TDR Targets

Basic information

Technical information

TDR Targets ID: 1611384
Name: (3R,3aR,6aR)-1,5-dimethyl-3-phenyl-3,3a,6,6a- tetrahydropyrrolo[4,3-c][1,2]oxazol-4-one
MW: 232.278 | Formula: C13H16N2O2
H donors: 0 H acceptors: 1 LogP: 0.92 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: CN1O[C@H]([C@H]2[C@@H]1CN(C2=O)C)c1ccccc1
InChi: 1S/C13H16N2O2/c1-14-8-10-11(13(14)16)12(17-15(10)2)9-6-4-3-5-7-9/h3-7,10-12H,8H2,1-2H3/t10-,11+,12-/m0/s1
InChiKey: XSOYHCDJOSZNBP-TUAOUCFPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3R,3aR,6aR)-1,5-dimethyl-3-phenyl-3,3a,6,6a-tetrahydropyrrolo[4,3-c]isoxazol-4-one
NCI60_025033

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	MH2 domain-containing protein	0.0113	0.0192	0.0192
Onchocerca volvulus		0.0296	0.0609	1
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0034	0.0013	0.0002
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0868	0.1908	0.1898
Schistosoma mansoni	hypothetical protein	0.0657	0.143	0.142
Loa Loa (eye worm)	FKBP-type peptidyl-prolyl cis-trans isomerase-12	0.0114	0.0195	0.0195
Entamoeba histolytica	hypothetical protein	0.0455	0.0969	0.0958
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.0079	0.0079
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59	0.0114	0.0195	0.0184
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0069	0.0058
Trichomonas vaginalis	fk506-binding protein, putative	0.0114	0.0195	0.0184
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0296	0.0609	0.0598
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0567	0.1224	0.1214
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0033	0.0011	0.0011
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0317	0.0656	0.0645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0856	0.1883	0.1873
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0424	0.09	0.0889
Schistosoma mansoni	voltage-gated potassium channel	0.0129	0.0228	0.0217
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0424	0.09	0.0889
Schistosoma mansoni	immunophilin	0.0114	0.0195	0.0184
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0856	0.1883	0.1873
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0296	0.0609	0.0598
Brugia malayi	Pre-SET motif family protein	0.0197	0.0383	0.0372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.241	0.5416	0.5411
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0296	0.0609	0.0598
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0034	0.0013	0.0002
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.7961	0.7959
Echinococcus multilocularis	voltage gated potassium channel	0.0034	0.0013	0.0002
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2406	0.5408	0.5403
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0856	0.1883	0.1873
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.1525	0.3403	0.3396
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0013	0.0013
Loa Loa (eye worm)	beta-lactamase	0.0033	0.0011	0.0011
Loa Loa (eye worm)	phosphatidylinositol 3	0.4425	1	1
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0114	0.0195	0.0184
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0497	0.1065	0.1055
Loa Loa (eye worm)	phosphatidylinositol 3	0.0296	0.0609	0.0609
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0868	0.1908	0.1899
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0069	0.0058
Trichomonas vaginalis	conserved hypothetical protein	0.0953	0.2104	0.2095
Brugia malayi	Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog	0.0034	0.0013	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0296	0.0609	0.0598
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0679	0.148	0.147
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0296	0.0609	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2969	0.6687	0.6684
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0201	0.0392	0.038
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0679	0.148	0.147
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Mycobacterium leprae	conserved hypothetical protein	0.0296	0.0609	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0317	0.0656	0.0645
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0317	0.0656	0.0645
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0039	0.0024	0.0012
Schistosoma mansoni	hypothetical protein	0.0296	0.0609	0.0598
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0296	0.0609	0.0803
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Entamoeba histolytica	hypothetical protein	0.0296	0.0609	0.0597
Trypanosoma cruzi	hypothetical protein, conserved	0.0096	0.0153	0.0142
Giardia lamblia	GTOR	0.4425	1	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0953	0.2104	0.2814
Brugia malayi	FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12	0.0114	0.0195	0.0184
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0497	0.1065	0.1055
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0296	0.0609	0.0422
Trypanosoma brucei	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0114	0.0195	0.0184
Onchocerca volvulus		0.0033	0.0011	0.0187
Trichomonas vaginalis	conserved hypothetical protein	0.056	0.1209	0.1199
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0296	0.0609	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0159	0.0159
Schistosoma mansoni	immunophilin FK506 binding protein FKBP12	0.0114	0.0195	0.0184
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0359	0.0752	0.0741
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0359	0.0752	0.0741
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.4425	1	1
Onchocerca volvulus		0.0224	0.0445	0.7301
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2645	0.5952	0.5947
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1566	0.3498	0.3491
Brugia malayi	Heterochromatin protein 1	0.0065	0.0083	0.0071
Trichomonas vaginalis	immunophilin, putative	0.0114	0.0195	0.0184
Schistosoma mansoni	hypothetical protein	0.0034	0.0013	0.0001
Entamoeba histolytica	hypothetical protein	0.0296	0.0609	0.0597
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.4425	1	1
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0455	0.0969	0.0958
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0018	0.0018
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.1566	0.3498	0.3491
Echinococcus granulosus	chromobox protein 1	0.0065	0.0083	0.0071
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.011	0.0186	0.0174
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0317	0.0656	0.0645
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.1566	0.3498	0.3491
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0424	0.09	0.0889
Mycobacterium ulcerans	FK-506 binding protein, peptidyl-prolyl cis-trans isomerase	0.0114	0.0195	1
Leishmania major	phosphatidylinositol 3-kinase, putative	0.1513	0.3378	0.337
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0317	0.0656	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.7961	0.7959
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0317	0.0656	0.0644
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0497	0.1065	0.1054
Echinococcus multilocularis	potassium voltage gated channel subfamily H	0.0118	0.0203	0.0192
Trichomonas vaginalis	chromobox protein, putative	0.0065	0.0083	0.0071
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0296	0.0609	0.0598
Entamoeba histolytica	protein kinase rad3, putative	0.0856	0.1883	0.1872
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.7961	0.7959
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0296	0.0609	0.0803
Echinococcus multilocularis	serine protein kinase ATM	0.0856	0.1883	0.1873
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0296	0.0609	0.0598
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.3532	0.7969	0.7967
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0317	0.0656	0.0645
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0098	0.0159	0.0148
Echinococcus granulosus	voltage gated potassium channel	0.0034	0.0013	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0063	0.0079	0.0067
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0214	0.0422	0.6865
Plasmodium vivax	hypothetical protein	0.0296	0.0609	0.9266
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0114	0.0195	0.0184
Loa Loa (eye worm)	transcription factor SMAD2	0.0113	0.0192	0.0192
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0432	0.0918	0.0908
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0317	0.0656	0.0867
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.2085	0.4678	0.4672
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.7961	0.7959
Schistosoma mansoni	chromobox protein	0.0065	0.0083	0.0071
Trichomonas vaginalis	PIKK family atypical protein kinase	0.241	0.5416	0.5411
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0359	0.0752	0.0742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1525	0.3403	0.3396
Echinococcus multilocularis	chromobox protein 1	0.0065	0.0083	0.0071
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0856	0.1883	0.1873
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0296	0.0609	0.8973
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0069	0.0058
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0317	0.0656	0.0645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4425	1	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0296	0.0609	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0359	0.0752	0.0742
Loa Loa (eye worm)	phosphatidylinositol 3	0.0296	0.0609	0.0609
Echinococcus multilocularis		0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0856	0.1883	0.1873
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.1513	0.3378	0.337
Loa Loa (eye worm)	heterochromatin protein 1	0.0065	0.0083	0.0083
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0317	0.0656	1
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0296	0.0609	0.0598
Echinococcus multilocularis	fk506 binding protein	0.0114	0.0195	0.0184
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0018	0.0006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2871	0.6466	0.6462
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0317	0.0656	0.0645
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4425	1	1
Brugia malayi	MH2 domain containing protein	0.0113	0.0192	0.0181
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.4425	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0065	0.0083	0.0071
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.039	0.0822	0.0639
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.1525	0.3403	0.3396
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0114	0.0195	0.0184
Echinococcus granulosus	tar DNA binding protein	0.0059	0.0069	0.0058
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.4425	1	1
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0317	0.0656	0.0645
Echinococcus granulosus	chromobox protein 1	0.0065	0.0083	0.0071
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0359	0.0752	0.0742
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1513	0.3378	0.337
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0317	0.0656	0.0645
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0168	0.0168
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.185	0.4142	0.4136
Loa Loa (eye worm)	phosphatidylinositol 3	0.0296	0.0609	0.0609
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP1A	0.0114	0.0195	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0296	0.0609	0.0609
Schistosoma mansoni	voltage-gated potassium channel	0.0034	0.0013	0.0002
Brugia malayi	chromobox protein homolog 3	0.0036	0.0018	0.0006
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1513	0.3378	0.337
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0039	0.0024	0.0396
Leishmania major	fk506-binding protein 1-like protein	0.0114	0.0195	0.0184
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.4425	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0359	0.0752	0.0742
Schistosoma mansoni	microtubule-associated protein tau	0.0652	0.1419	0.1409
Brugia malayi	TAR-binding protein	0.0059	0.0069	0.0058
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0317	0.0656	0.0645
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0197	0.0383	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0011	0.0011
Schistosoma mansoni	voltage-gated potassium channel	0.0129	0.0228	0.0217
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0296	0.0609	0.9266
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0296	0.0609	0.8973
Loa Loa (eye worm)	hypothetical protein	0.056	0.1209	0.1209
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.0024	0.0013
Echinococcus granulosus	microtubule associated protein 2	0.0652	0.1419	0.1409
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0069	0.0058
Trichomonas vaginalis	PIKK family atypical protein kinase	0.4425	1	1
Brugia malayi	RNA binding protein	0.0059	0.0069	0.0058
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0296	0.0609	0.0598
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0296	0.0609	0.0598
Toxoplasma gondii	FATC domain-containing protein	0.0856	0.1883	0.2517
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0296	0.0609	0.9266
Leishmania major	phosphatidylinositol kinase, putative	0.0296	0.0609	0.0598
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0034	0.0013	0.0001
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1513	0.3378	0.337
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.4425	1	1
Loa Loa (eye worm)	TAR-binding protein	0.0059	0.0069	0.0069
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.011	0.0186	0.0174
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0296	0.0609	0.0598
Leishmania major	hypothetical protein, conserved	0.0392	0.0827	0.0816
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0317	0.0656	0.0645
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0432	0.0918	0.0908
Brugia malayi	hypothetical protein	0.0034	0.0013	0.0001
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0182	0.035	0.0339
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.4425	1	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0011	0.0011
Schistosoma mansoni	immunophilin	0.0098	0.0159	0.0148
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0098	0.0159	0.0148
Entamoeba histolytica	hypothetical protein	0.0856	0.1883	0.1872
Brugia malayi	Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog	0.0118	0.0203	0.0192
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.3532	0.7969	0.7967
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0296	0.0609	0.0598
Entamoeba histolytica	hypothetical protein	0.0296	0.0609	0.0597
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Loa Loa (eye worm)	phosphatidylinositol 3	0.0296	0.0609	0.0609
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.4425	1	1
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0338	0.0705	0.052
Schistosoma mansoni	voltage-gated potassium channel	0.0034	0.0013	0.0002
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0856	0.1883	0.1873
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.1566	0.3498	0.3491
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0359	0.0752	0.0742
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0011	0.0011
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0296	0.0609	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2645	0.5952	0.5947
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2406	0.5408	0.5403
Trypanosoma cruzi	target of rapamycin kinase 3	0.3532	0.7969	0.7967
Onchocerca volvulus		0.0033	0.0011	0.0187
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0118	0.0203	0.0203
Trichomonas vaginalis	peptidylprolyl isomerase, putative	0.0114	0.0195	0.0184
Trichomonas vaginalis	conserved hypothetical protein	0.0657	0.143	0.142
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0296	0.0609	0.0598
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0856	0.1883	0.1873
Schistosoma mansoni	immunophilin	0.0114	0.0195	0.0184
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0856	0.1883	0.1873
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase, putative	0.0114	0.0195	0.0184
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.1566	0.3498	0.3491
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1513	0.3378	0.337
Echinococcus multilocularis	chromobox protein 1	0.0065	0.0083	0.0071
Onchocerca volvulus		0.0033	0.0011	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0953	0.2104	0.2104
Echinococcus multilocularis	peptidyl prolyl cis trans isomerase FKBP4	0.0114	0.0195	0.0184
Treponema pallidum	peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB)	0.0114	0.0195	0.5
Schistosoma mansoni	chromobox protein	0.0065	0.0083	0.0071
Trichomonas vaginalis	set domain proteins, putative	0.0224	0.0445	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0424	0.09	0.09
Onchocerca volvulus		0.0296	0.0609	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0657	0.143	0.142
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0036	0.0018	0.0293
Loa Loa (eye worm)	RNA binding protein	0.0059	0.0069	0.0069
Plasmodium vivax	hypothetical protein, conserved	0.0296	0.0609	0.9266
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.1566	0.3498	0.3491
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0296	0.0609	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0011	0.0011
Loa Loa (eye worm)	hypothetical protein	0.0856	0.1883	0.1883
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.4425	1	1
Echinococcus granulosus	peptidyl prolyl cis trans isomerase FKBP4	0.0114	0.0195	0.0184
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0856	0.1883	0.1873
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3302	0.7447	0.7444
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0296	0.0609	0.0598
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type , putative	0.0114	0.0195	0.0183
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0034	0.0013	0.0001
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.4425	1	1
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0856	0.1883	0.1873
Trichomonas vaginalis	PIKK family atypical protein kinase	0.241	0.5416	0.5411
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.056	0.1209	0.1199
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0382	0.0803	0.0792
Trichomonas vaginalis	PIKK family atypical protein kinase	0.056	0.1209	0.1199
Leishmania major	peptidylprolyl isomerase-like protein	0.0114	0.0195	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0101	0.0101
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0296	0.0609	0.0598
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase, putative	0.0114	0.0195	0.0184
Leishmania major	hypothetical protein, unknown function	0.0296	0.0609	0.0598
Trichomonas vaginalis	chromobox protein, putative	0.0039	0.0024	0.0013
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0497	0.1065	0.1055
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0657	0.143	0.142
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2645	0.5952	0.5947
Loa Loa (eye worm)	hypothetical protein	0.0657	0.143	0.143
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0317	0.0656	0.0867
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2406	0.5408	0.5403
Giardia lamblia	Hypothetical protein	0.0296	0.0609	0.0422
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0497	0.1065	0.1055
Loa Loa (eye worm)	phosphatidylinositol 3	0.0637	0.1383	0.1383
Entamoeba histolytica	peptidyl-prolyl cis-trans isomerase, FKBP-type, putative	0.0114	0.0195	0.0183
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0359	0.0752	0.0742
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0296	0.0609	0.0609
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2636	0.5931	0.5926
Plasmodium vivax	70 kDa peptidylprolyl isomerase, putative	0.0114	0.0195	0.2848
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0497	0.1065	0.1055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0296	0.0609	0.0598
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0011	0.0011
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0317	0.0656	0.0656
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3768	0.8505	0.8503
Loa Loa (eye worm)	FKBP5 protein	0.0114	0.0195	0.0195
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0296	0.0609	0.9266
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0317	0.0656	0.0645
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0317	0.0656	0.0644
Echinococcus multilocularis	Zinc finger, PHD finger	0.0317	0.0656	0.0645
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.4425	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.1525	0.3403	0.3403
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0317	0.0656	0.0645
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0317	0.0656	0.0645
Trichomonas vaginalis	PIKK family atypical protein kinase	0.3529	0.7961	0.7959
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0679	0.148	0.147
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0296	0.0609	0.0598
Echinococcus multilocularis	microtubule associated protein 2	0.0652	0.1419	0.1409
Trichomonas vaginalis	PIKK family atypical protein kinase	0.241	0.5416	0.5411
Toxoplasma gondii	target of rapamycin (TOR), putative	0.3302	0.7447	1
Echinococcus granulosus	serine protein kinase ATM	0.0856	0.1883	0.1873
Schistosoma mansoni	transcription factor LCR-F1	0.0034	0.0013	0.0001
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0296	0.0609	0.0803
Echinococcus multilocularis	tar DNA binding protein	0.0059	0.0069	0.0058
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0497	0.1065	0.1055
Trypanosoma cruzi	FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative	0.0114	0.0195	0.0184
Loa Loa (eye worm)	hypothetical protein	0.0893	0.1966	0.1966
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0567	0.1224	0.1214
Brugia malayi	FAT domain containing protein	0.0657	0.143	0.142
Echinococcus granulosus	potassium voltage gated channel subfamily H	0.0118	0.0203	0.0192
Schistosoma mansoni	tar DNA-binding protein	0.0059	0.0069	0.0058
Onchocerca volvulus		0.0039	0.0024	0.0387
Trichomonas vaginalis	PIKK family atypical protein kinase	0.1189	0.2639	0.2631
Trichomonas vaginalis	PIKK family atypical protein kinase	0.2636	0.5931	0.5926
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0359	0.0752	0.0742
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0018	0.0006
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0059	0.0069	0.0069
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0856	0.1883	0.1873
Brugia malayi	RNA recognition motif domain containing protein	0.0059	0.0069	0.0058

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.228	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1969901

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1611384