Detailed information for compound 1637354

Basic information

Technical information
  • TDR Targets ID: 1637354
  • Name: N-[[4-[2-[(3,4-dimethylphenyl)amino]-2-oxoeth oxy]-3-methoxyphenyl]methylideneamino]pyridin e-4-carboxamide
  • MW: 432.472 | Formula: C24H24N4O4
  • H donors: 2 H acceptors: 3 LogP: 3.34 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(/C=N/NC(=O)c2ccncc2)ccc1OCC(=O)Nc1ccc(c(c1)C)C
  • InChi: 1S/C24H24N4O4/c1-16-4-6-20(12-17(16)2)27-23(29)15-32-21-7-5-18(13-22(21)31-3)14-26-28-24(30)19-8-10-25-11-9-19/h4-14H,15H2,1-3H3,(H,27,29)(H,28,30)/b26-14+
  • InChiKey: ZNMIMCSLNQKTDR-VULFUBBASA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[[4-[2-[(3,4-dimethylphenyl)amino]-2-oxo-ethoxy]-3-methoxy-phenyl]methyleneamino]pyridine-4-carboxamide
  • N-[[4-[2-[(3,4-dimethylphenyl)amino]-2-oxoethoxy]-3-methoxyphenyl]methyleneamino]-4-pyridinecarboxamide
  • N-[[4-[2-[(3,4-dimethylphenyl)amino]-2-keto-ethoxy]-3-methoxy-benzylidene]amino]isonicotinamide
  • N-[[4-[2-[(3,4-dimethylphenyl)amino]-2-oxo-ethoxy]-3-methoxy-phenyl]methylideneamino]pyridine-4-carboxamide
  • ST073469
  • BAS 01248444

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Bromodomain containing protein 0.0034 0.0156 0.0393
Schistosoma mansoni hypothetical protein 0.0195 0.1074 0.1074
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0028 0.0192
Schistosoma mansoni ap endonuclease 0.0014 0.0045 0.0045
Brugia malayi MAP kinase sur-1 0.0039 0.0186 0.0467
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0156 0.0156
Entamoeba histolytica acyl-CoA synthetase, putative 0.0035 0.0167 0.7342
Giardia lamblia PHD finger protein 15 0.0034 0.0156 0.7903
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0008 0.0008
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0008 0.0008
Trypanosoma brucei protein kinase, putative 0.0039 0.0186 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0156 0.0156
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0045 0.0219 0.0219
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0008 0.0008
Onchocerca volvulus 0.001 0.0025 0.0801
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0008 0.0008
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0045 0.0219 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0157 0.0157
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0014 0.0045 0.1258
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0311 0.1736 1
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0186 0.0941
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0012 0.0035 0.0541
Brugia malayi AMP-binding enzyme family protein 0.001 0.0025 0.0062
Onchocerca volvulus Alhambra homolog 0.0034 0.0156 0.7031
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0039 0.0186 1
Schistosoma mansoni serine/threonine protein kinase 0.0039 0.0186 0.0186
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0157 0.0157
Echinococcus multilocularis geminin 0.0195 0.1074 0.1074
Loa Loa (eye worm) hypothetical protein 0.0035 0.0167 0.0167
Brugia malayi nuclear hormone receptor 0.0007 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0057 0.0292 0.0292
Leishmania major 4-coumarate:coa ligase-like protein 0.0035 0.0167 0.8854
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Echinococcus multilocularis cpg binding protein 0.0023 0.0094 0.0094
Brugia malayi MH2 domain containing protein 0.0089 0.047 0.1181
Echinococcus multilocularis mitogen activated protein kinase 3 0.0039 0.0186 0.0186
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0011 0.0027 0.0027
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0045 0.0219 0.0219
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0156 0.0156
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0045 0.0219 0.055
Treponema pallidum hypothetical protein 0.0045 0.0219 1
Schistosoma mansoni cpg binding protein 0.0023 0.0094 0.0094
Plasmodium vivax acyl-CoA synthetase, putative 0.0026 0.0116 0.4714
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0025
Schistosoma mansoni coup transcription factor 0.0007 0.0008 0.0008
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.001 0.0025 0.0407
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0008 0.0008
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.001 0.0025 0.0407
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0025 0.0407
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0034 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0025 0.0407
Brugia malayi PHD-finger family protein 0.0034 0.0156 0.0393
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0186 0.0941
Echinococcus multilocularis JmjC domain containing protein 4 0.0011 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0008 0.002
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0045 0.1043
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0008 0.0008
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0008 0.002
Loa Loa (eye worm) hypothetical protein 0.0705 0.398 0.398
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0034 0.0157 0.0157
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0035 0.0167 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0035 0.0167 0.745
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0008 0.002
Loa Loa (eye worm) MH2 domain-containing protein 0.0089 0.047 0.047
Brugia malayi CXXC zinc finger family protein 0.0021 0.0087 0.0219
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0157 0.0157
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0219 0.1134
Brugia malayi PHD-finger family protein 0.0012 0.0035 0.0088
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0027 0.0144
Loa Loa (eye worm) hypothetical protein 0.0034 0.0156 0.0156
Schistosoma mansoni phd/f-box containing protein 0.0011 0.0027 0.0027
Plasmodium falciparum JmjC domain-containing protein, putative 0.0011 0.0027 0.0119
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Plasmodium falciparum acyl-CoA synthetase 0.0026 0.0116 0.4714
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0003
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0011 0.0027 0.0068
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0065 0.0163
Loa Loa (eye worm) oxidoreductase 0.001 0.0025 0.0025
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0011 0.0027 0.0119
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0008 0.002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0108 0.4523
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0035 0.0167 1
Brugia malayi jmjC domain containing protein 0.0011 0.0027 0.0068
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.001 0.0025 0.0407
Brugia malayi AMP-binding enzyme family protein 0.001 0.0025 0.0062
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0045 0.0219 0.055
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0167 0.0167
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0219 0.1134
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0167 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0008 0.0008
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.059 0.059
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0034 0.0157 0.0395
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0011 0.0027 0.0144
Brugia malayi nuclear receptor NHR-88 0.0007 0.0008 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0008 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0008 0.0008
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0039 0.0186 0.8292
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0156 0.6773
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0167 0.745
Toxoplasma gondii manganese resistance 1 protein, putative 0.0045 0.0219 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0157 0.0157
Schistosoma mansoni na/ca exchanger 0.0045 0.0219 0.0219
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0167 1
Echinococcus granulosus JmjC domain containing protein 4 0.0011 0.0027 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0027 0.0027
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0167 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0008 0.0008
Brugia malayi ecdysteroid receptor 0.0007 0.0008 0.002
Toxoplasma gondii PHD-finger domain-containing protein 0.0011 0.0028 0.0159
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Brugia malayi jmjC domain containing protein 0.0042 0.0203 0.0511
Brugia malayi AF-10 protein 0.0011 0.0028 0.007
Plasmodium vivax hypothetical protein, conserved 0.0012 0.0035 0.0541
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0311 0.1736 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0008 0.002
Entamoeba histolytica acyl-CoA synthetase, putative 0.0035 0.0167 0.7342
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0008 0.002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0025 0.0407
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0039 0.0186 1
Loa Loa (eye worm) hypothetical protein 0.0045 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0359 0.0359
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0008 0.002
Plasmodium falciparum phd finger protein, putative 0.0034 0.0156 0.6773
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0014 0.0045 0.1043
Leishmania major 4-coumarate:coa ligase-like protein 0.0035 0.0167 0.8854
Schistosoma mansoni hypothetical protein 0.0034 0.0156 0.0156
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.001 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0035 0.0035
Loa Loa (eye worm) histone methyltransferase 0.0007 0.0003 0.0003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0008 0.002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.001 0.0025 0.0025
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0014 0.0045 0.1258
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0012 0.0034 0.0034
Loa Loa (eye worm) transcription factor SMAD2 0.0089 0.047 0.047
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0011 0.0027 0.0119
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0008 0.0008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0026 0.0116 0.493
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0008 0.002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0008 0.002
Entamoeba histolytica acyl-coA synthetase, putative 0.0035 0.0167 0.7342
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.001 0.0025 0.0407
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0231 0.0231
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0045 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Echinococcus granulosus phd:f box containing protein 0.0011 0.0027 0.0027
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0011 0.0027 0.0144
Schistosoma mansoni hypothetical protein 0.0195 0.1074 0.1074
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0008 0.002
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0014 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0045 0.0219 0.0219
Echinococcus multilocularis jumonji domain containing 1A 0.0011 0.0027 0.0027
Echinococcus multilocularis lysine specific demethylase 6a 0.0011 0.0027 0.0027
Plasmodium vivax JmjC domain containing protein 0.0011 0.0027 0.0119
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0196 0.0196
Onchocerca volvulus 0.001 0.0025 0.0801
Schistosoma mansoni protein phosphatase 2C 0.0011 0.0027 0.0027
Schistosoma mansoni jumonji domain containing protein 0.0011 0.0027 0.0027
Echinococcus multilocularis phd:f box containing protein 0.0011 0.0027 0.0027
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0045 0.0219 0.0219
Brugia malayi steroid hormone receptor 0.0007 0.0008 0.002
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.001 0.0025 0.0407
Onchocerca volvulus 0.0035 0.0167 0.7555
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0008 0.0008
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0045 0.0219 0.0219
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0034 0.0157 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0008 0.002
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0008 0.0008
Echinococcus multilocularis peregrin 0.0034 0.0156 0.0156
Echinococcus granulosus lysine specific demethylase 5A 0.0042 0.0203 0.0203
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0116 0.6421
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0156 0.6773
Toxoplasma gondii histone lysine methyltransferase SET1 0.004 0.0196 0.8796
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.001 0.0025 0.0407
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0027 0.0027
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0008 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0186 0.0941
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0008 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0014 0.0045 0.1421
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0156 0.6773
Onchocerca volvulus 0.001 0.0025 0.0801
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0008 0.0008
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0034 0.0157 0.0157
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0026 0.0116 0.5
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0108 0.4523
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0045 0.0118
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0231 0.0231
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0035 0.0167 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0014 0.0045 0.1258
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0008 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0108 0.4523
Giardia lamblia Kinase, CMGC MAPK 0.0039 0.0186 1
Loa Loa (eye worm) solute carrier family 8 0.1763 1 1
Schistosoma mansoni acetyl-CoA synthetase 0.001 0.0025 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0008 0.0008
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0167 0.042
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1165 0.6595 0.6595
Plasmodium falciparum cation/H+ antiporter 0.0045 0.0219 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0203 0.0203
Echinococcus granulosus lysine specific demethylase 6a 0.0011 0.0027 0.0027
Brugia malayi jmjC domain containing protein 0.0011 0.0027 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0008 0.002
Echinococcus granulosus geminin 0.0195 0.1074 0.1074
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0014 0.0045 0.1408
Echinococcus multilocularis sodium calcium exchanger 0.1763 1 1
Onchocerca volvulus 0.0021 0.0087 0.3746
Schistosoma mansoni jumonji/arid domain-containing protein 0.0042 0.0203 0.0203
Loa Loa (eye worm) hypothetical protein 0.0035 0.0167 0.0167
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0014 0.0045 0.0045
Loa Loa (eye worm) AMP-binding enzyme family protein 0.001 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0045 0.0219 0.0219
Echinococcus granulosus mitogen activated protein kinase 0.0039 0.0186 0.0186
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0462 0.0462
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0011 0.0028 0.0192
Entamoeba histolytica sodium/calcium exchanger protein, putative 0.0045 0.0219 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0167 1
Echinococcus granulosus mitogen activated protein kinase 3 0.0039 0.0186 0.0186
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0167 0.7342
Brugia malayi exodeoxyribonuclease III family protein 0.0014 0.0045 0.0113
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Leishmania major 4-coumarate:coa ligase-like protein 0.0035 0.0167 0.8854
Loa Loa (eye worm) hypothetical protein 0.0045 0.0219 0.0219
Echinococcus granulosus jumonji domain containing 1A 0.0011 0.0027 0.0027
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.001 0.0025 0.0062
Loa Loa (eye worm) jmjC domain-containing protein 0.0011 0.0027 0.0027
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0058 0.0058
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.001 0.0025 0.0025
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0045 0.0219 0.0219
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0014 0.0045 0.1043
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0045 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.0011 0.0027 0.0027
Schistosoma mansoni sodium/calcium exchanger 0.1763 1 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0021 0.0087 0.0087
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.001 0.0025 0.0407
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0008 0.0008
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0008 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0108 0.4523
Brugia malayi jmjC domain containing protein 0.0011 0.0027 0.0068
Schistosoma mansoni phosphatidylserine receptor 0.0011 0.0027 0.0027
Plasmodium vivax cation/H+ antiporter, putative 0.0045 0.0219 1
Trichomonas vaginalis ap endonuclease, putative 0.0014 0.0045 0.0118
Schistosoma mansoni ap endonuclease 0.0014 0.0045 0.0045
Echinococcus granulosus cpg binding protein 0.0023 0.0094 0.0094
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0008 0.002
Schistosoma mansoni cpg binding protein 0.0023 0.0094 0.0094
Brugia malayi Sodium/calcium exchanger protein 0.0705 0.398 1
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0039 0.0186 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0008 0.002
Onchocerca volvulus 0.001 0.0025 0.0801
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0008 0.0008
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0039 0.0186 1
Schistosoma mansoni hypothetical protein 0.0011 0.0028 0.0028
Echinococcus multilocularis mitogen activated protein kinase 0.0039 0.0186 0.0186
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0011 0.0027 0.0144
Trichomonas vaginalis CMGC family protein kinase 0.0039 0.0186 0.0941
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0008 0.0008
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0003 0.0003
Brugia malayi AMP-binding enzyme family protein 0.001 0.0025 0.0062
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.059 0.059
Brugia malayi AMP-binding enzyme family protein 0.001 0.0025 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0167 0.042
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0186 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0008 0.0008
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.0219 0.1134
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0039 0.0186 0.0186
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0008 0.0008
Mycobacterium ulcerans acyl-CoA synthetase 0.0035 0.0167 1
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0045 0.0219 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0007 0.0008 0.0008
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0039 0.0186 1
Brugia malayi acetyl-Coenzyme A synthetase 2 0.001 0.0025 0.0062
Brugia malayi jmjC domain containing protein 0.011 0.059 0.1483
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0011 0.0028 0.0159
Mycobacterium tuberculosis Probable ionic transporter integral membrane protein ChaA 0.0045 0.0219 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0008 0.0008
Loa Loa (eye worm) AMP-binding enzyme family protein 0.001 0.0025 0.0025
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.001 0.0025 0.0407
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0014 0.0045 0.0045
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0045 0.0219 0.0219
Loa Loa (eye worm) jmjC domain-containing protein 0.0042 0.0203 0.0203
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0012 0.0034 0.0034
Loa Loa (eye worm) hypothetical protein 0.0026 0.0116 0.0116
Echinococcus granulosus peregrin 0.0034 0.0156 0.0156
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0014 0.0045 0.5
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0039 0.0186 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0156 0.0156
Toxoplasma gondii exonuclease III APE 0.0014 0.0045 0.1043
Schistosoma mansoni cpg binding protein 0.0021 0.0087 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0035 0.0167 0.042
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0008 0.0008
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0008 0.002
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0014 0.0045 0.1258
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0167 0.7342

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 47.7548 uM PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Rango (Ran-regulated importin-beta cargo) - Importin beta complex formation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID540273] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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