Detailed information for compound 163290

Basic information

Technical information
  • TDR Targets ID: 163290
  • Name: 3,5-dichloro-N-(4-chlorophenyl)-2-hydroxybenz amide
  • MW: 316.567 | Formula: C13H8Cl3NO2
  • H donors: 2 H acceptors: 2 LogP: 4.84 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)NC(=O)c1cc(Cl)cc(c1O)Cl
  • InChi: 1S/C13H8Cl3NO2/c14-7-1-3-9(4-2-7)17-13(19)10-5-8(15)6-11(16)12(10)18/h1-6,18H,(H,17,19)
  • InChiKey: USFZGCVGLNMJPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3,5-dichloro-N-(4-chlorophenyl)-2-hydroxy-benzamide
  • 1151-51-5
  • Trichlorosalicylanilide
  • AE-848/32789054
  • ZINC00988783
  • Oprea1_377606
  • Benzamide, 3,5-dichloro-N-(4-chlorophenyl)-2-hydroxy-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Onchocerca volvulus Chitinase Starlite/ChEMBL References
Onchocerca volvulus References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 Get druggable targets OG5_130698 All targets in OG5_130698
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Mycobacterium ulcerans chitinase/cellulase Get druggable targets OG5_126929 All targets in OG5_126929
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Entamoeba histolytica chitinase, putative Get druggable targets OG5_126929 All targets in OG5_126929
Loa Loa (eye worm) microfilarial chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Loa Loa (eye worm) chitinase I Get druggable targets OG5_126929 All targets in OG5_126929
Mycobacterium tuberculosis Possible chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Plasmodium berghei conserved Plasmodium protein, unknown function Get druggable targets OG5_130698 All targets in OG5_130698
Onchocerca volvulus Get druggable targets OG5_130698 All targets in OG5_130698
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Neospora caninum hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Plasmodium knowlesi conserved Plasmodium protein, unknown function Get druggable targets OG5_130698 All targets in OG5_130698
Leishmania infantum chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 Get druggable targets OG5_130698 All targets in OG5_130698
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Onchocerca volvulus Get druggable targets OG5_130698 All targets in OG5_130698
Plasmodium yoelii Arabidopsis thaliana At1g02330/T6A9_12-related Get druggable targets OG5_130698 All targets in OG5_130698
Plasmodium vivax hypothetical protein, conserved Get druggable targets OG5_130698 All targets in OG5_130698
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein Get druggable targets OG5_130698 All targets in OG5_130698
Mycobacterium ulcerans chitinase/cellulase Get druggable targets OG5_126929 All targets in OG5_126929
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126929 All targets in OG5_126929
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Schistosoma japonicum IPR010756,Hepatocellular carcinoma-associated antigen 59,domain-containing Get druggable targets OG5_130698 All targets in OG5_130698
Leishmania donovani chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Leishmania major chitinase Get druggable targets OG5_126929 All targets in OG5_126929
Plasmodium falciparum conserved protein, unknown function Get druggable targets OG5_130698 All targets in OG5_130698
Brugia malayi Endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Brugia malayi endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Toxoplasma gondii hypothetical protein Get druggable targets OG5_130698 All targets in OG5_130698
Loa Loa (eye worm) cuticular endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Candida albicans chitinase similar to Ajellomyces capsulatus CTS1 Get druggable targets OG5_126929 All targets in OG5_126929
Brugia malayi endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
Candida albicans chitinase similar to Ajellomyces capsulatus CTS1 Get druggable targets OG5_126929 All targets in OG5_126929
Onchocerca volvulus Putative endochitinase Get druggable targets OG5_126929 All targets in OG5_126929
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 32 0.0143 0.1784 0.2504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0228 0.4661 0.6543
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0143 0.1784 0.2504
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0143 0.1784 0.5
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0177 0.292 0.41
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Echinococcus granulosus roundabout 2 0.0228 0.4661 0.3502
Toxoplasma gondii hypothetical protein 0.0144 0.1822 0.5
Schistosoma mansoni ephrin receptor 0.0185 0.322 0.2624
Onchocerca volvulus 0.0143 0.1784 0.6108
Onchocerca volvulus 0.0143 0.1784 0.6108
Onchocerca volvulus 0.0143 0.1784 0.6108
Loa Loa (eye worm) hypothetical protein 0.0144 0.1822 0.2558
Schistosoma mansoni tripartite motif protein trim9 0.0143 0.1784 0.0747
Echinococcus granulosus titin 0.0177 0.292 0.1383
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0143 0.1784 0.2504
Schistosoma mansoni cell adhesion molecule 0.0177 0.292 0.2232
Brugia malayi Endochitinase 0.0102 0.0374 0.0525
Schistosoma mansoni factor for adipocyte differentiation 0.0143 0.1784 0.0747
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Loa Loa (eye worm) projectin 0.0177 0.292 0.41
Loa Loa (eye worm) hypothetical protein 0.0241 0.5116 0.7182
Echinococcus granulosus neuroglian 0.0228 0.4661 0.3502
Onchocerca volvulus 0.0143 0.1784 0.6108
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0177 0.292 0.41
Echinococcus multilocularis transfer RNA-Phe 0.0177 0.292 0.1383
Loa Loa (eye worm) hypothetical protein 0.0177 0.292 0.41
Onchocerca volvulus 0.0143 0.1784 0.6108
Loa Loa (eye worm) hypothetical protein 0.0208 0.3979 0.5586
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Brugia malayi Hepatocellular carcinoma-associated antigen 59 family protein 0.0144 0.1822 0.2558
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0177 0.292 0.41
Schistosoma mansoni cell adhesion molecule 0.0351 0.8864 1
Loa Loa (eye worm) hypothetical protein 0.0157 0.2238 0.3143
Onchocerca volvulus 0.0143 0.1784 0.6108
Schistosoma mansoni nephrin 0.0228 0.4661 0.4507
Loa Loa (eye worm) hypothetical protein 0.0177 0.292 0.41
Loa Loa (eye worm) hypothetical protein 0.03 0.7123 1
Echinococcus multilocularis Immunoglobulin 0.0157 0.2238 0.0554
Echinococcus multilocularis Immunoglobulin 0.0157 0.2238 0.0554
Echinococcus multilocularis neuroglian 0.019 0.3375 0.1937
Echinococcus granulosus defective proboscis extension response 0.0157 0.2238 0.0554
Onchocerca volvulus 0.0143 0.1784 0.6108
Schistosoma mansoni myosin-binding protein-related 0.0177 0.292 0.2232
Schistosoma mansoni protein tyrosine phosphatase 0.0143 0.1784 0.0747
Entamoeba histolytica chitinase, putative 0.0091 0 0.5
Echinococcus granulosus roundabout 2 0.0228 0.4661 0.3502
Onchocerca volvulus Putative endochitinase 0.0102 0.0374 0.1281
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0157 0.2238 0.0554
Brugia malayi hypothetical protein 0.0143 0.1784 0.2504
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0157 0.2238 0.1341
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0157 0.2238 0.1341
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Onchocerca volvulus 0.0143 0.1784 0.6108
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0143 0.1784 0.2504
Echinococcus granulosus Hepatocellular carcinoma associated antigen 59 0.0144 0.1822 0.0047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Schistosoma mansoni titin 0.0177 0.292 0.2232
Loa Loa (eye worm) UNCoordinated family member 0.0143 0.1784 0.2504
Echinococcus granulosus titin 0.0177 0.292 0.1383
Echinococcus granulosus twitchin 0.019 0.3375 0.1937
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0228 0.4661 0.3502
Loa Loa (eye worm) TK/KIN16 protein kinase 0.025 0.5415 0.7603
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Onchocerca volvulus 0.0143 0.1784 0.6108
Plasmodium falciparum conserved protein, unknown function 0.0144 0.1822 0.5
Echinococcus multilocularis Hepatocellular carcinoma associated antigen 59 0.0144 0.1822 0.0047
Echinococcus multilocularis neuroglian 0.0228 0.4661 0.3502
Schistosoma mansoni hypothetical protein 0.0143 0.1784 0.0747
Loa Loa (eye worm) lethal protein 805 0.0143 0.1784 0.2504
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0143 0.1784 0.2504
Loa Loa (eye worm) CAMK protein kinase 0.0177 0.292 0.41
Brugia malayi myotactin form B 0.0143 0.1784 0.2504
Brugia malayi myotactin form A 0.0143 0.1784 0.2504
Plasmodium vivax hypothetical protein, conserved 0.0144 0.1822 0.5
Loa Loa (eye worm) hypothetical protein 0.0228 0.4661 0.6543
Onchocerca volvulus 0.0143 0.1784 0.6108
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Loa Loa (eye worm) hypothetical protein 0.03 0.7123 1
Schistosoma mansoni vesicular amine transporter 0.0157 0.2238 0.1341
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0177 0.292 0.41
Echinococcus multilocularis roundabout 2 0.0228 0.4661 0.3502
Brugia malayi Immunoglobulin I-set domain containing protein 0.0228 0.4661 0.6543
Schistosoma mansoni nephrin 0.0333 0.8259 0.921
Loa Loa (eye worm) hypothetical protein 0.0241 0.5116 0.7182
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Brugia malayi Lethal protein 805 0.0143 0.1784 0.2504
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0228 0.4661 0.4507
Schistosoma mansoni hypothetical protein 0.0144 0.1822 0.0797
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Brugia malayi Twik (KCNK-like) family of potassium channels, alpha subunit 30. 0.0143 0.1784 0.2504
Schistosoma mansoni titin 0.0143 0.1784 0.0747
Onchocerca volvulus Putative endochitinase 0.0102 0.0374 0.1281
Brugia malayi Fibronectin type III domain containing protein 0.0143 0.1784 0.2504
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0228 0.4661 0.6543
Loa Loa (eye worm) myotactin form A 0.0143 0.1784 0.2504
Schistosoma mansoni neuroglian 0.0228 0.4661 0.4507
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Echinococcus multilocularis titin 0.0177 0.292 0.1383
Loa Loa (eye worm) hypothetical protein 0.0157 0.2238 0.3143
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Brugia malayi Immunoglobulin I-set domain containing protein 0.03 0.7123 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0194 0.3524 0.4948
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0194 0.3524 0.2119
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0143 0.1784 0.2504
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0228 0.4661 0.3502
Onchocerca volvulus 0.0143 0.1784 0.6108
Brugia malayi Immunoglobulin I-set domain containing protein 0.025 0.5415 0.7603
Brugia malayi SPRY domain containing protein 0.0143 0.1784 0.2504
Leishmania major hypothetical protein, conserved 0.0143 0.1784 1
Trypanosoma brucei Fibronectin type III domain containing protein, putative 0.0143 0.1784 0.5
Onchocerca volvulus 0.0177 0.292 1
Schistosoma mansoni hypothetical protein 0.0143 0.1784 0.0747
Echinococcus multilocularis roundabout 2 0.0384 1 1
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0185 0.322 0.1748
Brugia malayi hypothetical protein 0.03 0.7123 1
Loa Loa (eye worm) hypothetical protein 0.03 0.7123 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0185 0.322 0.1748
Trypanosoma cruzi Fibronectin type III domain containing protein, putative 0.0143 0.1784 0.5
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0228 0.4661 0.3502
Schistosoma mansoni factor for adipocyte differentiation 0.0143 0.1784 0.0747
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0143 0.1784 0.0747
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0228 0.4661 0.6543
Brugia malayi Fibronectin type III domain containing protein 0.0143 0.1784 0.2504
Brugia malayi Fibronectin type III domain containing protein 0.0143 0.1784 0.2504
Trypanosoma cruzi hypothetical protein, conserved 0.0143 0.1784 0.5
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Echinococcus granulosus nephrin 0.0177 0.292 0.1383
Echinococcus granulosus contactin 0.0228 0.4661 0.3502
Brugia malayi Fibronectin type III domain containing protein 0.03 0.7123 1
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0177 0.292 0.1383
Loa Loa (eye worm) hypothetical protein 0.0157 0.2238 0.3143
Onchocerca volvulus 0.0144 0.1822 0.6239
Brugia malayi Lethal protein 805 0.0143 0.1784 0.2504
Brugia malayi protein unc-22 0.0177 0.292 0.41
Echinococcus multilocularis roundabout 2 0.0228 0.4661 0.3502
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0143 0.1784 0.0747
Echinococcus granulosus neuroglian 0.019 0.3375 0.1937
Onchocerca volvulus 0.0144 0.1822 0.6239
Onchocerca volvulus Putative endochitinase 0.0102 0.0374 0.1281
Schistosoma mansoni hypothetical protein 0.0177 0.292 0.2232
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0194 0.3524 0.2119
Onchocerca volvulus 0.0177 0.292 1
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0143 0.1784 0.0747
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Echinococcus granulosus Immunoglobulin 0.0157 0.2238 0.0554
Schistosoma mansoni cell adhesion molecule 0.0228 0.4661 0.4507
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0143 0.1784 0.0747
Brugia malayi Fibronectin type III domain containing protein 0.0143 0.1784 0.2504
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0208 0.3979 0.2672
Schistosoma mansoni serine/threonine protein kinase 0.0177 0.292 0.2232
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0228 0.4661 0.6543
Schistosoma mansoni factor for adipocyte differentiation 0.0143 0.1784 0.0747
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Schistosoma mansoni titin 0.0177 0.292 0.2232
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0228 0.4661 0.3502
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0228 0.4661 0.3502
Schistosoma mansoni hemicentin 0.0177 0.292 0.2232
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0194 0.3524 0.4948
Brugia malayi Fibronectin type III domain containing protein 0.0143 0.1784 0.2504
Onchocerca volvulus 0.0177 0.292 1
Brugia malayi Protein-tyrosine phosphatase 0.0143 0.1784 0.2504
Brugia malayi Immunoglobulin I-set domain containing protein 0.0177 0.292 0.41
Brugia malayi endochitinase 0.0102 0.0374 0.0525
Schistosoma mansoni cell adhesion molecule 0.0228 0.4661 0.4507
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Loa Loa (eye worm) hypothetical protein 0.0144 0.1822 0.2558
Loa Loa (eye worm) hypothetical protein 0.0143 0.1784 0.2504
Schistosoma mansoni cell adhesion molecule 0.0177 0.292 0.2232

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 12.4 uM Inhibition of Onchocerca volvulus L3 larvae chitinase using 4-methylumbelliferyl-N,N',N''-beta-chitotrioside as a profluorescent substrate after 10 mins by fluorometric analysis ChEMBL. 21534605
IC50 (functional) = 185 uM Inhibition of autophosphorylation of the two-component signal transduction system kinase was measured using the KinA/Spo0F regulatory system of B. subtilis. ChEMBL. 9685233
IC50 (functional) = 185 uM Inhibition of autophosphorylation of the two-component signal transduction system kinase was measured using the KinA/Spo0F regulatory system of B. subtilis. ChEMBL. 9685233
Inhibition (binding) Inhibition of PARP in human SCC25 cells assessed as inhibition of MNNG-induced NAD(H) depletion at 1 mM preincubated for 5 mins before MNNG challenge measured after 30 mins ChEMBL. 21692479
Inhibition (binding) Inhibition of SIRT1 ChEMBL. 21692479
Inhibition (binding) = 10 % Inhibition of PARG using [alpha-32P]ADP-ribose polymers at 500 uM after 5 mins by TRAP assay ChEMBL. 21692479

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.