulus 0.0011 0.0036 0.0079
Schistosoma mansoni microtubule-associated protein tau 0.0736 0.8497 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0036 0.0042
Brugia malayi Protein kinase domain containing protein 0.0086 0.0912 0.3113
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.015 0.5327
Schistosoma mansoni DNA ligase IV 0.001 0.0032 0.0023
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0205 0.7761
Echinococcus granulosus Polycystic kidney disease protein 0.0077 0.0809 0.0952
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0111
Echinococcus granulosus nibrin 0.001 0.0032 0.0038
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.015 0.5327
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0644 0.2185
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0037 0.0044
Echinococcus granulosus tumor protein p63 0.036 0.4114 0.4842
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0036 0.0079
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0256 0.2901 1
Echinococcus granulosus dna polymerase eta 0.0021 0.015 0.0176
Loa Loa (eye worm) hypothetical protein 0.0025 0.0205 0.0665
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0037 0.0037
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0037 0.0044
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0205 0.0665
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.015 0.0475
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0032 0.0023
Entamoeba histolytica hypothetical protein 0.0038 0.0357 0.1134
Echinococcus granulosus sterol regulatory element binding protein 0.0045 0.0435 0.0513
Brugia malayi RNA binding protein 0.0063 0.0644 0.2185
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0644 0.2185
Echinococcus multilocularis lamin dm0 0.0029 0.0245 0.0245
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0037 0.0018
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0068
Echinococcus granulosus expressed conserved protein 0.0099 0.1061 0.1248
Entamoeba histolytica P-glycoprotein-2, putative 0.0011 0.0037 0.0018
Echinococcus multilocularis Niemann Pick C1 protein 0.015 0.1661 0.1661
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0256 0.2901 1
Echinococcus granulosus replication factor c subunit 1 0.001 0.0032 0.0038
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.015 0.0467
Schistosoma mansoni loxhd1 0.0077 0.0809 0.0939
Echinococcus multilocularis dna polymerase kappa 0.0021 0.015 0.015
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0036 0.0027
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0644 0.0744
Trichomonas vaginalis abcb9, putative 0.0011 0.0037 0.0129
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0013 0.0015
Trichomonas vaginalis abcb9, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0013 0.0013
Schistosoma mansoni ferritin 0.0009 0.0015 0.0003
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0013 0.0015
Echinococcus multilocularis Ankyrin 0.0086 0.0912 0.0912
Schistosoma mansoni ferritin 0.0009 0.0015 0.0003
Trichomonas vaginalis ferritin, putative 0.0009 0.0015 0.0053
Brugia malayi TAR-binding protein 0.0063 0.0644 0.2185
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0032 0.0111
Onchocerca volvulus Protein ultraspiracle homolog 0.0011 0.0036 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0644 0.0744
Loa Loa (eye worm) multidrug resistance protein 3 0.0011 0.0037 0.0085
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.015 0.0176
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.015 0.5327
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0036 0.0036
Echinococcus granulosus multidrug resistance protein 1 0.0011 0.0037 0.0044
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.015 0.0467
Brugia malayi steroid hormone receptor 0.0011 0.0036 0.0079
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0037 0.0037
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.015 0.0517
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.0912 0.3113
Schistosoma mansoni multidrug resistance protein 0.0011 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0131 0.1439 0.1694
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0183
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Brugia malayi multidrug resistance protein 3 0.0011 0.0037 0.0085
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0086 0.0912 0.1073
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0131 0.1439 0.1694
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Echinococcus granulosus microtubule associated protein 2 0.0736 0.8497 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0036 0.0042
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump 0.0011 0.0037 0.0076
Entamoeba histolytica hypothetical protein 0.0038 0.0357 0.1134
Schistosoma mansoni ferritin light chain 0.0009 0.0015 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Trichomonas vaginalis taga, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.015 0.0517
Schistosoma mansoni hypothetical protein 0.0025 0.0196 0.0216
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0036 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0036 0.0079
Loa Loa (eye worm) ABC transporter 0.0025 0.0201 0.0652
Plasmodium falciparum multidrug resistance protein 1 0.0011 0.0037 0.0065
Echinococcus multilocularis protein dispatched 1 0.0051 0.051 0.051
Echinococcus multilocularis dna polymerase eta 0.0021 0.015 0.015
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0036 0.0079
Loa Loa (eye worm) doublecortin family protein 0.0077 0.0809 0.2757
Echinococcus multilocularis tumor protein p63 0.036 0.4114 0.4114
Echinococcus granulosus Niemann Pick C1 protein 0.0105 0.1135 0.1336
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0072 0.0072
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0075 0.1952
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0111
Brugia malayi nuclear receptor NHR-88 0.0011 0.0036 0.0079
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0036 0.0036
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0253 0.0253
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.2002 0.6886
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.015 0.0467
Schistosoma mansoni lamin 0.0029 0.0245 0.0274
Echinococcus multilocularis microtubule associated protein 2 0.0736 0.8497 0.8497
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Loa Loa (eye worm) hypothetical protein 0.0086 0.0912 0.3113
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0037 0.0129
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0357 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0205 0.0657
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0205 0.0657
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0036 0.0079
Entamoeba histolytica hypothetical protein 0.0038 0.0357 0.1134
Brugia malayi hypothetical protein 0.0077 0.0809 0.2757
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0037 0.0129
Brugia malayi Uncoordinated protein 44 0.0086 0.0912 0.3113
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0036 0.0027
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.015 0.0475
Echinococcus multilocularis protein patched 0.0045 0.0435 0.0435
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0036 0.0079
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.013 0.0398
Loa Loa (eye worm) hypothetical protein 0.0252 0.2852 0.9831
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0245 0.0805
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.009 0.0266
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0525 0.0604
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0036 0.0042
Entamoeba histolytica ABC transporter, putative 0.0029 0.0253 0.077
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.013 0.0398
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0036 0.0027
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0253 0.0824
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.015 0.5327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0036 0.0079
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0068
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0025 0.0196 0.0626
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0068
Brugia malayi ABC transporter family protein 0.0025 0.0201 0.0652
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0644 0.2185
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0256 0.2901 1
Schistosoma mansoni lipoxygenase 0.0322 0.3671 0.4311
Brugia malayi hypothetical protein 0.0077 0.0809 0.2757
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0644 0.0744
Echinococcus multilocularis lipoxygenase domain containing protein 0.0077 0.0809 0.0809
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0239 0.0784
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0205 0.0657
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0205 0.0657
Schistosoma mansoni hypothetical protein 0.0043 0.0417 0.0476
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0205 0.0657
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0011 0.0036 0.0079
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0037 0.0037
Brugia malayi Niemann-Pick C1 protein precursor 0.0105 0.1135 0.3885
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.015 0.0162
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0085
Leishmania major DNA polymerase kappa, putative 0.0021 0.015 0.5218
Echinococcus multilocularis musashi 0.0029 0.0245 0.0245
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0036 0.0042
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0011 0.0037 0.0129
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0036 0.0042
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0256 0.2901 1
Schistosoma mansoni survival motor neuron protein 0.0051 0.051 0.0586
Schistosoma mansoni apoferritin-2 0.0009 0.0015 0.0003
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0107 0.1154 0.1345
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0037 0.0044
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0037 0.0129
Leishmania major DNA polymerase eta, putative 0.0021 0.015 0.5218
Plasmodium falciparum ABC transporter G family member 2 0.0029 0.0253 0.2843
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0013 0.0015
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0205 1
Schistosoma mansoni coup transcription factor 0.0011 0.0036 0.0027
Loa Loa (eye worm) hypothetical protein 0.0025 0.0205 0.0665
Brugia malayi CHE-14 protein 0.0045 0.0435 0.1464
Echinococcus multilocularis expressed protein 0.0009 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.015 0.5327
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0013 0.0015
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Loa Loa (eye worm) hypothetical protein 0.0029 0.0245 0.0805
Schistosoma mansoni polycystin 1-related 0.0077 0.0809 0.0939
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0013 0.0013
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0105 0.1135 0.3843
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.015 0.5327
Schistosoma mansoni rab6-interacting 0.0077 0.0809 0.0939
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0037 0.0037
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0644 0.0644
Echinococcus multilocularis lamin 0.0029 0.0245 0.0245
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.015 0.0467
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0407
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 0.0011 0.0037 0.1023
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0407
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0205 1
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0032 0.0111
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.015 0.5327
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0205 0.7761
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0036 0.0027
Schistosoma mansoni apoferritin-2 0.0009 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0086 0.0912 0.3113
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0256 0.2901 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0036 0.0036
Mycobacterium ulcerans hypothetical protein 0.0025 0.0205 0.0657
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0205 0.0657
Plasmodium vivax ABC transporter G family member 2, putative 0.0029 0.0253 0.2843
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Schistosoma mansoni smdr2 0.0011 0.0037 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0036 0.0079
Entamoeba histolytica hypothetical protein 0.0038 0.0357 0.1134
Schistosoma mansoni topbp1 0.001 0.0032 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0036 0.0079
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.009 0.0266
Loa Loa (eye worm) hypothetical protein 0.0011 0.0037 0.0085
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0045 0.0435 0.1464
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0205 0.0665
Schistosoma mansoni ferritin light chain 0.0009 0.0015 0.0003
Schistosoma mansoni hypothetical protein 0.0051 0.051 0.0586
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0029 0.0253 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0205 0.0657
Loa Loa (eye worm) hypothetical protein 0.0021 0.015 0.0475
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0032 0.0111
Trypanosoma brucei unspecified product 0.0014 0.0075 0.1952
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0013 0.0013
Brugia malayi DKFZp564C0469 protein 0.001 0.0032 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0407
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Echinococcus multilocularis nibrin 0.001 0.0032 0.0032
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0205 0.0601
Onchocerca volvulus 0.0077 0.0809 0.2757
Schistosoma mansoni rab6-interacting 0.0077 0.0809 0.0939
Entamoeba histolytica P-glycoprotein-1 0.0011 0.0037 0.0018
Brugia malayi Doublecortin family protein 0.0077 0.0809 0.2757
Onchocerca volvulus 0.0256 0.2901 1
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0131 0.1439 0.1439
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.0912 0.3113
Loa Loa (eye worm) hypothetical protein 0.0013 0.0066 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0357 0.0421
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0037 0.0129
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0036 0.0036
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0013 0.0013
Onchocerca volvulus 0.0077 0.0809 0.2757
Schistosoma mansoni hypothetical protein 0.0038 0.0357 0.0406
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0256 0.2901 1
Brugia malayi ecdysteroid receptor 0.0011 0.0036 0.0079
Echinococcus granulosus Protein patched homolog 1 0.0045 0.0435 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Schistosoma mansoni tumor necrosis factor receptor related 0.0131 0.1439 0.1681
Schistosoma mansoni hypothetical protein 0.0077 0.0809 0.0939
Loa Loa (eye worm) hypothetical protein 0.0055 0.0554 0.1873
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0205 0.0665
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0036 0.0027
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0036 0.0079
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0011 0.0037 0.0129
Schistosoma mansoni hypothetical protein 0.0043 0.0417 0.0476
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0036 0.0036
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.015 0.0475
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0077 0.0809 0.2757
Echinococcus multilocularis Niemann Pick C1 protein 0.0105 0.1135 0.1135
Echinococcus multilocularis RUN 0.0077 0.0809 0.0809
Schistosoma mansoni ABC transporter 0.0025 0.0201 0.0222
Brugia malayi topoisomerase 0.001 0.0032 0.0068
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0407
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0253 0.0298
Plasmodium falciparum LCCL domain-containing protein 0.0077 0.0809 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0036 0.0036
Onchocerca volvulus Netrin receptor homolog 0.0086 0.0912 0.3113
Schistosoma mansoni hypothetical protein 0.0043 0.0417 0.0476
Echinococcus granulosus ferritin 0.0009 0.0015 0.0018
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.013 0.1261
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0036 0.0079
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0111
Trypanosoma cruzi ABC transporter, putative 0.0029 0.0253 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0036 0.0027
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0037 0.0129
Brugia malayi nuclear hormone receptor 0.0011 0.0036 0.0079
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0111
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0086 0.0912 0.0912
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0253 0.0298
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0644 0.0744
Echinococcus granulosus Ankyrin 0.0086 0.0912 0.1073
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0011 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.0025 0.0205 0.0665
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0644 0.0744
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0011 0.0037 0.1023
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.001 0.0032 0.0038
Brugia malayi intermediate filament protein 0.0029 0.0245 0.0805
Brugia malayi hypothetical protein 0.0038 0.0357 0.1194
Trichomonas vaginalis ABC transporter, putative 0.0011 0.0037 0.0129
Onchocerca volvulus 0.0011 0.0037 0.0085
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0032 0.0032
Giardia lamblia ABC transporter 0.0029 0.0248 0.0751
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0245 0.0805
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0029 0.0253 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0036 0.0079
Brugia malayi N-terminal motif family protein 0.0179 0.2002 0.6886
Schistosoma mansoni multidrug resistance protein 0.0011 0.0037 0.0029
Echinococcus granulosus Niemann Pick C1 protein 0.015 0.1661 0.1954
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0068
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0032 0.0000012059
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0036 0.0042
Schistosoma mansoni lamin 0.0029 0.0245 0.0274
Trypanosoma brucei ATP-binding cassette protein, putative 0.0029 0.0253 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0013 0.0015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0036 0.0079
Echinococcus granulosus expressed protein 0.0009 0.0015 0.0018
Onchocerca volvulus 0.0025 0.0205 0.0665
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0072 0.0084
Echinococcus multilocularis sterol regulatory element binding protein 0.0045 0.0435 0.0435
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0357
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Entamoeba histolytica P-glycoprotein-2 0.0011 0.0037 0.0018
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0205 0.0601
Brugia malayi hypothetical protein 0.001 0.0032 0.0068
Plasmodium vivax multidrug resistance protein 1, putative 0.0011 0.0037 0.0065
Echinococcus multilocularis lipoxygenase domain containing protein 0.0077 0.0809 0.0809
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0461 0.5289 0.5289
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0032 0.0068
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.015 0.041
Entamoeba histolytica P-glycoprotein-5 0.0011 0.0037 0.0018
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.015 0.5218
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0037 0.0037
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0256 0.2901 1
Echinococcus granulosus lamin dm0 0.0029 0.0245 0.0289
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0036 0.0027
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0086 0.0912 0.106
Brugia malayi ABC transporter family protein 0.0011 0.0037 0.0085
Loa Loa (eye worm) hypothetical protein 0.0019 0.013 0.0407
Echinococcus granulosus tar DNA binding protein 0.0063 0.0644 0.0758
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0036 0.0079
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0256 0.2901 1
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0256 0.2901 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0036 0.0079
Schistosoma mansoni patched 1 0.0045 0.0435 0.0498
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.051 0.1722
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.015 0.5327
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0067
Echinococcus granulosus RUN 0.0077 0.0809 0.0952
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0205 0.0657
Echinococcus granulosus intermediate filament protein 0.0029 0.0245 0.0289
Brugia malayi hypothetical protein 0.0252 0.2852 0.9831
Echinococcus multilocularis ferritin 0.0009 0.0015 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0036 0.0027
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0357
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0011 0.0037 0.0129
Trypanosoma brucei ABC transporter, putative 0.0029 0.0253 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0205 0.7761
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0011 0.0037 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0036 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0036 0.0079
Trichomonas vaginalis abcb9, putative 0.0011 0.0037 0.0129
Loa Loa (eye worm) hypothetical protein 0.0105 0.1135 0.3885
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0068
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0011 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0036 0.0079
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0256 0.2901 1
Entamoeba histolytica P-glyco protein 6, putative 0.0011 0.0037 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0036 0.0042
Onchocerca volvulus 0.0029 0.0245 0.0805
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0032 0.0898
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0357 0.0406
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0037 0.0044
Schistosoma mansoni lipoxygenase 0.0461 0.5289 0.622
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0036 0.0027
Schistosoma mansoni DNA polymerase eta 0.0021 0.015 0.0162
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0011 0.0037 0.0129
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.015 0.5327
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0461 0.5289 0.6225
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0032 0.0814
Loa Loa (eye worm) hypothetical protein 0.001 0.0032 0.0068
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0131 0.1439 0.1439
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0032 0.0814
Schistosoma mansoni topbp1 0.001 0.0032 0.0023
Loa Loa (eye worm) hypothetical protein 0.0045 0.0435 0.1464
Entamoeba histolytica P-glycoprotein 5, putative 0.0011 0.0037 0.0018
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0036 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0032 0.0111
Echinococcus granulosus death domain containing protein 0.0086 0.0912 0.1073
Echinococcus multilocularis multidrug resistance protein 1 0.0011 0.0037 0.0037
Echinococcus granulosus ATP binding cassette sub family G 0.0029 0.0253 0.0298
Onchocerca volvulus 0.001 0.0032 0.0068
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0253 0.0824
Loa Loa (eye worm) hypothetical protein 0.0179 0.2002 0.6886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0118 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0036 0.0079
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0032 0.0111
Echinococcus multilocularis expressed conserved protein 0.0099 0.1061 0.1061
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0011 0.0037 0.0044
Schistosoma mansoni hypothetical protein 0.0086 0.0912 0.106
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0253 0.0253
Trypanosoma brucei unspecified product 0.0014 0.0075 0.1952
Schistosoma mansoni netrin receptor unc5 0.0086 0.0912 0.106
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0011 0.0037 0.0514
Schistosoma mansoni ferritin 0.0009 0.0015 0.0003
Treponema pallidum DNA ligase (lig) 0.001 0.0032 1
Schistosoma mansoni ferritin 0.0009 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0204
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0205 0.0657
Giardia lamblia DINP protein human, muc B family 0.0021 0.015 0.041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0036 0.0027
Echinococcus granulosus lipoxygenase domain containing protein 0.0077 0.0809 0.0952
Schistosoma mansoni multidrug resistance protein 0.0011 0.0037 0.0029
Echinococcus granulosus dna polymerase kappa 0.0021 0.015 0.0176
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0029 0.0253 0.0824
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0075 0.1952
Loa Loa (eye worm) RNA binding protein 0.0063 0.0644 0.2185
Echinococcus granulosus lamin 0.0029 0.0245 0.0289
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0013 0.0013
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0032 0.0111
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0032 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.015 0.5327
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0029 0.0253 1
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0036 0.0042
Echinococcus multilocularis Polycystic kidney disease protein 0.0077 0.0809 0.0809
Trypanosoma brucei unspecified product 0.0021 0.015 0.5327
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.013 1
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0256 0.2901 1
Schistosoma mansoni intermediate filament proteins 0.0029 0.0245 0.0274
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.015 0.0162
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0036 0.0079
Echinococcus granulosus survival motor neuron protein 1 0.0252 0.2852 0.3357
Plasmodium vivax multidomain scavenger receptor, putative 0.0077 0.0809 1
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0036 0.0079
Echinococcus multilocularis survival motor neuron protein 1 0.0252 0.2852 0.2852
Onchocerca volvulus Bile acid receptor homolog 0.0011 0.0036 0.0079
Brugia malayi hypothetical protein 0.001 0.0032 0.0068
Loa Loa (eye worm) hypothetical protein 0.0077 0.0809 0.2757
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0032 0.0059
Loa Loa (eye worm) hypothetical protein 0.0011 0.0036 0.0079
Echinococcus multilocularis ATP binding cassette sub family G 0.0029 0.0253 0.0253
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0245 0.0805

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) = 0.003 mg l-1 Tested in vitro for minimum inhibitory concentration against Trichophyton mentagrophytes ChEMBL. 8410994
MIC (functional) = 0.003 mg l-1 Tested in vitro for minimum inhibitory concentration against Microsporum canis ChEMBL. 8410994
MIC (functional) = 0.1 mg l-1 Tested in vitro for minimum inhibitory concentration against Aspergillus fumigatus ChEMBL. 8410994
MIC (functional) = 0.1 mg l-1 Tested in vitro for minimum inhibitory concentration against Sporothrix schenck ii ChEMBL. 8410994
MIC (functional) = 0.1 mg l-1 Tested in vitro for minimum inhibitory concentration against Candida parapsilosis 39 ChEMBL. 8410994
MIC (functional) = 0.8 mg l-1 Tested in vitro for minimum inhibitory concentration against Candida albicans 9 ChEMBL. 8410994
MIC (functional) = 0.8 mg l-1 Tested in vitro for minimum inhibitory concentration against Candida albicans 9 ChEMBL. 8410994
MIC (functional) = 1.56 mg l-1 Tested in vitro for minimum inhibitory concentration against Candida albicans 124 ChEMBL. 8410994
MIC (functional) = 1.56 mg l-1 Tested in vitro for minimum inhibitory concentration against Candida albicans 124 ChEMBL. 8410994

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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