Detailed information for compound 1607221

Basic information

Technical information
  • TDR Targets ID: 1607221
  • Name: 3-methyl-3-pent-4-enylazepan-2-one
  • MW: 195.301 | Formula: C12H21NO
  • H donors: 1 H acceptors: 1 LogP: 2.72 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C=CCCCC1(C)CCCCNC1=O
  • InChi: 1S/C12H21NO/c1-3-4-5-8-12(2)9-6-7-10-13-11(12)14/h3H,1,4-10H2,2H3,(H,13,14)
  • InChiKey: FAOGVEXBWUZQDE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-methyl-3-pent-4-enyl-azepan-2-one
  • 3-methyl-3-pent-4-enyl-2-azepanone
  • AIDS-143185
  • AIDS143185
  • NSC663573
  • NCI60_021805
  • 3-Methyl-3-(4-pentenyl)-2-azepanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0093 0.087 0.5725
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0277 0.0401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.003 0.0185 0.1215
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0344 0.2261
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.013 0.0856
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0382 0.2239
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0653 0.4294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.023 0.1514
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0071 0.0635 0.1201
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0272 0.2843 0.4121
Mycobacterium ulcerans aldehyde dehydrogenase 0.003 0.0186 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Echinococcus granulosus fetal alzheimer antigen falz 0.0014 0.0006 0.0008
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0039 0.0285 0.3102
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0446 0.4753 0.5
Schistosoma mansoni tyrosine kinase 0.0184 0.1876 0.2753
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0111 0.1075 0.1558
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0048 0.0382 0.0554
Echinococcus granulosus sterol regulatory element binding protein 0.0027 0.0153 0.0224
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0048 0.0382 0.0561
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0023 0.0109 0.0158
Brugia malayi glutaminase DH11.1 0.0152 0.152 0.2204
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0021 0.0084 0.0123
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0009 0.0013
Onchocerca volvulus Matrilysin homolog 0.0115 0.1121 0.974
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0021 0.0084 0.0078
Giardia lamblia GTOR 0.0073 0.0653 0.446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0073 0.0653 0.4971
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0099 0.019
Echinococcus granulosus expressed conserved protein 0.006 0.0508 0.0745
Trichomonas vaginalis glutaminase, putative 0.0152 0.152 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0022 0.0099 0.019
Brugia malayi Protein kinase domain containing protein 0.0641 0.6899 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0048 0.0377 0.2477
Schistosoma mansoni rab6-interacting 0.0069 0.0611 0.0897
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.003 0.0186 0.0245
Onchocerca volvulus 0.0052 0.0425 0.36
Brugia malayi hypothetical protein 0.0069 0.0611 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0344 0.2261
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0022 0.0099 0.0651
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.037 0.0543
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0023 0.0108 0.0159
Brugia malayi hypothetical protein 0.0069 0.0611 0.0886
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0095 0.09 0.09
Loa Loa (eye worm) phosphatidylinositol 3 0.0073 0.0653 0.0946
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Loa Loa (eye worm) TK/EGFR protein kinase 0.034 0.3593 0.5208
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Loa Loa (eye worm) hypothetical protein 0.0088 0.0816 0.1183
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Leishmania major phosphatidylinositol 3-kinase, putative 0.0022 0.0099 0.1012
Echinococcus multilocularis Niemann Pick C1 protein 0.0063 0.055 0.055
Loa Loa (eye worm) matrixin family protein 0.0115 0.1121 0.1624
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0022 0.0099 0.019
Brugia malayi Pre-SET motif family protein 0.0104 0.0993 0.1439
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0111 0.1068 0.1567
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0446 0.4753 1
Echinococcus granulosus tumor protein p63 0.0425 0.452 0.6632
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0523 0.3438
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0095 0.09 0.1877
Brugia malayi Matrixin family protein 0.0052 0.0425 0.0616
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0014 0.0009 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.0552
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0153 0.1003
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0189 0.193 0.193
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0058
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0412 0.4385 0.6433
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0093 0.087 0.5725
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0023 0.0109 0.0718
Loa Loa (eye worm) hypothetical protein 0.0023 0.0109 0.0158
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0022 0.0099 0.0143
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0071 0.0635 0.122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.237
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0048 0.0382 0.2239
Schistosoma mansoni tyrosine kinase 0.0184 0.1876 0.2753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.023 0.1514
Entamoeba histolytica hypothetical protein 0.003 0.0183 0.0793
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0035 0.0243 0.1618
Trypanosoma cruzi target of rapamycin kinase 3 0.0061 0.0523 0.3971
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0653 0.4294
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0061 0.0523 0.5776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0507 0.3333
Schistosoma mansoni fkbp-rapamycin associated protein 0.0021 0.0084 0.0123
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0014 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.2366
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0014 0.0009 0.0013
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0088 0.0816 0.1197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0523 0.3438
Schistosoma mansoni hypothetical protein 0.0023 0.0108 0.0159
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0062 0.0533 0.3333
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0009 0.0058
Mycobacterium ulcerans hydrolase 0.0063 0.0549 0.1018
Loa Loa (eye worm) hypothetical protein 0.0044 0.0342 0.0496
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0146 0.1453 1
Schistosoma mansoni tyrosine kinase 0.034 0.3593 0.5271
Loa Loa (eye worm) hypothetical protein 0.0063 0.055 0.0797
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0014 0.0009 0.0013
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0023 0.0109 0.0158
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0048 0.0382 0.2881
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Toxoplasma gondii target of rapamycin (TOR), putative 0.0058 0.049 0.1014
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0015 0.0017 0.0018
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0048 0.0382 0.2513
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0344 0.2261
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Brugia malayi CHE-14 protein 0.0027 0.0153 0.0221
Plasmodium falciparum LCCL domain-containing protein 0.0069 0.0611 0.127
Echinococcus multilocularis G protein coupled receptor 139 0.0104 0.0996 0.0996
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0033 0.0219 0.2362
Brugia malayi Matrixin family protein 0.0126 0.1235 0.179
Trypanosoma brucei RNA helicase, putative 0.0041 0.0302 0.329
Echinococcus multilocularis epidermal growth factor receptor 0.0184 0.1876 0.1876
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0132 0.1305 0.1891
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0014 0.0006 0.0006
Echinococcus multilocularis lipoxygenase domain containing protein 0.0069 0.0611 0.0611
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.003 0.0183 0.1952
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0439 0.468 1
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0009 0.0058
Plasmodium vivax multidomain scavenger receptor, putative 0.0069 0.0611 0.127
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Schistosoma mansoni tyrosine kinase 0.018 0.1826 0.2679
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0095 0.09 0.6874
Schistosoma mansoni hypothetical protein 0.0074 0.0664 0.0974
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0412 0.4385 0.4385
Echinococcus granulosus Niemann Pick C1 protein 0.0091 0.0849 0.1245
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.0254
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0039 0.0285 0.3102
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.023 0.0334
Mycobacterium leprae PROBABLE HYDROLASE 0.0063 0.0549 0.1018
Toxoplasma gondii FATC domain-containing protein 0.003 0.0183 0.0366
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Schistosoma mansoni hypothetical protein 0.0026 0.0142 0.0208
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0023 0.0109 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0073 0.0653 0.4294
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0073 0.0653 0.7231
Brugia malayi Pre-SET motif family protein 0.0015 0.0017 0.0025
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0095 0.09 0.132
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0122 0.1199 0.8159
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0073 0.0723
Onchocerca volvulus Matrilysin homolog 0.0052 0.0425 0.36
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0009 0.0058
Loa Loa (eye worm) glutaminase 2 0.0152 0.152 0.2204
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.0254
Loa Loa (eye worm) TK/FAK protein kinase 0.0641 0.6899 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.023 0.1708
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Schistosoma mansoni bromodomain containing protein 0.0039 0.028 0.0411
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0132 0.1305 0.8581
Loa Loa (eye worm) hypothetical protein 0.002 0.0077 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.023 0.1514
Echinococcus granulosus histone lysine methyltransferase setb 0.0025 0.0132 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.037 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0523 0.3438
Onchocerca volvulus 0.0062 0.0537 0.4588
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0035 0.0236 0.2548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.237
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0439 0.468 0.9843
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0446 0.4753 1
Toxoplasma gondii hypothetical protein 0.0025 0.013 0.0256
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0186 0.0273
Schistosoma mansoni neuropeptide receptor 0.0104 0.0996 0.1461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.2366
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0089 0.0585
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0132 0.1305 0.8581
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0048 0.0382 0.4191
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0073 0.0723
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0446 0.4753 1
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0243 0.2526 0.3705
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0106
Schistosoma mansoni tyrosine kinase 0.018 0.1826 0.2679
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.003 0.0183 0.0268
Schistosoma mansoni aldehyde dehydrogenase 0.003 0.0186 0.0273
Entamoeba histolytica hypothetical protein 0.0106 0.1021 0.6872
Echinococcus granulosus lipoxygenase domain containing protein 0.0069 0.0611 0.0897
Echinococcus granulosus neuropeptide receptor 0.0104 0.0996 0.1461
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0088 0.0816 0.1183
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0073 0.0653 0.0958
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0132 0.1305 0.8581
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0014 0.0002 0.0003
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0021 0.0084 0.0084
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0014 0.0009 0.0013
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0014 0.0009 0.0058
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0022 0.0096 0.0141
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0027 0.0153 0.0221
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0099 0.0696
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0013
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0099 0.0696
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0023 0.0109 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0104 0.0993 0.1439
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0052 0.0425 0.0623
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.037 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.013 0.0856
Mycobacterium ulcerans aldehyde dehydrogenase 0.003 0.0186 0.0241
Brugia malayi Matrixin family protein 0.0052 0.0425 0.0616
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.037 0.0543
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0021 0.0084 0.058
Echinococcus multilocularis 0.0105 0.1002 0.1002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0256 0.0376
Leishmania major phosphatidylinositol kinase related protein, putative 0.0019 0.0058 0.0554
Echinococcus multilocularis neuropeptide receptor 0.0104 0.0996 0.0996
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0014 0.0009 0.0013
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0014 0.0002 0.0003
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0132 0.0194
Echinococcus granulosus protein tyrosine kinase 0.0634 0.6816 1
Loa Loa (eye worm) matrix metalloproteinase 0.0052 0.0425 0.0616
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0243 0.2526 0.3705
Schistosoma mansoni hypothetical protein 0.0026 0.0142 0.0208
Giardia lamblia Fructose-bisphosphate aldolase 0.0146 0.1453 1
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0039 0.0285 0.0418
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0022 0.0099 0.0145
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0039 0.0285 0.2132
Loa Loa (eye worm) phosphatidylinositol 3 0.0217 0.2243 0.3251
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0106 0.0694
Mycobacterium ulcerans glutaminase 0.0152 0.152 0.3092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.037 0.037
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0034 0.023 0.2485
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0022 0.0099 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0398 0.2619
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Echinococcus multilocularis epidermal growth factor receptor 0.034 0.3593 0.3593
Loa Loa (eye worm) hypothetical protein 0.0062 0.0537 0.0778
Echinococcus granulosus lipoxygenase domain containing protein 0.0069 0.0611 0.0897
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0132 0.1305 0.8924
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0014 0.0009 0.0013
Loa Loa (eye worm) hypothetical protein 0.0052 0.0425 0.0616
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0038 0.0277 0.2066
Brugia malayi Furin-like cysteine rich region family protein 0.034 0.3593 0.5208
Echinococcus multilocularis Niemann Pick C1 protein 0.0091 0.0849 0.0849
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0088 0.0816 0.0816
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0095 0.09 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.023 0.1514
Schistosoma mansoni lipoxygenase 0.0412 0.4385 0.6433
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0022 0.0099 0.0651
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0039 0.0285 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Brugia malayi Bromodomain containing protein 0.0024 0.0112 0.0162
Echinococcus multilocularis protein dispatched 1 0.0031 0.0195 0.0195
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0025 0.0132 0.0192
Echinococcus granulosus epidermal growth factor receptor 0.0184 0.1876 0.2753
Toxoplasma gondii aldehyde dehydrogenase 0.003 0.0186 0.0374
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0022 0.0099 0.0187
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.003 0.0183 0.1342
Schistosoma mansoni hypothetical protein 0.0026 0.0142 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0523 0.3438
Brugia malayi Doublecortin family protein 0.0069 0.0611 0.0886
Schistosoma mansoni hypothetical protein 0.0026 0.0142 0.0208
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Loa Loa (eye worm) hypothetical protein 0.0024 0.0112 0.0163
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0015 0.0017 0.0025
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0014 0.0009 0.0009
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.037 0.037
Schistosoma mansoni tyrosine kinase 0.0634 0.6816 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0009 0.0013
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.037 0.0543
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0025 0.0132 0.0132
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0023 0.0109 0.0718
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0034 0.023 0.023
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0446 0.4753 0.5
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0073 0.0653 0.0946
Plasmodium vivax SET domain protein, putative 0.0015 0.0017 0.0018
Echinococcus multilocularis sterol regulatory element binding protein 0.0027 0.0153 0.0153
Loa Loa (eye worm) hypothetical protein 0.0025 0.0128 0.0186
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0071 0.0635 0.1201
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0446 0.4753 1
Entamoeba histolytica protein kinase rad3, putative 0.0021 0.0084 0.0078
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0058 0.0381
Loa Loa (eye worm) hypothetical protein 0.0069 0.0611 0.0886
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0014 0.0006 0.0008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0023 0.0109 0.0718
Onchocerca volvulus 0.0074 0.0664 0.5707
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0183 0.1201
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.002 0.0077 0.0527
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0015 0.0019 0.0021
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0243 0.2526 0.2526
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0014 0.0009 0.0013
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0015 0.0017 0.0017
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0009 0.0058
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0022 0.0099 0.0145
Schistosoma mansoni glutaminase 0.0152 0.152 0.2231
Schistosoma mansoni hypothetical protein 0.0069 0.0611 0.0897
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Loa Loa (eye worm) hypothetical protein 0.0023 0.0106 0.0153
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0014 0.0009 0.0058
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0039 0.0285 0.2132
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.003 0.0185 0.1358
Schistosoma mansoni tyrosine kinase 0.018 0.1826 0.2679
Schistosoma mansoni loxhd1 0.0069 0.0611 0.0897
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0272 0.2843 0.4171
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0067 0.0587 0.4006
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0023 0.0106 0.0204
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0048 0.0382 0.2513
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0014 0.0011 0.0016
Loa Loa (eye worm) hypothetical protein 0.002 0.0073 0.0106
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0014 0.0009 0.0058
Echinococcus granulosus Polycystic kidney disease protein 0.0069 0.0611 0.0897
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0106 0.1021 0.6872
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.037 0.0537
Schistosoma mansoni polycystin 1-related 0.0069 0.0611 0.0897
Schistosoma mansoni transcription factor LCR-F1 0.0023 0.0108 0.0159
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0132 0.1305 1
Echinococcus granulosus Protein patched homolog 1 0.0027 0.0153 0.0224
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0048 0.0382 0.2513
Loa Loa (eye worm) hypothetical protein 0.0052 0.0425 0.0616
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0039 0.0285 0.2132
Echinococcus multilocularis tumor protein p63 0.0425 0.452 0.452
Echinococcus multilocularis Polycystic kidney disease protein 0.0069 0.0611 0.0611
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0393 0.2586
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0111 0.1068 0.1068
Onchocerca volvulus 0.0069 0.0611 0.5245
Echinococcus granulosus RUN 0.0069 0.0611 0.0897
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0022 0.0099 0.0145
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0132 0.1305 1
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0014 0.0009 0.0009
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0256 0.0256
Schistosoma mansoni lipoxygenase 0.0288 0.3021 0.4433
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Loa Loa (eye worm) matrixin family protein 0.0126 0.1235 0.179
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0272 0.2843 0.2843
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0039 0.0285 0.0418
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0285 0.1875
Loa Loa (eye worm) phosphatidylinositol 3 0.0034 0.023 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.237
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.237
Loa Loa (eye worm) doublecortin family protein 0.0069 0.0611 0.0886
Echinococcus multilocularis expressed conserved protein 0.006 0.0508 0.0508
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0061 0.0523 0.5776
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.023 0.1514
Schistosoma mansoni voltage-gated potassium channel 0.0015 0.0016 0.0023
Brugia malayi Protein kinase domain containing protein 0.0111 0.1068 0.1549
Loa Loa (eye worm) hypothetical protein 0.0063 0.0549 0.0796
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.013 0.0856
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0099 0.1012
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Schistosoma mansoni hypothetical protein 0.0041 0.0302 0.0443
Brugia malayi Matrixin family protein 0.0052 0.0425 0.0616
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0064 0.0561 0.0823
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0015 0.0019 0.0021
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.003 0.0186 0.0273
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0095 0.09 1
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0014 0.0009 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Echinococcus multilocularis serine protein kinase ATM 0.003 0.0183 0.0183
Brugia malayi Hemopexin family protein 0.0074 0.0664 0.0962
Brugia malayi AMP-binding enzyme family protein 0.002 0.0073 0.0106
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.003 0.0186 0.0186
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0073 0.0653 0.4201
Trichomonas vaginalis set domain proteins, putative 0.0118 0.115 0.7563
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0095 0.09 0.6874
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0189 0.193 0.2832
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.037 0.0543
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0073 0.0653 0.4201
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0034 0.023 0.0338
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0073 0.0653 0.4971
Echinococcus granulosus epidermal growth factor receptor 0.034 0.3593 0.5271
Echinococcus multilocularis insulin receptor 0.0111 0.1068 0.1068
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0014 0.0009 0.0013
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0022 0.0099 0.0143
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0039 0.0285 0.1875
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0073 0.0653 0.7231
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0446 0.4753 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0141 0.0205
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0226 0.2341 0.4922
Onchocerca volvulus Matrix metalloproteinase homolog 0.0115 0.1121 0.974
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0025 0.0132 0.0194
Onchocerca volvulus 0.0118 0.115 1
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0039 0.0285 0.1875
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.003 0.0185 0.1215
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0073 0.0653 0.7231
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0009 0.0058
Loa Loa (eye worm) glutaminase 0.0152 0.152 0.2204
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0034 0.023 0.0338
Onchocerca volvulus 0.0069 0.0611 0.5245
Schistosoma mansoni tyrosine kinase 0.0111 0.1068 0.1567
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0039 0.0285 0.1875
Brugia malayi PHD-finger family protein 0.0015 0.0022 0.0032
Schistosoma mansoni cellular tumor antigen P53 0.0062 0.0537 0.0788
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0184 0.1876 0.2753
Schistosoma mansoni tyrosine kinase 0.0111 0.1068 0.1567
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0034 0.023 0.2485
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0014 0.0009 0.0058
Loa Loa (eye worm) TK/INSR protein kinase 0.0111 0.1068 0.1549
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.023 0.1708
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.023 0.2485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.036 0.2366
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0073 0.0653 0.0958
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0022 0.0099 0.0651
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0183 0.0265
Echinococcus multilocularis Zinc finger, PHD finger 0.0022 0.0099 0.0099
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0023 0.0109 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0425 0.0616
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0095 0.09 0.1877
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0146 0.1453 1
Brugia malayi AMP-binding enzyme family protein 0.002 0.0073 0.0106
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0146 0.1453 0.9557
Echinococcus multilocularis RUN 0.0069 0.0611 0.0611
Mycobacterium ulcerans aldehyde dehydrogenase 0.003 0.0186 0.0241
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0022 0.0099 0.1012
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0022 0.0099 0.0145
Brugia malayi hypothetical protein 0.0023 0.0108 0.0157
Brugia malayi Niemann-Pick C1 protein precursor 0.0063 0.055 0.0797
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0014 0.0009 0.0009
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0022 0.0099 0.019
Entamoeba histolytica hypothetical protein 0.0023 0.0108 0.0254
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0021 0.0084 0.0122
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0272 0.2843 0.4171
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0063 0.0549 0.0796
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0063 0.055 0.3455
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0014 0.0009 0.0058
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0022 0.0099 0.0187
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0034 0.023 0.2485
Schistosoma mansoni rab6-interacting 0.0069 0.0611 0.0897
Loa Loa (eye worm) hypothetical protein 0.0021 0.0084 0.0122
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0073 0.0653 0.0653
Loa Loa (eye worm) hypothetical protein 0.0069 0.0611 0.0886
Leishmania major 4-coumarate:coa ligase-like protein 0.002 0.0073 0.0723
Echinococcus multilocularis protein patched 0.0027 0.0153 0.0153
Brugia malayi Matrixin family protein 0.0052 0.0425 0.0616
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0095 0.09 0.1877
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.003 0.0186 0.1991
Echinococcus multilocularis protein tyrosine kinase 0.0634 0.6816 0.6816
Echinococcus granulosus insulin receptor 0.0111 0.1068 0.1567
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0015 0.0017 0.0025
Schistosoma mansoni patched 1 0.0027 0.0153 0.0224
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0523 0.3438
Loa Loa (eye worm) hypothetical protein 0.0027 0.0153 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0084 0.0552
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0073 0.0653 0.7231
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0039 0.0285 0.1875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0058 0.049 0.3222
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0014 0.0009 0.0013
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0014 0.0002 0.0003
Brugia malayi Bromodomain containing protein 0.0046 0.0359 0.0521
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0022 0.0096 0.0096
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0063 0.0549 0.1034
Echinococcus granulosus Niemann Pick C1 protein 0.0063 0.055 0.0807
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0023 0.0108 0.0108
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0014 0.0002 0.0002
Onchocerca volvulus 0.002 0.0073 0.0494
Loa Loa (eye worm) PDE1B protein 0.0272 0.2843 0.4121
Echinococcus multilocularis lipoxygenase domain containing protein 0.0069 0.0611 0.0611
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0446 0.4753 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.022 0.0319
Loa Loa (eye worm) hypothetical protein 0.0043 0.0331 0.0479
Echinococcus granulosus serine protein kinase ATM 0.003 0.0183 0.0268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0393 0.2586
Brugia malayi AMP-binding enzyme family protein 0.002 0.0073 0.0106

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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