Detailed information for compound 159543

Basic information

Technical information
  • TDR Targets ID: 159543
  • Name: 9-methoxy-2,2,4-trimethyl-5-phenyl-1,5-dihydr ochromeno[3,4-f]quinoline
  • MW: 383.482 | Formula: C26H25NO2
  • H donors: 1 H acceptors: 0 LogP: 5.61 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)c1ccc3c(c1C(O2)c1ccccc1)C(=CC(N3)(C)C)C
  • InChi: 1S/C26H25NO2/c1-16-15-26(2,3)27-21-12-11-19-20-14-18(28-4)10-13-22(20)29-25(24(19)23(16)21)17-8-6-5-7-9-17/h5-15,25,27H,1-4H3
  • InChiKey: QYGXPNCCWFGVRU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-methoxy-2,2,4-trimethyl-5-phenyl-1,5-dihydro[1]benzopyrano[3,4-f]quinoline

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens progesterone receptor Starlite/ChEMBL References
Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0128 0.1689
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0693 0.0395 0.5338
Trichomonas vaginalis PIKK family atypical protein kinase 0.0723 0.0412 0.5576
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1265 0.0739 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.005 0.0007 0.008
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.013 0.0055 0.0156
Leishmania major cytochrome p450-like protein 0.0059 0.0012 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.1244 0.0727 0.9831
Leishmania major phosphatidylinositol kinase, putative 0.0251 0.0128 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Schistosoma mansoni fkbp-rapamycin associated protein 0.0702 0.04 0.5304
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0381 0.0206 0.273
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0323 0.0171 0.0711
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1265 0.0739 0.2125
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0128 0.0127
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.005 0.0007 0.0006
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.0113 0.8812
Trichomonas vaginalis PIKK family atypical protein kinase 0.1255 0.0733 0.9915
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0007 0.008
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0714 0.0407 0.4568
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0128 0.1739
Loa Loa (eye worm) phosphatidylinositol 3 0.013 0.0055 0.0736
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0739 1
Schistosoma mansoni retinoic acid receptor RXR 0.005 0.0007 0.008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.005 0.0007 0.008
Brugia malayi Glycosyl hydrolases family 31 protein 0.0162 0.0074 0.0977
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1288 0.0753 0.0752
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.005 0.0007 0.0081
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1265 0.0739 1
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0308 0.0162 0.0162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0451 0.0249 0.3363
Loa Loa (eye worm) hypothetical protein 0.0491 0.0273 0.3684
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0251 0.0128 0.1689
Brugia malayi Nuclear hormone receptor family member nhr-40 0.005 0.0007 0.008
Echinococcus granulosus serine protein kinase ATM 0.0718 0.041 0.0409
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0128 0.1739
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0128 0.0127
Loa Loa (eye worm) phosphatidylinositol kinase 0.0251 0.0128 0.1721
Loa Loa (eye worm) phosphatidylinositol 3 0.0816 0.0468 0.6332
Schistosoma mansoni RAR-like nuclear receptor 0.005 0.0007 0.008
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0693 0.0395 0.1133
Brugia malayi Nuclear hormone receptor family member nhr-31 0.005 0.0007 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.005 0.0007 0.0081
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0251 0.0128 0.0366
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1288 0.0753 0.2165
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0128 0.1721
Entamoeba histolytica hypothetical protein 0.0621 0.0351 0.3653
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0194 0.0094 0.1239
Schistosoma mansoni alpha-glucosidase 0.0139 0.0061 0.0797
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0007 0.008
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0308 0.0162 0.2198
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0042 0.0002 0.0001
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0074 0.0074
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0381 0.0206 0.2787
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0888 0.0512 0.0511
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0012 0.0161
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0739 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0693 0.0395 0.5236
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0251 0.0128 0.0366
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0042 0.0002 0.0015
Brugia malayi Ets-domain containing protein 0.0073 0.0021 0.0265
Loa Loa (eye worm) hypothetical protein 0.005 0.0006 0.0079
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0888 0.0512 0.6794
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0308 0.0162 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0251 0.0128 0.1689
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0308 0.0162 1
Echinococcus multilocularis FTZ F1 alpha 0.005 0.0007 0.0006
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.005 0.0007 0.0081
Leishmania major hypothetical protein, conserved 0.6058 0.3627 1
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0381 0.0206 0.0591
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.005 0.0007 0.0081
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0006 0.0079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0723 0.0412 0.5576
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0381 0.0206 0.2787
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0007 0.0006
Schistosoma mansoni alpha-glucosidase 0.0139 0.0061 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Echinococcus granulosus ecdysone induced protein 78C 0.005 0.0007 0.0006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.0462 0.0461
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.053 0.0296 0.0295
Loa Loa (eye worm) hypothetical protein 0.0202 0.0098 0.1326
Loa Loa (eye worm) steroid hormone receptor 0.005 0.0007 0.0081
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0693 0.0395 0.1133
Echinococcus multilocularis ecdysone induced protein 78C 0.005 0.0007 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.0685 0.039 0.0389
Loa Loa (eye worm) hypothetical protein 0.078 0.0447 0.6042
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0693 0.0395 0.5338
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1255 0.0733 0.9916
Trichomonas vaginalis PIKK family atypical protein kinase 0.0725 0.0414 0.5597
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.005 0.0007 0.008
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0162 0.2192
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0702 0.04 0.0399
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1265 0.0739 1
Loa Loa (eye worm) fli-1 protein 0.0221 0.011 0.1481
Brugia malayi MH2 domain containing protein 0.0119 0.0048 0.0631
Mycobacterium tuberculosis Conserved hypothetical protein 0.0251 0.0128 1
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0162 0.0446
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0308 0.0162 0.2152
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1265 0.0739 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.1231 0.0719 0.9725
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0308 0.0162 0.057
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1288 0.0753 1
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0308 0.0162 0.2192
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0251 0.0128 0.0366
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0004 0.0045
Schistosoma mansoni hypothetical protein 0.053 0.0296 0.3923
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0308 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.053 0.0296 0.3997
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0693 0.0395 0.4364
Echinococcus granulosus GA binding protein alpha chain 0.0073 0.0021 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.1244 0.0726 0.9824
Brugia malayi Pre-SET motif family protein 0.0204 0.01 0.1316
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0128 0.1689
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0048 0.0643
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0381 0.0206 0.273
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.053 0.0296 0.0295
Echinococcus granulosus retinoic acid receptor rxr beta a 0.005 0.0007 0.0006
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0693 0.0395 0.5338
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0308 0.0162 0.2152
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Loa Loa (eye worm) hypothetical protein 0.0702 0.04 0.5404
Brugia malayi Nuclear hormone receptor family member nhr-14 0.005 0.0007 0.008
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0251 0.0128 0.1739
Brugia malayi Ets-domain containing protein 0.0073 0.0021 0.0265
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0419 0.0229 0.166
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0006 0.0078
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0583 0.0328 0.4436
Leishmania major hypothetical protein, unknown function 0.0251 0.0128 0.035
Trichomonas vaginalis PIKK family atypical protein kinase 0.1255 0.0733 0.9915
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.005 0.0007 0.0081
Schistosoma mansoni ets-related 0.0221 0.011 0.1454
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0012 0.0161
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1265 0.0739 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Schistosoma mansoni microtubule-associated protein tau 0.0685 0.039 0.5171
Trichomonas vaginalis PIKK family atypical protein kinase 0.0718 0.041 0.5542
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0042 0.0002 0.0001
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0718 0.041 0.5436
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Mycobacterium leprae conserved hypothetical protein 0.0251 0.0128 1
Echinococcus multilocularis GA binding protein alpha chain 0.0073 0.0021 0.002
Entamoeba histolytica hypothetical protein 0.0718 0.041 0.4611
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1288 0.0753 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.005 0.0007 0.0081
Entamoeba histolytica protein kinase rad3, putative 0.0702 0.04 0.4448
Echinococcus granulosus FTZ F1 alpha 0.005 0.0007 0.0006
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0251 0.0128 0.0366
Toxoplasma gondii non-specific serine/threonine protein kinase 0.078 0.0447 0.6107
Brugia malayi Nuclear hormone receptor family member nhr-41 0.005 0.0007 0.008
Schistosoma mansoni thyroid hormone receptor 0.005 0.0007 0.008
Trichomonas vaginalis conserved hypothetical protein 0.0451 0.0249 0.3363
Schistosoma mansoni hypothetical protein 0.0179 0.0085 0.1117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0261 0.0134 0.1811
Brugia malayi steroid hormone receptor 0.005 0.0007 0.008
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0012 0.0161
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.005 0.0007 0.008
Brugia malayi Nuclear hormone receptor family member nhr-1 0.005 0.0007 0.008
Toxoplasma gondii FATC domain-containing protein 0.0718 0.041 0.5598
Leishmania major phosphatidylinositol 3-kinase, putative 0.1231 0.0719 0.198
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0073 0.0021 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.01 0.1341
Loa Loa (eye worm) hypothetical protein 0.0062 0.0014 0.0184
Brugia malayi FAT domain containing protein 0.053 0.0296 0.3923
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.005 0.0007 0.0006
Schistosoma mansoni coup transcription factor 0.005 0.0007 0.008
Brugia malayi Steroid receptor seven-up type 2 0.005 0.0007 0.008
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0621 0.0351 0.3653
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0251 0.0128 0.1689
Trichomonas vaginalis PIKK family atypical protein kinase 0.0803 0.0461 0.6235
Trichomonas vaginalis PIKK family atypical protein kinase 0.1265 0.0739 1
Schistosoma mansoni gabp alpha 0.0073 0.0021 0.0265
Trypanosoma cruzi target of rapamycin kinase 3 0.1255 0.0733 0.2107
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0251 0.0128 0.1721
Trichomonas vaginalis set domain proteins, putative 0.0232 0.0117 0.1578
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.005 0.0007 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1255 0.0733 0.9915
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0267 0.0138 0.0394
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1265 0.0739 0.9816
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0308 0.0162 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.0308 0.0162 0.0446
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0128 0.0127
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.005 0.0007 0.0006
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0128 0.1721
Echinococcus multilocularis lysosomal alpha glucosidase 0.0162 0.0074 0.0074
Onchocerca volvulus 0.0232 0.0117 0.9087
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1255 0.0733 0.2019
Trichomonas vaginalis PIKK family atypical protein kinase 0.1255 0.0733 0.9915
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0702 0.04 0.5304
Trichomonas vaginalis PIKK family atypical protein kinase 0.0736 0.042 0.5682
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0251 0.0128 0.0127
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0583 0.0328 0.4436
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0251 0.0128 0.1727
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0251 0.0128 0.1721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0702 0.04 0.5407
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0007 0.008
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0791 0.0453 0.6127
Schistosoma mansoni Tr4/Tr2 (homologue) 0.005 0.0007 0.008
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1265 0.0739 0.2125
Brugia malayi Cytochrome P450 family protein 0.0126 0.0052 0.0687
Echinococcus multilocularis serine protein kinase ATM 0.0718 0.041 0.0409
Schistosoma mansoni steroid hormone receptor ad4bp 0.005 0.0007 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1231 0.0719 0.9725
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0004 0.0045
Echinococcus granulosus lysosomal alpha glucosidase 0.0162 0.0074 0.0074
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1244 0.0726 0.9824
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1265 0.0739 0.2036
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0251 0.0128 0.0127
Schistosoma mansoni retinoid-x-receptor (RXR) 0.005 0.0007 0.008
Onchocerca volvulus 0.0251 0.0128 1
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1244 0.0726 0.2
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0251 0.0128 0.1727
Schistosoma mansoni thyroid hormone receptor 0.005 0.0007 0.008
Loa Loa (eye worm) hypothetical protein 0.0468 0.0259 0.3493
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0012 0.0034
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0491 0.0273 0.0272
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0162 0.0074 0.0996
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0718 0.041 0.5538
Echinococcus multilocularis Zinc finger, PHD finger 0.0308 0.0162 0.0162
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0042 0.0002 0.0014
Echinococcus granulosus microtubule associated protein 2 0.0685 0.039 0.0389
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0702 0.04 0.1148
Trichomonas vaginalis PIKK family atypical protein kinase 0.1255 0.0733 0.9915
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0128 0.1721
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0006 0.0078
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0048 0.0643
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.005 0.0007 0.0006
Brugia malayi nuclear receptor NHR-88 0.005 0.0007 0.008
Trichomonas vaginalis conserved hypothetical protein 0.078 0.0447 0.6045
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0702 0.04 0.0399
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0511 0.0284 0.2563
Onchocerca volvulus 0.0094 0.0033 0.2183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.005 0.0007 0.0006
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.005 0.0007 0.008
Leishmania major phosphatidylinositol kinase related protein, putative 0.0267 0.0138 0.0378
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1288 0.0753 0.2165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.005 0.0007 0.0006
Brugia malayi Cytochrome P450 family protein 0.0059 0.0012 0.0158
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0443 0.0243 0.1894
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1231 0.0719 0.9725
Brugia malayi Nuclear hormone receptor-like 1 0.005 0.0007 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.5807 0.3476 1
Schistosoma mansoni hypothetical protein 0.0251 0.0128 0.1689
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0162 0.0466
Brugia malayi Nuclear hormone receptor family member nhr-3 0.005 0.0007 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.1231 0.0719 0.9725
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0128 0.1727
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0012 0.0034
Echinococcus multilocularis geminin 0.0179 0.0085 0.0084
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0308 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.005 0.0007 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.1252 0.0731 0.9894
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0162 0.2216
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0381 0.0206 0.2787
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1288 0.0753 0.0752
Leishmania major phosphatidylinositol 4-kinase, putative 0.0251 0.0128 0.035
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0271 0.014 0.189
Trichomonas vaginalis PIKK family atypical protein kinase 0.0723 0.0412 0.5576
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0251 0.0128 0.1689
Loa Loa (eye worm) phosphatidylinositol 3 0.1244 0.0726 0.9824
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0381 0.0206 0.2781
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0718 0.041 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0251 0.0128 0.1727
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.005 0.0007 0.0081
Trichomonas vaginalis PIKK family atypical protein kinase 0.1231 0.0719 0.9725
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.005 0.0007 0.0006
Brugia malayi photoreceptor-specific nuclear receptor 0.005 0.0007 0.008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.005 0.0007 0.008
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0491 0.0273 0.3616
Brugia malayi Cytochrome P450 family protein 0.0059 0.0012 0.0158
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1265 0.0739 0.0739
Trichomonas vaginalis PIKK family atypical protein kinase 0.1244 0.0727 0.9831
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0308 0.0162 0.2216
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.005 0.0007 0.0006
Echinococcus granulosus geminin 0.0179 0.0085 0.0084
Loa Loa (eye worm) hypothetical protein 0.0251 0.0128 0.1721
Brugia malayi nuclear hormone receptor 0.005 0.0007 0.008
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1265 0.0739 0.9816
Schistosoma mansoni nuclear hormone receptor 0.005 0.0007 0.008
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0308 0.0162 0.2198
Loa Loa (eye worm) phosphatidylinositol 3 0.1265 0.0739 1
Onchocerca volvulus 0.0251 0.0128 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0714 0.0407 0.5506
Echinococcus multilocularis 0.0251 0.0128 0.0127
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0718 0.041 0.5436
Loa Loa (eye worm) cytochrome P450 family protein 0.0126 0.0052 0.07
Trichomonas vaginalis conserved hypothetical protein 0.053 0.0296 0.4001
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0308 0.0162 0.2198
Loa Loa (eye worm) phosphatidylinositol 3 0.0251 0.0128 0.1721
Brugia malayi ecdysteroid receptor 0.005 0.0007 0.008
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0308 0.0162 0.2152
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1265 0.0739 0.2036
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0888 0.0512 0.0511
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Echinococcus multilocularis thyroid hormone receptor alpha 0.005 0.0007 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-49 0.005 0.0007 0.008
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0308 0.0162 0.0466
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0468 0.0259 0.0742
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0012 0.0161
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0012 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0007 0.0006
Brugia malayi Fli-1 protein 0.0221 0.011 0.1454
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.6631 1 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.005 0.0007 0.008
Echinococcus granulosus nuclear receptor 2DBD gamma 0.005 0.0007 0.0006
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0491 0.0273 0.0272
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0381 0.0206 0.1281
Giardia lamblia GTOR 0.1265 0.0739 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0381 0.0206 0.1281
Toxoplasma gondii target of rapamycin (TOR), putative 0.1252 0.0731 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1242 0.0725 0.981
Schistosoma mansoni hypothetical protein 0.0179 0.0085 0.1117

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18 nM Binding affinity for glucocorticoid receptor ChEMBL. 11520196
Ki (binding) = 18 nM Binding affinity for glucocorticoid receptor ChEMBL. 11520196
Ki (binding) = 390 nM Binding affinity for progesterone receptor ChEMBL. 11520196
Ki (binding) = 390 nM Binding affinity for progesterone receptor ChEMBL. 11520196

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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