TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 412.61 | Formula: C29H36N2++
H donors: 0 H acceptors: 0 LogP: 7.44 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: C[n+]1ccc2c(c1CCCc1[n+](C)ccc3c1c(ccc3)C(C)C)c(ccc2)C(C)C
InChi: 1S/C29H36N2/c1-20(2)24-12-7-10-22-16-18-30(5)26(28(22)24)14-9-15-27-29-23(17-19-31(27)6)11-8-13-25(29)21(3)4/h7-8,10-13,16-21H,9,14-15H2,1-6H3/q+2
InChiKey: FIUWYIYFUPSRSD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.0376	0.0372
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0004	0.0004
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0028	0.0004	1
Schistosoma mansoni	hypothetical protein	0.0143	0.1216	0.1146
Entamoeba histolytica	hypothetical protein	0.0185	0.1658	0.1658
Trypanosoma cruzi	DNA polymerase eta, putative	0.0052	0.0263	0.0242
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0778	0.7903	0.7903
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0185	0.1658	0.1602
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0063	0.0376	0.051
Echinococcus granulosus	survival motor neuron protein 1	0.0277	0.2625	0.2576
Trichomonas vaginalis	conserved hypothetical protein	0.0206	0.188	0.1687
Onchocerca volvulus		0.0277	0.263	1
Trypanosoma brucei	DNA polymerase eta, putative	0.0052	0.0263	0.0263
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0185	0.1658	0.1658
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0042	0.0155	0.009
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0063	0.0376	1
Leishmania major	hypothetical protein, unknown function	0.0063	0.0376	0.0376
Entamoeba histolytica	hypothetical protein	0.0063	0.0376	0.0376
Brugia malayi	Pre-SET motif family protein	0.0035	0.008	0.0076
Schistosoma mansoni	patched 1	0.0049	0.0232	0.0154
Schistosoma mansoni	hypothetical protein	0.0048	0.0214	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0185	0.1658	0.1654
Onchocerca volvulus		0.0035	0.008	0.0288
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0063	0.0376	0.0298
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0143	0.1216	0.1146
Trichomonas vaginalis	conserved hypothetical protein	0.0143	0.1216	0.1007
Loa Loa (eye worm)	phosphatidylinositol 3	0.0328	0.3162	0.3159
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0097	0.0736	0.0662
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0004	1
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0063	0.0376	0.0354
Schistosoma mansoni	hypothetical protein	0.0056	0.0306	0.0228
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0328	0.3162	0.3159
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0063	0.0376	0.0147
Onchocerca volvulus		0.0056	0.0306	0.115
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0117	0.0944	0.0871
Echinococcus granulosus	L aminoadipate semialdehyde	0.0097	0.0736	0.0675
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.0376	0.0312
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0328	0.3162	0.3107
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0925	0.0921
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0328	0.3162	0.2999
Echinococcus multilocularis	serine protein kinase ATM	0.0185	0.1658	0.1591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0063	0.0376	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5267	0.5155
Echinococcus granulosus	sterol regulatory element binding protein	0.0049	0.0232	0.0167
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0063	0.0376	0.0354
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0063	0.0376	0.0376
Leishmania major	DNA polymerase eta, putative	0.0052	0.0263	0.0263
Leishmania major	DNA polymerase eta, putative	0.0037	0.01	0.01
Echinococcus multilocularis	expressed conserved protein	0.0108	0.0851	0.0778
Schistosoma mansoni	hypothetical protein	0.0048	0.0214	0.0135
Entamoeba histolytica	hypothetical protein	0.0063	0.0376	0.0376
Entamoeba histolytica	hypothetical protein	0.0063	0.0376	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0584	0.5859	0.5761
Echinococcus granulosus	Niemann Pick C1 protein	0.0165	0.1445	0.1388
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	0.0147
Toxoplasma gondii	FATC domain-containing protein	0.0185	0.1658	0.2251
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5267	0.5155
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0328	0.3162	0.3147
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0122	0.0994	0.0974
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.0376	0.0372
Leishmania major	phosphatidylinositol kinase, putative	0.0063	0.0376	0.0376
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0736	0.0732
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0063	0.0376	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0262	0.2472	0.2293
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.0376	0.0372
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0777	0.7895	0.7845
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0063	0.0376	0.0147
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0063	0.0376	0.0298
Echinococcus multilocularis	protein dispatched 1	0.0056	0.0306	0.0228
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0063	0.0376	0.051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0376	0.0372
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0028	0.0004	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0004	0.0004
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0185	0.1658	0.1639
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0004	0.0106
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0143	0.1216	0.1158
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0185	0.1658	0.1459
Echinococcus granulosus	Niemann Pick C1 protein	0.0115	0.0925	0.0864
Schistosoma mansoni	hypothetical protein	0.0048	0.0214	0.0135
Onchocerca volvulus		0.0097	0.0736	0.2788
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0004	0.0004
Trypanosoma brucei	phosphatidylinositol 3-kinase catalytic subunit, putative	0.0063	0.0376	0.0376
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0328	0.3162	0.3117
Leishmania major	4-coumarate:coa ligase-like protein	0.0028	0.0004	0.0004
Schistosoma mansoni	hypothetical protein	0.0198	0.1799	0.1734
Loa Loa (eye worm)	hypothetical protein	0.0061	0.035	0.0346
Leishmania major	hypothetical protein, conserved	0.0029	0.0022	0.0022
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0028	0.0004	1
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0063	0.0376	0.0298
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0263	0.026
Trichomonas vaginalis	conserved hypothetical protein	0.0122	0.0994	0.078
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0063	0.0376	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0004	1
Loa Loa (eye worm)	hypothetical protein	0.0199	0.1809	0.1805
Echinococcus multilocularis	protein patched	0.0049	0.0232	0.0154
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.0376	0.0372
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0035	0.008	0.0108
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0063	0.0376	0.0298
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0028	0.0004	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0834	0.8496	0.846
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0328	0.3162	0.3162
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0063	0.0376	0.0298
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0042	0.0155	0.0076
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.0376	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0206	0.188	0.1877
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0063	0.0376	0.0298
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0028	0.0004	0.0106
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0777	0.7895	0.7845
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0022	0.003
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0122	0.0994	0.078
Echinococcus multilocularis	geminin	0.0198	0.1799	0.1734
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0063	0.0376	0.0354
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Echinococcus granulosus	serine protein kinase ATM	0.0185	0.1658	0.1602
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.0376	0.0312
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0063	0.0376	0.0312
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0028	0.0004	0.0106
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0063	0.0376	0.0298
Mycobacterium ulcerans	acyl-CoA synthetase	0.0028	0.0004	1
Plasmodium vivax	hypothetical protein	0.0063	0.0376	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0115	0.0925	0.0921
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0063	0.0376	0.0312
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0063	0.0376	0.0298
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0063	0.0376	0.051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0058	0.0326	0.0322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0185	0.1658	0.1459
Schistosoma mansoni	hypothetical protein	0.004	0.0132	0.0052
Loa Loa (eye worm)	hypothetical protein	0.004	0.0132	0.0128
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5259	0.5146
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0063	0.0376	0.0376
Mycobacterium leprae	conserved hypothetical protein	0.0063	0.0376	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.0376	0.0372
Entamoeba histolytica	hypothetical protein	0.0063	0.0376	0.0376
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.0376	0.0372
Entamoeba histolytica	hypothetical protein	0.0042	0.0155	0.0155
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Entamoeba histolytica	acyl-coA synthetase, putative	0.0028	0.0004	0.0004
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0777	0.7895	0.7845
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0063	0.0376	0.0312
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0326	0.0322
Echinococcus granulosus	Protein patched homolog 1	0.0049	0.0232	0.0167
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0655	0.6613	0.6532
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0185	0.1658	0.1591
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0063	0.0376	0.0372
Loa Loa (eye worm)	hypothetical protein	0.0122	0.0994	0.099
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0063	0.0376	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0328	0.3162	0.2999
Loa Loa (eye worm)	hypothetical protein	0.0177	0.1574	0.157
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.0376	0.0372
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0063	0.0376	0.0372
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0726	0.7364	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0328	0.3162	0.2999
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0328	0.3162	0.2999
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0063	0.0376	0.0298
Brugia malayi	ImpB/MucB/SamB family protein	0.0052	0.0263	0.026
Trichomonas vaginalis	set domain proteins, putative	0.0277	0.263	0.2455
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0063	0.0376	0.0147
Entamoeba histolytica	hypothetical protein	0.0042	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0277	0.2625	0.2622
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0022	0.0598
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0578	0.5798	0.5698
Plasmodium vivax	hypothetical protein, conserved	0.0063	0.0376	1
Schistosoma mansoni	hypothetical protein	0.0198	0.1799	0.1734
Echinococcus multilocularis	survival motor neuron protein 1	0.0277	0.2625	0.2566
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0328	0.3162	0.3147
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0063	0.0376	0.051
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Echinococcus multilocularis		0.0063	0.0376	0.0298
Onchocerca volvulus		0.0063	0.0376	0.1415
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0063	0.0376	0.0372
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0948	0.9702	0.9699
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0063	0.0376	1
Echinococcus granulosus	dna polymerase eta	0.0052	0.0263	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0035	0.008	0.0076
Brugia malayi	latrophilin 2 splice variant baaae	0.004	0.0132	0.0128
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0063	0.0376	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0634	0.6391	0.6305
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0063	0.0376	0.0376
Brugia malayi	hypothetical protein	0.0029	0.0022	0.0018
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	0.0376
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0037	0.01	0.0135
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0097	0.0736	0.0732
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0058	0.0326	0.0322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0063	0.0376	0.0147
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.0376	0.0372
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0185	0.1658	0.1654
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0063	0.0376	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0584	0.5859	0.5761
Onchocerca volvulus		0.0177	0.1574	0.5977
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0063	0.0376	0.0312
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0028	0.0004	0.0004
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0185	0.1658	0.1654
Echinococcus granulosus	histone lysine methyltransferase setb	0.0035	0.008	0.0014
Brugia malayi	Pre-SET motif family protein	0.0243	0.2276	0.2273
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.0376	0.0298
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0328	0.3162	0.3107
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0185	0.1658	0.1639
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	1
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.0376	0.0372
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0778	0.7903	0.7903
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0063	0.0376	0.0354
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0063	0.0376	0.0147
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0584	0.5859	0.5761
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0328	0.3162	0.3162
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0063	0.0376	0.0147
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0063	0.0376	0.0147
Brugia malayi	hypothetical protein	0.0042	0.0155	0.0151
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0049	0.0232	0.0229
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0022	0.0598
Schistosoma mansoni	hypothetical protein	0.0042	0.0155	0.0076
Trypanosoma cruzi	target of rapamycin kinase 3	0.0778	0.7903	0.7899
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0232	0.0229
Loa Loa (eye worm)	hypothetical protein	0.0063	0.0376	0.0372
Brugia malayi	hypothetical protein	0.0277	0.2625	0.2622
Plasmodium vivax	SET domain protein, putative	0.0035	0.008	0.2121
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0777	0.7895	0.7845
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0328	0.3162	0.2999
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0063	0.0376	0.0354
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0063	0.0376	0.0147
Brugia malayi	CHE-14 protein	0.0049	0.0232	0.0229
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0063	0.0376	0.0298
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0022	0.0022
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0206	0.188	0.2553
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Echinococcus multilocularis	Zinc finger, PHD finger	0.0063	0.0376	0.0298
Schistosoma mansoni	survival motor neuron protein	0.0056	0.0306	0.0228
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0028	0.0004	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0022	0.0018
Schistosoma mansoni	hypothetical protein	0.0063	0.0376	0.0298
Schistosoma mansoni	hypothetical protein	0.0048	0.0214	0.0135
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	1
Schistosoma mansoni	transcription factor LCR-F1	0.0042	0.0155	0.0076
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0063	0.0376	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0056	0.0306	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0143	0.1216	0.1213
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0185	0.1658	0.1658
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0063	0.0376	0.0372
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0328	0.3162	0.3162
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0328	0.3162	0.3162
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0578	0.5798	0.5698
Toxoplasma gondii	phosphatidylinositol 3- and 4-kinase	0.0063	0.0376	0.051
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	0.0354
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0243	0.2276	0.2273
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0185	0.1658	0.1591
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5267	0.5155
Brugia malayi	hypothetical protein	0.0177	0.1574	0.157
Loa Loa (eye worm)	phosphatidylinositol 3	0.0063	0.0376	0.0372
Echinococcus multilocularis	Niemann Pick C1 protein	0.0115	0.0925	0.0852
Entamoeba histolytica	protein kinase rad3, putative	0.0185	0.1658	0.1658
Echinococcus multilocularis	sterol regulatory element binding protein	0.0049	0.0232	0.0154
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	0.0376
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	0.0376
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Brugia malayi	FAT domain containing protein	0.0143	0.1216	0.1213
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0063	0.0376	0.0312
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0462	0.4577	0.4577
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0376
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0406	0.3985	0.3985
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0063	0.0376	0.0312
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0058	0.0326	0.0322
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0777	0.7895	0.7845
Echinococcus multilocularis	Niemann Pick C1 protein	0.0165	0.1445	0.1377
Leishmania major	hypothetical protein, conserved	0.0063	0.0376	0.0376
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0185	0.1658	0.1459
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0022	0.0598
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0185	0.1658	0.1591
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0063	0.0376	0.0354
Echinococcus granulosus	expressed conserved protein	0.0108	0.0851	0.079
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0063	0.0376	0.0376
Echinococcus multilocularis	dna polymerase eta	0.0052	0.0263	0.0185
Echinococcus granulosus	geminin	0.0198	0.1799	0.1745
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0726	0.7364	0.7301
Entamoeba histolytica	hypothetical protein	0.0042	0.0155	0.0155
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0115	0.0925	0.0925
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.0063	0.0376	0.0376
Entamoeba histolytica	hypothetical protein	0.0042	0.0155	0.0155
Schistosoma mansoni	DNA polymerase eta	0.0052	0.0263	0.0185
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0063	0.0376	1
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0097	0.0736	0.0662
Mycobacterium ulcerans	hypothetical protein	0.0028	0.0004	1
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0063	0.0376	0.0298
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0063	0.0376	0.0298
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0063	0.0376	0.0147
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0063	0.0376	0.0354
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5267	0.5155
Trypanosoma cruzi	DNA polymerase eta, putative	0.0037	0.01	0.0077
Onchocerca volvulus		0.0063	0.0376	0.1415
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5259	0.5146
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0527	0.5259	0.5146
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0063	0.0376	0.0354

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1962732

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1621368