TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 377.483 | Formula: C22H27N5O
H donors: 1 H acceptors: 2 LogP: 4.65 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: C1CCC(CC1)Nc1c(nc2n1cccn2)c1ccc(cc1)N1CCOCC1
InChi: 1S/C22H27N5O/c1-2-5-18(6-3-1)24-21-20(25-22-23-11-4-12-27(21)22)17-7-9-19(10-8-17)26-13-15-28-16-14-26/h4,7-12,18,24H,1-3,5-6,13-16H2
InChiKey: GRTTYDAVEXPIIC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	arachidonate 5-lipoxygenase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative	Get druggable targets OG5_127482	All targets in OG5_127482
Echinococcus multilocularis	arachidonate 5 lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma japonicum	IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing	Get druggable targets OG5_127482	All targets in OG5_127482
Schistosoma mansoni	lipoxygenase	Get druggable targets OG5_127482	All targets in OG5_127482

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	Polycystic kidney disease protein	0.0024	0.009	0.009
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.054	0.3513	0.3513
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0114	0.0038
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	0.0439
Brugia malayi	YY1-associated factor 2	0.054	0.3513	0.3476
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0027	0.0114	0.0114
Echinococcus multilocularis	ring finger protein 170	0.0027	0.0114	0.0114
Echinococcus granulosus	RING finger protein 185	0.0027	0.0114	0.0114
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Schistosoma mansoni	rab6-interacting	0.0024	0.009	0.0071
Giardia lamblia	Kinase	0.0027	0.0114	1
Plasmodium falciparum	trophozoite exported protein 1	0.0027	0.0114	0.0038
Entamoeba histolytica	hypothetical protein	0.0083	0.0484	1
Schistosoma mansoni	hypothetical protein	0.0037	0.0174	0.0156
Brugia malayi	hypothetical protein	0.0024	0.009	0.0033
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Loa Loa (eye worm)	hypothetical protein	0.054	0.3513	0.3513
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trypanosoma brucei	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trichomonas vaginalis	ankyrin, putative	0.0027	0.0114	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Brugia malayi	exodeoxyribonuclease III family protein	0.0022	0.0076	0.002
Schistosoma mansoni	zinc finger protein	0.054	0.3513	0.3501
Trypanosoma cruzi	WLM domain containing protein, putative	0.054	0.3513	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.054	0.3513	0.3476
Echinococcus granulosus	SWI:SNF matrix associated	0.1519	1	1
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1519	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0027	0.0114	0.0038
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.054	0.3513	0.3455
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Toxoplasma gondii	hypothetical protein	0.0027	0.0114	0.0038
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.054	0.3513	0.3513
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Giardia lamblia	Zinc finger domain	0.0027	0.0114	1
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0027	0.0114	0.0114
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0029	0.0125	0.005
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Echinococcus multilocularis	tumor protein p63	0.1401	0.9221	0.9221
Brugia malayi	RING finger protein 20	0.0027	0.0114	0.0058
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0176	0.1099	1
Trypanosoma brucei	hypothetical protein, conserved	0.054	0.3513	1
Chlamydia trachomatis	SWIB complex protein	0.1519	1	1
Schistosoma mansoni	hypothetical protein	0.1519	1	1
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Schistosoma mansoni	serine/threonine protein kinase	0.0027	0.0114	0.0096
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Brugia malayi	hypothetical protein	0.0024	0.009	0.0033
Echinococcus multilocularis	Aminotransferase class III	0.0025	0.0098	0.0098
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0027	0.0114	0.0114
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Schistosoma mansoni	ring finger protein 151	0.0027	0.0114	0.0096
Plasmodium falciparum	zinc finger protein, putative	0.0027	0.0114	0.0038
Schistosoma mansoni	cpg binding protein	0.0035	0.0165	0.0147
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0063	0.035	0.0275
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0174	0.0174
Echinococcus granulosus	ornithine aminotransferase	0.0025	0.0098	0.0098
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0125	0.005
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Brugia malayi	4-aminobutyrate aminotransferase, mitochondrial precursor	0.0025	0.0098	0.0041
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Entamoeba histolytica	hypothetical protein	0.0027	0.0114	0.0928
Loa Loa (eye worm)	hypothetical protein	0.054	0.3513	0.3513
Echinococcus multilocularis	muscleblind protein	0.0346	0.2225	0.2225
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trypanosoma brucei	DNA repair protein, putative	0.0027	0.0114	0.011
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.054	0.3513	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Echinococcus granulosus	RUN	0.0024	0.009	0.009
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0142	0.0876	0.0876
Giardia lamblia	Kinase, NEK	0.0027	0.0114	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.054	0.3513	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0176	0.1099	0.1031
Mycobacterium tuberculosis	Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at)	0.0025	0.0098	0.0211
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0027	0.0114	0.0038
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0027	0.0114	0.0114
Schistosoma mansoni	ap endonuclease	0.0022	0.0076	0.0058
Echinococcus multilocularis	SWI:SNF matrix associated	0.1519	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger) containing protein, putative	0.0027	0.0114	0.011
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Plasmodium vivax	RING zinc finger protein, putative	0.0027	0.0114	0.0038
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0028	0.0115	0.004
Schistosoma mansoni	peptidase Clp (S14 family)	0.0091	0.0532	0.0515
Brugia malayi	Doublecortin family protein	0.0024	0.009	0.0033
Mycobacterium tuberculosis	Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase)	0.0025	0.0098	0.0211
Echinococcus multilocularis	muscleblind protein 1	0.0346	0.2225	0.2225
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0027	0.0114	0.0038
Echinococcus granulosus	muscleblind protein	0.0346	0.2225	0.2225
Loa Loa (eye worm)	hypothetical protein	0.0205	0.1291	0.1291
Leishmania major	hypothetical protein, unknown function	0.0027	0.0114	0.011
Brugia malayi	Neuralized family protein	0.0027	0.0114	0.0058
Schistosoma mansoni	hypothetical protein	0.0079	0.0455	0.0437
Schistosoma mansoni	hypothetical protein	0.0037	0.0174	0.0156
Onchocerca volvulus		0.1519	1	1
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0027	0.0114	0.0114
Leishmania major	hypothetical protein	0.0027	0.0114	0.011
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Onchocerca volvulus	Protein neuralized homolog	0.0027	0.0114	0.0025
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	1
Trypanosoma cruzi	WLM domain containing protein, putative	0.054	0.3513	1
Brugia malayi	Latrophilin receptor protein 2	0.0037	0.0174	0.0118
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Trypanosoma brucei	predicted zinc finger protein	0.0027	0.0114	0.011
Onchocerca volvulus		0.0027	0.0114	0.0025
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Loa Loa (eye worm)	doublecortin family protein	0.0024	0.009	0.009
Brugia malayi	B-box zinc finger family protein	0.0027	0.0114	0.0058
Schistosoma mansoni	hypothetical protein	0.0037	0.0174	0.0156
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Brugia malayi	RING zinc finger protein	0.0027	0.0114	0.0058
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0114	0.0038
Trypanosoma brucei	hypothetical protein, conserved	0.054	0.3513	1
Schistosoma mansoni	cpg binding protein	0.0035	0.0165	0.0147
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Loa Loa (eye worm)	brahma associated protein	0.1519	1	1
Leishmania major	hypothetical protein, conserved	0.054	0.3513	1
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Echinococcus granulosus	Zinc finger RanBP2 type	0.054	0.3513	0.3513
Onchocerca volvulus		0.0027	0.0114	0.0025
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0059	0.0325	0.2436
Echinococcus granulosus	peptidase Clp S14 family	0.0059	0.0325	0.0325
Brugia malayi	Zinc finger, C2H2 type family protein	0.0027	0.0114	0.0058
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1519	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0059	0.0325	0.2274
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Brugia malayi	hypothetical protein	0.0027	0.0114	0.0058
Onchocerca volvulus		0.0033	0.0152	0.0063
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0027	0.0114	0.0038
Onchocerca volvulus	RING finger protein 141 homolog	0.0027	0.0114	0.0025
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Echinococcus granulosus	ring and YY1 binding protein	0.054	0.3513	0.3513
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Trichomonas vaginalis	hypothetical protein	0.0027	0.0114	0.0038
Echinococcus multilocularis	ring and YY1 binding protein	0.054	0.3513	0.3513
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0027	0.0114	0.0038
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	1
Schistosoma mansoni	cellular tumor antigen P53	0.0205	0.1291	0.1275
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	0.4459
Trypanosoma cruzi	hypothetical protein	0.0027	0.0114	0.011
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.054	0.3513	1
Schistosoma mansoni	lipoxygenase	0.01	0.0592	0.0574
Loa Loa (eye worm)	RiNg Finger protein family member	0.0028	0.0115	0.0115
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0037	0.0174	0.0174
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0027	0.0114	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.054	0.3513	0.3476
Schistosoma mansoni	hypothetical protein	0.0083	0.0484	0.0466
Schistosoma mansoni	hypothetical protein	0.0027	0.0114	0.0096
Brugia malayi	hypothetical protein	0.0027	0.0114	0.0058
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0025	0.0098	0.0211
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0091	0.0532	0.434
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0176	0.1099	1
Onchocerca volvulus		0.0205	0.1291	0.1213
Onchocerca volvulus	Putative RING finger protein 207	0.0027	0.0114	0.0025
Wolbachia endosymbiont of Brugia malayi	acetylornithine transaminase protein	0.0025	0.0098	0.0472
Schistosoma mansoni	TRABID protein (C64 family)	0.054	0.3513	0.3501
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0022	0.0076	0.0076
Plasmodium falciparum	RING zinc finger protein, putative	0.0027	0.0114	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Brugia malayi	latrophilin 2 splice variant baaae	0.0079	0.0455	0.0401
Loa Loa (eye worm)	hypothetical protein	0.0346	0.2225	0.2225
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.054	0.3513	0.3513
Trypanosoma cruzi	hypothetical protein, conserved	0.054	0.3513	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Echinococcus multilocularis	RUN	0.0024	0.009	0.009
Toxoplasma gondii	helicase, putative	0.0027	0.0114	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0037	0.0174	0.0174
Schistosoma mansoni	fusion	0.054	0.3513	0.3501
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.0532	0.0459
Leishmania major	hypothetical protein, conserved	0.054	0.3513	1
Echinococcus granulosus	Aminotransferase class III	0.0025	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0346	0.2225	0.2225
Loa Loa (eye worm)	RING finger protein 20	0.0027	0.0114	0.0114
Trypanosoma cruzi	hypothetical protein, conserved	0.054	0.3513	1
Schistosoma mansoni	hypothetical protein	0.0024	0.009	0.0071
Schistosoma mansoni	peter pan-related	0.0027	0.0114	0.0096
Plasmodium vivax	zinc finger protein, putative	0.0027	0.0114	0.0038
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0027	0.0114	0.0038
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Brugia malayi	Muscleblind-like protein	0.0346	0.2225	0.2181
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0027	0.0114	0.011
Trichomonas vaginalis	ion channel nompc, putative	0.0027	0.0114	0.0038
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0115	0.0697	0.0644
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0059	0.0325	0.2436
Toxoplasma gondii	hypothetical protein	0.0027	0.0114	0.0038
Giardia lamblia	Kinase, NEK	0.0027	0.0114	1
Brugia malayi	SWIB/MDM2 domain containing protein	0.1519	1	1
Leishmania major	hypothetical protein, conserved	0.054	0.3513	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0027	0.0114	0.0038
Schistosoma mansoni	mind bomb	0.0027	0.0114	0.0096
Loa Loa (eye worm)	hypothetical protein	0.0115	0.0697	0.0697
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0027	0.0114	0.0114
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.009	0.009
Mycobacterium ulcerans	glutamate-1-semialdehyde aminotransferase	0.0025	0.0098	0.0211
Echinococcus multilocularis	cpg binding protein	0.0035	0.0165	0.0165
Schistosoma mansoni	transcription factor LCR-F1	0.0083	0.0484	0.0466
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0027	0.0114	0.0058
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1519	1	1
Schistosoma mansoni	peter pan-related	0.0027	0.0114	0.0096
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Plasmodium vivax	multidomain scavenger receptor, putative	0.0024	0.009	0.0014
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Schistosoma mansoni	hypothetical protein	0.0027	0.0114	0.0096
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0071	0.0399	0.0382
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0027	0.0114	0.0114
Leishmania major	DNA repair protein-like protein	0.0027	0.0114	0.011
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Entamoeba histolytica	hypothetical protein	0.0083	0.0484	1
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1519	1	1
Plasmodium vivax	DNA repair protein RAD5, putative	0.0027	0.0114	0.0038
Trypanosoma cruzi	hypothetical protein	0.0027	0.0114	0.011
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Schistosoma mansoni	rab6-interacting	0.0024	0.009	0.0071
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0024	0.009	0.009
Echinococcus granulosus	ring finger protein 170	0.0027	0.0114	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0027	0.0114	0.0038
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0939	0.6157	0.6157
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.009	0.009
Toxoplasma gondii	hypothetical protein	0.0027	0.0114	0.0038
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	0.0459
Onchocerca volvulus		0.054	0.3513	0.3455
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Onchocerca volvulus		0.0027	0.0114	0.0025
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0139	0.137
Schistosoma mansoni	rnf5	0.0027	0.0114	0.0096
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0115	0.0697	0.0697
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0027	0.0114	0.0038
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Loa Loa (eye worm)	hypothetical protein	0.054	0.3513	0.3513
Echinococcus multilocularis	ornithine aminotransferase	0.0025	0.0098	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0013	0.0019	0.0019
Onchocerca volvulus		0.0027	0.0114	0.0025
Mycobacterium tuberculosis	Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase)	0.0025	0.0098	0.0211
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Brugia malayi	Zinc finger protein 183 homolog	0.0028	0.0115	0.0059
Chlamydia trachomatis	DNA topoisomerase I	0.1519	1	1
Echinococcus multilocularis		0.0027	0.0114	0.0114
Plasmodium vivax	ornithine aminotransferase, putative	0.0025	0.0098	0.0022
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0027	0.0114	0.0038
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.054	0.3513	1
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0125	0.0125
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0125	0.0143
Mycobacterium ulcerans	hypothetical protein	0.0176	0.1099	1
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.054	0.3513	0.3463
Giardia lamblia	Zinc finger domain	0.0027	0.0114	1
Brugia malayi	hypothetical protein	0.0029	0.0125	0.0069
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Brugia malayi	hypothetical protein	0.0027	0.0114	0.0058
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.054	0.3513	1
Schistosoma mansoni	ornithine--oxo-acid transaminase	0.0025	0.0098	0.0079
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Leishmania major	hypothetical protein, conserved	0.054	0.3513	1
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0022	0.0076	0.0076
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Leishmania major	hypothetical protein, conserved	0.054	0.3513	1
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1519	1	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Plasmodium vivax	hypothetical protein, conserved	0.1519	1	1
Echinococcus granulosus	lipoxygenase domain containing protein	0.0024	0.009	0.009
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0455	0.0455
Brugia malayi	hypothetical protein	0.0083	0.0484	0.043
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.054	0.3513	0.3513
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Mycobacterium ulcerans	L-lysine aminotransferase	0.0025	0.0098	0.0211
Trypanosoma cruzi	hypothetical protein, conserved	0.0027	0.0114	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.0031	0.0139	0.0409
Trypanosoma brucei	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Loa Loa (eye worm)	hypothetical protein	0.054	0.3513	0.3513
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Echinococcus granulosus	GPCR family 2	0.0037	0.0174	0.0174
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	0.0439
Schistosoma mansoni	loxhd1	0.0024	0.009	0.0071
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.054	0.3513	1
Schistosoma mansoni	hypothetical protein	0.054	0.3513	0.3501
Toxoplasma gondii	hypothetical protein	0.0031	0.0139	0.0063
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.054	0.3513	0.3476
Trypanosoma cruzi	Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.009
Schistosoma mansoni	ap endonuclease	0.0022	0.0076	0.0058
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Giardia lamblia	Ribonuclease	0.0027	0.0114	1
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0027	0.0114	0.0096
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0027	0.0114	1
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0027	0.0114	0.0038
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1519	1	1
Echinococcus multilocularis	ornithine aminotransferase	0.0025	0.0098	0.0098
Trichomonas vaginalis	ankyrin, putative	0.0027	0.0114	0.0038
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0115	0.0697	0.0644
Brugia malayi	hypothetical protein	0.0027	0.0114	0.0058
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.054	0.3513	1
Leishmania major	hypothetical protein, conserved	0.0029	0.0125	0.0143
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0027	0.0114	0.0038
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0027	0.0114	0.0114
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0083	0.0484	0.0484
Echinococcus multilocularis	SWI:SNF matrix associated	0.1519	1	1
Onchocerca volvulus		0.0027	0.0114	0.0025
Mycobacterium tuberculosis	Probable aminotransferase	0.0176	0.1099	1
Brugia malayi	Probable ClpP-like protease	0.0091	0.0532	0.0478
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0091	0.0532	0.0532
Schistosoma mansoni	hypothetical protein	0.1519	1	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trypanosoma brucei	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Entamoeba histolytica	hypothetical protein	0.0083	0.0484	1
Plasmodium falciparum	ornithine aminotransferase	0.0025	0.0098	0.0022
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Entamoeba histolytica	hypothetical protein	0.0083	0.0484	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0037	0.0174	0.0174
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0037	0.0174	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0091	0.0532	0.0532
Toxoplasma gondii	RING zinc finger protein	0.0027	0.0114	0.0038
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Toxoplasma gondii	ran binding protein	0.054	0.3513	0.3463
Onchocerca volvulus		0.0027	0.0114	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.1519	1	1
Trypanosoma cruzi	Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Echinococcus granulosus	tumor protein p63	0.1401	0.9221	0.9221
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Echinococcus granulosus	dnaJ subfamily B	0.0474	0.3072	0.3072
Schistosoma mansoni	RNA binding protein	0.054	0.3513	0.3501
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0013	0.0019	0.0019
Echinococcus granulosus	cpg binding protein	0.0035	0.0165	0.0165
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0091	0.0532	0.4459
Mycobacterium ulcerans	ornithine aminotransferase RocD1 and RocD2	0.0025	0.0098	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0037	0.0174	0.0118
Brugia malayi	CXXC zinc finger family protein	0.0033	0.0152	0.0096
Trypanosoma brucei	ring finger containing protein	0.0027	0.0114	0.011
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0059	0.0325	0.0325
Giardia lamblia	Ser/Thr protein kinase	0.0027	0.0114	1
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1519	1	1
Entamoeba histolytica	SPRY domain protein	0.0027	0.0114	0.0928
Mycobacterium ulcerans	4-aminobutyrate aminotransferase	0.0025	0.0098	0.0211
Schistosoma mansoni	hypothetical protein	0.0037	0.0174	0.0156
Schistosoma mansoni	hypothetical protein	0.0028	0.0115	0.0097
Schistosoma mansoni	hypothetical protein	0.0474	0.3072	0.3059
Echinococcus granulosus	Polycystic kidney disease protein	0.0024	0.009	0.009
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0033	0.0152	0.0152
Entamoeba histolytica	hypothetical protein	0.0027	0.0114	0.0928
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0114	0.0114
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Brugia malayi	hypothetical protein	0.0027	0.0114	0.0058
Toxoplasma gondii	hypothetical protein	0.0027	0.0114	0.0038
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0152	0.0134
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0027	0.0114	0.0038
Echinococcus multilocularis	dnaJ subfamily B	0.0474	0.3072	0.3072
Echinococcus granulosus	zinc finger protein Ran binding	0.054	0.3513	0.3513
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0027	0.0114	0.0114
Echinococcus multilocularis	SWI:SNF matrix associated	0.1519	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0027	0.0114	0.0038
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Echinococcus multilocularis	ring finger protein 113a	0.0028	0.0115	0.0115
Schistosoma mansoni	lipoxygenase	0.0142	0.0876	0.0859
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Schistosoma mansoni	hypothetical protein	0.1519	1	1
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0027	0.0114	0.0114
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0031	0.0139	0.0063
Giardia lamblia	Hypothetical protein	0.0027	0.0114	1
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Mycobacterium ulcerans	acetylornithine aminotransferase	0.0025	0.0098	0.0211
Echinococcus granulosus	ring finger protein 113a	0.0028	0.0115	0.0115
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1519	1	1
Brugia malayi	brahma associated protein 60 kDa	0.1519	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Onchocerca volvulus		0.054	0.3513	0.3455
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0027	0.0114	0.0114
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Leishmania major	hypothetical protein, conserved	0.0027	0.0114	0.011
Echinococcus multilocularis	GPCR, family 2	0.0037	0.0174	0.0174
Toxoplasma gondii	ornithine aminotransferase, mitochondrial precursor, putative	0.0025	0.0098	0.0022
Trypanosoma cruzi	Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative	0.0027	0.0114	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0083	0.0484	0.0484
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Plasmodium falciparum	ataxin-2 like protein, putative	0.0029	0.0125	0.005
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.054	0.3513	0.3476
Onchocerca volvulus		0.054	0.3513	0.3455
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Schistosoma mansoni	polycystin 1-related	0.0024	0.009	0.0071
Trypanosoma brucei	SNF2 family N-terminal domain/Ring finger domain containing protein, putative	0.0027	0.0114	0.011
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Trichomonas vaginalis	ankyrin, putative	0.0027	0.0114	0.0038
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0091	0.0532	0.0459
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0091	0.0532	0.0459
Entamoeba histolytica	zinc finger domain containing protein	0.0027	0.0114	0.0928
Schistosoma mansoni	zinc finger protein	0.0027	0.0114	0.0096
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0027	0.0114	0.0038
Plasmodium falciparum	LCCL domain-containing protein	0.0024	0.009	0.0014
Plasmodium vivax	ataxin-2 like protein, putative	0.0029	0.0125	0.005
Brugia malayi	hypothetical protein	0.0027	0.0114	0.0058
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Trypanosoma brucei	Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Giardia lamblia	Protein 21.1	0.0027	0.0114	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0037	0.0174	0.0174
Schistosoma mansoni	brg-1 associated factor	0.1519	1	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0029	0.0125	0.0143
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.054	0.3513	0.3463
Trypanosoma cruzi	UEV domain/Zinc finger, C3HC4 type (RING finger), putative	0.0027	0.0114	0.011
Plasmodium vivax	trophozoite exported protein 1, putative	0.0027	0.0114	0.0038
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.054	0.3513	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0029	0.0125	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0024	0.009	0.009
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0031	0.0139	0.0063
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0114	0.0038
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0022	0.0076	0.0076
Echinococcus multilocularis	RING finger protein 185	0.0027	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0532	0.0532
Echinococcus multilocularis	zinc finger protein Ran binding	0.054	0.3513	0.3513
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0176	0.1099	1
Mycobacterium tuberculosis	Probable acetylornithine aminotransferase ArgD	0.0025	0.0098	0.0211
Onchocerca volvulus		0.054	0.3513	0.3455
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0142	0.0876	0.0876
Giardia lamblia	Protein 21.1	0.0027	0.0114	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 3.55 uM	Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as reduction in A23187 and AA-stimulated 5-LO product formation preincubated for 15 mins prior stimulation measured after 10 mins by HPLC analysis	ChEMBL.	22326163
IC50 (binding)	= 6.1 uM	Inhibition of 5-lipoxygenase in S100 cell free fraction of human polymorphonuclear leukocytes assessed as reduction in 5-LO product formation preincubated for 15 mins measured after 10 mins by HPLC analysis	ChEMBL.	22326163

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1957977

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1623245