TDR Targets

Basic information

Technical information

TDR Targets ID: 1610284
Name: 2-(4-methoxyphenyl)-4-methyl-5,5-di(phenyl)py razolidin-3-one
MW: 358.433 | Formula: C23H22N2O2
H donors: 1 H acceptors: 1 LogP: 4.31 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)N1NC(C(C1=O)C)(c1ccccc1)c1ccccc1
InChi: 1S/C23H22N2O2/c1-17-22(26)25(20-13-15-21(27-2)16-14-20)24-23(17,18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-17,24H,1-2H3
InChiKey: IGVATZBOONVYEJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

2-(4-methoxyphenyl)-4-methyl-5,5-di(phenyl)-3-pyrazolidinone
NSC671945
NCI60_025450
2-(4-Methoxyphenyl)-4-methyl-5,5-diphenyl-3-pyrazolidinone
AIDS-145990
AIDS145990

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	sulfakinin receptor protein	0.0138	0.201	0.201
Schistosoma mansoni	amine GPCR	0.0138	0.201	1
Echinococcus granulosus	neuropeptide receptor	0.0138	0.201	0.2201
Echinococcus granulosus	fmrfamide receptor	0.0138	0.201	0.2201
Echinococcus multilocularis	orexin receptor type 2	0.0138	0.201	0.2142
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0056	0.0713	0.0711
Schistosoma mansoni	voltage-gated potassium channel	0.0035	0.0377	0.1878
Echinococcus multilocularis	serine threonine protein kinase	0.0049	0.0607	0.0594
Echinococcus granulosus	RNA directed DNA polymerase	0.0039	0.0438	0.0479
Onchocerca volvulus		0.0138	0.201	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0138	0.201	0.2142
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Echinococcus multilocularis	g-protein coupled receptor	0.0138	0.201	0.2142
Schistosoma mansoni	opsin-like receptor	0.0138	0.201	1
Echinococcus granulosus	Protein kinase C brain isozyme	0.0055	0.0701	0.0768
Trichomonas vaginalis	cAMP-dependent protein kinase regulatory subunit, putative	0.0016	0.0077	0.0477
Onchocerca volvulus		0.0138	0.201	1
Schistosoma mansoni	hypothetical protein	0.0055	0.0693	0.3447
Echinococcus multilocularis	fmrfamide receptor	0.0138	0.201	0.2142
Echinococcus granulosus	p21 activated protein kinase 1 Dpak1	0.0056	0.0713	0.0781
Schistosoma mansoni	60S ribosomal protein L21	0.0019	0.0126	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Treponema pallidum	cyclic nucleotide binding protein	0.0016	0.0077	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0138	0.201	0.2142
Schistosoma mansoni	voltage-gated potassium channel	0.0024	0.0202	0.1006
Onchocerca volvulus		0.0138	0.201	1
Schistosoma mansoni	hypothetical protein	0.0138	0.201	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Brugia malayi	Melatonin receptor type 1A	0.0138	0.201	0.201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Trichomonas vaginalis	STE family protein kinase	0.0056	0.0713	0.4437
Brugia malayi	neuropeptide F receptor	0.0138	0.201	0.201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	adenoreceptor	0.0138	0.201	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Mycobacterium ulcerans	transmembrane transport protein	0.0016	0.0077	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0532	0.0458
Mycobacterium ulcerans	regulatory protein	0.0016	0.0077	0.5
Loa Loa (eye worm)	G-protein coupled receptor	0.0138	0.201	0.1948
Echinococcus multilocularis	serine:threonine protein kinase PAK 4	0.0586	0.9132	1
Brugia malayi	neuropeptide F receptor	0.0138	0.201	0.201
Trichomonas vaginalis	cAMP-dependent protein kinase type I-beta regulatory subunit, putative	0.0016	0.0077	0.0477
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0041	0.0477	0.0404
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0077	0.5
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0138	0.201	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	neural Wiskott Aldrich syndrome protein	0.0055	0.0693	0.0689
Onchocerca volvulus		0.0138	0.201	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0138	0.201	0.201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	g protein coupled receptor	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	protein kinase	0.0056	0.0713	0.3547
Echinococcus multilocularis	neuropeptides capa receptor	0.0138	0.201	0.2142
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0138	0.201	0.2201
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0138	0.201	1
Onchocerca volvulus		0.0138	0.201	1
Echinococcus granulosus	protein kinase C gamma type	0.0049	0.0607	0.0665
Brugia malayi	larval opioid receptor	0.0138	0.201	0.201
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0138	0.201	1
Trypanosoma cruzi	cAMP binding protein, putative	0.0017	0.0096	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0138	0.201	0.2142
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Leishmania major	protein kinase, putative	0.0017	0.0097	1
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0024	0.0202	0.1006
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.012	0.1732	0.1668
Treponema pallidum	cyclic nucleotide binding protein	0.0016	0.0077	0.5
Echinococcus multilocularis	sex peptide receptor	0.0138	0.201	0.2142
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0035	0.0377	0.0413
Echinococcus granulosus	potassium:sodium hyperpolarization activated	0.0024	0.0202	0.0221
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0016	0.0077	0.0381
Echinococcus granulosus	7tm_1 domain containing protein	0.0138	0.201	0.2201
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0138	0.201	1
Echinococcus multilocularis	PAK box P21 Rho binding	0.0055	0.0693	0.0689
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0138	0.201	0.201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Onchocerca volvulus		0.0138	0.201	1
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0017	0.0097	0.0031
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0055	0.0701	0.0698
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Schistosoma mansoni	hypothetical protein	0.0138	0.201	1
Trypanosoma brucei	protein kinase A regulatory subunit	0.0016	0.0077	0.744
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0024	0.0202	0.1006
Schistosoma mansoni	protein kinase	0.0056	0.0713	0.3547
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0016	0.0077	0.0381
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0016	0.0077	0.0381
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0138	0.201	1
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0024	0.0202	0.0147
Loa Loa (eye worm)	G-protein coupled receptor	0.0138	0.201	0.1948
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0017	0.0097	0.0106
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0138	0.201	0.2142
Echinococcus multilocularis	somatostatin receptor	0.0138	0.201	0.2142
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0138	0.201	0.1948
Schistosoma mansoni	opsin-like receptor	0.0138	0.201	1
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0024	0.0202	0.1006
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0016	0.0077	0.0009
Brugia malayi	WH1 domain containing protein	0.0055	0.0693	0.0693
Echinococcus multilocularis	cAMP dependent protein kinase type I beta	0.0016	0.0077	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	voltage-gated potassium channel	0.0035	0.0377	0.1878
Brugia malayi	P21-Rho-binding domain containing protein	0.0055	0.0693	0.0693
Schistosoma mansoni	neuropathy target esterase/swiss cheese-related protein	0.0016	0.0077	0.0381
Onchocerca volvulus		0.0138	0.201	1
Mycobacterium ulcerans	transcriptional regulatory protein	0.0016	0.0077	0.5
Onchocerca volvulus		0.0138	0.201	1
Plasmodium vivax	CAMP-dependent protein kinase regulatory subunit, putative	0.0016	0.0077	0.5
Echinococcus granulosus	neuropeptide receptor A26	0.0138	0.201	0.2201
Brugia malayi	AKH receptor	0.0138	0.201	0.201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0138	0.201	1
Entamoeba histolytica	protein kinase, putative	0.0056	0.0713	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0138	0.201	0.2201
Schistosoma mansoni	wiskott-aldrich syndrome protein	0.0055	0.0693	0.3447
Entamoeba histolytica	p21-activated kinase	0.0056	0.0713	1
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0693	0.3447
Schistosoma mansoni	cyclic nucleotide-gated ion channel	0.0016	0.0077	0.0381
Schistosoma mansoni	amine GPCR	0.0138	0.201	1
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0693	0.0621
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0112	0.1607	1
Schistosoma mansoni	myosin xvIII	0.0138	0.201	1
Schistosoma mansoni	voltage-gated potassium channel	0.0131	0.1908	0.949
Echinococcus multilocularis	protein kinase c epsilon type	0.0017	0.0088	0.0022
Schistosoma mansoni	neuropeptide F-like receptor	0.0138	0.201	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0138	0.201	1
Schistosoma mansoni	camp-dependent protein kinase type II regulatory subunit	0.0016	0.0077	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	protein kinase c iota type	0.0015	0.0069	0.0075
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0138	0.201	0.201
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0039	0.0438	0.0407
Mycobacterium tuberculosis	Probable conserved transmembrane protein	0.0016	0.0077	0.5
Brugia malayi	Cyclic-nucleotide gated cation channel	0.0024	0.0202	0.0202
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0024	0.0202	0.0221
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0077	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0097	0.0481
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0138	0.201	0.2142
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0024	0.0202	0.0126
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0024	0.0202	0.0147
Echinococcus granulosus	cAMP dependent protein kinase type I beta	0.0016	0.0077	0.0084
Brugia malayi	N-terminal motif family protein	0.0016	0.0077	0.0077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Onchocerca volvulus		0.0138	0.201	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0138	0.201	0.2142
Brugia malayi	Protein kinase domain	0.0056	0.0713	0.0713
Echinococcus multilocularis	cyclic nucleotide gated cation channel	0.0016	0.0077	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Toxoplasma gondii	protein kinase G AGC kinase family member PKG	0.0017	0.0097	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Schistosoma mansoni	amine GPCR	0.0138	0.201	1
Brugia malayi	Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative	0.0016	0.0077	0.0077
Echinococcus multilocularis	neuropeptides capa receptor	0.0138	0.201	0.2142
Schistosoma mansoni	voltage-gated potassium channel	0.0131	0.1908	0.949
Plasmodium falciparum	cGMP-dependent protein kinase	0.0017	0.0097	1
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0016	0.0077	0.744
Mycobacterium leprae	Conserved hypothetical protein	0.0016	0.0077	1
Schistosoma mansoni	hypothetical protein	0.0055	0.0693	0.3447
Echinococcus granulosus	hyperpolarization activated cyclic	0.0024	0.0202	0.0221
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0017	0.0097	0.0031
Echinococcus multilocularis	voltage gated potassium channel	0.0035	0.0377	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0097	0.0481
Echinococcus multilocularis	neuropeptide receptor	0.0138	0.201	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Mycobacterium tuberculosis	Conserved protein	0.0016	0.0077	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0016	0.0077	0.0477
Schistosoma mansoni	camp-dependent protein kinase type I-beta regulatory subunit	0.0016	0.0077	0.0381
Schistosoma mansoni	amine GPCR	0.0138	0.201	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0138	0.201	0.2201
Echinococcus granulosus	cyclic nucleotide gated cation channel alpha 3	0.0024	0.0202	0.0221
Brugia malayi	Egg laying defective protein 4	0.0017	0.0097	0.0097
Brugia malayi	Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog	0.0016	0.0077	0.0077
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0017	0.0097	0.0106
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0138	0.201	0.2142
Onchocerca volvulus		0.0138	0.201	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0438	0.0364
Echinococcus multilocularis	p21 activated protein kinase 1 Dpak1	0.0056	0.0713	0.0711
Echinococcus multilocularis	g protein coupled receptor	0.0138	0.201	0.2142
Schistosoma mansoni	neuropeptide receptor	0.0138	0.201	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0138	0.201	0.201
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0112	0.1607	1
Echinococcus granulosus	cAMP dependent protein kinase regulatory	0.0016	0.0077	0.0084
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0138	0.201	1
Leishmania major	protein kinase, putative	0.0017	0.0097	1
Schistosoma mansoni	camp-dependent rap1 guanine-nucleotide exchange factor	0.0016	0.0077	0.0381
Brugia malayi	Protein kinase c protein 2	0.0047	0.0571	0.0571
Brugia malayi	Dopamine receptor protein 2	0.0138	0.201	0.201
Mycobacterium tuberculosis	Probable glutamine-transport ATP-binding protein ABC transporter GlnQ	0.0016	0.0077	0.5
Echinococcus granulosus	cAMP dependent protein kinase type II regulatory	0.0016	0.0077	0.0084
Treponema pallidum	catabolite gene activator	0.0016	0.0077	0.5
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Brugia malayi	ORL1-like opioid receptor	0.0138	0.201	0.201
Echinococcus granulosus	biogenic amine 5HT receptor	0.0138	0.201	0.2201
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0138	0.201	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0024	0.0202	0.1258
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0077	0.5
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0138	0.201	1
Echinococcus multilocularis	fmrfamide receptor	0.0138	0.201	0.2142
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	neuropeptide receptor	0.0138	0.201	1
Trypanosoma brucei	cAMP response protein 1, putative	0.0016	0.0077	0.744
Echinococcus granulosus	sex peptide receptor	0.0138	0.201	0.2201
Echinococcus multilocularis	cAMP dependent protein kinase regulatory	0.0016	0.0077	0.0009
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Schistosoma mansoni	cyclic-nucleotide-gated cation channel	0.0024	0.0202	0.1006
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	3'partial\|serine:threonine protein kinase PAK 2	0.0055	0.0693	0.0759
Schistosoma mansoni	biogenic amine receptor	0.0138	0.201	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0138	0.201	1
Brugia malayi	cAMP-dependent protein kinase regulatory chain, putative	0.0016	0.0077	0.0077
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0138	0.201	1
Echinococcus multilocularis	cyclic nucleotide gated cation channel alpha 3	0.0024	0.0202	0.0147
Echinococcus granulosus	serine:threonine protein kinase PAK 4	0.0586	0.9132	1
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0016	0.0077	0.0084
Loa Loa (eye worm)	P21-Rho-binding domain-containing protein	0.0055	0.0693	0.0621
Loa Loa (eye worm)	STE/STE20/PAKB protein kinase	0.0641	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0138	0.201	0.2201
Echinococcus granulosus	biogenic amine 5HT receptor	0.0138	0.201	0.2201
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Schistosoma mansoni	histamine h1 receptor	0.0138	0.201	1
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0202	0.0126
Mycobacterium tuberculosis	Probable transcriptional regulatory protein Cmr	0.0016	0.0077	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0138	0.201	0.2142
Brugia malayi	follicle stimulating hormone receptor	0.0138	0.201	0.201
Entamoeba histolytica	protein kinase, putative	0.0056	0.0713	1
Trichomonas vaginalis	STE family protein kinase	0.0056	0.0713	0.4437
Schistosoma mansoni	camp-dependent protein kinase type II-alpha regulatory subunit	0.0016	0.0077	0.0381
Echinococcus multilocularis	cAMP dependent protein kinase type II regulatory	0.0016	0.0077	0.0009
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0056	0.0713	0.0781
Brugia malayi	Serotonin receptor	0.0138	0.201	0.201
Brugia malayi	G protein-coupled receptor	0.0138	0.201	0.201
Echinococcus multilocularis	serotonin receptor	0.0138	0.201	0.2142
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Loa Loa (eye worm)	cyclic-nucleotide gated cation channel	0.0024	0.0202	0.0126
Echinococcus multilocularis	neuropeptide Y receptor	0.0138	0.201	0.2142
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0017	0.0088	0.0012
Echinococcus multilocularis	neuropeptide receptor A26	0.0138	0.201	0.2142
Schistosoma mansoni	atypical protein kinase C	0.0015	0.0069	0.0342
Echinococcus granulosus	g protein coupled receptor	0.0138	0.201	0.2201
Echinococcus granulosus	G protein coupled receptor 139	0.0138	0.201	0.2201
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0138	0.201	0.1948
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Onchocerca volvulus		0.0138	0.201	1
Schistosoma mansoni	protein kinase	0.0056	0.0713	0.3547
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0077	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0138	0.201	1
Schistosoma mansoni	biogenic amine receptor	0.0138	0.201	1
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0088	0.0439
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Onchocerca volvulus		0.0138	0.201	1
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.012	0.1732	0.1732
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0016	0.0077	0.5
Echinococcus granulosus	PAK box P21 Rho binding	0.0055	0.0693	0.0759
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Echinococcus granulosus	hyperpolarization activated cyclic	0.0024	0.0202	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Entamoeba histolytica	protein kinase, putative	0.0056	0.0713	1
Trichomonas vaginalis	conserved hypothetical protein	0.0055	0.0693	0.4313
Schistosoma mansoni	voltage-gated potassium channel	0.0019	0.0126	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0104	0.148	0.1415
Brugia malayi	GnHR receptor homolog	0.0138	0.201	0.201
Schistosoma mansoni	serine/threonine protein kinase	0.0017	0.0097	0.0481
Brugia malayi	Dopamine receptor protein 1	0.0138	0.201	0.201
Schistosoma mansoni	hypothetical protein	0.0016	0.0077	0.0381
Onchocerca volvulus		0.0138	0.201	1
Echinococcus granulosus	neural Wiskott Aldrich syndrome protein	0.0055	0.0693	0.0759
Onchocerca volvulus		0.0138	0.201	1
Trypanosoma brucei	Flagellar Member 6	0.0016	0.0077	0.744
Echinococcus granulosus	neuropeptide Y receptor	0.0138	0.201	0.2201
Brugia malayi	G-protein coupled receptor	0.0138	0.201	0.201
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0138	0.201	1
Echinococcus multilocularis	g protein coupled receptor	0.0138	0.201	0.2142
Echinococcus multilocularis	expressed conserved protein	0.0017	0.0097	0.0031
Echinococcus granulosus	neuropeptide Y receptor	0.0138	0.201	0.2201
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0138	0.201	0.2142
Echinococcus granulosus	g-protein coupled receptor	0.0138	0.201	0.2201
Echinococcus multilocularis	serotonin receptor	0.0138	0.201	0.2142
Echinococcus granulosus	neuropeptide receptor	0.0138	0.201	0.2201
Brugia malayi	putative neuropeptide receptor NPR1	0.0138	0.201	0.201
Echinococcus granulosus	tm gpcr rhodopsin	0.0138	0.201	0.2201
Entamoeba histolytica	protein kinase, putative	0.0056	0.0713	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0138	0.201	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0138	0.201	0.2142
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.012	0.1732	0.1836
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Brugia malayi	G-protein coupled receptor	0.0138	0.201	0.201
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0138	0.201	0.201
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0016	0.0077	0.0381
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0138	0.201	0.1948
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Echinococcus granulosus	orexin receptor type 2	0.0138	0.201	0.2201
Schistosoma mansoni	hypothetical protein	0.0055	0.0693	0.3447
Schistosoma mansoni	opsin-like receptor	0.0138	0.201	1
Trypanosoma brucei	cAMP binding protein, putative	0.0017	0.0096	1
Loa Loa (eye worm)	TYRA-2 protein	0.0138	0.201	0.1948
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0138	0.201	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0138	0.201	0.2142
Echinococcus granulosus	protein kinase c epsilon type	0.0017	0.0088	0.0097
Echinococcus granulosus	serotonin receptor	0.0138	0.201	0.2201
Echinococcus granulosus	neuropeptides capa receptor	0.0138	0.201	0.2201
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Schistosoma mansoni	camp-dependent protein kinase regulatory chain	0.0016	0.0077	0.0381
Echinococcus granulosus	allatostatin A receptor	0.0138	0.201	0.2201
Echinococcus granulosus	voltage gated potassium channel	0.0035	0.0377	0.0413
Echinococcus multilocularis	neuropeptide s receptor	0.0138	0.201	0.2142
Treponema pallidum	catabolite gene activator (Crp)	0.0016	0.0077	0.5
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0024	0.0202	0.1258
Brugia malayi	Dopamine receptor	0.0138	0.201	0.201
Plasmodium vivax	rap guanine nucleotide exchange factor, putative	0.0016	0.0077	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0138	0.201	0.2142
Loa Loa (eye worm)	neuropeptide F receptor	0.0138	0.201	0.1948
Echinococcus granulosus	patatin phospholipase domain containing protein	0.0016	0.0077	0.0084
Echinococcus granulosus	dro:myosuppressin receptor	0.0138	0.201	0.2201
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Echinococcus multilocularis	RNA directed DNA polymerase	0.0039	0.0438	0.0407
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	cGMP dependent protein kinase	0.0017	0.0097	0.0106
Trichomonas vaginalis	STE family protein kinase	0.0056	0.0713	0.4437
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0377	0.0303
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0138	0.201	0.2201
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0138	0.201	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0138	0.201	0.2201
Mycobacterium tuberculosis	Probable conserved transmembrane transport protein	0.0016	0.0077	0.5
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0701	0.3488
Echinococcus multilocularis	neuropeptide receptor	0.0138	0.201	0.2142
Echinococcus multilocularis	hyperpolarization activated cyclic	0.0024	0.0202	0.0147
Brugia malayi	putative neuropeptide receptor	0.0138	0.201	0.201
Schistosoma mansoni	hypothetical protein	0.0138	0.201	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	dro:myosuppressin receptor	0.0138	0.201	0.2142
Echinococcus granulosus	neuropeptide s receptor	0.0138	0.201	0.2201
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0138	0.201	0.1948
Schistosoma mansoni	serine/threonine protein kinase	0.0055	0.0701	0.3488
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0035	0.0377	0.0377
Trichomonas vaginalis	STE family protein kinase	0.0056	0.0713	0.4437
Echinococcus multilocularis	allatostatin A receptor	0.0138	0.201	0.2142
Loa Loa (eye worm)	neuropeptide F receptor	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0138	0.201	0.2142
Schistosoma mansoni	similar to Protein C20orf152 homolog	0.0016	0.0077	0.0381
Schistosoma mansoni	tyrosine kinase	0.0055	0.0693	0.3447
Leishmania major	hypothetical protein, conserved	0.0017	0.0096	0.9768
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Schistosoma mansoni	neuropeptide receptor	0.0138	0.201	1
Schistosoma mansoni	neuropeptide receptor	0.0138	0.201	1
Echinococcus multilocularis	potassium:sodium hyperpolarization activated	0.0024	0.0202	0.0147
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Loa Loa (eye worm)	melatonin receptor type 1A	0.0138	0.201	0.1948
Schistosoma mansoni	hypothetical protein	0.0138	0.201	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0138	0.201	1
Echinococcus granulosus	g protein coupled receptor	0.0138	0.201	0.2201
Echinococcus granulosus	cyclic nucleotide gated cation channel	0.0024	0.0202	0.0221
Echinococcus multilocularis	g protein coupled receptor	0.0138	0.201	0.2142
Schistosoma mansoni	amine GPCR	0.0138	0.201	1
Trichomonas vaginalis	STE family protein kinase	0.0056	0.0713	0.4437
Onchocerca volvulus		0.0138	0.201	1
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Trypanosoma brucei	cyclic nucleotide-binding domain containing protein, putative	0.0016	0.0077	0.744
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus granulosus	rhodopsin orphan GPCR	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0138	0.201	0.2142
Echinococcus multilocularis	patatin phospholipase domain containing protein	0.0016	0.0077	0.0009
Echinococcus multilocularis	PAK box P21 Rho binding	0.0056	0.0713	0.0711
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0016	0.0077	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	serine:threonine protein kinase PAK 3	0.0056	0.0713	0.0711
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0138	0.201	0.2142
Brugia malayi	Serotonin receptor	0.0138	0.201	0.201
Echinococcus granulosus	7TM GPCR rhodopsin	0.0138	0.201	0.2201
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0138	0.201	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0138	0.201	0.201
Schistosoma mansoni	hyperpolarization activated cyclic nucleotide-gated potassium channel	0.0024	0.0202	0.1006
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0138	0.201	0.2142
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.012	0.1732	0.1897
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0138	0.201	0.2201
Chlamydia trachomatis	cAMP-dependent protein kinase regulatory subunit	0.0016	0.0077	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0138	0.201	0.2201
Echinococcus granulosus	tm gpcr rhodopsin	0.0138	0.201	0.2201
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0138	0.201	1
Echinococcus granulosus	serine:threonine protein kinase PAK 3	0.0056	0.0713	0.0781
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0138	0.201	0.1948
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0138	0.201	1
Echinococcus granulosus	somatostatin receptor	0.0138	0.201	0.2201
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0138	0.201	0.2142
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0138	0.201	0.2142
Brugia malayi	hypothetical protein	0.0138	0.201	0.201
Brugia malayi	P21-Rho-binding domain containing protein	0.0055	0.0693	0.0693
Schistosoma mansoni	biogenic amine receptor	0.0138	0.201	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0035	0.0377	0.0341
Brugia malayi	protein kinase C II.	0.0017	0.0088	0.0088
Onchocerca volvulus		0.0138	0.201	1
Echinococcus granulosus	hypothetical protein	0.0138	0.201	0.2201
Brugia malayi	RE15519p	0.0138	0.201	0.201
Brugia malayi	G protein-coupled receptor F59B2.13	0.0138	0.201	0.201
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0138	0.201	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0138	0.201	1
Trichomonas vaginalis	conserved hypothetical protein	0.0016	0.0077	0.0477
Schistosoma mansoni	protein kinase	0.0055	0.0693	0.3447
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0017	0.0097	0.002
Loa Loa (eye worm)	hypothetical protein	0.0138	0.201	0.1948
Giardia lamblia	Kinase, STE STE20	0.0056	0.0713	1
Onchocerca volvulus		0.0138	0.201	1
Mycobacterium ulcerans	hypothetical protein	0.0016	0.0077	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-4.521	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.452	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.408	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.37	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.314	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.23	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.183	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.082	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.07	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1973179

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1610284