Detailed information for compound 1603098

Basic information

Technical information
  • TDR Targets ID: 1603098
  • Name: 5-acetyl-4-amino-2-methyl-6-phenylpyridazin-3 -one
  • MW: 243.261 | Formula: C13H13N3O2
  • H donors: 1 H acceptors: 2 LogP: 1.42 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1c(nn(c(=O)c1N)C)c1ccccc1
  • InChi: 1S/C13H13N3O2/c1-8(17)10-11(14)13(18)16(2)15-12(10)9-6-4-3-5-7-9/h3-7H,14H2,1-2H3
  • InChiKey: RZDNYNCXGHYUOC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-acetyl-4-amino-2-methyl-6-phenyl-pyridazin-3-one
  • 5-acetyl-4-amino-2-methyl-6-phenyl-3-pyridazinone
  • 4-amino-5-ethanoyl-2-methyl-6-phenyl-pyridazin-3-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cyclin-dependent kinase 5 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL No references
Homo sapiens kinase insert domain receptor Starlite/ChEMBL No references
Homo sapiens CDC-like kinase 4 Starlite/ChEMBL No references
Homo sapiens glycogen synthase kinase 3 alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana Get druggable targets OG5_126990 All targets in OG5_126990
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 10 Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus dual specificity protein kinase clk2 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08823 CDC-like kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) CMGC/CLK protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum expressed protein Get druggable targets OG5_126990 All targets in OG5_126990
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii protein serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Neospora caninum hypothetical protein Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Babesia bovis protein serine/threonine kinase 1 Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense kinetoplastid kinetochore protein, putative Get druggable targets OG5_126990 All targets in OG5_126990
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Cryptosporidium hominis serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Cryptosporidium parvum serine/threonine kinase-1 Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC CLK Get druggable targets OG5_126990 All targets in OG5_126990
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative Get druggable targets OG5_126990 All targets in OG5_126990
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei kinetoplastid kinetochore protein 19 Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium berghei serine/threonine kinase-1, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Schistosoma japonicum Serine/threonine-protein kinase Doa, putative Get druggable targets OG5_126990 All targets in OG5_126990
Theileria parva serine/threonine protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_126990 All targets in OG5_126990
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126990 All targets in OG5_126990
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 5 260 aa 307 aa 28.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus granulosus dual specificity protein kinase clk2 0.0075 0.117 0.1131
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0289 0.1001
Trypanosoma brucei cdc2-related kinase 3 0.0054 0.0799 0.3304
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0075 0.117 0.323
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0142
Giardia lamblia Kinase, CMGC GSK 0.0117 0.1923 1
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0017 0.0153 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Plasmodium falciparum protein serine/threonine kinase-1 0.0075 0.117 0.3299
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0117 0.1923 0.1888
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.0799 0.0758
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0054 0.0799 0.3304
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0799 0.3806
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.0518
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.004 0.0552 0.1836
Leishmania major hypothetical protein, conserved 0.0208 0.3533 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0109 0.0065
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.004 0.0552 0.051
Echinococcus multilocularis 0.0072 0.113 0.1091
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0244 0.0657
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.0552 0.179
Echinococcus multilocularis cyclin dependent kinase 5 0.0054 0.0799 0.0758
Giardia lamblia Kinase, CMGC CDK 0.0054 0.0799 0.1798
Echinococcus granulosus twitchin 0.0016 0.0134 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Brugia malayi intracellular kinase 0.0117 0.1923 0.6182
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0054 0.0799 0.259
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0025 0.0289 0.0271
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0017 0.0153 0.011
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Loa Loa (eye worm) hypothetical protein 0.0025 0.0289 0.0938
Loa Loa (eye worm) hypothetical protein 0.0015 0.0109 0.0353
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.1923 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.004 0.0552 0.2704
Loa Loa (eye worm) hypothetical protein 0.0072 0.113 0.3665
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus granulosus roundabout 2 0.0018 0.016 0.0116
Plasmodium vivax glycogen synthase kinase 3, putative 0.0117 0.1923 1
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0153 0.0251
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.117 0.599
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0075 0.117 0.323
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0075 0.117 0.323
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0142
Brugia malayi Protein kinase domain containing protein 0.0075 0.117 0.3703
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.1923 0.6237
Entamoeba histolytica protein kinase, putative 0.0117 0.1923 1
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0054 0.0799 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0799 0.4015
Echinococcus multilocularis neuroglian 0.0014 0.0095 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.004 0.0552 0.1352
Schistosoma mansoni nephrin 0.0014 0.0095 0.0271
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.004 0.0552 0.051
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.004 0.0552 0.1836
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Giardia lamblia Kinase, CMGC GSK 0.0117 0.1923 1
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0117 0.1923 0.1888
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0117 0.1923 1
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0054 0.0799 0.0827
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Loa Loa (eye worm) hypothetical protein 0.0015 0.0107 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus multilocularis cyclin dependent kinase 1 0.0054 0.0799 0.0758
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0117 0.1923 0.5521
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.004 0.0552 0.051
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0075 0.117 0.3793
Plasmodium vivax serine/threonine kinase-1, putative 0.0075 0.117 0.3299
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.1923 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.004 0.0552 0.051
Giardia lamblia Kinase, CMGC CLK 0.0075 0.117 0.4504
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0022 0.0244 0.0414
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0117 0.1923 0.6237
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0552 0.1672
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0075 0.117 0.5513
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0142
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0142
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.004 0.0552 0.1352
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.004 0.0552 0.1836
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0142
Echinococcus multilocularis protein kinase shaggy 0.0117 0.1923 0.1888
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0075 0.117 0.5513
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus granulosus serine protein kinase ATM 0.0022 0.0244 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0022 0.0244 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.0117 0.1923 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.004 0.0552 0.1836
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.004 0.0552 0.1352
Leishmania major protein kinase, putative 0.0075 0.117 0.2072
Echinococcus granulosus neuroglian 0.0014 0.0095 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0075 0.117 0.599
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.004 0.0552 0.1836
Echinococcus granulosus cyclin dependent kinase 1 0.0054 0.0799 0.0758
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.0799 0.3304
Giardia lamblia Kinase, CMGC CDK 0.0054 0.0799 0.1798
Echinococcus multilocularis dual specificity protein kinase clk2 0.0075 0.117 0.1131
Trypanosoma brucei cdc2-related kinase 1 0.0054 0.0799 0.3304
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus granulosus protein kinase shaggy 0.0117 0.1923 0.1888
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Toxoplasma gondii target of rapamycin (TOR), putative 0.004 0.0552 0.1836
Loa Loa (eye worm) hypothetical protein 0.0018 0.016 0.0518
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0572 1 1
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.0799 0.2101
Echinococcus granulosus cyclin dependent kinase 0.0054 0.0799 0.0758
Loa Loa (eye worm) hypothetical protein 0.0011 0.0044 0.0142
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.004 0.0552 0.1352
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0022 0.0244 0.0414
Loa Loa (eye worm) phosphatidylinositol 3 0.004 0.0552 0.179
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0799 0.4015
Trypanosoma cruzi cdc2-related kinase 1 0.0054 0.0799 0.2101
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.3084 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0799 0.259
Plasmodium falciparum glycogen synthase kinase 3 0.0117 0.1923 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0022 0.0244 0.0657
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0799 0.3806
Loa Loa (eye worm) hypothetical protein 0.0052 0.0759 0.2461
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.0799 0.2101
Trichomonas vaginalis CMGC family protein kinase 0.0075 0.117 0.585
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Loa Loa (eye worm) hypothetical protein 0.0017 0.0153 0.0496
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0054 0.0799 0.0758
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.004 0.0552 0.1672
Echinococcus multilocularis serine protein kinase ATM 0.0022 0.0244 0.0201
Echinococcus multilocularis cyclin dependent kinase 0.0054 0.0799 0.0758
Leishmania major protein kinase, putative 0.0075 0.117 0.2072
Trypanosoma cruzi hypothetical protein, conserved 0.02 0.3396 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trypanosoma brucei target of rapamycin kinase 3, putative 0.004 0.0552 0.1836
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0799 0.3806
Brugia malayi cell division control protein 2 homolog 0.0054 0.0799 0.2482
Onchocerca volvulus 0.0167 0.2802 0.9271
Echinococcus granulosus hypothetical protein 0.0072 0.113 0.1091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0117 0.1923 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0022 0.0244 0.1062
Trypanosoma cruzi target of rapamycin kinase 3 0.004 0.0552 0.1352
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.004 0.0552 0.2704
Brugia malayi FAT domain containing protein 0.0017 0.0153 0.0359
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.2871 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0289 0.1001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0025 0.0289 0.0271
Echinococcus granulosus cyclin dependent kinase 5 0.0054 0.0799 0.0758
Entamoeba histolytica protein kinase domain containing protein 0.0117 0.1923 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0244 0.075
Loa Loa (eye worm) hypothetical protein 0.0022 0.0244 0.079
Entamoeba histolytica cell division protein kinase 2, putative 0.0054 0.0799 0.3304
Brugia malayi Protein kinase domain containing protein 0.0054 0.0799 0.2482
Trypanosoma brucei protein kinase, putative 0.0117 0.1923 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0075 0.117 0.323
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0022 0.0244 0.0201
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Schistosoma mansoni cell adhesion molecule 0.0015 0.0109 0.0346
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0054 0.0799 0.259
Trypanosoma cruzi cdc2-related kinase 3 0.0054 0.0799 0.2101
Echinococcus multilocularis roundabout 2 0.0018 0.016 0.0116
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0552 0.2448
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0075 0.117 0.5513
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0117 0.1923 0.4601
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.3084 1
Schistosoma mansoni hypothetical protein 0.0017 0.0153 0.0581
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.004 0.0552 0.1836
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0022 0.0244 0.1062

Activities

Activity type Activity value Assay description Source Reference
Ki (functional) = 4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FLT1 ChEMBL. No reference
Ki (functional) > 4 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CAMK1D ChEMBL. No reference
Ki (functional) = 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSF1R ChEMBL. No reference
Ki (functional) > 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1A ChEMBL. No reference
Ki (functional) = 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: DYRK1B ChEMBL. No reference
Ki (functional) = 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: LRRK2 ChEMBL. No reference
Ki (functional) > 4.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PDGFRB ChEMBL. No reference
Ki (functional) > 4.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: STK6 ChEMBL. No reference
Ki (functional) = 4.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: FGFR1 ChEMBL. No reference
Ki (functional) > 4.2 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK9 ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKCQ ChEMBL. No reference
Ki (functional) = 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CSNK1A1 ChEMBL. No reference
Ki (functional) > 4.3 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: PRKACA ChEMBL. No reference
Ki (functional) = 4.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK8 ChEMBL. No reference
Ki (functional) = 4.7 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: KDR ChEMBL. No reference
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3A ChEMBL. No reference
Ki (functional) = 5.1 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CLK4 ChEMBL. No reference
Ki (functional) = 5.5 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: CDK5 ChEMBL. No reference
Ki (functional) = 5.9 PUBCHEM_BIOASSAY: Navigating the Kinome. (Class of assay: other) Panel member name: GSK3B ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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