Detailed information for compound 1591587

Basic information

Technical information
  • TDR Targets ID: 1591587
  • Name: 2-amino-3-bromo-N-[[(2S)-1-ethylpyrrolidin-2- yl]methyl]-5,6-dimethoxybenzamide
  • MW: 386.284 | Formula: C16H24BrN3O3
  • H donors: 2 H acceptors: 1 LogP: 2.66 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCC[C@H]1CNC(=O)c1c(N)c(Br)cc(c1OC)OC
  • InChi: 1S/C16H24BrN3O3/c1-4-20-7-5-6-10(20)9-19-16(21)13-14(18)11(17)8-12(22-2)15(13)23-3/h8,10H,4-7,9,18H2,1-3H3,(H,19,21)/t10-/m0/s1
  • InChiKey: JVZAYLSEXNKOFB-JTQLQIEISA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-amino-3-bromo-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-5,6-dimethoxy-benzamide
  • 2-amino-3-bromo-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-5,6-dimethoxybenzamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Dopamine D2 receptor   444 aa 386 aa 19.7 %
Onchocerca volvulus Dopamine D2 receptor   444 aa 418 aa 23.0 %
Echinococcus granulosus g protein coupled receptor Dopamine D2 receptor   444 aa 457 aa 21.0 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Schistosoma mansoni amine GPCR Dopamine D2 receptor   444 aa 424 aa 32.1 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Dopamine D2 receptor   444 aa 432 aa 30.8 %
Loa Loa (eye worm) hypothetical protein Dopamine D2 receptor   444 aa 433 aa 21.2 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine D2 receptor   444 aa 440 aa 30.0 %
Echinococcus multilocularis g protein coupled receptor Dopamine D2 receptor   444 aa 465 aa 21.5 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Dopamine D2 receptor   444 aa 476 aa 24.2 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus biogenic amine 5HT receptor 0.0083 0.0507 0.0507
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0076 0.0112
Brugia malayi putative neuropeptide receptor NPR1 0.0083 0.0507 0.1014
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0316 0.078
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0039 0.0184 0.0184
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.0507 0.0507
Schistosoma mansoni L-lactate dehydrogenase 0.0374 0.2657 0.2657
Echinococcus granulosus malate dehydrogenase 0.0481 0.345 0.345
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0131 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0025 0.0078 0.0078
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0029 0.0109 0.0109
Echinococcus granulosus cytosolic malate dehydrogenase 0.0522 0.3748 0.3748
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0131 0.0284
Onchocerca volvulus 0.0083 0.0507 0.2665
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0507 0.0507
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0052 0.0052
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0079 0.0478 0.0957
Echinococcus multilocularis chromobox protein 1 0.0086 0.0533 0.0533
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0064 0.017
Onchocerca volvulus 0.012 0.0781 0.4271
Brugia malayi Pre-SET motif family protein 0.0222 0.1533 0.3069
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0137
Brugia malayi hypothetical protein 0.0021 0.0052 0.0104
Brugia malayi chromobox protein homolog 3 0.0054 0.0293 0.0586
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0026 0.0051
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.0507 0.0507
Schistosoma mansoni cpg binding protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0522 0.3748 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.0565 0.1131
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0083 0.0507 0.2665
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0039 0.0186 0.0186
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0522 0.3748 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Echinococcus multilocularis neuropeptide FF receptor 2 0.0083 0.0507 0.0507
Brugia malayi follicle stimulating hormone receptor 0.0083 0.0507 0.1014
Schistosoma mansoni loxhd1 0.0021 0.0052 0.0052
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0118 0.0248
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0076
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0167 0.1131 0.2264
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0078 0.0157
Trypanosoma brucei glycosomal malate dehydrogenase 0.0481 0.345 0.9206
Echinococcus multilocularis allatostatin A receptor 0.0083 0.0507 0.0507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Schistosoma mansoni RAR-like nuclear receptor 0.0025 0.0078 0.0078
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0076 0.0169
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.0507 0.0507
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0076 0.0112
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0064 0.017
Echinococcus granulosus alpha 1A adrenergic receptor 0.0083 0.0507 0.0507
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0078 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0109 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0131 0.0351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0118 0.0248
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0083 0.0507 0.0507
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0507 0.0507
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0076 0.0169
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi M-phase phosphoprotein, mpp8 0.012 0.0781 0.1563
Schistosoma mansoni coup transcription factor 0.0025 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Schistosoma mansoni amine GPCR 0.0083 0.0507 0.0507
Toxoplasma gondii lactate dehydrogenase LDH1 0.0624 0.4508 1
Plasmodium vivax lactate dehydrogenase 0.0624 0.4508 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0131 0.0284
Echinococcus granulosus tachykinin peptides receptor 99D 0.0083 0.0507 0.0507
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0507 0.0507
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0025 0.0078 0.0078
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0743 0.1982
Echinococcus granulosus microtubule associated protein 2 0.0484 0.3468 0.3468
Brugia malayi nuclear receptor NHR-88 0.0025 0.0078 0.0157
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0184 0.0184
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0025 0.0078 0.0078
Echinococcus multilocularis G protein coupled receptor 139 0.0083 0.0507 0.0507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Schistosoma mansoni hypothetical protein 0.0025 0.0081 0.0081
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.009 0.0565 0.1131
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0076 0.0112
Echinococcus multilocularis lactate dehydrogenase a 0.0624 0.4508 0.4508
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0114 0.0237
Schistosoma mansoni biogenic amine receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Loa Loa (eye worm) hypothetical protein 0.069 0.4995 0.4995
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0131 0.0284
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0507 0.0507
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0055 0.0147
Schistosoma mansoni rab6-interacting 0.0021 0.0052 0.0052
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0026
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0114 0.0237
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0083 0.0507 0.1014
Schistosoma mansoni malate dehydrogenase 0.0522 0.3748 0.3748
Brugia malayi Heterochromatin protein 1 0.0086 0.0533 0.1067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0025 0.0078 0.0157
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0076 0.0135
Echinococcus granulosus neuropeptide receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Toxoplasma gondii endonuclease IV APN 0.0081 0.0498 0.1105
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0025 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0083 0.0507 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0025 0.0078 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0076 0.0135
Trypanosoma brucei malate dehydrogenase-related 0.0374 0.2657 0.709
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0076 0.0076
Schistosoma mansoni cpg binding protein 0.0027 0.0094 0.0094
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0083 0.0507 0.0507
Onchocerca volvulus Bile acid receptor homolog 0.0025 0.0078 0.0156
Echinococcus multilocularis carbonic anhydrase II 0.0167 0.1131 0.1131
Echinococcus granulosus lamin 0.0029 0.0109 0.0109
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0248 0.173 0.3731
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Echinococcus granulosus FTZ F1 alpha 0.0025 0.0078 0.0078
Schistosoma mansoni carbonic anhydrase-related 0.009 0.0565 0.0565
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0026 0.0068
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0032 0.0131 0.0131
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0167 0.1131 0.1131
Schistosoma mansoni neuropeptide receptor 0.0083 0.0507 0.0507
Trypanosoma brucei mitochondrial malate dehydrogenase 0.0481 0.345 0.9206
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0167 0.0381
Echinococcus granulosus neuropeptides capa receptor 0.0083 0.0507 0.0507
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0268 0.0715
Leishmania major malate dehydrogenase, putative 0.0374 0.2657 0.5894
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.1368 1 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0076
Schistosoma mansoni neuropeptide receptor 0.0083 0.0507 0.0507
Schistosoma mansoni neuropeptide receptor 0.0083 0.0507 0.0507
Brugia malayi Glycosyl hydrolases family 31 protein 0.0032 0.0131 0.0263
Onchocerca volvulus 0.0083 0.0507 0.2665
Brugia malayi Calcitonin receptor-like protein seb-1 0.0079 0.0478 0.0957
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0135 0.0135
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.0481 0.345 0.9206
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0083 0.0507 0.0507
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.0081 0.0081
Onchocerca volvulus 0.0083 0.0507 0.2665
Leishmania major malate dehydrogenase, putative 0.0624 0.4508 1
Echinococcus granulosus ecdysone induced protein 78C 0.0025 0.0078 0.0078
Echinococcus multilocularis lamin dm0 0.0029 0.0109 0.0109
Chlamydia trachomatis malate dehydrogenase 0.0522 0.3748 1
Onchocerca volvulus 0.0083 0.0507 0.2665
Entamoeba histolytica malate dehydrogenase, putative 0.0522 0.3748 0.8285
Brugia malayi CHD4 protein 0.0026 0.0087 0.0173
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.001 0.0021
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus sex peptide receptor 0.0083 0.0507 0.0507
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0083 0.0507 0.0507
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0026
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0025 0.0078 0.0078
Schistosoma mansoni biogenic amine (5HT) receptor 0.0083 0.0507 0.0507
Leishmania major alpha glucosidase II subunit, putative 0.0032 0.0131 0.0291
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0076 0.0076
Echinococcus multilocularis sex peptide receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) helicase 0.0024 0.0076 0.0076
Echinococcus multilocularis neutral alpha glucosidase AB 0.0032 0.0131 0.0131
Schistosoma mansoni lamin 0.0029 0.0109 0.0109
Onchocerca volvulus 0.0083 0.0507 0.2665
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0127
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0055
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0123 0.0123
Schistosoma mansoni hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus dro:myosuppressin receptor 0.0083 0.0507 0.0507
Schistosoma mansoni microtubule-associated protein tau 0.0484 0.3468 0.3468
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0068
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus carbonic anhydrase II 0.0167 0.1131 0.1131
Schistosoma mansoni hypothetical protein 0.0024 0.0076 0.0076
Echinococcus multilocularis lactate dehydrogenase protein 0.0624 0.4508 0.4508
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.0081 0.0162
Loa Loa (eye worm) hypothetical protein 0.0032 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.009 0.0565 0.0565
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Onchocerca volvulus 0.0056 0.0314 0.1537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Trichomonas vaginalis sucrase-isomaltase, putative 0.0032 0.0131 0.0284
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0025 0.0078 0.0078
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0064 0.017
Plasmodium falciparum carbonic anhydrase 0.009 0.0565 0.1203
Brugia malayi lactate dehydrogenase. 0.0624 0.4508 0.9026
Echinococcus multilocularis neuropeptide receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0293 0.0718
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0268 0.0268
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus g-protein coupled receptor 0.0083 0.0507 0.0507
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0083 0.0507 0.2665
Echinococcus granulosus malate dehydrogenase 0.0481 0.345 0.345
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0507 0.0507
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0078 0.0157
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.0953 0.0953
Schistosoma mansoni alpha-1 adrenergic receptor 0.0083 0.0507 0.0507
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0248 0.173 0.3731
Loa Loa (eye worm) CHromoDomain protein family member 0.0026 0.0087 0.0087
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0025 0.0078 0.0157
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.001
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Echinococcus granulosus allatostatin A receptor 0.0083 0.0507 0.0507
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0078 0.0078
Treponema pallidum fructose-bisphosphate aldolase 0.0248 0.173 1
Schistosoma mansoni rab6-interacting 0.0021 0.0052 0.0052
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0025 0.0078 0.0078
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0167 0.1131 0.2264
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0054 0.0294 0.0294
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Echinococcus granulosus lactate dehydrogenase protein 0.0624 0.4508 0.4508
Schistosoma mansoni lamin 0.0029 0.0109 0.0109
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis neuropeptide Y receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni biogenic amine (5HT) receptor 0.1368 1 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.1533 0.1533
Echinococcus granulosus neuropeptide receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0118 0.0248
Brugia malayi Melatonin receptor type 1A 0.0083 0.0507 0.1014
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0083 0.0507 0.0507
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0837 0.2234
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0083 0.0507 0.0507
Echinococcus granulosus somatostatin receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0064
Echinococcus multilocularis carbonic anhydrase 0.009 0.0565 0.0565
Echinococcus granulosus hypothetical protein 0.0083 0.0507 0.0507
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0076 0.0135
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0507 0.0507
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0057
Echinococcus multilocularis chromobox protein 1 0.0086 0.0533 0.0533
Echinococcus multilocularis RUN 0.0021 0.0052 0.0052
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.6255 0.6255
Echinococcus multilocularis malate dehydrogenase 0.0481 0.345 0.345
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0026 0.0057
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0522 0.3748 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0076 0.0135
Entamoeba histolytica malate dehydrogenase, putative 0.0624 0.4508 1
Trichomonas vaginalis chromobox protein, putative 0.0086 0.0533 0.1363
Echinococcus multilocularis malate dehydrogenase 0.0481 0.345 0.345
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0743 0.1982
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0076 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0025 0.0078 0.0157
Echinococcus granulosus lactate dehydrogenase a 0.0624 0.4508 0.4508
Mycobacterium ulcerans endonuclease IV 0.0081 0.0498 0.1329
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0026 0.0068
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0743 0.1982
Loa Loa (eye worm) hypothetical protein 0.0624 0.4508 0.4508
Toxoplasma gondii histone lysine methyltransferase SET1 0.0049 0.0258 0.0573
Toxoplasma gondii thioredoxin reductase 0.005 0.0268 0.0594
Echinococcus multilocularis chromobox protein 2 0.0024 0.0076 0.0076
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0083 0.0507 0.0507
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0743 0.1982
Schistosoma mansoni thyroid hormone receptor 0.0025 0.0078 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Echinococcus granulosus RUN 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0337 0.2385 0.2385
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0025 0.0078 0.0078
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0052 0.0052
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0167 0.1131 0.3016
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0076 0.0169
Leishmania major malate dehydrogenase 0.0481 0.345 0.7653
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Trypanosoma brucei cytosolic malate dehydrogenase 0.0522 0.3748 1
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0481 0.345 0.9206
Loa Loa (eye worm) CXXC zinc finger family protein 0.0025 0.0083 0.0083
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0135 0.03
Schistosoma mansoni myosin xvIII 0.0083 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus carbonic anhydrase 0.009 0.0565 0.0565
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0268 0.054
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0052 0.0052
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0268 0.0268
Echinococcus multilocularis serotonin receptor 0.1368 1 1
Toxoplasma gondii hypothetical protein 0.009 0.0565 0.1253
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0268 0.0268
Brugia malayi Dopamine receptor 0.0083 0.0507 0.1014
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0025 0.0078 0.0078
Echinococcus granulosus dnaJ subfamily B 0.0359 0.2547 0.2547
Schistosoma mansoni alpha glucosidase 0.0032 0.0131 0.0131
Echinococcus multilocularis carbonic anhydrase 0.009 0.0565 0.0565
Loa Loa (eye worm) neuropeptide F receptor 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0083 0.0507 0.2665
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0052 0.0052
Trypanosoma cruzi malate dehydrogenase, putative 0.0374 0.2657 0.709
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0078 0.0078
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0507 0.0507
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0083 0.0507 0.0507
Echinococcus multilocularis dnaJ subfamily B 0.0359 0.2547 0.2547
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Onchocerca volvulus 0.0083 0.0507 0.2665
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0068
Giardia lamblia Malate dehydrogenase 0.0522 0.3748 1
Leishmania major mitochondrial malate dehydrogenase 0.0481 0.345 0.7653
Schistosoma mansoni polycystin 1-related 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0025 0.0078 0.0078
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0068
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0139 0.0139
Echinococcus multilocularis cpg binding protein 0.0027 0.0094 0.0094
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni opsin-like receptor 0.0083 0.0507 0.0507
Schistosoma mansoni opsin-like receptor 0.0083 0.0507 0.0507
Brugia malayi GnHR receptor homolog 0.0083 0.0507 0.1014
Brugia malayi AKH receptor 0.0083 0.0507 0.1014
Brugia malayi G-protein coupled receptor 0.0083 0.0507 0.1014
Leishmania major carbonic anhydrase-like protein 0.0167 0.1131 0.2508
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.0081 0.0081
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0078 0.0078
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Brugia malayi Dopamine receptor protein 1 0.0083 0.0507 0.1014
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0039 0.0186 0.0373
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.0081 0.0081
Onchocerca volvulus 0.0083 0.0507 0.2665
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0131 0.0125
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.0481 0.345 0.6908
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0083 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0119 0.0774 0.0774
Loa Loa (eye worm) malate dehydrogenase 0.0481 0.345 0.345
Schistosoma mansoni hypothetical protein 0.0359 0.2547 0.2547
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni voltage-gated potassium channel 0.0043 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni biogenic amine receptor 0.0083 0.0507 0.0507
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0064 0.017
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0039 0.0186 0.0186
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.012 0.0781 0.0781
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0083 0.0507 0.0507
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0095 0.0602 0.0602
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0025 0.0078 0.0078
Echinococcus granulosus peptide allatostatin:somatostatin 0.0083 0.0507 0.0507
Brugia malayi Serotonin/octopamine receptor family protein 7 0.069 0.4995 1
Schistosoma mansoni amine GPCR 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0025 0.0081 0.0081
Schistosoma mansoni steroid hormone receptor ad4bp 0.0025 0.0078 0.0078
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0068
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Trichomonas vaginalis malate dehydrogenase, putative 0.0374 0.2657 0.707
Schistosoma mansoni neuropeptide f receptor 76f 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Trichomonas vaginalis set domain proteins, putative 0.0252 0.1759 0.4655
Echinococcus multilocularis lactate dehydrogenase a 0.0624 0.4508 0.4508
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0079 0.0478 0.0478
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0837 0.2234
Schistosoma mansoni hypothetical protein 0.0025 0.0081 0.0081
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0078 0.0078
Onchocerca volvulus 0.0083 0.0507 0.2665
Brugia malayi glutathione reductase 0.005 0.0268 0.0536
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0026 0.0068
Trichomonas vaginalis malate dehydrogenase, putative 0.0182 0.1242 0.3267
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0059 0.033 0.033
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis dro:myosuppressin receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis lamin 0.0029 0.0109 0.0109
Toxoplasma gondii lactate dehydrogenase LDH2 0.0624 0.4508 1
Schistosoma mansoni chromobox protein 0.0024 0.0076 0.0076
Loa Loa (eye worm) steroid hormone receptor 0.0025 0.0078 0.0078
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0068
Schistosoma mansoni amine GPCR 0.0083 0.0507 0.0507
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0076 0.0152
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.009 0.0565 0.1131
Plasmodium vivax SET domain protein, putative 0.0032 0.0135 0.0245
Leishmania major glycosomal malate dehydrogenase 0.0481 0.345 0.7653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0025 0.0081 0.0081
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0083 0.0507 0.1014
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0743 0.1982
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0109 0.0109
Brugia malayi Steroid receptor seven-up type 2 0.0025 0.0078 0.0157
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.0481 0.345 0.9206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi Tachykinin-like peptides receptor 99D 0.0083 0.0507 0.1014
Echinococcus multilocularis g protein coupled receptor 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0252 0.1759 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0025 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0083 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus lysosomal alpha glucosidase 0.0143 0.0953 0.0953
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0837 0.2234
Onchocerca volvulus 0.0025 0.0083 0.0184
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0099 0.0196
Echinococcus multilocularis neuropeptides capa receptor 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0083 0.0507 0.2665
Brugia malayi larval opioid receptor 0.0083 0.0507 0.1014
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0083 0.0507 0.0507
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0135 0.0135
Echinococcus granulosus cpg binding protein 0.0027 0.0094 0.0094
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0076 0.0076
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0027 0.0099 0.0196
Echinococcus granulosus orexin receptor type 2 0.0083 0.0507 0.0507
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0076 0.0152
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0076 0.0135
Echinococcus multilocularis ecdysone induced protein 78C 0.0025 0.0078 0.0078
Mycobacterium tuberculosis Probable reductase 0.0115 0.0743 0.1982
Echinococcus granulosus 7TM GPCR rhodopsin 0.0083 0.0507 0.0507
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0055 0.0111
Mycobacterium ulcerans hypothetical protein 0.0021 0.0055 0.0147
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0167 0.1131 0.1131
Schistosoma mansoni adenoreceptor 0.0083 0.0507 0.0507
Giardia lamblia Fructose-bisphosphate aldolase 0.0248 0.173 0.4578
Echinococcus granulosus g protein coupled receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0025 0.0078 0.0078
Brugia malayi Serotonin receptor 0.0083 0.0507 0.1014
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0522 0.3748 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0025 0.0078 0.0157
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0507 0.0507
Trichomonas vaginalis maltase-glucoamylase, putative 0.0032 0.0131 0.0284
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0118 0.0248
Onchocerca volvulus 0.012 0.0781 0.4271
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0025 0.0078 0.0078
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0032 0.0131 0.0125
Brugia malayi Serotonin receptor 0.0083 0.0507 0.1014
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0083 0.0507 0.0507
Schistosoma mansoni chromobox protein 0.0086 0.0533 0.0533
Echinococcus granulosus L lactate dehydrogenase B chain 0.0624 0.4508 0.4508
Echinococcus multilocularis FTZ F1 alpha 0.0025 0.0078 0.0078
Echinococcus multilocularis L lactate dehydrogenase B chain 0.0624 0.4508 0.4508
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0025 0.0078 0.0157
Loa Loa (eye worm) heterochromatin protein 1 0.0086 0.0533 0.0533
Echinococcus granulosus chromobox protein 1 0.0086 0.0533 0.0533
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.009 0.0565 0.0565
Schistosoma mansoni lipoxygenase 0.0059 0.033 0.033
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi SET domain containing protein 0.0026 0.0089 0.0177
Plasmodium vivax glutathione reductase, putative 0.005 0.0268 0.054
Loa Loa (eye worm) carbonic anhydrase 3 0.0167 0.1131 0.1131
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0068
Schistosoma mansoni malate dehydrogenase 0.0522 0.3748 0.3748
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.0118 0.0248
Echinococcus granulosus G protein coupled receptor 139 0.0083 0.0507 0.0507
Echinococcus granulosus serotonin receptor 0.0083 0.0507 0.0507
Brugia malayi G protein-coupled receptor F59B2.13 0.0083 0.0507 0.1014
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0522 0.3748 0.3748
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0743 0.1982
Trichomonas vaginalis chromobox protein, putative 0.0086 0.0533 0.1363
Echinococcus granulosus GPCR family 2 0.0025 0.0081 0.0081
Echinococcus multilocularis serotonin receptor 0.1368 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0184 0.0184
Echinococcus granulosus neuropeptide Y receptor 0.0083 0.0507 0.0507
Leishmania major cytochrome p450-like protein 0.0023 0.0064 0.0141
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0025 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0076
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0076 0.0112
Echinococcus multilocularis neuropeptide receptor A26 0.0083 0.0507 0.0507
Leishmania major cytosolic malate dehydrogenase 0.0522 0.3748 0.8313
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0032 0.0131 0.0284
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0028 0.0105 0.0105
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.0081 0.0081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0118 0.0248
Schistosoma mansoni intermediate filament proteins 0.0029 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0522 0.3748 0.8285
Brugia malayi nuclear hormone receptor 0.0025 0.0078 0.0157
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0507 0.0507
Echinococcus granulosus 7tm_1 domain containing protein 0.0083 0.0507 0.0507
Schistosoma mansoni malate dehydrogenase 0.0481 0.345 0.345
Trichomonas vaginalis malate dehydrogenase, putative 0.033 0.2333 0.6197
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0507 0.0507
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0522 0.3748 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0026 0.0068
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0121 0.0792 0.2114
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni carbonic anhydrase-related 0.009 0.0565 0.0565
Mycobacterium ulcerans epimerase 0.0021 0.0055 0.0147
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0037 0.0167 0.0381
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0314 0.0314
Brugia malayi hypothetical protein 0.0021 0.0052 0.0104
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.069 0.4995 0.4995
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0507 0.0507
Echinococcus granulosus neutral alpha glucosidase AB 0.0032 0.0131 0.0131
Plasmodium vivax lactate/malate dehydrogenase, putative 0.0374 0.2657 0.5871
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0078 0.0078
Echinococcus multilocularis orexin receptor type 2 0.0083 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0119 0.0774 0.0774
Echinococcus granulosus geminin 0.0119 0.0774 0.0774
Echinococcus multilocularis GPCR, family 2 0.0025 0.0081 0.0081
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0026 0.0057
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0837 0.2234
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0025 0.0078 0.0078
Echinococcus granulosus L lactate dehydrogenase 0.0251 0.1748 0.1748
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0083 0.0507 0.0507
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0026 0.0057
Onchocerca volvulus 0.0083 0.0507 0.2665
Onchocerca volvulus 0.0029 0.0109 0.0333
Schistosoma mansoni amine GPCR 0.0083 0.0507 0.0507
Echinococcus granulosus cytosolic malate dehydrogenase 0.0522 0.3748 0.3748
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0054 0.0293 0.0293
Loa Loa (eye worm) hypothetical protein 0.0034 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0078 0.0157
Schistosoma mansoni biogenic amine receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0109 0.0109
Mycobacterium ulcerans malate dehydrogenase 0.0522 0.3748 1
Echinococcus granulosus neuropeptide s receptor 0.0083 0.0507 0.0507
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0057 0.0316 0.1548
Brugia malayi ORL1-like opioid receptor 0.0083 0.0507 0.1014
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus g protein coupled receptor 0.0083 0.0507 0.0507
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0055 0.002
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0052 0.0058
Schistosoma mansoni amine GPCR 0.0083 0.0507 0.0507
Loa Loa (eye worm) glutathione reductase 0.005 0.0268 0.0268
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0121 0.0792 0.2114
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0118 0.0248
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0025 0.0078 0.0078
Echinococcus multilocularis carbonic anhydrase 0.009 0.0565 0.0565
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Brugia malayi neuropeptide F receptor 0.0083 0.0507 0.1014
Echinococcus multilocularis geminin 0.0119 0.0774 0.0774
Echinococcus multilocularis fmrfamide receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) TYRA-2 protein 0.0083 0.0507 0.0507
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0184 0.0184
Plasmodium falciparum L-lactate dehydrogenase 0.0624 0.4508 1
Brugia malayi putative neuropeptide receptor 0.0083 0.0507 0.1014
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0055 0.0147
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0026 0.0087 0.0087
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0025 0.0078 0.0157
Trichomonas vaginalis chromobox protein, putative 0.0057 0.0316 0.078
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Brugia malayi G protein-coupled receptor 0.0083 0.0507 0.1014
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi hypothetical protein 0.0129 0.0852 0.1705
Schistosoma mansoni malate dehydrogenase 0.0624 0.4508 0.4508
Brugia malayi Latrophilin receptor protein 2 0.0025 0.0081 0.0162
Echinococcus granulosus intermediate filament protein 0.0029 0.0109 0.0109
Echinococcus granulosus neuropeptide FF receptor 2 0.0083 0.0507 0.0507
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0025 0.0078 0.0078
Chlamydia trachomatis endonuclease IV 0.0081 0.0498 0.1269
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0054 0.0293 0.1412
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0081 0.0498 0.0498
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.009 0.0565 0.0565
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0184 0.0184
Echinococcus granulosus neuropeptide receptor A26 0.0083 0.0507 0.0507
Loa Loa (eye worm) malate dehydrogenase 0.0522 0.3748 0.3748
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0055 0.0147
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0076 0.0152
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0131 0.0284
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0039 0.0184 0.0368
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0026 0.0068
Schistosoma mansoni neuropeptide receptor 0.0083 0.0507 0.0507
Loa Loa (eye worm) G-protein coupled receptor 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0033 0.0137 0.0501
Loa Loa (eye worm) hypothetical protein 0.009 0.0565 0.0565
Echinococcus granulosus Chromobox protein 3 0.0024 0.0076 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0083 0.0507 0.0507
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0026 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Echinococcus granulosus Chromo domain 0.0024 0.0076 0.0076
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0081 0.0498 0.0997
Onchocerca volvulus 0.0083 0.0507 0.2665
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0083 0.0507 0.0507
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0025 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0293 0.0718
Schistosoma mansoni chromobox protein 0.0086 0.0533 0.0533
Plasmodium vivax malate dehydrogenase, putative 0.0624 0.4508 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Schistosoma mansoni hypothetical protein 0.0025 0.0081 0.0081
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0268 0.0715
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0076 0.0112
Echinococcus granulosus chromobox protein 2 0.0024 0.0076 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0135 0.0135
Onchocerca volvulus 0.0029 0.0109 0.0333
Brugia malayi Glycosyl hydrolases family 31 protein 0.0143 0.0953 0.1907
Brugia malayi Protein cec-1. 0.0024 0.0076 0.0152
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.0624 0.4508 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0078 0.0078
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus lamin dm0 0.0029 0.0109 0.0109
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0026 0.0057
Onchocerca volvulus 0.0083 0.0507 0.2665
Plasmodium falciparum thioredoxin reductase 0.005 0.0268 0.054
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0081 0.0498 0.1329
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Loa Loa (eye worm) hypothetical protein 0.0079 0.0478 0.0478
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0143 0.0953 0.0953
Schistosoma mansoni alpha-glucosidase 0.0123 0.0806 0.0806
Echinococcus multilocularis neuropeptide receptor 0.0083 0.0507 0.0507
Schistosoma mansoni histamine h1 receptor 0.0083 0.0507 0.0507
Schistosoma mansoni hypothetical protein 0.0021 0.0052 0.0052
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0026 0.0087 0.0087
Echinococcus granulosus g protein coupled receptor 0.0083 0.0507 0.0507
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus granulosus chromobox protein 1 0.0086 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0025 0.0078 0.0078
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0025 0.0078 0.0078
Schistosoma mansoni L-lactate dehydrogenase 0.0624 0.4508 0.4508
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0052 0.0058
Schistosoma mansoni neuropeptide F-like receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis somatostatin receptor 0.0083 0.0507 0.0507
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0083 0.0507 0.1014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0076
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0026 0.0068
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) hypothetical protein 0.012 0.0781 0.0781
Brugia malayi Cytochrome P450 family protein 0.0023 0.0064 0.0127
Onchocerca volvulus Protein ultraspiracle homolog 0.0025 0.0078 0.0156
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0498 0.1054
Echinococcus granulosus tm gpcr rhodopsin 0.0083 0.0507 0.0507
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0083 0.0507 0.0507
Plasmodium falciparum lactate dehydrogenase, putative 0.0374 0.2657 0.5871
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Onchocerca volvulus 0.0083 0.0508 0.2671
Brugia malayi Doublecortin family protein 0.0021 0.0052 0.0104
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0052 0.0052
Echinococcus multilocularis fmrfamide receptor 0.0083 0.0507 0.0507
Plasmodium falciparum malate dehydrogenase 0.0624 0.4508 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0083 0.0507 0.0507
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0167 0.1131 0.1131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0025 0.0078 0.0078
Brugia malayi intermediate filament protein 0.0029 0.0109 0.0217
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0167 0.1131 0.3016
Loa Loa (eye worm) melatonin receptor type 1A 0.0083 0.0507 0.0507
Trypanosoma cruzi malate dehydrogenase, putative 0.0481 0.345 0.9206
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Schistosoma mansoni growth hormone secretagogue receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0083 0.0507 0.0507
Echinococcus multilocularis lactate dehydrogenase a 0.0624 0.4508 0.4508
Trypanosoma brucei carbonic anhydrase-like protein 0.0167 0.1131 0.3016
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0522 0.3748 1
Echinococcus granulosus fmrfamide receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0248 0.173 0.4578
Brugia malayi G-protein coupled receptor 0.0083 0.0507 0.1014
Echinococcus multilocularis microtubule associated protein 2 0.0484 0.3468 0.3468
Loa Loa (eye worm) hypothetical protein 0.0024 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.009 0.0565 0.0565
Echinococcus multilocularis lysosomal alpha glucosidase 0.0143 0.0953 0.0953
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0081 0.0498 0.1054
Schistosoma mansoni chromobox protein 0.0024 0.0076 0.0076
Schistosoma mansoni hypothetical protein 0.0083 0.0507 0.0507
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0602 0.0602
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.0565 0.1131
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.009 0.0565 0.1131
Loa Loa (eye worm) hypothetical protein 0.1368 1 1
Onchocerca volvulus 0.0083 0.0507 0.2665
Trypanosoma brucei glucosidase, putative 0.0032 0.0131 0.0351
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Onchocerca volvulus 0.0025 0.0078 0.0156
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0039 0.0184 0.0184
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0025 0.0078 0.0078
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0135 0.0135
Brugia malayi CXXC zinc finger family protein 0.0025 0.0083 0.0167
Schistosoma mansoni retinoic acid receptor RXR 0.0025 0.0078 0.0078
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0083 0.0507 0.0507
Trichomonas vaginalis hypothetical protein 0.0024 0.0076 0.0135
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0076 0.0112
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0059 0.033 0.033
Echinococcus granulosus lactate dehydrogenase a 0.0624 0.4508 0.4508
Brugia malayi neuropeptide F receptor 0.0083 0.0507 0.1014
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0064 0.0064
Schistosoma mansoni carbonic anhydrase-related 0.009 0.0565 0.0565
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0055 0.03 0.03
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0076 0.0135
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0081 0.0498 0.1329
Brugia malayi RE15519p 0.0083 0.0507 0.1014
Brugia malayi ecdysteroid receptor 0.0025 0.0078 0.0157
Brugia malayi latrophilin 2 splice variant baaae 0.0054 0.0294 0.0589
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0095 0.0602 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0025 0.0078 0.0157
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0121 0.0792 0.2114
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0039 0.0186 0.0186
Schistosoma mansoni cpg binding protein 0.0025 0.0083 0.0083
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0076 0.0135
Echinococcus granulosus carbonic anhydrase 0.009 0.0565 0.0565
Loa Loa (eye worm) hypothetical protein 0.0021 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Echinococcus multilocularis neuropeptide s receptor 0.0083 0.0507 0.0507
Plasmodium falciparum glutathione reductase 0.005 0.0268 0.054
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis L lactate dehydrogenase 0.0251 0.1748 0.1748
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0039 0.0184 0.0184
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0025 0.0078 0.0157
Brugia malayi hypothetical protein 0.0083 0.0507 0.1014
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0522 0.3748 0.7504
Trichomonas vaginalis malate dehydrogenase, putative 0.0522 0.3748 1
Schistosoma mansoni alpha-glucosidase 0.0123 0.0806 0.0806
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0083 0.0507 0.2665
Brugia malayi Dopamine receptor protein 2 0.0083 0.0507 0.1014
Trypanosoma brucei trypanothione reductase 0.005 0.0268 0.0715
Toxoplasma gondii malate dehydrogenase MDH 0.0624 0.4508 1
Brugia malayi sulfakinin receptor protein 0.0083 0.0507 0.1014
Trichomonas vaginalis alpha-glucosidase, putative 0.0032 0.0131 0.0284
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0039 0.0184 0.0184
Schistosoma mansoni hypothetical protein 0.0054 0.0294 0.0294
Brugia malayi Thioredoxin reductase 0.005 0.0268 0.0536
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0522 0.3748 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.003 0.0118 0.0248
Brugia malayi Cytochrome P450 family protein 0.0033 0.0139 0.0278
Brugia malayi Pre-SET motif family protein 0.0032 0.0135 0.0271
Echinococcus multilocularis musashi 0.0029 0.0109 0.0109
Echinococcus granulosus carbonic anhydrase 0.009 0.0565 0.0565
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0083 0.0507 0.1014
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0025 0.0078 0.0156
Schistosoma mansoni carbonic anhydrase 0.009 0.0565 0.0565
Schistosoma mansoni lipoxygenase 0.0021 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0078 0.0078
Brugia malayi photoreceptor-specific nuclear receptor 0.0025 0.0078 0.0157
Brugia malayi steroid hormone receptor 0.0025 0.0078 0.0157
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0026 0.0068
Brugia malayi hypothetical protein 0.012 0.0781 0.1563
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0083 0.0507 0.0507
Onchocerca volvulus 0.0083 0.0507 0.2665
Schistosoma mansoni opsin-like receptor 0.0083 0.0507 0.0507
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0096 0.0188
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0076 0.0076
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0522 0.3748 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0026 0.0087 0.0087
Echinococcus multilocularis g-protein coupled receptor 0.0083 0.0507 0.0507
Echinococcus multilocularis Chromo domain 0.0024 0.0076 0.0076
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Echinococcus multilocularis rhodopsin orphan GPCR 0.0083 0.0507 0.0507
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0025 0.0078 0.0157
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0095 0.0602 0.0602
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0032 0.0131 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0032 0.0131 0.0351
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.069 0.4995 0.4995
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0522 0.3748 0.3748
Echinococcus multilocularis G-protein coupled receptor, putative 0.0083 0.0507 0.0507
Onchocerca volvulus Neuropeptide F receptor homolog 0.0083 0.0507 0.2665
Leishmania major trypanothione reductase 0.005 0.0268 0.0594
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0083 0.0507 0.0507
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0064 0.0064

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 21 nM In vitro ability to inhibit the binding of [3H]-spiperone to dopamine receptor D2 in rat striatal membranes. ChEMBL. 1969484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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