Detailed information for compound 1611391

Basic information

Technical information
  • TDR Targets ID: 1611391
  • Name: NCI60_019640
  • MW: 438.475 | Formula: C27H22N2O4
  • H donors: 3 H acceptors: 4 LogP: 1.92 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1Nc2ccccc2[C@@]2([C@H](C1)[C@@H](c1ccccc1)[C@H]1[C@H]2C(=O)Nc2c(C1=O)cccc2)O
  • InChi: 1S/C27H22N2O4/c30-21-14-18-22(15-8-2-1-3-9-15)23-24(27(18,33)17-11-5-7-13-20(17)28-21)26(32)29-19-12-6-4-10-16(19)25(23)31/h1-13,18,22-24,33H,14H2,(H,28,30)(H,29,32)/t18-,22-,23+,24+,27+/m1/s1
  • InChiKey: BZVXSMHETRHAGD-MUPGJOOLSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC656722

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0017 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.138 0.1891 0.1884
Brugia malayi hypothetical protein 0.004 0.002 0.0017
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0009 0.0009
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0542 0.0721 0.0712
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.002 0.0011
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0123 0.0137 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.4271 0.5928 0.5925
Entamoeba histolytica protein kinase, putative 0.0032 0.0009 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.193 0.2659 0.2653
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0643 0.0862 0.0856
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0009 0.0003
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0475 0.0628 0.941
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0905 0.1227 0.1219
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.088 0.1194 0.1186
Loa Loa (eye worm) hypothetical protein 0.1455 0.1996 0.1991
Loa Loa (eye worm) hypothetical protein 0.0106 0.0113 0.0106
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.088 0.1194 0.1186
Trichomonas vaginalis PIKK family atypical protein kinase 0.3903 0.5413 0.5409
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Schistosoma mansoni fkbp-rapamycin associated protein 0.138 0.1891 0.1891
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0628 0.0619
Schistosoma mansoni hypothetical protein 0.1062 0.1447 0.1447
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0497 0.0658 0.0876
Trichomonas vaginalis PIKK family atypical protein kinase 0.5727 0.796 0.7958
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0497 0.0658 0.0658
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0497 0.0658 0.0876
Plasmodium vivax hypothetical protein 0.0475 0.0628 0.941
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0123 0.0137 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.6126 0.8518 0.8516
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0497 0.0658 0.065
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.2454 0.339 0.3384
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.7188 1 1
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0497 0.0658 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0628 0.0619
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0688 0.0924 0.0872
Mycobacterium leprae conserved hypothetical protein 0.0475 0.0628 0.5
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0137 0.008
Entamoeba histolytica hypothetical protein 0.0643 0.0862 0.0856
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.088 0.1194 0.1194
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0475 0.0628 0.0619
Trichomonas vaginalis PIKK family atypical protein kinase 0.3897 0.5405 0.5401
Trichomonas vaginalis PIKK family atypical protein kinase 0.4271 0.5928 0.5925
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0137 0.0128
Plasmodium vivax hypothetical protein, conserved 0.0475 0.0628 0.941
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0542 0.0721 0.0721
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0688 0.0924 0.0916
Brugia malayi Cyclic-nucleotide gated cation channel 0.0032 0.0009 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0905 0.1228 0.122
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0497 0.0658 0.0655
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.1062 0.1447 0.1439
Trichomonas vaginalis PIKK family atypical protein kinase 0.4296 0.5963 0.5959
Schistosoma mansoni immunophilin 0.0123 0.0137 0.0137
Entamoeba histolytica hypothetical protein 0.0475 0.0628 0.0621
Echinococcus granulosus voltage gated potassium channel 0.0047 0.003 0.0021
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0688 0.0924 0.0921
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0106 0.0049
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0542 0.0721 0.0712
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0475 0.0628 0.0573
Giardia lamblia GTOR 0.7188 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0137 0.0128
Entamoeba histolytica hypothetical protein 0.0475 0.0628 0.0621
Toxoplasma gondii target of rapamycin (TOR), putative 0.5358 0.7445 1
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0761 0.1027 0.1019
Trichomonas vaginalis PIKK family atypical protein kinase 0.3903 0.5413 0.5409
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.138 0.1891 0.1888
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.138 0.1891 0.1884
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.2498 0.3452 0.3446
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0628 0.0625
Toxoplasma gondii FATC domain-containing protein 0.138 0.1891 0.2533
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0123 0.0137 0.0134
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.7188 1 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.1062 0.1447 0.1441
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0628 0.0625
Schistosoma mansoni hypothetical protein 0.0038 0.0017 0.0017
Toxoplasma gondii non-specific serine/threonine protein kinase 0.1537 0.211 0.2828
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.0628 0.0619
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0574 0.0766 0.0638
Schistosoma mansoni voltage-gated potassium channel 0.0177 0.0211 0.0211
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0047 0.003 0.0027
Schistosoma mansoni immunophilin 0.0106 0.0113 0.0113
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0123 0.0137 0.0128
Entamoeba histolytica hypothetical protein 0.138 0.1891 0.1886
Brugia malayi Bromodomain containing protein 0.0084 0.0081 0.0078
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.3373 0.3367
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2498 0.3452 0.3414
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0137 0.0127
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.138 0.1891 0.1891
Trichomonas vaginalis PIKK family atypical protein kinase 0.0905 0.1228 0.122
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0475 0.0628 0.0628
Trypanosoma cruzi target of rapamycin kinase 3 0.5733 0.7968 0.7956
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0137 0.0127
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0123 0.0137 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.3897 0.5405 0.5401
Trichomonas vaginalis PIKK family atypical protein kinase 0.4296 0.5963 0.5959
Loa Loa (eye worm) phosphatidylinositol kinase 0.0475 0.0628 0.0621
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.052 0.069 0.0561
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.2498 0.3452 0.345
Loa Loa (eye worm) hypothetical protein 0.138 0.1891 0.1886
Trichomonas vaginalis PIKK family atypical protein kinase 0.7188 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0475 0.0628 0.0619
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0497 0.0658 0.0652
Leishmania major hypothetical protein, unknown function 0.0475 0.0628 0.0498
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Echinococcus multilocularis serine protein kinase ATM 0.138 0.1891 0.1884
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0056 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0031 0.0024
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0475 0.0628 0.941
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.5733 0.7968 0.794
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0137 0.008
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.7188 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0176 0.0167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0017 0.0011
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.7188 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.061 0.0817 0.0814
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0566 0.0754 0.0748
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0497 0.0658 0.065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0475 0.0628 0.0625
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0057 0.0048
Schistosoma mansoni hypothetical protein 0.0475 0.0628 0.0628
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.138 0.1891 0.1883
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0475 0.0628 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.3373 0.3367
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0628 0.0835
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.002 0.0011
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0905 0.1228 0.1177
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0628 0.0621
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.002 0.0011
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.7188 1 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0761 0.1027 0.1019
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0213 0.0261 0.0255
Entamoeba histolytica hypothetical protein 0.0475 0.0628 0.0621
Loa Loa (eye worm) hypothetical protein 0.0141 0.0161 0.0154
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0009 0.0009
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0162 0.019 0.0187
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0497 0.0658 0.0658
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0014
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0497 0.0658 0.0604
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.7188 1 1
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0123 0.0137 0.0128
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0032 0.0009 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.3373 0.3367
Loa Loa (eye worm) hypothetical protein 0.0905 0.1228 0.1222
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0475 0.0628 0.0619
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0123 0.0137 0.013
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0032 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0032 0.0009 0.0003
Brugia malayi Calcitonin receptor-like protein seb-1 0.0056 0.0042 0.0039
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0497 0.0658 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.2442 0.3373 0.3367
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.2998 0.415 0.4145
Echinococcus multilocularis 0.0475 0.0628 0.0619
Schistosoma mansoni voltage-gated potassium channel 0.0047 0.003 0.003
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0497 0.0658 0.0652
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.7188 1 1
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0014
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0542 0.0721 0.0712
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0021
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.7188 1 1
Schistosoma mansoni immunophilin 0.0123 0.0137 0.0137
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0542 0.0721 0.0667
Trichomonas vaginalis PIKK family atypical protein kinase 0.2454 0.339 0.3384
Schistosoma mansoni bromodomain containing protein 0.0071 0.0063 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.7188 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0475 0.0628 0.0621
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0497 0.0658 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0024 0.0018
Leishmania major phosphatidylinositol 3-kinase, putative 0.2442 0.3373 0.3282
Brugia malayi Protein kinase domain containing protein 0.0032 0.0009 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.4665 0.6478 0.6474
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0193 0.0234 0.0231
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0497 0.0658 0.0604
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0475 0.0628 0.0619
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0123 0.0137 0.0137
Loa Loa (eye worm) phosphatidylinositol 3 0.7188 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0628 0.0621
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0542 0.0721 0.0715
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0497 0.0658 0.065
Echinococcus granulosus serine:threonine protein kinase SMG1 0.138 0.1891 0.1884
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0628 0.0621
Giardia lamblia Hypothetical protein 0.0475 0.0628 0.0498
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0542 0.0721 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.3903 0.5413 0.5409
Schistosoma mansoni hypothetical protein 0.004 0.002 0.002
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0475 0.0628 0.0628
Entamoeba histolytica protein kinase rad3, putative 0.138 0.1891 0.1886
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0047 0.003 0.0021
Loa Loa (eye worm) phosphatidylinositol 3 0.2454 0.339 0.3386
Brugia malayi Bromodomain containing protein 0.0043 0.0024 0.0021
Loa Loa (eye worm) hypothetical protein 0.061 0.0817 0.0811
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0057 0.0048
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0113 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.5727 0.796 0.7958
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.3391 0.4699 0.4694
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0497 0.0658 0.0652
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.0007 0.0003
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0475 0.0628 0.941
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0162 0.019 0.0184
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0014
Trypanosoma brucei target of rapamycin kinase 3, putative 0.5733 0.7968 0.7966
Loa Loa (eye worm) hypothetical protein 0.0056 0.0042 0.0035
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0497 0.0658 0.065
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0628 0.0835
Trichomonas vaginalis PIKK family atypical protein kinase 0.5727 0.796 0.7958
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.138 0.1891 0.1844
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0475 0.0628 0.0573
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.138 0.1891 0.1844
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0688 0.0924 0.0916
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0123 0.0137 0.008
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0497 0.0658 0.0529
Leishmania major phosphatidylinositol kinase, putative 0.0475 0.0628 0.0498
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0047 0.003 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.5727 0.796 0.7958
Mycobacterium tuberculosis Conserved hypothetical protein 0.0475 0.0628 0.5
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.2442 0.3373 0.3367
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.2498 0.3452 0.3414
Entamoeba histolytica hypothetical protein 0.004 0.002 0.0014
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.061 0.0817 0.0808
Trichomonas vaginalis fk506-binding protein, putative 0.0123 0.0137 0.0128
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.2498 0.3452 0.3446
Leishmania major phosphatidylinositol 3-kinase, putative 0.0497 0.0658 0.0529
Loa Loa (eye worm) phosphatidylinositol 3 0.0067 0.0058 0.0051
Giardia lamblia Phosphatidylinositol 4-kinase 0.0475 0.0628 0.0498
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.7188 1 1
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0009 0.0003
Trichomonas vaginalis immunophilin, putative 0.0123 0.0137 0.0128
Loa Loa (eye worm) hypothetical protein 0.0047 0.003 0.0023
Schistosoma mansoni voltage-gated potassium channel 0.0032 0.0009 0.0009
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0619 0.0829 0.082
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.7188 1 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0542 0.0721 0.0715
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0542 0.0721 0.0718
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.2498 0.3452 0.3452
Trichomonas vaginalis PIKK family atypical protein kinase 0.4296 0.5963 0.5959
Schistosoma mansoni voltage-gated potassium channel 0.0177 0.0211 0.0211
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0123 0.0137 0.0128
Leishmania major phosphatidylinositol kinase related protein, putative 0.0475 0.0628 0.0498
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0688 0.0924 0.0918
Loa Loa (eye worm) hypothetical protein 0.0079 0.0074 0.0068
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0056 0.0042 0.0039
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0688 0.0924 0.0872
Onchocerca volvulus 0.0475 0.0628 0.5
Trichomonas vaginalis conserved hypothetical protein 0.1537 0.211 0.2103
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.7188 1 1
Loa Loa (eye worm) FKBP5 protein 0.0123 0.0137 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0475 0.0628 0.0573
Leishmania major phosphatidylinositol 4-kinase, putative 0.0475 0.0628 0.0498
Echinococcus multilocularis voltage gated potassium channel 0.0047 0.003 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Onchocerca volvulus 0.0475 0.0628 0.5
Entamoeba histolytica protein kinase, putative 0.0032 0.0009 0.0003
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0475 0.0628 0.0835
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0497 0.0658 0.065
Echinococcus multilocularis Zinc finger, PHD finger 0.0497 0.0658 0.065
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0475 0.0628 0.0619
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0162 0.019 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Trichomonas vaginalis PIKK family atypical protein kinase 0.4822 0.6697 0.6694
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0475 0.0628 0.0619
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.1062 0.1447 0.1439
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.1392 0.1908 0.1902
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0628 0.0619
Loa Loa (eye worm) hypothetical protein 0.0475 0.0628 0.0621
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0688 0.0924 0.0916
Brugia malayi FAT domain containing protein 0.1062 0.1447 0.1444
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0475 0.0628 0.0628
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.002 0.0011
Loa Loa (eye worm) hypothetical protein 0.1537 0.211 0.2105
Trichomonas vaginalis PIKK family atypical protein kinase 0.7188 1 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0123 0.0137 0.008
Leishmania major phosphatidylinositol 3-related kinase, putative 0.2454 0.339 0.3299
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.138 0.1891 0.1888
Trichomonas vaginalis PIKK family atypical protein kinase 0.3903 0.5413 0.5409
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0475 0.0628 0.941
Trichomonas vaginalis PIKK family atypical protein kinase 0.5727 0.796 0.7958
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0162 0.019 0.0182
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0475 0.0628 0.941
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0475 0.0628 0.0573
Trichomonas vaginalis PIKK family atypical protein kinase 0.3897 0.5405 0.5401
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0123 0.0137 0.013
Leishmania major hypothetical protein, conserved 0.0577 0.0769 0.0641
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0151 0.0176 0.0167
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.061 0.0817 0.0808
Trichomonas vaginalis PIKK family atypical protein kinase 0.138 0.1891 0.1884
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0497 0.0658 0.065
Loa Loa (eye worm) phosphatidylinositol 3 0.0836 0.1131 0.1125
Echinococcus granulosus serine protein kinase ATM 0.138 0.1891 0.1884
Trichomonas vaginalis PIKK family atypical protein kinase 0.5358 0.7445 0.7443
Loa Loa (eye worm) phosphatidylinositol 3 0.0475 0.0628 0.0621
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0106 0.0113 0.0104
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0123 0.0137 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0032 0.0009 0.0003
Schistosoma mansoni transcription factor LCR-F1 0.004 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.1062 0.1447 0.1439
Trichomonas vaginalis PIKK family atypical protein kinase 0.1392 0.1908 0.19
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0619 0.0829 0.082
Echinococcus multilocularis fk506 binding protein 0.0123 0.0137 0.0128
Loa Loa (eye worm) hypothetical protein 0.0077 0.0072 0.0066
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0475 0.0628 0.0619

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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