Detailed information for compound 1624363

Basic information

Technical information
  • TDR Targets ID: 1624363
  • Name: 1-tert-butylsulfanylsulfonyl-4-methylbenzene
  • MW: 244.374 | Formula: C11H16O2S2
  • H donors: 0 H acceptors: 2 LogP: 2.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(cc1)S(=O)(=O)SC(C)(C)C
  • InChi: 1S/C11H16O2S2/c1-9-5-7-10(8-6-9)15(12,13)14-11(2,3)4/h5-8H,1-4H3
  • InChiKey: DWUPUYSPVAQOBQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-tert-butylsulfanylsulfonyl-4-methyl-benzene
  • 1-(tert-butylthio)sulfonyl-4-methylbenzene
  • 1-(tert-butylthio)sulfonyl-4-methyl-benzene
  • 2943-19-3
  • NCI60_003034
  • NSC 342017
  • AIDS-129338
  • AIDS129338
  • NSC342017
  • S-(tert-Butyl) 4-methylbenzenesulfonothioate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0456 0.0458
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0466 0.3085 0.3212
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0263 0.1665 0.1725
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0264 0.0264
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0044 0.0138 0.0018
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0065 0.0281 0.0281
Loa Loa (eye worm) hypothetical protein 0.0062 0.0264 0.0146
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0456 0.0458
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.1249 0.1062
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.009 0.0456 0.0207
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0263 0.1665 0.1511
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1106 0.7558 0.7867
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0546 0.0546
Brugia malayi Bromodomain containing protein 0.0081 0.0397 0.0397
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.009 0.0456 0.0207
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0264 0.0258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0373 0.2434 0.234
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0456 0.0207
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.009 0.0456 0.0456
Plasmodium falciparum phosphatidylinositol 3-kinase 0.009 0.0456 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1389 0.9537 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0932 0.6341 0.6553
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.1665 0.1511
Trichomonas vaginalis PIKK family atypical protein kinase 0.0749 0.5063 0.5175
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.1394 0.9565 0.956
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0068 0.0307 0.0047
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.009 0.0456 1
Loa Loa (eye worm) hypothetical protein 0.0203 0.1249 0.1143
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.009 0.0456 0.0207
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0466 0.3085 0.3085
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.3085 0.3042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0101 0.0101
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.009 0.0456 0.0207
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0263 0.1665 0.1511
Trichomonas vaginalis PIKK family atypical protein kinase 0.1105 0.755 0.7858
Trichomonas vaginalis PIKK family atypical protein kinase 0.1105 0.755 0.7858
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.009 0.0456 0.0456
Giardia lamblia Phosphatidylinositol 4-kinase 0.009 0.0456 0.0197
Echinococcus multilocularis serine protein kinase ATM 0.0263 0.1665 0.1665
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.009 0.0456 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0456 0.0458
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1389 0.9537 1
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.009 0.0456 0.0456
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.009 0.0456 0.0456
Leishmania major hypothetical protein, conserved 0.009 0.0456 0.0207
Leishmania major phosphatidylinositol 4-kinase, putative 0.009 0.0456 0.0207
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1106 0.7558 0.7867
Trypanosoma cruzi target of rapamycin kinase 3 0.1106 0.7558 0.7867
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0234 0.0234
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.009 0.0456 0.0456
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.1394 0.9565 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0466 0.3085 0.3085
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0062 0.0264 0.0258
Loa Loa (eye worm) hypothetical protein 0.0173 0.1039 0.093
Giardia lamblia Hypothetical protein 0.009 0.0456 0.0197
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0062 0.0264 0.0264
Schistosoma mansoni hypothetical protein 0.0203 0.1249 0.1249
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.009 0.0456 0.0207
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0062 0.0264 0.0264
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0062 0.0264 0.0258
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.009 0.0456 0.0207
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.1389 0.9537 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.009 0.0456 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.1105 0.755 0.7858
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.5071 0.5184
Brugia malayi RNA recognition motif domain containing protein 0.0058 0.0234 0.0227
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0062 0.0264 0.0264
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1456 1 1
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.009 0.0456 0.0456
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0546 0.0546
Brugia malayi RNA binding protein 0.0058 0.0234 0.0227
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.5572 0.5725
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.009 0.0456 0.0207
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0546 0.0546
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0062 0.0264 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.5071 0.5184
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.3085 0.3042
Schistosoma mansoni hypothetical protein 0.009 0.0456 0.0456
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1389 0.9537 1
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.009 0.0456 0.0456
Brugia malayi Melibiase family protein 0.0068 0.0307 0.0303
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0173 0.1039 0.0836
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0234 0.0234
Plasmodium falciparum phosphatidylinositol 4-kinase 0.009 0.0456 1
Schistosoma mansoni fkbp-rapamycin associated protein 0.0263 0.1665 0.1665
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1389 0.9537 1
Leishmania major phosphatidylinositol kinase, putative 0.009 0.0456 0.0207
Loa Loa (eye worm) hypothetical protein 0.0263 0.1665 0.1564
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.1389 0.9537 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.009 0.0456 0.0207
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0264 0.0258
Loa Loa (eye worm) hypothetical protein 0.0046 0.0152 0.0033
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.009 0.0456 0.0197
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.009 0.0456 0.0207
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0546 0.029
Loa Loa (eye worm) hypothetical protein 0.009 0.0456 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.563 0.5787
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1389 0.9537 1
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0234 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.009 0.0456 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.0749 0.5063 0.5175
Echinococcus multilocularis tar DNA binding protein 0.0058 0.0234 0.0234
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0293 0.1875 0.1655
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.009 0.0456 0.0207
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.009 0.0456 0.0207
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0456 0.034
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.1456 1 1
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.009 0.0456 0.0458
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.009 0.0456 1
Leishmania major phosphatidylinositol kinase related protein, putative 0.009 0.0456 0.0207
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0466 0.3085 0.3042
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0657 0.442 0.4482
Brugia malayi TAR-binding protein 0.0058 0.0234 0.0227
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.009 0.0456 0.0197
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0062 0.0264 0.0264
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0456 0.034
Schistosoma mansoni phosphatidylinositol 4-kinase 0.009 0.0456 0.0456
Trichomonas vaginalis PIKK family atypical protein kinase 0.1105 0.755 0.7858
Loa Loa (eye worm) phosphatidylinositol kinase 0.009 0.0456 0.034
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.009 0.0456 0.0456
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1456 1 1
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.1456 1 1
Loa Loa (eye worm) RNA binding protein 0.0058 0.0234 0.0116
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.5071 0.5184
Loa Loa (eye worm) hypothetical protein 0.0062 0.0264 0.0146
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.1456 1 1
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.009 0.0456 0.0207
Echinococcus granulosus tar DNA binding protein 0.0058 0.0234 0.0234
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.009 0.0456 0.0207
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0466 0.3085 0.3085
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.009 0.0456 0.0207
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Plasmodium vivax hypothetical protein 0.009 0.0456 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.563 0.5787
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0062 0.0264 0.0264
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.009 0.0456 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.3085 0.3042
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0062 0.0264 0.0264
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1389 0.9537 1
Onchocerca volvulus 0.009 0.0456 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.1665 0.1511
Loa Loa (eye worm) hypothetical protein 0.009 0.0456 0.034
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.009 0.0456 0.0456
Loa Loa (eye worm) hypothetical protein 0.0077 0.0365 0.0248
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.009 0.0456 0.0207
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.009 0.0456 0.0456
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0203 0.1249 0.1249
Entamoeba histolytica hypothetical protein 0.0263 0.1665 0.1332
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0101 0.0101
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.1394 0.9565 0.9565
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0456 0.0458
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.009 0.0456 0.0207
Loa Loa (eye worm) hypothetical protein 0.0293 0.1875 0.1776
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.009 0.0456 0.0207
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.3085 0.3042
Trichomonas vaginalis PIKK family atypical protein kinase 0.1389 0.9537 1
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0264
Plasmodium vivax hypothetical protein, conserved 0.009 0.0456 1
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0456 0.034
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.009 0.0456 0.0456
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0546 0.0546
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.009 0.0456 0.0456
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1394 0.9565 0.9565
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0062 0.0264 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0234 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0263 0.1665 0.1511
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0307 0.0307
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1389 0.9537 1
Leishmania major phosphatidylinositol 3-kinase, putative 0.009 0.0456 0.0207
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.009 0.0456 0.0456
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1389 0.9537 0.9537
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1389 0.9537 0.9537
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.009 0.0456 0.0456
Onchocerca volvulus 0.009 0.0456 0.5
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0263 0.1665 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.083 0.563 0.5787
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0456 0.0207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0456 0.0458
Trichomonas vaginalis PIKK family atypical protein kinase 0.1105 0.755 0.7858
Trichomonas vaginalis PIKK family atypical protein kinase 0.0902 0.6131 0.6327
Loa Loa (eye worm) phosphatidylinositol 3 0.1389 0.9537 0.9531
Loa Loa (eye worm) hypothetical protein 0.0068 0.0307 0.019
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0062 0.0264 0.0258
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.009 0.0456 1
Entamoeba histolytica protein kinase rad3, putative 0.0263 0.1665 0.1332
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0466 0.3085 0.3042
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.0293 0.1875 0.1737
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0062 0.0264 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0822 0.5572 0.5725
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0577 0.3861 0.3879
Loa Loa (eye worm) TAR-binding protein 0.0058 0.0234 0.0116
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0466 0.3085 0.3042
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0062 0.0264 0.0264
Loa Loa (eye worm) hypothetical protein 0.0062 0.0264 0.0146
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0058 0.0234 0.0116
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.009 0.0456 0.0456
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.009 0.0456 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0456 0.0458
Toxoplasma gondii FATC domain-containing protein 0.0263 0.1665 0.1439
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.009 0.0456 0.0197
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.075 0.5071 0.5184
Loa Loa (eye worm) hypothetical protein 0.0283 0.1807 0.1708
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.1456 1 1
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0062 0.0264 0.0264
Leishmania major phosphatidylinositol 3-kinase, putative 0.0466 0.3085 0.3042
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.009 0.0456 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.1186 0.8117 0.8469
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0062 0.0264 0.0264
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1389 0.9537 0.997
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0263 0.1665 0.1665
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0203 0.1249 0.1249
Toxoplasma gondii target of rapamycin (TOR), putative 0.1033 0.7049 0.6969
Echinococcus multilocularis Zinc finger, PHD finger 0.009 0.0456 0.0456
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Brugia malayi FAT domain containing protein 0.0203 0.1249 0.1289
Schistosoma mansoni tar DNA-binding protein 0.0058 0.0234 0.0234
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0062 0.0264 0.0264
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.009 0.0456 0.0197
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.009 0.0456 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.1039 0.0836
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Echinococcus granulosus serine protein kinase ATM 0.0263 0.1665 0.1665
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0263 0.1665 0.1332
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0456 0.034
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.009 0.0456 0.0456
Brugia malayi follicle stimulating hormone receptor 0.0232 0.1451 0.1501
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0546 0.0546
Loa Loa (eye worm) PDE1B protein 0.0062 0.0264 0.0146
Mycobacterium leprae conserved hypothetical protein 0.009 0.0456 0.5
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0068 0.0307 0.0307
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.009 0.0456 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0173 0.1039 0.0836
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.009 0.0456 0.0197
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.009 0.0456 0.0207
Giardia lamblia GTOR 0.1389 0.9537 0.9524
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0065 0.0281 0.0281
Leishmania major hypothetical protein, unknown function 0.009 0.0456 0.0207
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.009 0.0456 0.0456
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.009 0.0456 0.0207
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0456 0.0207
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.1456 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0749 0.5063 0.5175
Echinococcus multilocularis 0.009 0.0456 0.0456
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1389 0.9537 0.9537
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0456 0.034
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0263 0.1665 0.1511
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.009 0.0456 0.0456
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1389 0.9537 1
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0263 0.1665 0.1665
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0466 0.3085 0.3042
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.009 0.0456 0.0456
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0546 0.0546
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0062 0.0264 0.0258
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0232 0.1451 0.1347
Loa Loa (eye worm) phosphatidylinositol 3 0.0466 0.3085 0.3001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0263 0.1665 0.1725
Brugia malayi Bromodomain containing protein 0.0042 0.0119 0.0106
Schistosoma mansoni bromodomain containing protein 0.0069 0.0309 0.0309
Trichomonas vaginalis PIKK family atypical protein kinase 0.0466 0.3085 0.3042
Trichomonas vaginalis PIKK family atypical protein kinase 0.1033 0.7049 0.7317
Mycobacterium tuberculosis Conserved hypothetical protein 0.009 0.0456 0.5
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0466 0.3085 0.3042

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -5 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.951 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.745 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.494 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.414 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.41 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.353 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.201 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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